Migrant Farm Workers in Mexico: State of Knowledge

This article presents the results of a scientific social-pedagogical research, which goal was displaying an overview of the current situation of migrant farm workers in Mexico, from a first approach to the state of knowledge on this issue through a documentary-bibliographic study. The study showed that the most researchers approach the issues of migrant farm workers from economic theory, however, is not enough to analyze the economic and social status of this group of people, it is necessary to place it in a multidisciplinary level (including economics, sociology, political science, psychology, education, etc.), study it from the theory of marginality and qualitative approach. &nbsp

Representaciones sociales de los participantes sobre los beneficios del programa Trabaja Perú, en los distritos de Ocuviri y Pusi - 2017

La presente investigación tiene como propósito comprender las representaciones sociales de los participantes sobre los beneficios del programa Trabaja Perú en el distrito de Ocuviri y Pusi. Cuyo procedimiento de investigación se logró interpretando las opiniones, caracterizando las actitudes e identificando las expectativas de la unidad de análisis. Los segmentos vulnerables se focalizan en participantes asignados como líderes, padres o madres de familia, jóvenes y adultos mayores. La metodología utilizada es de carácter cualitativo, desde la perspectiva fenomenológica, utilizando la entrevista como técnica de recolección de información para cuyo análisis se elaboró redes hermenéuticas. El procesamiento y análisis de datos se realizaron a través del software Atlas ti. El método que se ha diseñado es de tipo analítico-interpretativo que se asocia. La muestra fue seleccionada de manera intencional y estuvo conformada por veintiséis participantes del programa Trabaja Perú del distrito de Ocuviri (18) y Pusi (8). Los resultados señalan que las opiniones de la mayoría de los participantes son aceptables debido que, a través del empleo temporal, reciben un incentivo económico de 37 nuevos soles por día trabajado; asimismo la infraestructura básica que realiza el programa, beneficia a su distrito dándole una imagen presentable para una mejor calidad de vida de los pobladores. Por otro lado, las actitudes que tienen los participantes sobre los beneficios son favorables de modo que gracias al incentivo económico que recibieron, priorizan para la compra de alimentos de primera necesidad y para la educación. Finalmente, las expectativas que tienen sobre los beneficios son esperanzadoras porque se espera que el programa siga ejecutando más obras y que genere más empleo temporal.Tesi

Persecución del Ministerio de Transportes y Comunicaciones a radio la voz de Bagua Grande en marco del “Baguazo” durante los años 2009 -2016

La presente investigación denominada “PERSECUCIÓN DEL MINISTERIO DE TRANSPORTES Y COMUNICACIONES A RADIO LA VOZ DE BAGUA GRANDE EN MARCO DEL “BAGUAZO” DURANTE LOS AÑOS 2009 -2016”, utilizó un diseño descriptivo simple donde las técnicas de recolección de datos fueron la entrevista y la observación utilizando como instrumentos la elaboración de preguntas para realizar la entrevista, y la revisión de archivos periodísticos y documentos legales en la observación para sistematizar la información acorde a los objetivos planteados. El objetivo principal fue describir el proceso de persecución del Estado Peruano a radio La Voz en marco del Baguazo teniendo como subvariables , la persecución administrativa – legal y política. De acuerdo a la investigación, para el análisis e interpretación de los resultados, se ha partido de forma insoslayable del “diseño descriptivo simple”, puesto que se ha recopilado, analizado y descrito la persecución del Ministerio de Transportes y Comunicaciones a radio La Voz de Bagua Grande en el marco del “Baguazo” durante los años 2009 – 2016. Se concluyó que existió persecución administrativa – legal y política a este medio, debido a su línea editorial de apoyo al paro amazónico promovido por los nativos Awajún y Wampis. También se evidenció en la dación inmediata de una resolución de suspensión de licencia por parte del Ministerio de Transportes y Comunicaciones, aduciendo a causas administrativas.Tesi

Differences in the S value between male and female murine model for diagnostic, therapeutic and theragnostic radionuclides

The aim of this work was to calculate S values for 99mTc, 67Ga, 68Ga, 18F, 223Ra, 166Ho, 90Y, 161Tb 131I and 177Lu, using a mouse phantom (MOBY) standard and considering the anatomic sizes from males and females, the simulation of radiation transport was performed with GATE/Geant4 platform. This indicates that in the internal dosimetry the use of a customized geometry is relevant for each gender and a standard model is not a good choice

FARMACOVID : Retrospective cohort study of the profile and 2 management of drug interactions in critically ill patients with 3 COVID-19 in a tertiary care hospital in Colombia

