114 research outputs found
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
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- Barberio EL
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- Bardin DY
- Barillari T
- Barisonzi M
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- Barnett RM
- Baroncelli A
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- Barreiro F
- Barrera CO
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- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
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- Batley JR
- Battaglia A
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- Beauchemin PH
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- Becks KH
- Beddall A
- Beddall AJ
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- Bednyakov VA
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- Beimforde M
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- Belenguer MJ
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- Bellina F
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- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
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- Bensinger JR
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- Bilokon H
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- Bingul A
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- Blanchot G
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- Blocker C
- Blocki J
- Blondel A
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- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
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- Bogaerts JA
- Bogdanchikov A
- Bogouch A
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- Bondarenko VG
- Bondioli M
- Boonekamp M
- Boorman G
- Booth CN
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borroni S
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Bourdarios C
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- Boveia A
- Boyd J
- Boyko IR
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- Bozovic-Jelisavcic I
- Bracinik J
- Braem A
- Branchini P
- Brandenburg GW
- Brandt A
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- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
- Brenner R
- Bressler S
- Breton D
- Britton D
- Brochu FM
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- Brodbeck TJ
- Brodet E
- Broggi F
- Bromberg C
- Brooijmans G
- Brooks WK
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- Bruncko D
- Bruneliere R
- Brunet S
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- Bruni G
- Bruschi M
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- Buchanan J
- Buchanan NJ
- Buchholz P
- Buckingham RM
- Buckley AG
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- Budagov IA
- Budick B
- Bueso XP
- Bugge L
- Buira-Clark D
- Bulekov O
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
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- Butin F
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- Buttar CM
- Butterworth JM
- Buttinger W
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- Caforio D
- Cakir IT
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
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- Camarri P
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- Camilocci ES
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- Canepaa A
- Cantero J
- Capasso L
- Caprini I
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- Capriotti D
- Capua M
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- Carminati L
- Caron B
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- Carter AA
- Carter JR
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- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
- Cataneo F
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cauz D
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- Cavalleri P
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Cevenini F
- Chafaq A
- Chakraborty D
- Chan K
- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen T
- Chen X
- Cheng S
- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciba K
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciobotaru MD
- Cioccaa C
- Ciocio A
- Cirilli M
- Citterio M
- Ciubancan M
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- Clark PJ
- Cleland W
- Clemens JC
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- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Codina EP
- Coe P
- Cogan JG
- Coggeshall J
- Cogneras E
- Cojocaru CD
- Colas J
- Colijn AP
- Collaboration ATLAS
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- Constantinescu S
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- Correia AMH
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- Cortes-Gonzalez A
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- Costa G
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- Costin T
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- Cowden C
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- Cranshaw J
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Crosetti G
- Crupi R
- Cuciuc C-M
- Curatolo M
- Curtis CJ
- Curull XE
- Cwetanski P
- Czirr H
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Costa JBG
- Da Costa JGPF
- Da Silva PVM
- Da Via C
- Dabrowski W
- Dai T
- Dallapiccola C
- Daly CH
- Dam M
- Damazio DO
- Dameri M
- Damiani DS
- Danielsson HO
- Dannheim D
- Dao V
- Darbo G
- Darlea GL
- Daum C
- Dauvergne JP
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Dawson JW
- Daya-Ishmukhametova RK
- de Asmundis R
- De Castro S
- De Cecco S
- De Graat J
- De Groot N
- De Jong P
- De la Hoz SG
- De la Taille C
- De la Torre H
- De Lima JGR
- De Lotto B
- De Mora L
- De Nooij L
- De Pedis D
- De Regie JBDV
