Interpreting measures of tuberculosis transmission : a case study on the Portuguese population

Background: Tuberculosis remains a high burden for Human society despite considerable investments in its control. Unique features in the history of infection and transmission dynamics of tuberculosis pose serious limitations on the direct interpretation of surveillance data and call for models that incorporate latent processes and simulate specific interventions.Methods: A transmission model was adjusted to the dataset of active tuberculosis cases reported in Portugal between 2002 and 2009. We estimated key transmission parameters from the data (i.e. time to diagnosis, treatment length, default proportion, proportion of pulmonary TB cases). Using the adjusted model to the Portuguese case, we estimated the total burden of tuberculosis in Portugal. We further performed sensitivity analysis to heterogeneities in susceptibility to infection and exposure intensity.Results: We calculated a mean time to diagnose of 2.81 months and treatment length of 8.80 months in Portugal. The proportion defaulting treatment was calculated as 0.04 and the proportion of pulmonary cases as 0.75. Using these values, we estimated a TB burden of 1.6 million infected persons, corresponding to more than 15% of the Portuguese population. We further described the sensitivity of these estimates to heterogeneity.Conclusions: We showed that the model reproduces well the observed dynamics of the Portuguese data, thus demonstrating its adequacy for devising control strategies for TB and predicting the effects of interventions

Características socio-demográficas de los pacientes con exacerbación de la enfermedad pulmonar obstructiva crónica (EPOC)

Introduction, Chronic obstructive pulmonary disease (COPD) is an irreversible pathological process characterized by a limitation of airflow that increases progressively and is associated with an abnormal pulmonary inflammatory response to harmful particles or gases, mainly caused by smoking. It directly affects the patient since it is a pathology with which he will have to carry the rest of his life, adapt to the limitations that he will develop over time and cope with the exacerbations that he develops, Objectives, Validate the instrument to determine the socio demographic characteristics of patients with exacerbation of Chronic Obstructive Pulmonary Disease, Methodology, it is a mixed investigation; quantitative, qualitative, retrospective, with a snowball selection sample technique, it is a field work, cross-sectional and descriptive, Instruments, the quantitative instrument-questionnaire and the qualitative instrument-interview were validated by the judgment of 16 experts, a Master of Public Health Respiratory Therapist participated, a specialist in Pneumology, 3 General Practitioners, 2 Master of Public Health Dentists, 4 graduates Master in Public Health Nursing, 3 Respiratory Therapists with experience in the management of patients with COPD and 2 master nutritionists in Public Health, Results, the pilot plan was with the snowball selection technique and its result showed that in the quantitative instrument: Cronbach's alpha, a score of 0.8 was obtained, a reliability of Good-High, in the qualitative instrument: an average of 89; category: emotional 85, family 83 and socioeconomic 87 as a result is rated 80-100 very reliable, Conclusions, the instrument was validated by expert judgment, reaching a score of 89 "Reliability" is considered a "Very Reliable" instrument to determine the socio demographic characteristics of patients with               exacerbation of COPD.Introducción, La enfermedad pulmonar obstructiva crónica (EPOC) es un proceso patológico irreversible que se caracteriza por una limitación del flujo aéreo que incrementa de manera progresiva y se asocia con una respuesta inflamatoria pulmonar anormal a partículas o a gases nocivos, principalmente causada por el tabaquismo, afecta de manera directa al paciente ya que es una patología con la que tendrá que conllevar es resto de su vida, adaptarse a las limitaciones que esta ira desarrollando con el pasar del tiempo y sobrellevar las exacerbaciones que desarrolle, Objetivos, Validar del instrumento para determinar las características socio demográficas de los pacientes con exacerbación de Enfermedad Pulmonar Obstructiva Crónica, Metodología, es una investigación mixta; cuantitativa, cualitativa, retrospectivo, con técnica para muestra de selección bola de nieve, es un trabajo de campo, de corte transversal y descriptiva, Instrumentos, el instrumento cuantitativo-cuestionario y el instrumento cualitativo-entrevista fueron validados por juicio de 16 expertos, , participó un Terapeuta respiratorio magister en Salud Pública, un médico especialista en Neumología, 3 Médicos generales, 2 Odontólogos maestrante en Salud Publica, 4 licenciados/as en Enfermería maestrantes en Salud Publica, 3 Terapeutas Respiratorios con experiencia en el manejo de pacientes con la EPOC y 2 nutricionistas maestrantes en Salud Publica, Resultados, el plan piloto fue con la técnica de selección bola de nieve y su resultado demostró que en el instrumento cuantitativo: alfa de Cronbach se obtuvo una calificación de 0.8 una confiabilidad de Bueno-Alto, en el instrumento cualitativo: se obtuvo un promedio de 89; categoría: emocional 85, familiar 83 y socioeconómica 87 como resultado se califica de 80-100 muy confiable, Conclusiones, se realizó la validación del instrumento por juicio de expertos alcanzando puntaje de 89 “Confiabilidad” queda considerado como instrumento “Muy Confiable” determinar las características socio demográficas de los pacientes con exacerbación de la EPOC

