Déconvolution de données hyperspectrales pour l'instrument MUSE du VLT

Le traitement et l'analyse de cubes de données hyperspectrales, tels que fournis par le spectro-imageur MUSE capable d'acquérir simultanément des images à un grand nombre de longueurs d'onde, est un challenge pour la communauté signal-image. Une difficulté particulière pour les observations depuis le sol est due à la réponse de la chaîne d'acquisition, plus précisément sa composante spatiale FSF. Cette thèse aborde un problème de déconvolution de cubes hyperspectraux, nécessitant au préalable la modélisation et l'estimation de la FSF. Nous montrons que la FSF, due à l'instrument et aux turbulences atmosphériques éventuellement corrigées par l'optique adaptative (OA), peut être modélisée en tout point du cube par une fonction de Moffat. Dans le cas sans OA, une variation spectrale linéaire des paramètres de cette fonction permet une bonne approximation de la FSF dans tout le cube, avec seulement quatre paramètres. Puis nous étudions l'estimation des paramètres de ce modèle de FSF pour l'ensemble des longueurs d'onde, à partir de l'observation d'une étoile isolée. Nous proposons des schémas d'estimation, au sens du maximum de vraisemblance et de la moyenne a posteriori, pour ces paramètres ainsi que pour des paramètres de nuisance tels que le spectre et la position de l'étoile. Enfin, nous abordons un problème de déconvolution hyperspectrale pour l'étude de la cinématique de galaxies. Par effet Doppler, ce problème se traduit en l'estimation de cartes de flux, de position et de largeur d'une raie spectrale d'émission de la galaxie. Pour cela, nous proposons des estimateurs de type moyenne a posteriori calculés par des simulation de Monte Carlo par Chaînes de Markov (MCMC).Hyperspectral instruments can acquire images simultaneously at a large number of wavelengths. Processing and analysing such data is a challenge for the signal-image community. For ground-based observations, one cornerstone is the Point Spread Function (PSF) and particularly its spatial component (FSF). During this thesis, we tackled a hyperspectral deconvolution problem, which requires to model and estimate the FSF. First, we looked into the modelling of the FSF at every position of the hyperspectral data cube. We showed that this FSF can be approximated, at each wavelength, by a Moffat function. Without a correction by adaptive optics, modelling the scale and shape parameters of the Moffat function by a linear function with respect to the wavelength allows the FSF to be well approximated in the whole cube, with only 4 parameters. Then, we studied the FSF estimation for all wavelengths, based on the former model, from the observation of an isolated star. We proposed several estimation strategies, using maximum likelihood and posterior mean estimators for the FSF model parameters, as well as for the nuisance parameters, such as the star's spectrum and position. Finally, we focused on hyperspectral deconvolution for the study of galaxies kinematics. Thanks to the Doppler effect, this issue is reflected by the estimation of flux maps, position and width from an emission line in the galaxy spectrum, taking into account the 3D PSF. We proposed to estimate these parameters with posterior mean estimators, which are computed with Monte Carlo Markov Chains (MCMC) algorithms

Detailed examination of a packet collision model for Bluetooth Low Energy advertising mode

The aim of this paper is to investigate the amount of energy that is required to successfully transmit information inside the Bluetooth Low Energy (BLE) advertising packets. There are applications that require more than one BLE node to simultaneously transmit data. The BLE protocol utilizes a specific communication method termed advertising mode to perform unidirectional broadcasts of data from the advertising devices. However, with an increased number of BLE devices advertising simultaneously, there will be inevitable packet collisions from the advertising devices. This results in a waste of energy, specifically in low-power applications where lower consumption is desirable to minimize the need for battery replacements. This paper examines a packet collision model for the BLE advertising mode with the results validated using experimental data. Our analysis shows that when the throughput of the BLE network starts to fall due to an increase in the number of packet collisions, the energy consumption of the BLE nodes increase exponentially with respect to the number of nodes

Signal Quality and Compactness of a Dual-Accelerometer System for Gyro-Free Human Motion Analysis

There is a growing interest in measuring human activities via worn inertial sensors, and situating two accelerometers on a body segment allows accessing rotational kinematic information, at a significantly lower energy cost when compared with gyroscopes. However, the placement of sensors has not been widely considered in the literature. In practice, dual-accelerometer systems should be built as compact as possible to ensure long-term wearability. In this paper, the impact of sensor placement and nature of human activity on signal quality is quantified by individual and differential signal-to-noise ratios (SNRs). To do so, noise-free signals are described by a 2-D kinematic model of a body segment as a function of kinematic variables and sensor location on the segment. Measurements are modelled as kinematic signals disturbed by zero mean additive Gaussian noise. Depending on the accuracy needed, one can choose a minimal SNR to achieve, with such dual-accelerometer arrangement. We estimate SNR and minimal sensor separations for three data sets, two from the public domain and one collected for this paper. The data sets give arm motion profiles for reaching, inertial data collected during locomotion on a treadmill and during activities of daily life. With a dual-accelerometer arrangement, we show that it is possible to achieve a good differential SNR for the analysis of various human activities if the separation between the two sensors and their placement is well chosen