- De Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
- De K
- Dean S
- Debbe R
- Dedovich DV
- Degenhardt J
- Dehchar M
- Del Papa C
- Del Peso J
- Del Prete T
- Deliyergiyev M
- Dell'Acqua A
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- Della Pietra M
- Della Porta GZ
- della Volpe D
- Delmastro M
- Delpierre P
- Delruelle N
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
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- Denis RDS
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
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- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
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- Di Girolamo A
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- Di Luise S
- Di Mattia A
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- Di Nardo R
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- Diblen F
- Diehl EB
- Dietrich J
- Dietzscha TA
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- Doan TKO
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- Dolgoshein BA
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- Donszelmann TC
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- Dowell JD
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- Fatholahzadeh B
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
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- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
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- Ahmed K
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- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
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- Alemanno G
- Alfieri S
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- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhady S
- Abdelhamed R
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- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
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- Madrid Barrientos LA
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- Mohamed I
- Mohamed M
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- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
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- Mohammad A
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- Montrimaite M
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- Sokratous A
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- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
- Ting JRS
- To K
- To K
- Todd KO
- Toeema AG
- Tolba H
- Tolg C
- Tolonen M
- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola SK
- Tugnoli G
- Tugnoli G
- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
- Author
- Abdelmeguid Y
- Adams C
- Agrafiotou A
- Agrimbau Vázquez J
- Ahmed YHHZ
- Akomolafe T
- Akyüz Özkan E
- Al-Abadi E
- Alacheva ZA
- Alders N
- Alexeeva E
- Alifieraki S
- Almeida Farias CG
- Almeida FJ
- Altman M
- Alves Leal I
- Amer MA
- Ampuero C
- Ananin PV
- Anaya-Enriquez N
- Andreozzi L
- Angoulvant F
- Ansumanu H
- Antachopoulos C
- Antsupova M
- Araujo da Silva AR
- Araujo e Silva AE
- Aravena J
- Aslam N
- Aston E
- Avila-Aguero ML
- Avram P
- Badheka A
- Badib A
- Badran S
- Badreldin K
- Bailey DM
- Bakradze MD
- Bamford A
- Banegas Pineda LY
- Banks M
- Barreiro STA
- Basu Roy R
- Beattie T
- Belot A
- Berbenyuk A
- Beske F
- Bianco F
- Biggs CM
- Blyuss O
- Bobkova P
- Boleti O
- Bomfim Prado da Silva DG
- Borisova G
- Borjas Aguilar KL
- Borzakova S
- Boyarchuk O
- Boychenko L
- Boyko Y
- Bracken A
- Brenes-Chacón H
- Britton PN
- Broad J
- Broderick C
- Brodin P
- Brotschi B
- Bucciarelli V
- Buonsenso D
- Burch AK
- Burgner DP
- Burns JC
- Bustos B R
- Cai J
- Camacho-Badilla K
- Camacho-Moreno G
- Cantillano Quintero EM
- Carey E
- Carmona R
- Carreon-Guerrero JM
- Carrera JM
- Carrol ED
- Carter M
- Carter MJ
- Casanova D
- Castaño E
- Cervi MC
- Cetin BS
- Chacon-Cruz E
- Chandran A
- Channon-Wells S
- Charisi K
- Charlesworth J
- Chashchina IL
- Chawla J
- Cheung López M
- Chouli M
- Cichon C
- Cimaz R
- Cirks B
- Collia AG
- Cooper H
- Cooray S
- Crawford NW
- Cruces P
- Cunnington AJ
- D'Souza G
- Dallman MD
- David M
- Davies P
- Davis F
- Daza Timana CA
- De Leon T
- De Luca M
- De T
- Dehoorne J
- Delany DR
- Dellepiane RM
- Diaz F
- Dimitrova A
- Diudenko N
- Dos Santos Naja Cardoso MV
- Drysdale SB
- Dunk J
- Dyvonyak O
- Dzora E
- El-Taravi Y
- Eleftheriou I
- Elkhashab Y
- Ellis A
- Emonts M
- Epalza C
- Erdeniz EH
- Estripeaut D
- Evans C
- Fabi M
- Fairchok M
- Farkas D
- Farmaki E
- Faugier Fuentes E
- Fidler K
- Filice E
- Fisenko AP
- Fonseca Flores M
- Foster C
- Fotis L
- Friedman S
- Gadzinska J
- Ganeva M
- García-Domínguez M
- García-Salum T
- Gautier MS
- Geracht J
- Giron Vargas AL
- Giuliano H
- Glazyrina A
- Godoy L
- Gong C
- Gongrun B
- Gonzalez C
- Gorgun B
- Gorlenko C
- Grandjean L
- Grant K
- Grasa CD
- Grosheva M
- Guo J
- Hacohen Y
- Haerynck F
- Hall J
- Hamadouche N
- Hamdan A
- Hamid HKS
- Hassell J
- Heep A
- Heinonen S
- Henriques Teixeira C
- Herberg JA
- Hernandez R
- Heshmat H
- Hesketh C
- Hewlett J
- Hnieno A
- Hoggart C
- Holt-Davis H
- Holter W
- Horne A
- Hossain A
- Hoste L
- Hu S
- Huamán G
- Hudson LD
- Hussein A
- Iakovleva E
- Ibrahim S
- Inchley C
- Ip P
- Iramain R
- Ivankovich-Escoto G
- Jarovsky D
- Jheeta S
- Johnson M
- Johnson S
- Jyothish D
- Kafetzis D
- Kaforou M
- Kalcakosz S
- Kampmann B
- Kandawasvika G
- Kasiyan O
- Katerynych K
- Kavirayani A
- Kelly D
- Keren I
- Ketharanathan N
- Kirubakaran A
- Kiselev H
- Klevberg S
- Knudsen PK
- Koletsi P
- Kondrikova E
- Korobyants E
- Korsunskiy AA
- Kostyuchenko L
- Kourtesi K
- Kovygina K
- Krainz M
- Krasnaya E
- Kucera F
- Kurbanova S
- Kurdup MK
- Kwan MYW
- Kwok J
- Ladj MS
- Lampidi S
- Lanari M
- Langer D
