Chronic Migraines and Couples: A Grounded Theory of Adaptation to Chronic Migraines for Patients and their Partners

This study was completed to better understand and treat couples wherein one partner suffers from chronic migraines. I interviewed eight couples about their experiences in dealing with migraines as a patient, as a partner, and together. The interviews were transcribed and analyzed by a team of seven researchers. We developed a theory that can be used to understand how patients and their partners adapt to chronic migraines. The theory was grounded in the experiences of the patients and partners who were interviewed. We found that patients and partners alike dealt with burdens and costs associated with chronic migraines. Coping, healthcare, couple experience, and identity were found to be the means through which patients and partners adapted to their burdens. These concepts are broken down and discussed in greater detail. A model is provided that can be used to create a visual representation of how well a couple deals with migraines. Suggestions for couples who are dealing with chronic migraines, and for medical providers and therapists who work with couples affected by chronic migraines, are provided

The Potential of Antimicrobial Peptides as Biocides

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and development stagnates. This review will examine the potential of antimicrobial peptides, both natural and synthetic, as novel biocidal agents in the battle against multi-drug resistant pathogen infections

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Organizational context and the discursive construction of organizing

Organizational discourse has very little meaning outside its context. To understand any discourse's meaning, we must theorize about both the discourse's possibility and the circumstances of its constitution. Otherwise, we abstract text, sundering it from context. The present article asks what is context and what types of discourse structures and discourse strategies construct context? The author develops four distinct dimensions of context: when, where, as whom, and why people speak. To collaboratively construct meaning, an organization's members use several discursive means whereby a discourse from one context can be inserted, reframed, appropriated, and recursively placed into a discourse from another context-to achieve cross-contextual organizing of their accounts. Through such cross-contextual discursive work, members strive to balance these four (sometimes conflicting) contextual dimensions