Threshold Corrections and Gauge Symmetry in Twisted Superstring Models

Threshold corrections to the running of gauge couplings are calculated for superstring models with free complex world sheet fermions. For two N=1 $SU(2)\times U(1)^5$ models, the threshold corrections lead to a small increase in the unification scale. Examples are given to illustrate how a given particle spectrum can be described by models with different boundary conditions on the internal fermions. We also discuss how complex twisted fermions can enhance the symmetry group of an N=4 $SU(3)\times U(1)\times U(1)$ model to the gauge group $SU(3)\times SU(2)\times U(1)$. It is then shown how a mixing angle analogous to the Weinberg angle depends on the boundary conditions of the internal fermions.Comment: easier to Tex version, figures to be sent separatel

Extreme multi-millennial slip rate variations on the Garlock fault, California: Strain super-cycles, potentially time-variable fault strength, and implications for system-level earthquake occurrence

Pronounced variations in fault slip rate revealed by new measurements along the Garlock fault have basic implications for understanding how faults store and release strain energy in large earthquakes. Specifically, dating of a series of 26.0+3.5/−2.5 m fault offsets with a newly developed infrared-stimulated luminescence method shows that the fault was slipping at >14.0+2.2/−1.8 mm/yr, approximately twice as fast as the long-term average rate, during a previously documented cluster of four earthquakes 0.5–2.0 ka. This elevated late Holocene rate must be balanced by periods of slow or no slip such as that during the ca. 3300-yr-long seismic lull preceding the cluster. Moreover, whereas a comparison of paleoseismic data and stress modeling results suggests that individual Garlock earthquakes may be triggered by periods of rapid San Andreas fault slip or very large-slip events, the “on–off” behavior of the Garlock suggests a longer-term mechanism that may involve changes in the rate of elastic strain accumulation on the fault over millennial time scales. This inference is consistent with most models of the geodetic velocity field, which yield slip-deficit rates that are much slower than the average latest Pleistocene-early Holocene (post-8–13 ka) Garlock slip rate of 6.5±1.5 mm/yr. These observations indicate the occurrence of millennia-long strain “super-cycles” on the Garlock fault that may be associated with temporal changes in elastic strain accumulation rate, which may in turn be controlled by variations in relative strength of the various faults in the Garlock-San Andreas-Eastern California Shear Zone fault system and/or changes in relative plate motion rates

Paleoseismology of the southern Panamint Valley fault: Implications for regional earthquake occurrence and seismic hazard in southern California

Paleoseismologic data from the southern Panamint Valley fault (PVF) reveal evidence of at least four surface ruptures during late Holocene time (0.33-0.48 ka, 0.9-3.0 ka, 3.3-3.6 ka, and >4.1 ka). These paleo-earthquake ages indicate that the southern PVF has ruptured at least once and possibly twice during the ongoing (≤1.5 ka) seismic cluster in the Mojave section of the eastern California shear zone (ECSZ). The most recent event (MRE) on the PVF is also similar in age to the 1872 Owens Valley earthquake and the geomorphically youthful MRE on the Death Valley fault. The timing of the three oldest events at our site shows that the PVF ruptured at least once and possibly thrice during the well-defined 2-5 ka seismic lull in the Mojave section of the ECSZ. Interestingly, the 3.3-3.6 ka age of Event 3 overlaps with the 3.3-3.8 ka age of the penultimate (i.e., pre-1872) rupture on the central Owens Valley fault. These new PVF data support the notion that earthquake occurrence in the ECSZ may be spatially and temporally complex, with earthquake clusters occurring in different regions at different times. Coulomb failure function modeling of the Panamint Valley and Garlock faults reveals significant stress interactions between these two faults that may influence future earthquake occurrence. Specifically, our models suggest a possible rupture sequence whereby an event on the southern Panamint Valley fault can lead to the potential triggering of an event on the Garlock fault, which in turn could trigger the Mojave section of the San Andreas Fault. Key Points Four surface ruptures during late Holocene on the Panamint Valley faultData support notion that earthquake occurrences in the ECSZ are complexCFF modeling of the Garlock and Panamint Valley fault

Effective Field Theories on Non-Commutative Space-Time

We consider Yang-Mills theories formulated on a non-commutative space-time described by a space-time dependent anti-symmetric field $\theta^{\mu\nu}(x)$. Using Seiberg-Witten map techniques we derive the leading order operators for the effective field theories that take into account the effects of such a background field. These effective theories are valid for a weakly non-commutative space-time. It is remarkable to note that already simple models for $\theta^{\mu\nu}(x)$ can help to loosen the bounds on space-time non-commutativity coming from low energy physics. Non-commutative geometry formulated in our framework is a potential candidate for new physics beyond the standard model.Comment: 22 pages, 1 figur

Twistor Strings with Flavour

We explore the tree-level description of a class of N=2 UV-finite SYM theories with fundamental flavour within a topological B-model twistor string framework. In particular, we identify the twistor dual of the Sp(N) gauge theory with one antisymmetric and four fundamental hypermultiplets, as well as that of the SU(N) theory with 2N hypermultiplets. This is achieved by suitably orientifolding/orbifolding the original N=4 setup of Witten and adding a certain number of new topological 'flavour'-branes at the orientifold/orbifold fixed planes to provide the fundamental matter. We further comment on the appearance of these objects in the B-model on CP(3|4). An interesting aspect of our construction is that, unlike the IIB description of these theories in terms of D3 and D7-branes, on the twistor side part of the global flavour symmetry is realised geometrically. We provide evidence for this correspondence by calculating and matching amplitudes on both sides.Comment: 38+12 pages; uses axodraw.sty. v2: References added, minor clarification

Dynamic Vortex Phases and Pinning in Superconductors with Twin Boundaries

We investigate the pinning and driven dynamics of vortices interacting with twin boundaries using large scale molecular dynamics simulations on samples with near one million pinning sites. For low applied driving forces, the vortex lattice orients itself parallel to the twin boundary and we observe the creation of a flux gradient and vortex free region near the edges of the twin boundary. For increasing drive, we find evidence for several distinct dynamical flow phases which we characterize by the density of defects in the vortex lattice, the microscopic vortex flow patterns, and orientation of the vortex lattice. We show that these different dynamical phases can be directly related to microscopically measurable voltage - current V(I) curves and voltage noise. By conducting a series of simulations for various twin boundary parameters we derive several vortex dynamic phase diagrams.Comment: 5 figures, to appear in Phys. Rev.