- Langs-Barlow A
- Lau YL
- Lawson G
- Lees EA
- Lenihan R
- Levin M
- Levy J
- Liakopoulou T
- Lillie J
- Lo Vecchio A
- Longbottom K
- Lopez Hernández L
- Lopez Segura N
- Lopez A
- Lopez-Delgado I
- Luder A
- Ludwikowska K
- Lyall H
- Macharia A-M
- Mackdermott N
- Maltby S
- Mamenko M
- Mamutova AV
- Mandziuk J
- Mann K
- Maritsi D
- Martinon-Torres F
- Martins Araujo J
- Masjosthusmann K
- Mastrolia MV
- Mauro A
- Mazankova L
- Mazza A
- McArdle AJ
- Mclelland T
- McMahon A-M
- McMinn A
- Medina RA
- Melendo S
- Melhem I
- Melnyk K
- Menchaca Aguayo HF
- Mendez-Echevarria A
- Mesa Guzmán JM
- Meyer Sauteur P
- Miagka N
- Michailidou E
- Milioudi M
- Miller D
- Miranda M
- Mirza L
- Mitushin IL
- Mohamed Hussein AH
- Montaño-Duron JG
- Morrison Z
- Moshal K
- Moussa A
- Mparmpounaki I
- Mujuru HA
- Muller J
- Munaico M
- Munblit D
- Munblit D
- Musiime G
- Musuka P
- Myttaraki E
- Måseide PH
- Naaman Berezin E
- Nadel S
- Nair S
- Naranjo-Zuniga G
- Nargizyan A
- Natta D
- Nazarenko L
- Nezgoda I
- Nijman RG
- Norero X
- Nuttall L
- Okarska-Napierała M
- Oremakinde O
- Orlova YO
- Osaghae D
- Osman F
- Osmanov IM
- Ostrzewska A
- Ouldali N
- Paccagnella D
- Pace D
- Pachlopnik Schmid J
- Padhye A
- Palacios Argueta JR
- Palazzi Sáfadi MA
- Palmblad K
- Panthula M
- Papa MV
- Papachatzi E
- Papadimitriou E
- Papadopoulou C
- Papaevangelou V
- Patel F
- Patel H
- Patel H
- Paternina-de la Ossa RA
- Payne H
- Pazukhina E
- Penner J
- Peralta C
- Polandi S
- Polyakova AS
- Prader S
- Prendergast AJ
- Pushkareva A
- Pérez L
- Pérez-Gaxiola G
- Quade A
- Ramirez KA
- Ramnarayan P
- Ramnarayan P
- Ramos Tiñini P
- Ranasinghe L
- Ravichandran M
- Record J
- Reel B
- Reiter K
- Relly C
- Rhys-Evans S
- Riordan A
- Rivero-Calle I
- Rivière J
- Rockett J
- Rodrigues CMC
- Rodríguez-González M
- Roe L
- Roilides E
- Rojas-Bonilla M
- Rojo P
- Romaine S
- Romani L
- Romanova O
- Rubiños M
- Rykova S
- Samitova E
- Sanchez Manubens J
- Santos RP
- Sayed IA
- Scarano SM
- Schelstraete P
- Schlapbach LJ
- Schobi N
- Scuccimarri R
- Seaby EG
- Seddon J
- Seiler M
- Seminario D
- Shah P
- Shahin AA
- Shingadia D
- Shoman W
- Shvedova A
- Sikdar O
- Simonini G
- Soler-Palacin P
- Sologub A
- Soriano-Arandes A
- Soriano-Fallas A
- Souza Vieira C
- Srivastava A
- Stefanov S
- Strasser S
- Struik S
- Sun T
- Svyst O
- Szekeres K
- Tagarro A
- Tan R
- Tan RW
- Taylor A
- Taylor A
- Taylor A
- Telcharova-Mihaylovska A
- Tepaev RF
- Teslenko M
- Tipo V
- Tkacheva AA
- To K
- Torpiano P
- Tostado-Morales E
- Tran S
- Tremoulet A
- Tremoulet A
- Trykosh M
- Trück J
- Tsagkaris S
- Tsiatsiou O
- Tsolas G
- Tsolia M
- Tudor-Williams G
- Ulloa-Gutierrez R
- Ulloa-Gutierrez R
- Ulreich R
- Umaru S
- Valadez J
- Valenzuela Galaz G
- Van den Berg S
- Van den Heuvel I
- Van der Velden F
- Vandekerckhove K
- Vantsi P
- Vasilenko N
- Veliz N
- Ventilacion L
- Verdoni L
- Vermont C
- Villaverde S
- Vito O
- Volokha A
- Von Both U
- Wangai F
- Wasserman S
- Weber K
- Wellman PA
- Whittaker E
- Widener R
- Willems J
- Wilson C
- Withers Green J
- Withington D
- Wong JSC
- Wong M
- Wong S
- Wood N
- Wütz D
- Yakout RM
- Yanney MP
- Yegiyan M
- Yeung S
- Yock-Corrales A
- Yori S
- Yusupova V
- Zapata Yarlequé EH
- Zholobova E
- Zsigmond B
- Zurl C
- Şahin IO
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/01/2023
- Field of study
Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt AH
- Abedi Vida
- Adams Hieab
- Adebajo OJ
- Adeoye AM
- Afzal S
- Ago Tetsuro
- Agunloye A
- Akinyemi J
- Akinyemi Rufus
- Akpa O
- Akpalu A
- Almgren P
- Alvarez-Sabin J
- Amin N
- Amouyel Philippe
- Anderson CD
- Anderson Christopher D.
- Aparicio HJ
- Arenillas JF
- Armasu SM
- Armstrong Nicole D.
- Arnett DK
- Arulogun O
- Attia J
- Ay H
- Bae Hee-Joon
- Bakker Mark K.
- Bammler TK
- Bartz Traci M.
- Bastarache Lisa
- Beiser AS
- Bell S
- Benavente OR
- Benn M
- Bennett David A.
- Berr C
- Bevan S
- Bis JC
- Bis Joshua C.
- Blay N
- Boerwinkle E
- Boncoraglio GB
- Bordes Constance
- Braekkan SK
- Brody JA
- Brouwers PJAM
- Brown RD
- Brumpton BM
- Buring JE
- Bustamante M
- Butterworth AS
- Børte Sigrid
- Cain Anael
- Campos F
- Camps-Renom P
- Caro Ilana
- Carrera C
- Carty CL
- Caso V
- Castillo J
- Chasman Daniel I.
- Chauhan Ganesh
- Chen JS
- Chen MH
- Chen Pei-Hsin
- Chen WM
- Chen YP
- Chen Zhengming
- Cheng YC
- Cho Kelly
- Choi SH
- Chong Michael R.
- Chowhan A
- Christensen Kaare
- Clarke R
- Cole John W.
- Collins R
- Correa A
- Cotlarciuc I
- Cruchaga Carlos
- Cullell N
- Curtze S
- Cushman M
- Cárcel-Márquez Jara
- Damrauer Scott M.
- Danesh J
- Dartigues JF
- de Andrade M
- de Bakker PIW
- de Cid R
- de Cid Rafael
- de Jager Phil L.
- de Jager PL
- de Kort PL
- de Laat KF
- de Leeuw FE
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran H
- Deleuze JF
- Delgado P
- Delgado-Mederos R
- den Heijer T
- den Hoed M
- DeStefano AL
- Dhar R
- Diaz-Navarro R
- Dichgans Martin
- Dorr M
- Duan Q
- Ellekjaer H
- Endres Matthias
- Engelter ST
- Engstrom G
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Fakunle AG
- Falcone GJ
- Fernández-Cadenas Israel
- Ferreira LE
- Ferreira Leslie E.
- Fongang B
- Ford I
- Fornage Myriam
- Frantz S
- França Paulo H. C.
- Frazer KA
- Freijo M
- Frikke-Schmidt Ruth
- Fritsche LG
- Furie KL
- Gabrielsen ME
- Gallego-Fabrega C
- Gasca Natalie C.
- Gasca NC
- Geerlings MI
- Geerlings Mirjam I.
- Georgakis Marios K.
- Germain M
- Ghanbari M
- Gieger Christian
- Giese AK
- Giulianini F
- Gons RAR
- Gordon W
- Gottesman RF
- Grabe Hans J.
- Gravel S
- Gretarsdottir S
- Grewal RP
- Gudnason V
- Gudnason Vilmundur
- Guo Y
- Gurpreet WS
- Gustafsson S
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler J
- Haeusler Karl Georg
- Hagen K
- Hamsten A
- Hansen JB
- Harris TB
- Hassan A
- Hata Jun
- Havulinna Aki S.