Reconstruction of Angular Kinematics From Wrist-Worn Inertial Sensor Data for Smart Home Healthcare

This paper tackles the problem of the estimation of simplified human limb kinematics for home health care. Angular kinematics are widely used for gait analysis, for rehabilitation, and more generally for activity recognition. Residential monitoring requires particular sensor constraints to enable long-term user compliance. The proposed strategy is based on measurements from two low-power accelerometers placed only on the forearm, which makes it an ill-posed problem. The system is considered in a Bayesian framework, with a linear-Gaussian transition model with hard boundaries and a nonlinear-Gaussian observation model. The state vector and the associated covariance are estimated by a post-regularized particle filter (constrained-extended-RPF or C-ERPF), with an importance function whose moments are computed via an extended Kalman filter (EKF) linearization. Several sensor configurations are compared in terms of estimation performance, as well as power consumption and user acceptance. The proposed constrained-EKF (CERPF) is compared to other methods (EKF, constrained-EKF, and ERPF without transition constraints) on the basis of simulations and experimental measurements with motion capture reference. The proposed C-ERPF method coupled with two accelerometers on the wrist provides promising results with 19% error in average on both angles, compared with the motion capture reference, 10% on velocities and 7% on accelerations. This comparison highlights that arm kinematics can be estimated from only two accelerometers on the wrist. Such a system is a crucial step toward enabling machine monitoring of users health and activity on a daily basis

The Effects of Mindful Movement and Exercise on Depression

This evidence based review looked at any correlation between aerobics, running, Qi\u27 gong and mindfulness practices like meditation and yoga. What were their effects if any on depression? The findings from meta-analysis concluded that each in their own way did in fact relieve, improve or prevent signs and symptoms of depression as well as other dysregulatory and co-occurring health concerns like PTSD, Anxiety, Chronic Pain, insomnia and addiction issues. There was a clear correlation that an integrative approach to treatments and therapies needs further research in conventional medicine. Some treatments were found to be as effective if not more so than pharmaceuticals. As health care costs continue to rise, alternative, complementary and integrative cost effective treatments and therapies should be researched and considered. This review helps open the door for policy makers and medical professionals to look at treatment modalities in their own professions

Application of data fusion techniques and technologies for wearable health monitoring

Technological advances in sensors and communications have enabled discrete integration into everyday objects, both in the home and about the person. Information gathered by monitoring physiological, behavioural, and social aspects of our lives, can be used to achieve a positive impact on quality of life, health, and well-being. Wearable sensors are at the cusp of becoming truly pervasive, and could be woven into the clothes and accessories that we wear such that they become ubiquitous and transparent. To interpret the complex multidimensional information provided by these sensors, data fusion techniques are employed to provide a meaningful representation of the sensor outputs. This paper is intended to provide a short overview of data fusion techniques and algorithms that can be used to interpret wearable sensor data in the context of health monitoring applications. The application of these techniques are then described in the context of healthcare including activity and ambulatory monitoring, gait analysis, fall detection, and biometric monitoring. A snap-shot of current commercially available sensors is also provided, focusing on their sensing capability, and a commentary on the gaps that need to be bridged to bring research to market

Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10–24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10–14, 15–19, and 20–24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10–24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010–19, the rate per 100 000 of transport injury DALYs was reduced by 16·7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48·5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0·2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010–19. Interpretation: As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low–middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding: Bill & Melinda Gates Foundation

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019 a systematic analysis for the Global Burden of Disease Study 2019