A Conformally Invariant Holographic Two-Point Function on the Berger Sphere

We apply our previous work on Green's functions for the four-dimensional quaternionic Taub-NUT manifold to obtain a scalar two-point function on the homogeneously squashed three-sphere (otherwise known as the Berger sphere), which lies at its conformal infinity. Using basic notions from conformal geometry and the theory of boundary value problems, in particular the Dirichlet-to-Robin operator, we establish that our two-point correlation function is conformally invariant and corresponds to a boundary operator of conformal dimension one. It is plausible that the methods we use could have more general applications in an AdS/CFT context.Comment: 1+49 pages, no figures. v2: Several typos correcte

Quantitative N- or C-Terminal Labelling of Proteins with Unactivated Peptides by Use of Sortases and a d-Aminopeptidase

Quantitative and selective labelling of proteins is widely used in both academic and industrial laboratories, and catalytic labelling of proteins using transpeptidases, such as sortases, has proved to be a popular strategy for such selective modification. A major challenge for this class of enzymes is that the majority of procedures require an excess of the labelling reagent or, alternatively, activated substrates rather than simple commercially sourced peptides. We report the use of a coupled enzyme strategy which enables quantitative N- and C-terminal labelling of proteins using unactivated labelling peptides. The use of an aminopeptidase in conjunction with a transpeptidase allows sequence-specific degradation of the peptide by-product, shifting the equilibrium to favor product formation, which greatly enhances the reaction efficiency. Subsequent optimisation of the reaction allows N-terminal labelling of proteins using essentially equimolar ratios of peptide label to protein and C-terminal labelling with only a small excess. Minimizing the amount of substrate required for quantitative labelling has the potential to improve industrial processes and facilitate the use of transpeptidation as a method for protein labelling

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths in the GBD. The present iteration of the GBD, GBD 2017, improves on previous assessments and provides timely estimates of the mortality experience of populations globally. METHODS: The GBD uses all available data to produce estimates of mortality rates between 1950 and 2017 for 23 age groups, both sexes, and 918 locations, including 195 countries and territories and subnational locations for 16 countries. Data used include vital registration systems, sample registration systems, household surveys (complete birth histories, summary birth histories, sibling histories), censuses (summary birth histories, household deaths), and Demographic Surveillance Sites. In total, this analysis used 8259 data sources. Estimates of the probability of death between birth and the age of 5 years and between ages 15 and 60 years are generated and then input into a model life table system to produce complete life tables for all locations and years. Fatal discontinuities and mortality due to HIV/AIDS are analysed separately and then incorporated into the estimation. We analyse the relationship between age-specific mortality and development status using the Socio-demographic Index, a composite measure based on fertility under the age of 25 years, education, and income. There are four main methodological improvements in GBD 2017 compared with GBD 2016: 622 additional data sources have been incorporated; new estimates of population, generated by the GBD study, are used; statistical methods used in different components of the analysis have been further standardised and improved; and the analysis has been extended backwards in time by two decades to start in 1950. FINDINGS: Globally, 18·7% (95% uncertainty interval 18·4–19·0) of deaths were registered in 1950 and that proportion has been steadily increasing since, with 58·8% (58·2–59·3) of all deaths being registered in 2015. At the global level, between 1950 and 2017, life expectancy increased from 48·1 years (46·5–49·6) to 70·5 years (70·1–70·8) for men and from 52·9 years (51·7–54·0) to 75·6 years (75·3–75·9) for women. Despite this overall progress, there remains substantial variation in life expectancy at birth in 2017, which ranges from 49·1 years (46·5–51·7) for men in the Central African Republic to 87·6 years (86·9–88·1) among women in Singapore. The greatest progress across age groups was for children younger than 5 years; under-5 mortality dropped from 216·0 deaths (196·3–238·1) per 1000 livebirths in 1950 to 38·9 deaths (35·6–42·83) per 1000 livebirths in 2017, with huge reductions across countries. Nevertheless, there were still 5·4 million (5·2–5·6) deaths among children younger than 5 years in the world in 2017. Progress has been less pronounced and more variable for adults, especially for adult males, who had stagnant or increasing mortality rates in several countries. The gap between male and female life expectancy between 1950 and 2017, while relatively stable at the global level, shows distinctive patterns across super-regions and has consistently been the largest in central Europe, eastern Europe, and central Asia, and smallest in south Asia. Performance was also variable across countries and time in observed mortality rates compared with those expected on the basis of development. INTERPRETATION: This analysis of age-sex-specific mortality shows that there are remarkably complex patterns in population mortality across countries. The findings of this study highlight global successes, such as the large decline in under-5 mortality, which reflects significant local, national, and global commitment and investment over several decades. However, they also bring attention to mortality patterns that are a cause for concern, particularly among adult men and, to a lesser extent, women, whose mortality rates have stagnated in many countries over the time period of this study, and in some cases are increasing