- He Jing
- He Yunye
- Heath AK
- Heath Alicia K.
- Heckbert SR
- Heit JA
- Heitsch L
- Heuch I
- Heuschmann Peter Ulrich
- Hill M
- Ho Yuk-Lam
- Holliday EG
- Hopewell Jemma C.
- Howard G
- Howson Joanna M. M.
- Hozawa A
- Hsu FC
- Huffman Jennifer E.
- Hveem K
- Hyacinth Hyacinth I.
- Ibanez L
- Ibrahim M
- Ikram MK
- Ikram Mohammad A.
- Ilinca A
- Ingelsson E
- Ingelsson M
- Inouye Michael
- Irvin Marguerite R.
- Irvin MR
- Iwasaki M
- Jackson RD
- Jacob Mina A.
- Jee Yon Ho
- Jenkins C
- Jensen GB
- Jeon Christina E.
- Jern Christina
- Jian XQ
- Jimenez-Conde J
- Johnson AD
- Johnson JA
- Jood K
- Jousilahti P
- Judy Renae L.
- Jukema J. Wouter
- Jung Keum J.
- Jürgenson Tuuli
- Kabrhel C
- Kaffashian S
- Kalra L
- Kamanu Frederick K.
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup PR
- Kanai M
- Kappelle LJ
- Keene Keith L.
- Kim BJ
- Kim J
- Kim Young Jin
- Kinnunen J
- Kissela BM
- Kitazono Takanari
- Kittner Steven J.
- Kjartansson O
- Kleindorfer DO
- Kleinschnitz C
- Kloss M
- Knol Maria J.
- Koido Masaru
- Komolafe M
- Konuma Takahiro
- Kooperberg C
- Koudstaal PJ
- Kraft P
- Krebs Kristi
- Kristoffersen ES
- Krupinski J
- Kubo M
- Kumar Amit
- Kõrv Janika
- Labovitz DL
- Lacaze Paul
- Lange LA
- Langefeld CD
- Langenberg C
- Lathrop G. Mark
- Launer Lenore J.
- Laurie CC
- Le Grand Q
- Le Grand Quentin
- Lee JM
- Lee Keon-Joo
- Lee TH
- Lemmens R
- Lemmons R
- Leonard Hampton L.
- Lepik Kaido
- Levi CR
- Lewis Adam J.
- Lewis CM
- Leys D
- Li Jiang
- Li Liming
- Li LN
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin WY
- Lind L
- Lindgren AG
- Lindgren CM
- Lindstrom S
- Linkohr B
- Lioutas V
- Liu YM
- Lledos M
- Llucia-Carol L
- Longstreth W. T.
- Lopez OL
- Lopez-Cancio E
- Lorentzen E
- Luijckx GJ
- Lv J
- MacDonald J
- Magi R
- Magnusson PK
- Maguire J
- Makoto H
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S.
- Marston Nicholas A.
- Marti-Fabregas J
- Martinez-Majander N
- Martinsen AE
- Matsuda K
- Mayerhofer Ernst
- McArdle PF
- McCauley BM
- McDonough CW
- McKnight B
- Meitinger Thomas
- Melander O
- Menon V
- Meschia JF
- Metspalu A
- Milani Lili
- Millan M
- Millwood Iona Y.
- Minegishi N
- Mishra Aniket
- Mitchell Braxton D.
- Molina CA
- Montaner J
- Montellano Felipe A.
- Morange PE
- Morisaki Takayuki
- Morris AP
- Mosley Thomas H.
- Muino E
- Muller-Nurasyid M
- Munoz-Narbona L
- Murakami Y
- Nagai A
- Nalls Mike A.
- Namba Shinichi
- Nederkoorn PJ
- Nelis M
- Nielsen JB
- Niiranen Teemu J.
- Ninomiya Toshiharu
- Nordestgaard BG
- Nordestgaard Børge G.
- Norrving B
- Nygaard Marianne
- O'Donnell CJ
- O'Donnell Martin J.
- Obach V
- Obiako R
- Ogbole G
- Ogishima S
- Okada Yukinori
- Olalere A
- Onland-Moret N. Charlotte
- Onland-Moret NC
- Osaigbovo G
- Ovbiagele Bruce
- Owolabi L
- Owolabi Mayowa O.
- Pankow JS
- Pankratz N
- Parati EA
- Parodi Livia
- Paré Guillaume
- Pattee JW
- Peddareddygari LR
- Pedersen LM
- Pedersen NL
- Pera J
- Perola M
- Peters Annette
- Peto R
- Pezzini A
- Pileggi S
- Posner Daniel C.
- Pozarickij A
- Prasad Kameshwar
- Prats-Sanchez L
- Psaty Bruce M.
- Pulit SL
- Putaala J
- Puurunen MK
- Rabionet R
- Rannikmae K
- Reiner A
- Reiner AP
- Rexrode KM
- Riaz Moeen
- Riba-Llena I
- Ribases M
- Ribo M
- Rice K
- Rich Stephen S.
- Ridker Paul M.
- Rissanen Ina L.
- Rolfs A
- Romero JR
- Roquer J
- Rosand Jonathan
- Rosendaal FR
- Roshchupkin Gennady V.
- Ross OA
- Rost NS
- Rothwell PM
- Rotter Jerome I.
- Rudd AG
- Ruff Christian T.
- Ruigrok Ynte M.
- Rundek Tatjana
- Rutten-Jacobs L
- Sabatine Marc S.
- Sacco Ralph L.
- Saillour-Glenisson F
- Sakaue S
- Sale MM
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera DK
- Sapkota BR
- Sarfo FS
- Sargurupremraj M
- Sargurupremraj Muralidharan
- Sarin AP
- Sarju R
- Sarnowski C
- Sasaki Makoto
- Satizabal Claudia L.
- Satoh M
- Sattar N
- Sawada N
- Schmidt Carsten O.
- Schmidt D
- Schmidt R
- Schminke U
- Schnohr P
- Segura T
- Serrano-Heras G
- Seshadri Sudha
- Sharma P
- Shi Mingyang
- Shimizu Atsushi
- Shiroma EJ
- Sibolt G
- Sigurdsson A
- Sigurdsson S
- Simonsick Eleanor M.
- Skogholt AH
- Sloane Kelly L.
- Slowik A
- Smith A
- Smith EN
- Smith Nicholas L.
- Sobrino T
- Sobue K
- Soderholm M
- Soriano-Tarraga C
- Srinivasasainagendra Vinodh
- Stanne TM
- Stefansson K
- Stevens B
- Stine OC
- Stott DJ
- Strauch K
- Strbian Daniel
- Suchon P
- Sudlow CLM
- Sumoy L
- Sun Yan V.
- Sung YJ
- Sutoh Yoichi
- Takai T
- Tanaka H
- Tang WH
- Tanislav C
- Tanno Kozo
- Tatlisumak Turgut
- Taylor KD
- Teumer A
- Thijs VNS
- Thomas LF
- Thomassen Jesper Qvist
- Thorleifsson G
- Thorsteinsdottir U
- Tiainen M
- Tiedt Steffen
- Tiwari Hemant K.
- Tomppo Liisa
- Torres-Aguila Nuria P.
- Touze E
- Traylor M
- Trompet Stella
- Trégouët David-Alexandre
- Tsugane S
- Tuladhar Anil Man
- Turman C
- Turnbull I
- Tybjærg-Hansen Anne
- Tzourio C
- Uitterlinden AG
- Ungethum K
- Uvere E
- Valdimarsson EM
- van der Laan SW
- van der Lee SJ
- van Dijk EJ
- van Dijk GW
- van Duijn CM
- van Norden AGW
- van Oostenbrugge RJ
- van Rooij FGW
- van Setten J
- van Vugt M
- van Vugt Marion
- Vaura Felix C.
- Verma SS
- Verma Stefali S.
- Vermeer SE
- Vibo Riina
- Visser MC
- Vives-Bauza C
- Vlieg AV
- Volker U
- Volzke H
- Vonk JMJ
- Wahab K
- Wakai K
- Walters M
- Walters Robin G.
- Wang C
- Wang L
- Wang RQ
- Wareham NJ
- Wassertheil-Smoller Sylvia
- Weir D
- Wennberg Patrik
- Wermer MJH
- Wiggins Kerri L.
- Willer CJ
- Williams SR
- Wilson JG
- Wilson Peter W. F.
- Winsvold Bendik Slagsvold
- Wolfe CDA
- Wong QN
- Woo Daniel
- Worrall Bradford B.
- Xu Huichun
- Yaffe K
- Yamaji T
- Yang Chaojie
- Yang CR
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu CQ
- Yusuf S
- Zand Ramin
- Zhou W
- Zonderman AB
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/12/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.</p
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt AH
- Abedi V
- Adams H
- Adebajo OJ
- Adeoye AM
- Afzal S
- Ago T
- Agunloye A
- Akinyemi J
- Akinyemi R
- Akpa O
- Akpalu A
- Almgren P
- Amin N
- Amouyel P
- Anderson CD
- Anderson CD
- Aparicio HJ
- Arenillas JF
- Armasu SM
- Armstrong ND
- Arnett DK
- Arulogun O
- Attia J
- Ay H
- Bae H-J
- Bakker MK
- Bammler TK
- Bartz TM
- Bastarache L
- Beiser AS
- Beiser AS
- Bell S
- Benavente OR
- Benn M
- Bennett DA
- Berr C
- Bevan S
- Bis JC
- Bis JC
- Blay N
- Boerwinkle E
- Boncoraglio GB
- Bordes C
- Braekkan SK
- Brody JA
- Brouwers PJAM
- Brown RD
- Brumpton BM
- Brumpton BM
- Buring JE
- Bustamante M
- Butterworth AS
- Børte S
- Cain A
- Campos F
- Camps-Renom P
- Caro I
- Carrera C
- Carty CL
- Caso V
- Castillo J
- Chasman DI
- Chauhan G
- Chen J
- Chen M-H
- Chen P-H
- Chen W-M
- Chen WM
- Chen Y
- Chen Z
- Cheng Y-C
- Cho K
- Choi SH
- Chong MR
- Chowhan A
- Christensen K
- Clarke R
- Cole JW
- Collins R
- Correa A
- Cotlarciuc I
- Cruchaga C
- Cullell N
- Curtze S
- Cushman M
- Cárcel-Márquez J
- Damrauer SM
- Danesh J
- Dartigues J-F
- De Andrade M
- De Bakker PIW
- De Cid R
- De Cid R
- De Jager PL
- De Jager PL
- De Kort PL
- De Laat KF
- De Leeuw F-E
- De Leeuw F-E
- Debette S
- Delavaran H
- Deleuze J-F
- Delgado P
- Delgado P
- Delgado-Mederos R
- Den Heijer T
- Den Hoed M
- DeStefano AL
- Dhar R
- Diaz-Navarro R
- Dichgans M
- Duan Q
- Dörr M
- Ellekjær H
- Endres M
- Engelter ST
- Engström G
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Fakunle AG
- Falcone GJ
- Fernández-Cadenas I
- Ferreira LE
- Ferreira LE
- Fongang B
- Ford I
- Fornage M
- Frantz S
- França PHC
- Frazer KA
- Freijó M
- Frikke-Schmidt R
- Fritsche LG
- Furie KL
- Gabrielsen ME
- Gabrielsen ME
- Gallego-Fabrega C
- Gasca NC
- Gasca NC
- Geerlings MI
- Geerlings MI
- Georgakis MK
- Germain M
- Ghanbari M
- Gieger C
- Giese A-K
- Giese A-K
- Giulianini F
- Gons RAR
- Gordon W
- Gottesman RF
- Gottesman RF
- Gottesman RF
- Grabe HJ
- Gravel S
- Gretarsdottir S
- Grewal RP
- Gudnason V
- Gudnason V
- Guo Y
- Gurpreet WS
- Gustafsson S
- Habib N
- Hachiya T
- Haessler J
- Haessler J
- Haeusler KG
- Hagen K
- Hamsten A
- Hansen J-B
- Harris TB
- Hassan A
- Hata J
- Havulinna AS
- He J
- He Y
- Heath AK
- Heath AK
- Heckbert SR
- Heit JA
- Heitsch L
- Heuch I
- Heuschmann PU
- Hill M
- Ho Y-L
- Holliday EG
- Hopewell JC
- Howard G
- Howson JMM
- Hozawa A
- Hsu F-C
- Huffman JE
- Hveem K
- Hveem K
- Hyacinth HI
- Ibañez L
- Ibrahim M
- Ikram MA
- Ikram MK
- Ilinca A
- Ingelsson E
- Ingelsson M
- Inouye M
- Irvin MR
- Irvin MR
- Iwasaki M
- Jackson RD
- Jackson RD
- Jacob MA
- Jee YH
- Jenkins C
- Jensen GB
- Jeon CE
- Jern C
- Jian X
- Jiménez-Conde J
- Johnson AD
- Johnson JA
- Jood K
- Jousilahti P
- Judy RL
- Jukema JW
- Jung KJ
- Jürgenson T
- Kabrhel C
- Kaffashian S
- Kalra L
- Kamanu FK
- Kamatani Y
- Kamouchi M
- Kamstrup PR
- Kanai M
- Kappelle LJ
- Keene KL
- Kim B-J
- Kim J
- Kim YJ
- Kinnunen J
- Kissela BM
- Kitazono T
- Kittner SJ
- Kjartansson O
- Kleindorfer DO
- Kleinschnitz C
- Kloss M
- Knol MJ
- Koido M
- Komolafe M
- Konuma T
- Kooperberg C
- Kooperberg C
- Koudstaal PJ
- Kraft P
- Krebs K
- Kristoffersen ES
- Krupinski J
- Kubo M
- Kumar A
- Kõrv J
- Labovitz DL
- Lacaze P
- Lange LA
- Langefeld CD
- Langenberg C
- Lathrop GM
- Launer LJ
- Laurie CC
- Le Grand Q
- Le Grand Q
- Lee J-M
- Lee K-J
- Lee T-H
- Lemmens R
- Lemmons R
- Leonard HL
- Lepik K
- Levi CR
- Lewis AJ
- Lewis CM
- Leys D
- Li J
- Li L
- Li L
- Liaw Y-C
- Liaw Y-P
- Liman T
- Lin K
- Lin W-Y
- Lind L
- Lindgren AG
- Lindgren CM
- Lindstrom S
- Linkohr B
- Lioutas V
- Liu YM
- Lledós M
- Llucià-Carol L
- Longstreth WT
- Lopez OL
- Lopez-Cancio E
- Lorentzen E
- Luijckx G-J
- Lv J
- MacDonald J
- Magnusson PK
- Maguire J
- Makoto H
- Malik R
- Manichaikul A
- Markus HS
- Marston NA
- Martinez-Majander N
- Martinsen AE
- Martí-Fàbregas J
- Matsuda K
- Mayerhofer E
- McArdle PF
- McCauley BM
- McDonough CW
- McKnight B
- Meitinger T
- Melander O
- Menon V
- Meschia JF
- Metspalu A
- Milani L
- Millwood IY
- Millán M
- Minegishi N
- Mishra A
- Mitchell BD
- Molina CA
- Montaner J
- Montellano FA
- Morange P-E
- Morisaki T
- Morris AP
- Mosley TH
- Muiño E
- Murakami Y
- Muñoz-Narbona L
- Mägi R
- Müller-Nurasyid M
- Nagai A
- Nalls MA
- Namba S
- Nederkoorn PJ
- Nederkoorn PJ
- Nelis M
- Nielsen JB
- Nielsen JB
- Niiranen TJ
- Ninomiya T
- Nordestgaard BG
- Nordestgaard BG
- Norrving B
- Nygaard M
- Obach V
- Obiako R
- Ogbole G
- Ogishima S
- Okada Y
- Olalere A
- Onland-Moret NC
- Onland-Moret NC
- Osaigbovo G
- Ovbiagele B
- Owolabi L
- Owolabi MO
- O’Donnell CJ
- O’Donnell MJ
- Pankow JS
- Pankratz N
- Parati EA
- Parodi L
- Paré G
- Pattee JW
- Peddareddygari LR
- Pedersen LM
- Pedersen NL
- Pera J
- Perola M
- Peters A
- Peto R
- Pezzini A
- Pileggi S
- Posner DC
- Pozarickij A
- Prasad K
- Prats-Sánchez L
- Psaty BM
- Pulit SL
- Putaala J
- Puurunen MK
- Rabionet R
- Rannikmäe K
- Reiner A
- Reiner AP
- Rexrode KM
- Riaz M
- Riba-Llena I
- Ribasés M
- Ribó M
- Rice K
- Rich SS
- Ridker PM
- Rissanen IL
- Rolfs A
- Romero JR
- Roquer J
- Rosand J
- Rosendaal FR
- Roshchupkin GV
- Ross OA
- Rost NS
- Rothwell PM
- Rotter JI
- Rudd AG
- Ruff CT
- Ruigrok YM
- Rundek T
- Rutten-Jacobs L
- Sabatine MS
- Sacco RL
- Saillour-Glenisson F
- Sakaue S
- Sale MM
- Saleheen D
- Salomaa V
- Sandset EC
- Sanghera DK
- Sapkota BR
- Sarfo FS
- Sargurupremraj M
- Sargurupremraj M
- Sarin A-P
- Sarju R
- Sarnowski C
- Sasaki M
- Satizabal CL
- Satoh M
- Sattar N
- Sawada N
- Schmidt CO
- Schmidt D
- Schmidt R
- Schminke U
- Schnohr P
- Segura T
- Serrano-Heras G
- Seshadri S
- Sharma P
- Shi M
- Shimizu A
- Shiroma EJ
- Sibolt G
- Sigurdsson S
- Sigurdsson Á
- Simonsick EM
- Skogholt AH
- Sloane KL
- Slowik A
- Smith A
- Smith EN
- Smith NL
- Sobrino T
- Sobue K
- Soderholm M
- Soriano-Tárraga C
- Srinivasasainagendra V
- Stanne TM
- Stefansson K
- Stevens B
- Stine OC
- Stott DJ
- Strauch K
- Strbian D
- Suchon P
- Sudlow CLM
- Sumoy L
- Sun YV
- Sung YJ
- Sutoh Y
- Takai T
- Tanaka H
- Tang W
- Tanislav C
- Tanno K
- Tatlisumak T
- Taylor KD
- Taylor KD
- Teumer A
- Thijs VNS
- Thomas LF
- Thomassen JQ
- Thorleifsson G
- Thorsteinsdottir U
- Tiainen M
- Tiedt S
- Tiwari HK
- Tomppo L
- Torres-Aguila NP
- Touze E
- Traylor M
- Trompet S
- Trégouët D-A
- Tsugane S
- Tuladhar AM
- Turman C
- Turnbull I
- Tybjærg-Hansen A
- Tzourio C
- Uitterlinden AG
- Ungethüm K
- Uvere E
- Valdimarsson EM
- Van der Laan SW
- Van der Lee SJ
- Van Dijk EJ
- Van Dijk GW
- Van Duijn CM
- Van Hylckama Vlieg A
- Van Norden AGW
- Van Oostenbrugge RJ
- Van Rooij FGW
- Van Setten J
- Van Vugt M
- Van Vugt M
- Vaura FC
- Verma SS
- Verma SS
- Vermeer SE
- Vibo R
- Visser MC
- Vives-Bauza C
- Vonk JMJ
- Völker U
- Völzke H
- Wahab K
- Wakai K
- Walters M
- Walters RG
- Wang C
- Wang L
- Wang R
- Wareham NJ
- Wassertheil-Smoller S
- Weir D
- Wennberg P
- Wermer MJH
- Wiggins KL
- Willer CJ
- Williams SR
- Wilson JG
- Wilson PWF
- Winsvold BS
- Wolfe CDA
- Wong Q
- Woo D
- Worrall BB
- Xu H
- Yaffe K
- Yamaji T
- Yang C
- Yang C
- Yang Q
- Yonova-Doing E
- Yoon K
- Yu C
- Yusuf S
- Zand R
- Zhou W
- Zonderman AB
- Zwart J-A
- Álvarez-Sabín J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/07/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
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- Ali M
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- Balasubramaniam A
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- Ball A
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- Ballabio M
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- Bandyopadhyay Sk
- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
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- Barnieh W
- Baronio G
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- Barrie A
- Barter Ca
- Bartoli A
- Bascuas-Rodrigo B
- Baseggio M
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- Bazán-Hinojo Mc
- Bazán-Hinojo Mc
- Beasley Wd
- Bedoya S
- Beggs A
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- Bell J
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- Beltran-De-Heredia J
- Beltran-De-Heredia J
- Belvedere A
- Benevento A
- Bennett Jm
- Beral D
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- Bernal-Sprekelsen Jc
- Berry B
- Berti S
- Bevan Ke
- Bevan V
- Beverstock A
- Bhanderi S
- Bhanderi S
- Bhanderi S
- Bhanderi S
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- Bhangu A. Nepogodiev D
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Biancafarina A
- Biancafarina A
- Bianchi Cl
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- Bianco A
- Bilku D
- Birindelli A
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- Birindelli A
- Blackford Od
- Blackwell J
- Blake L
- Blanco F
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- Blazeby Jm
- Blencowe N. S.
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- Boddy Ap
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- Bogdan M
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- Bolton W
- Bolzon S
- Bond S
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- Bondurri A
- Bonfante P
- Bonomo M
- Borg Cm
- Borges Fc
- Borghi F
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- Boshier Pr
- Botelho P
- Bowen J
- Bowerman H
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- Bowman Cr
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- Boyd-Carson H
- Boza K
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- Branagan G
- Bravo-Gutiérrez Af
- Bravo-Gutiérrez Af
- Brennan S
- Brett M
- Brewer H
- Brewer Hk
- Brewer Hk
- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
- Brown M
- Brown Od
- Brown R
- Bruce Js
- Brunelli Db
- Bryan Es
- Buckley-Jones S
- Bukhari W
- Bull C
- Bullivant Jk
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- Busuttil A
- Byrne Be
- Byrnes Ck
- Caballero A
- Caldeira Ab
- Caldwell M
- Callan R
- Calussi M
- Calvo H
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- Cameron Fc
- Campagnaro T
- Campagnaro T
- Campbell U
- Campbell Um
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- Cannata G
- Cannavò M
- Cantafio S
- Capelli P
- Carcoforo P
- Carden Ca
- Carder C
- Cardona R
- Cardoso D
- Carlucci M
- Carney K
- Caro A
- Carral-Freire M
- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
- Caula C
- Cavallo D
- Cavero A
- Cay P
- Ceccarelli G
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cervellera M
- Cesari Mc
- Chalk A
- Chambers B
- Chan D
- Chan T
- Chan Wh
- Chandler Sb
- Chandratreya N
- Chandratreya N
- Chapman J
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- Chapple Ks
- Charalabopoulos A
- Charalambous Mp
- Chasty B
- Chatzikonstantinou M
- Chatzikonstantinou M
- Chauhan P
- Chauhan P
- Chauhan P.
- Cheah Wl
- Chean Cs
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- Checcacci P
- Cheng Sa
- Cheruvu M
- Chessa A
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- Chetta G
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- Chianese G
- Chillitupa Cz
- Chimetto A
- Chin My
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- Chitsabesan P
- Chng S
- Choi S
- Chok Sm
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- Chong B
- Choolani-Bhojwani E
- Choong Jh
- Choong Jh
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- Chowdhary M
- Chowdhury F
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- Christopoulos P
- Chudek D
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- Clements B
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- Clements Ja
- Clements Jd
- Clements Jm
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- Clerici F
- Clingan R
- Cloney L
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- Coe Po
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- Colangelo E
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- Coletta D
- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
- Colvin Da
- Colvin Da
- Compagnoni B
- Conci S
- Connelly Tm
- Connor Kl
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- Contine Ac
- Contreras Rg
- Contreras-Saiz E
- Cook V
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- Cormenzana Ob
- Correia D
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- Cortés Gv
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- Costamagna D
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- Cynthia G
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- D'Auria M
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- Danquah-Boateng D
- Dar Fa
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- Davidson Jr
- Davidson S
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- Davis S
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- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
- De Marchi F
- De Marco P
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- De Nisco C
- De Padua C
- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Marchi Ja
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- Dean Ea
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- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
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- Delogu D
- Denley S
- Dennison G
- Depalma N
- Deserra A
- Desiderio J
- Devezas V
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- Dhar M
- Dharamavaram S
- Dhari Aa
- Dhesi S
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- Di Gioia P
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- Dixon F
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- Donohoe No
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- Drye N
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- Earnshaw L
- Easdon S
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- Erdas E
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- Eretta Co
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- Faulkner G
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- Feleppa C
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- Feroci F
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- Ferrer-Vilela I
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- Forouzanfar A
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- García V
- García-Carrero M
- García-Catalá L
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- García-Granero A
- García-Granero A
- García-Gutierrez C
- García-Novoa A
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- Hraishawi I
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- Ibrahim Y
- Ikram S
- Ilozue T
- Imperatore M
- Inama M
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- Infante H
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- Irwin R
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- Krishnamoorthy A
- Krivan S
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- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
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- Ž
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- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
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- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
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- Abdelmotaleb I
- Abdelraheim M
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- Allen-Ingabire Jc
- Allott R
- Almallah A
- Almanon Cl
- Almoflihi A
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- Almy J
- Alnaby Mh
- Alnawam E
- Alnuqaydan Sa
- Alnusairat A
- Alomar In
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzahrani M
- Alzahrani Mna
- Alzayat T
- Aman Nf
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
- Amin J
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- Amjad M
- Ammar M
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- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika Ffa
- Andreotti D
- Andress C
- Andriola V
- Ang Yl
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
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- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
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- Ardley R
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- Arnaud Ap
- Arshad Mm
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- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
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- Asilah Smd
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- Ata Aaa
- Ata Ay
- Atiyeh A
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- Atobatele K
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- Attard M
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- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
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- Azodo Ia
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- Azzie G
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- Bachri H
- Badawy M
- Badenjki Ma
- Badicel M
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- Badr Mfm
- Badwi Nm
- Badwi Nm
- Badwy A
- Bahar S
- Baheeg M
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- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
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- Baldacchino M
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- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
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- Bamford R
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- Barendegere V
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- Barmayehvar B
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- Barreda Lma
- Barrientos Lam
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- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
- Basto Caa
- Batt J
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- Bautista Acm
- Bayram S
- Beamon M
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- Bediako-Bowan A
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- Beisa V
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- Bekhet Nm
- Beleñ
- Belkouchi A
- Belli A
- Bello B
- Benammi S
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- Benevento A
- Benger M
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- Benyaiche C
- Bermú
- Bernardo Cg
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- Bertuello I
- Beuran M
- Beuran M
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- Bezzina M
- Bhangu A
- Bhangu A
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- Bhangu A
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- Bhat S
- Bhatnagar A
- Bhattacharya S
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- Bhopal Kf
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- Billy M
- Birindelli A
- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
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- Blundell R
- Boakye-Yiadom K
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- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
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- Bondurri A
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- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
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- Botto N
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- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bré
- Bradulskis S
- Bradulskis S
- Bratu M
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- Bray Ld
- Breistrand M
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- Bukari M
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- Cardozo Jt
- Cardozo Ram
- Careta Mc
- Carlucci M
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- Carpio J
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- Cassar K
- Castillo Vdp
- Castro Mr
- Catani M
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- Chachulski W
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- Chai Fy
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- Chan Z
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- Chang Ky
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- Chin Yr
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- Chiong Jac
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- Chong Hy
- Chong Hy
- Choudhry A
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- Chowdhury D
- Chu K
- Chun A
- Chun T
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- Chung S
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- Clegg-Lampety Jn
- Clegg-Lamptey Jn
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- Contreras-Vergara Al
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- Corbellini C
- Corbellino M
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- Correa Jc
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- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
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- Court E
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- Cox M
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- Cruz H
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- Dé
- D&apos
- D&apos
- D&apos
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- D&apos
- D&apos
- Da Silva LA
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- Dahy A
- Dainius E
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- Dambrauskas Z
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- Daniyan M
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- Daqeeq A
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- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
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- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
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- Deichsel F
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- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
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- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
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- Dimech T
- Din F
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- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
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- Doughty J
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- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
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- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
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- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
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- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
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- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
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- Elhamouly S
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- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
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- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
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- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
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- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
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- Fraga Gp
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- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
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- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
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- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
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- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
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- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
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- Giuliani S
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- Giuriato Tf
- Gkiokas G
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- Glynn M
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- Goldin E
- Golding D
- Gomaa A
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- Gonzalez Sc
- Goodstein M
- Gosling S
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- Grant A
- Grasset E
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- Grassi V
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- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
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- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
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- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
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- Hamsho W
- Hanafy M
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- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
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- Hany E
- Haque M
- Har Pa
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- Harper E
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- Harvey N
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- Hashim A
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Performance of the CMS muon trigger system in proton-proton collisions at root s=13 TeV
- Author
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2021
- Field of study
The muon trigger system of the CMS experiment uses a combination of hardware and software to identify events containing a muon. During Run 2 (covering 2015–2018) the LHC achieved instantaneous luminosities as high as 2 × 1034 while delivering proton-proton collisions at √(s) = 13. The challenge for the trigger system of the CMS experiment is to reduce the registered event rate from about 40MHz to about 1kHz. Significant improvements important for the success of the CMS physics program have been made to the muon trigger system via improved muon reconstruction and identification algorithms since the end of Run 1 and throughout the Run 2 data-taking period. The new algorithms maintain the acceptance of the muon triggers at the same or even lower rate throughout the data-taking period despite the increasing number of additional proton-proton interactions in each LHC bunch crossing. In this paper, the algorithms used in 2015 and 2016 and their improvements throughout 2017 and 2018 are described. Measurements of the CMS muon trigger performance for this data-taking period are presented, including efficiencies, transverse momentum resolution, trigger rates, and the purity of the selected muon sample. This paper focuses on the single- and double-muon triggers with the lowest sustainable transverse momentum thresholds used by CMS. The efficiency is measured in a transverse momentum range from 8 to several hundred
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