Active thermal mass enhancement using phase change materials

Buildings account for around 40% of energy consumption in the UK. For over twenty years active thermal mass systems have been a feature in low-energy buildings in northern Europe. By passing ventilation air, and utilising night ventilation, through the hollow core structures efficient heating and cooling has been achieved. Despite the success, such systems suffer from space overheating and efficiency losses during extended hot periods. Control strategies have largely mitigated this effect however low cost retrofit solutions that enhance the system are of interest. This research therefore investigates the benefit of using innovative phase change material (PCM) solutions to enhance thermal comfort and reduced energy usage of traditional active thermal mass systems. A prototype PCM enhancement was constructed, with energy saving and comfort benefits investigated under controlled laboratory conditions. In absolute terms the PCM solution offered an additional 12.5% energy storage capacity and a 29% increase in active surface area, coupled with the existing sensible thermal mass. Under laboratory conditions the PCM addition saved an additional 0.1 kWh per day, delayed AC onset by 1.2 h and offered an average 1.0 °C reduction in room temperature during 8 h of fixed internal heat gain, contrasted against the original active thermal mass system

A standardisation framework for bio‐logging data to advance ecological research and conservation

Bio‐logging data obtained by tagging animals are key to addressing global conservation challenges. However, the many thousands of existing bio‐logging datasets are not easily discoverable, universally comparable, nor readily accessible through existing repositories and across platforms, slowing down ecological research and effective management. A set of universal standards is needed to ensure discoverability, interoperability and effective translation of bio‐logging data into research and management recommendations. We propose a standardisation framework adhering to existing data principles (FAIR: Findable, Accessible, Interoperable and Reusable; and TRUST: Transparency, Responsibility, User focus, Sustainability and Technology) and involving the use of simple templates to create a data flow from manufacturers and researchers to compliant repositories, where automated procedures should be in place to prepare data availability into four standardised levels: (a) decoded raw data, (b) curated data, (c) interpolated data and (d) gridded data. Our framework allows for integration of simple tabular arrays (e.g. csv files) and creation of sharable and interoperable network Common Data Form (netCDF) files containing all the needed information for accuracy‐of‐use, rightful attribution (ensuring data providers keep ownership through the entire process) and data preservation security. We show the standardisation benefits for all stakeholders involved, and illustrate the application of our framework by focusing on marine animals and by providing examples of the workflow across all data levels, including filled templates and code to process data between levels, as well as templates to prepare netCDF files ready for sharing. Adoption of our framework will facilitate collection of Essential Ocean Variables (EOVs) in support of the Global Ocean Observing System (GOOS) and inter‐governmental assessments (e.g. the World Ocean Assessment), and will provide a starting point for broader efforts to establish interoperable bio‐logging data formats across all fields in animal ecology

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV

The Lambda(b) differential production cross section and the cross section ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on Lambda(b) decays reconstructed in the exclusive final state J/Psi Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and Lambda to proton pion, using a data sample corresponding to an integrated luminosity of 1.9 inverse femtobarns. The product of the cross section times the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls faster than that of b mesons. The measured value of the cross section times the branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06 +/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are statistical and systematic, respectively.Comment: Submitted to Physics Letters

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO

Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV

Isolated photon production is measured in proton-proton and lead-lead collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80 GeV with the CMS detector at the LHC. The measured ET spectra are found to be in good agreement with next-to-leading-order perturbative QCD predictions. The ratio of PbPb to pp isolated photon ET-differential yields, scaled by the number of incoherent nucleon-nucleon collisions, is consistent with unity for all PbPb reaction centralities.Comment: Submitted to Physics Letters