Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

First on-sky results with ARGOS at LBT

One year and an half after ARGOS first light, the Large Binocular Telescope (LBT) laser guided ground-layer adaptive optics (GLAO) system has been operated on both sides of the LBT. The system fulfills the GLAO promise and typically delivers an improvement by a factor of 2 in FWHM over the 4'×4' field of view of both Luci instruments, the two near-infrared imagers and multi-object spectrographs. In this paper, we report on the first on-sky results and analyze the performances based on the data collected so far. We also discuss adaptive optics procedures and the joint operations with Luci for science observations

Timing, drivers and impacts of the historic Masiere di Vedana rock avalanche (Belluno Dolomites, NE Italy)

The "Masiere di Vedana" rock avalanche, located in the Belluno Dolomites (NE Italy) at the foot of Mt. Peron, is reinterpreted as historic on the base of archeological information and cosmogenic Cl-36 exposure dates. The deposit is 9 km(2) wide, has a volume of similar to 170 Mm(3) corresponding to a pre-detachment rock mass of similar to 130 Mm(3) , and has a maximum runout distance of 6 km and an H/L ratio of similar to 0.2. Differential velocities of the rock avalanche moving radially over different topography and path material lead to the formation of specific landforms (tomas and compressional ridges). In the Mt. Peron crown the bedding is subvertical and includes carbonate lithologies from Lower Jurassic (Calcan Grigi Group) to Cretaceous (Majolica) in age. The stratigraphic sequence is preserved in the deposit with the formations represented in the boulders becoming younger with distance from the source area. In the release area the bedding, the SSE-verging frontal thrust planes, the NW-verging backthrust planes, the NW-SE fracture planes, and the N- S Jurassic fault planes controlled the failure and enhanced the rock mass fragmentation. The present Mt. Peron crown still shows hundreds-of-metres-high rock prisms bounded by backwall trenches. Cosmogenic Cl-36 exposure ages, mean 1.90 +/- 0.45 ka, indicate failure occurred between 340 BCE and 560 CE. Although abundant Roman remains were found in sites surrounding the rock avalanche deposit, none were found within the deposit, and this is consistent with a late Roman or early Middle Ages failure. Seismic and climatic conditions as landslide predisposing factors are discussed. Over the last few hundred years, earthquakes up to M-w = 6.3, including that at 365 CE, have affected the Belluno area. Early in the first millennium, periods of climate worsening with increasing rainfall occurred in the NE Alps. The combination of climate and earthquakes induced progressive long-term damage to the rock until a critical threshold was reached and the Masiere di Vedana rock avalanche occurred.ISSN:1561-8633ISSN:1684-998

First Results of the Ground Layer Adaptive Optics System ARGOS

We present the first results of Argos, the multiple laser guide star and wavefront sensing facility for the Large Binocular Telescope. This system will deliver an improvement by a factor of two in FWHM over the 4′×4′ field of view of both Luci instruments. Luci 1 and Luci 2 are two near-infrared wide field imagers and multi-object spectrographs which capability and efficiency will be boosted by the increased resolution and encircled energy.The first on-sky ground-layer adaptive optics (GLAO) loop closure with Argos has been achieved in Fall 2014 on the right eye of the telescope. Stable operations in closed-loop have been demonstrated in May 2015 with hour-long integration and repeated good performances over several nights. Since then, the commissioning has been proceeding with the installation of the left system and the beginning of the left on-sky operations in this Fall 2015. The next achievements will be to strengthen the operational aspects and to perform science demonstration in both imaging and spectroscopic modes. We first present the current status of the project and review the operational aspects. Then, we analyze the first combined Luci and Argos observations and discuss the performances and the gains provided by Argos in term of scientific capabilities

Commissioning of ARGOS at LBT: adaptive optics procedures

ARGOS is the laser guide star facility of the Large Binocular Telescope (LBT). It implements a Rayleigh Laser Guide Star system that provides Ground Layer Adaptive Optics (GLAO) correction for the LUCIs, the 2 wide- field near-infrared imagers and multi-object spectrographs installed on the 2 eyes of LBT. In this paper we describe how LBT’s adaptive optics operations have been tailored to ARGOS’s use cases based on the experience developed during over the ARGOS commissioning. We focus on all the aspects that are influenced by the use of the Laser Guide Stars, from collimation to acquisition and LGS guiding and we details the sequences to start, pause and resume the adaptive correction

Commissioning of ARGOS at LBT: adaptive optics procedures

ARGOS is the laser guide star facility of the Large Binocular Telescope (LBT). It implements a Rayleigh Laser Guide Star system that provides Ground Layer Adaptive Optics (GLAO) correction for the LUCIs, the 2 wide- field near-infrared imagers and multi-object spectrographs installed on the 2 eyes of LBT. In this paper we describe how LBT’s adaptive optics operations have been tailored to ARGOS’s use cases based on the experience developed during over the ARGOS commissioning. We focus on all the aspects that are influenced by the use of the Laser Guide Stars, from collimation to acquisition and LGS guiding and we details the sequences to start, pause and resume the adaptive correction