Background Prevention, control, and treatment of respiratory tract cancers are important steps towards achieving target 3.4 of the UN Sustainable Development Goals (SDGs)-a one-third reduction in premature mortality due to non-communicable diseases by 2030. We aimed to provide global, regional, and national estimates of the burden of tracheal, bronchus, and lung cancer and larynx cancer and their attributable risks from 1990 to 2019. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 methodology, we evaluated the incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) of respiratory tract cancers (ie, tracheal, bronchus, and lung cancer and larynx cancer). Deaths from tracheal, bronchus, and lung cancer and larynx cancer attributable to each risk factor were estimated on the basis of risk exposure, relative risks, and the theoretical minimum risk exposure level input from 204 countries and territories, stratified by sex and Socio-demographic Index (SDI). Trends were estimated from 1990 to 2019, with an emphasis on the 2010-19 period. Findings Globally, there were 2.26 million (95% uncertainty interval 2.07 to 2.45) new cases of tracheal, bronchus, and lung cancer, and 2.04 million (1.88 to 2.19) deaths and 45.9 million (42.3 to 49.3) DALYs due to tracheal, bronchus, and lung cancer in 2019. There were 209 000 (194 000 to 225 000) new cases of larynx cancer, and 123 000 (115 000 to 133 000) deaths and 3.26 million (3.03 to 3.51) DALYs due to larynx cancer globally in 2019. From 2010 to 2019, the number of new tracheal, bronchus, and lung cancer cases increased by 23.3% (12.9 to 33.6) globally and the number of larynx cancer cases increased by 24.7% (16.0 to 34.1) globally. Global age-standardised incidence rates of tracheal, bronchus, and lung cancer decreased by 7.4% (-16.8 to 1.6) and age-standardised incidence rates of larynx cancer decreased by 3.0% (-10.5 to 5.0) in males over the past decade; however, during the same period, age-standardised incidence rates in females increased by 0.9% (-8.2 to 10.2) for tracheal, bronchus, and lung cancer and decreased by 0.5% (-8.4 to 8.1) for larynx cancer. Furthermore, although age-standardised incidence and death rates declined in both sexes combined from 2010 to 2019 at the global level for tracheal, bronchus, lung and larynx cancers, some locations had rising rates, particularly those on the lower end of the SDI range. Smoking contributed to an estimated 64.2% (61.9-66.4) of all deaths from tracheal, bronchus, and lung cancer and 63.4% (56.3-69.3) of all deaths from larynx cancer in 2019. For males and for both sexes combined, smoking was the leading specific risk factor for age-standardised deaths from tracheal, bronchus, and lung cancer per 100 000 in all SDI quintiles and GBD regions in 2019. However, among females, household air pollution from solid fuels was the leading specific risk factor in the low SDI quintile and in three GBD regions (central, eastern, and western sub-Saharan Africa) in 2019. Interpretation The numbers of incident cases and deaths from tracheal, bronchus, and lung cancer and larynx cancer increased globally during the past decade. Even more concerning, age-standardised incidence and death rates due to tracheal, bronchus, lung cancer and larynx cancer increased in some populations-namely, in the lower SDI quintiles and among females. Preventive measures such as smoking control interventions, air quality management programmes focused on major air pollution sources, and widespread access to clean energy should be prioritised in these settings. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd

Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10-24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10-24 years by age group (10-14 years, 15-19 years, and 20-24 years) and sex in 204 countries and territories between 1950 and 2019 for all causes, and between 1980 and 2019 by cause of death. We analyse variation in outcomes by region, age group, and sex, and compare annual rate of change in mortality in young people aged 10-24 years with that in children aged 0-9 years from 1990 to 2019. We then analyse the association between mortality in people aged 10-24 years and socioeconomic development using the GBD Socio-demographic Index (SDI), a composite measure based on average national educational attainment in people older than 15 years, total fertility rate in people younger than 25 years, and income per capita. We assess the association between SDI and all-cause mortality in 2019, and analyse the ratio of observed to expected mortality by SDI using the most recent available data release (2017). Findings In 2019 there were 1.49 million deaths (95% uncertainty interval 1.39-1.59) worldwide in people aged 10-24 years, of which 61% occurred in males. 32.7% of all adolescent deaths were due to transport injuries, unintentional injuries, or interpersonal violence and conflict; 32.1% were due to communicable, nutritional, or maternal causes; 27.0% were due to non-communicable diseases; and 8.2% were due to self-harm. Since 1950, deaths in this age group decreased by 30.0% in females and 15.3% in males, and sex-based differences in mortality rate have widened in most regions of the world. Geographical variation has also increased, particularly in people aged 10-14 years. Since 1980, communicable and maternal causes of death have decreased sharply as a proportion of total deaths in most GBD super-regions, but remain some of the most common causes in sub-Saharan Africa and south Asia, where more than half of all adolescent deaths occur. Annual percentage decrease in all-cause mortality rate since 1990 in adolescents aged 15-19 years was 1.3% in males and 1.6% in females, almost half that of males aged 1-4 years (2.4%), and around a third less than in females aged 1-4 years (2.5%). The proportion of global deaths in people aged 0-24 years that occurred in people aged 10-24 years more than doubled between 1950 and 2019, from 9.5% to 21.6%. Interpretation Variation in adolescent mortality between countries and by sex is widening, driven by poor progress in reducing deaths in males and older adolescents. Improving global adolescent mortality will require action to address the specific vulnerabilities of this age group, which are being overlooked. Furthermore, indirect effects of the COVID-19 pandemic are likely to jeopardise efforts to improve health outcomes including mortality in young people aged 10-24 years. There is an urgent need to respond to the changing global burden of adolescent mortality, address inequities where they occur, and improve the availability and quality of primary mortality data in this age group. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd