332 research outputs found
Quantum capacity under adversarial quantum noise: arbitrarily varying quantum channels
We investigate entanglement transmission over an unknown channel in the
presence of a third party (called the adversary), which is enabled to choose
the channel from a given set of memoryless but non-stationary channels without
informing the legitimate sender and receiver about the particular choice that
he made. This channel model is called arbitrarily varying quantum channel
(AVQC). We derive a quantum version of Ahlswede's dichotomy for classical
arbitrarily varying channels. This includes a regularized formula for the
common randomness-assisted capacity for entanglement transmission of an AVQC.
Quite surprisingly and in contrast to the classical analog of the problem
involving the maximal and average error probability, we find that the capacity
for entanglement transmission of an AVQC always equals its strong subspace
transmission capacity. These results are accompanied by different notions of
symmetrizability (zero-capacity conditions) as well as by conditions for an
AVQC to have a capacity described by a single-letter formula. In he final part
of the paper the capacity of the erasure-AVQC is computed and some light shed
on the connection between AVQCs and zero-error capacities. Additionally, we
show by entirely elementary and operational arguments motivated by the theory
of AVQCs that the quantum, classical, and entanglement-assisted zero-error
capacities of quantum channels are generically zero and are discontinuous at
every positivity point.Comment: 49 pages, no figures, final version of our papers arXiv:1010.0418v2
and arXiv:1010.0418. Published "Online First" in Communications in
Mathematical Physics, 201
A supernova constraint on bulk majorons
In models with large extra dimensions all gauge singlet fields can in
principle propagate in the extra dimensional space. We have investigated
possible constraints on majoron models of neutrino masses in which the majorons
propagate in extra dimensions. It is found that astrophysical constraints from
supernovae are many orders of magnitude stronger than previous accelerator
bounds. Our findings suggest that unnatural types of the "see-saw" mechanism
for neutrino masses are unlikely to occur in nature, even in the presence of
extra dimensions.Comment: Minor changes, matches the version to appear in PR
Revisiting the design intent concept in the context of mechanical CAD education
[EN] Design intent is generally understood simply as a CAD model¿s anticipated behavior when altered.
However, this representation provides a simplified view of the model¿s construction and purpose,
which may hinder its general understanding and future reusability. Our vision is that design intent
communication may be improved by recognizing the multifaceted nature of design intent, and by
instructing users to convey each facet of design intent through the better-fitted CAD resource. This
paper reviews the current understanding of design intent and its relationship to design rationale and
builds on the idea that communication of design intent conveyed via CAD models can be satisfied
at three levels provided that specialized instruction is used to instruct users in selection of the most
suitable level for each intent.Otey, J.; Company, P.; Contero, M.; Camba, J. (2018). Revisiting the design intent concept in the context of mechanical CAD education. Computer-Aided Design and Applications. 15(1):47-60. https://doi.org/10.1080/16864360.2017.1353733S476015
A Phenomenological Study of the Process at High Energy Colliders and Measurement of the and Couplings
We perform a detailed study of the process including all contributions. The contributions other
than from real gauge boson production leads to a rich phenomenology. We explore
the use of the process as a means of precision measurement of the and
vertices. We concentrate on LEP II energies, GeV,
and energies appropriate to the proposed Next Linear Collider (NLC) high energy
collider with center of mass energies and 1~TeV. At 200
GeV, the process offers, at best, a consistency check of other processes being
considered at LEP200. At 500~GeV, the parameters ,
, , and can be measured to about or better at 95\% C.L. while at 1 TeV, they can be measured to about . At the high luminosities anticipated at high energy linear colliders
precision measurements are likely to be limited by systematic rather than
statistical errors.Comment: 33 pages, OCIP/C 93-18, UQAM-PHE-930
Green function techniques in the treatment of quantum transport at the molecular scale
The theoretical investigation of charge (and spin) transport at nanometer
length scales requires the use of advanced and powerful techniques able to deal
with the dynamical properties of the relevant physical systems, to explicitly
include out-of-equilibrium situations typical for electrical/heat transport as
well as to take into account interaction effects in a systematic way.
Equilibrium Green function techniques and their extension to non-equilibrium
situations via the Keldysh formalism build one of the pillars of current
state-of-the-art approaches to quantum transport which have been implemented in
both model Hamiltonian formulations and first-principle methodologies. We offer
a tutorial overview of the applications of Green functions to deal with some
fundamental aspects of charge transport at the nanoscale, mainly focusing on
applications to model Hamiltonian formulations.Comment: Tutorial review, LaTeX, 129 pages, 41 figures, 300 references,
submitted to Springer series "Lecture Notes in Physics
Lives versus Livelihoods? Perceived economic risk has a stronger association with support for COVID-19 preventive measures than perceived health risk
This paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative samples were collected from 24 countries (N = 25,435). The main predictors were (1) perceived risk to contract coronavirus, (2) perceived risk to suffer economic losses due to coronavirus, and (3) their interaction effect. Individual and country-level variables were added as covariates in multilevel regression models. We examined compliance with various preventive health behaviors and support for strict containment policies. Results show that perceived economic risk consistently predicted mitigation behavior and policy support—and its effects were positive. Perceived health risk had mixed effects. Only two significant interactions between health and economic risk were identified—both positive
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
A muon-track reconstruction exploiting stochastic losses for large-scale Cherenkov detectors
IceCube is a cubic-kilometer Cherenkov telescope operating at the South Pole. The main goal of IceCube is the detection of astrophysical neutrinos and the identification of their sources. High-energy muon neutrinos are observed via the secondary muons produced in charge current interactions with nuclei in the ice. Currently, the best performing muon track directional reconstruction is based on a maximum likelihood method using the arrival time distribution of Cherenkov photons registered by the experiment\u27s photomultipliers. A known systematic shortcoming of the prevailing method is to assume a continuous energy loss along the muon track. However at energies >1 TeV the light yield from muons is dominated by stochastic showers. This paper discusses a generalized ansatz where the expected arrival time distribution is parametrized by a stochastic muon energy loss pattern. This more realistic parametrization of the loss profile leads to an improvement of the muon angular resolution of up to 20% for through-going tracks and up to a factor 2 for starting tracks over existing algorithms. Additionally, the procedure to estimate the directional reconstruction uncertainty has been improved to be more robust against numerical errors
Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review
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