15 páginasCritically ill patients with COVID-19 have important risk factors for the occurrence of 21 drug-drug interactions. The aim of this study was to characterize and describe the profile and 22 management of drug-drug interactions in critically ill patients affected by COVID-19 in a tertiary 23 care hospital in Colombia. A descriptive retrospective cohort with an exploratory analytical com- 24 ponent was performed. The medical records of 191 patients were reviewed from August 2020 to 25 February 2021. An initial descriptive analysis was performed, and a bivariate approach was de- 26 veloped to include variables of significance in a multivariate analysis. In our cohort of critically ill 27 patients the following factors were associated with a higher risk of major outcome development: a 28 higher age, Charlson comorbidity index (CCI), Sequential Organ Failure Assessment (SOFA) 29 score, a greater number of prescribed drugs, number of interactions, and the presence of type D 30 interactions.Especialización en Farmacología ClínicaEspecialista en Farmacología Clínic

TcVac1 vaccine delivery by intradermal electroporation enhances vaccine induced immune protection against Trypanosoma cruzi infection in mice

Trabajo de investigación doctoral de Wael Hegazy Hassan Moustafa bajo la dirección de Juan Carlos Vázquez ChagoyánThe efforts for the development and testing of vaccines against Trypanosoma cruzi infection have increased during the past years. We have designed a TcVac series of vaccines composed of T. cruzi derived, GPI-anchored membrane antigens. The TcVac vaccines have been shown to elicit humoral and cellular mediated immune responses and provide significant (but not complete) control of experimental infection in mice and dogs. Herein, we aimed to test two immunization protocols for the delivery of DNA-prime/ DNA-boost vaccine (TcVac1) composed of TcG2 and TcG4 antigens in a BALB/c mouse model. Mice were immunized with TcVac1 through intradermal/electroporation (IDE) or intramuscular (IM) routes, challenged with T. cruzi, and evaluated during acute phase of infection. The humoral immune response was evaluated through the assessment of anti-TcG2 and anti-TcG4 IgG subtypes by using an ELISA. Cellular immune response was assessed through a lymphocyte proliferation assay. Finally, clinical and morphopathological aspects were evaluated for all experimental animals. Our results demonstrated that when comparing TcVac1 IDE delivery vs IM delivery, the former induced significantly higher level of antigen-specific antibody response (IgG2a + IgG2b > IgG1) and lymphocyte proliferation, which expanded in response to challenge infection. Histological evaluation after challenge infection showed infiltration of inflammatory cells (macrophages and lymphocytes) in the heart and skeletal tissue of all infected mice. However, the largest increase in inflammatory infiltrate was observed in TcVac1_IDE/Tc mice when compared with TcVac1_IM/Tc or non-vaccinated/infected mice. The extent of tissue inflammatory infiltrate was directly associated with the control of tissue amastigote nests in vaccinated/ infected (vs. non-vaccinated/infected) mice. Our results suggest that IDE delivery improves the protective efficacy of TcVac1 vaccine against T. cruzi infection in mice when compared with IM delivery of the vaccine.Universidad Autónoma de Estado de México (proyecto No. 3326/2012C), Consejo Nacional de Ciencia y Tecnología (Proyecto No. 156701) . Beca CONACyT a M.Sc. Wael Hegazy Hassan Moustafa (Beca numero No. 518232/291117)

Differentiation of Mouse Embryonic Stem Cells toward Functional Pancreatic ß-Cell Surrogates through Epigenetic Regulation of Pdx1 by Nitric Oxide

Pancreatic and duodenal homeobox 1 (Pdx1) is a transcription factor that regulates the embryonic development of the pancreas and the differentiation toward ß cells. Previously, we have shown that exposure of mouse embryonic stem cells (mESCs) to high concentrations of diethylenetriamine nitric oxide adduct (DETA-NO) triggers differentiation events and promotes the expression of Pdx1. Here we report evidence that Pdx1 expression is associated with release of polycomb repressive complex 2 (PRC2) and P300 from its promoter region. These events are accompanied by epigenetic changes in bivalent markers of histones trimethylated histone H3 lysine 27 (H3K27me3) and H3K4me3, site-specific changes in DNA methylation, and no change in H3 acetylation. On the basis of these findings, we developed a protocol to differentiate mESCs toward insulin-producing cells consisting of sequential exposure to DETA-NO, valproic acid, and P300 inhibitor (C646) to enhance Pdx1 expression and a final maturation step of culture in suspension to form cell aggregates. This small molecule-based protocol succeeds in obtaining cells that express pancreatic ß-cell markers such as PDX1, INS1, GCK, and GLUT2 and respond in vitro to high glucose and KClCentro Anadaluz de Biología Molecular y Medicina Regenerativa (CABIMER)Postprin

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe