Search for primordial black hole dark matter with X-ray spectroscopic and imaging satellite experiments and prospects for future satellite missions

Ultra-light primordial black holes (PBHs) in the mass range of 10$^{16}$ - 10$^{22}$ g are allowed by current observations to constitute a significant fraction, if not all, of the dark matter in the Universe. In this work, we present limits on ultra-light, non-rotating PBHs which arise from the non-detection of the Hawking radiation signals from such objects in the keV-MeV energy band. Namely, we consider observations from the current-generation missions XMM-Newton and INTEGRAL/SPI and discuss the observational perspectives of the future missions Athena, eXTP, and THESEUS for PBH searches. Based on 3.4 Msec total exposure time XMM-Newton observations of Draco dwarf spheroidal galaxy, we conclude that PBH with masses $\lesssim 10^{16}$ g can not make all dark matter at 95% confidence level. Our ON-OFF-type analysis of $>100$ Msec of INTEGRAL/SPI data on the Milky Way halo puts significantly stronger constraints. Only $\lesssim 10$% dark matter can be presented by PBHs with masses $\lesssim 3\cdot 10^{16}$ g while the majority of dark matter can not be represented by PBHs lighter than $7\cdot 10^{16}$ g at 95% confidence level. We discuss the strong impact of systematic uncertainty related to the variations of instrumental and astrophysical INTEGRAL/SPI background on the derived results and estimate its level. We also show that future large-field-of-view missions such as THESEUS/X-GIS will be able to improve the constraints by a factor of 10-100 depending on the level of control under the systematics of these instruments.Comment: To match accepted for publication in Phys. Rev. D. versio

Limits on the Primordial Black Holes Dark Matter with current and future missions

In this proceeding we consider primordial black holes (PBHs) as a dark matter candidate. We discuss the existing limits on the fraction $f_{pbh}$ of the dark matter constituting of PBHs as a function of PBHs mass. The discussed limits cover almost all possible mass range with the currently only open window in $3\cdot 10^{16}-10^{18}$ g in which the PBHs can make up to 100% of the dark matter content of the universe. We present the estimates of the capabilities of the near-future instruments (Einstein Probe/WXT, SVOM/MXT) and discuss the potential of next-generation missions(Athena, THESEUS, eXTP) to probe this mass range. We discuss the targets most suitable for the PBH dark matter searches with these missions and the potential limiting factor of the systematics on the derived results.Comment: to appear in PoS (MULTIF2023

Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) programme with a 2 year follow-up--an observational prospective study.

POPULATION: Spinal cord injury (SCI) patients with neurogenic bladder have an increased risk for symptomatic urinary tract infection (UTI). Recurrent UTI requires multiple courses of antibiotic therapy, markedly increasing the incidence of multidrug-resistant (MDR) bacteria. METHODS: During an observational prospective study, we determined the safety and efficacy of a weekly oral cyclic antibiotic (WOCA) regimen to prevent UTI in SCI adult patients with neurogenic bladder undergoing clean intermittent catheterization. The WOCA regimen consisted of the alternate administration of an antibiotic once per week over a period of at least 2 years. The antibiotics chosen were efficient for UTI, well tolerated and with low selection pressure. RESULTS: There was a significant decrease in antimicrobial consumption linked to the dramatic decrease in the incidence of UTI. Before intervention, there were 9.4 symptomatic UTIs per patient-year, including 197 episodes of febrile UTI responsible for 45 hospitalizations. Under the WOCA regimen there were 1.8 symptomatic UTIs per patient-year, including 19 episodes of febrile UTI. No severe adverse events and no new cases of colonization with MDR bacteria were reported. CONCLUSIONS: In this prospective, observational pilot study a novel approach to the prevention and treatment of UTI in SCI was investigated. Our study shows the benefit of WOCA in preventing UTI in SCI patients

Describing São Tomense Using a Tree-Adjoining Meta-Grammar

Poster sessionInternational audienceIn this paper, we show how the interactions between the tense, aspect and mood preverbal markers in São Tomense can be formally and concisely described at an abstract level, using the concept of projection. More precisely, we show how to encode the different valid orders of preverbal markers in an abstract description of a Tree-Adjoining Grammar of São Tomense. This description is written using the XMG meta-grammar language (Crabbé and Duchier, 2004)

Décrire la morphologie des verbes en ikota au moyen d'une métagrammaire

Association pour le Traitement Automatique des Langues. This article has been published in the Proceedings of the JEP-TALN-RECITAL 2012 conference. Available on-line at https://www.aclweb.org/anthology/W/W12/W12-1309.pdfNational audienceDans cet article, nous montrons comment le concept des métagrammaires introduit initialement par Candito (1996) pour la conception de grammaires d'arbres adjoints décrivant la syntaxe du français et de l'italien, peut être appliquée à la description de la morphologie de l'ikota, une langue bantoue parlé au Gabon. Ici, nous utilisons l'expressivité du formalisme XMG (eXtensible MetaGrammar) pour décrire les variations morphologiques des verbes en ikota. Cette spécification XMG capture les généralisations entre ces variations. Afin de produire un lexique de formes fléchies, il est possible de compiler la spécification XMG, et de sauvegarder le résultat dans un fichier XML, ce qui permet sa réutilisation dans des applications dédiées

Urogenital dysfunction in male patients with Charcot-Marie-Tooth: a systematic review

Aims Purposes of this study were to describe lower urinary tract symptoms (LUTS) and related urodynamic patterns in patients with hereditary spastic paraplegia (HSP), and to characterize LUTS management and associated uronephrological complications. Methods We retrospectively reviewed medical files of HSP patients, consecutively followed in our Physical and Rehabilitation Medicine Department between 1999 and 2016. Clinical, urodynamic, and radiological data were collected and analyzed. Different treatments which have been prescribed and uronephrological complications were also recorded. Patients with other neurological or urological diseases were excluded. Results Thirty-three patients with HSP were included. Mean duration of follow-up was 8.1 ± 5 years, mean age 62 ± 14 years, and 70% were men. The most frequent LUTS was urgency and voiding dysfunction (both 69.7%). Incontinence and retention with a significant postvoid residue above 100 mL accounted for 66.7% and 57.6% of initial symptoms respectively. Neurogenic detrusor overactivity was diagnosed in 80.7% of patients. Two-thirds of our cohort were treated with anticholinergics and 9.1% required intradetrusor botulinum-toxin injections. Only 27.3% of patients performed clean intermittent self-catheterization. Febrile urinary tract infections (21.2%), urolithiasis (15,1%), hydronephrosis (6%), and chronic renal failure (9.1%) were found. Conclusion Given their high prevalence and the risk of uronephrological complications, LUTS should be systematically assessed in HSP patients. The systematic screening of urological dysfunction in this population would improve its management, decrease the incidence of uronephrological complications, and increase the quality of life

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis

: The prevention and management of bleeding and thrombosis in patients with cirrhosis poses several difficult clinical questions. These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy regarding the need to correct thrombocytopenia and abnormalities in the coagulation system in patients undergoing invasive procedures, and the need for thromboprophylaxis in hospitalised patients with haemostatic abnormalities. Multiple recommendations in this document are based on interventions that the panel feels are not useful, even though widely applied in clinical practice

Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex

To study the nuclear export of preribosomes, ribosomal RNAs were detected by in situ hybridization using fluorescence and EM, in the yeast Saccharomyces cerevisiae. In wild-type cells, semiquantitative analysis shows that the distributions of pre-40S and pre-60S particles in the nucleolus and the nucleoplasm are distinct, indicating uncoordinated transport of the two subunits within the nucleus. In cells defective for the activity of the GTPase Gsp1p/Ran, ribosomal precursors accumulate in the whole nucleus. This phenotype is reproduced with pre-60S particles in cells defective in pre-rRNA processing, whereas pre-40S particles only accumulate in the nucleolus, suggesting a tight control of the exit of the small subunit from the nucleolus. Examination of nucleoporin mutants reveals that preribosome nuclear export requires the Nup82p–Nup159p–Nsp1p complex. In contrast, mutations in the nucleoporins forming the Nup84p complex yield very mild or no nuclear accumulation of preribosome. Interestingly, domains of Nup159p required for mRNP trafficking are not necessary for preribosome export. Furthermore, the RNA helicase Dbp5p and the protein Gle1p, which interact with Nup159p and are involved in mRNP trafficking, are dispensable for ribosomal transport. Thus, the Nup82p–Nup159p–Nsp1p nucleoporin complex is part of the nuclear export pathways of preribosomes and mRNPs, but with distinct functions in these two processes

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements