509 research outputs found
MuSR method and tomographic probability representation of spin states
Muon spin rotation/relaxation/resonance (MuSR) technique for studying matter
structures is considered by means of a recently introduced probability
representation of quantum spin states. A relation between experimental MuSR
histograms and muon spin tomograms is established. Time evolution of muonium,
anomalous muonium, and a muonium-like system is studied in the tomographic
representation. Entanglement phenomenon of a bipartite muon-electron system is
investigated via tomographic analogues of Bell number and positive partial
transpose (PPT) criterion. Reconstruction of the muon-electron spin state as
well as the total spin tomography of composed system is discussed.Comment: 20 pages, 4 figures, LaTeX, submitted to Journal of Russian Laser
Researc
Qubit portrait of the photon-number tomogram and separability of two-mode light states
In view of the photon-number tomograms of two-mode light states, using the
qubit-portrait method for studying the probability distributions with infinite
outputs, the separability and entanglement detection of the states are studied.
Examples of entangled Gaussian state and Schr\"{o}dinger cat state are
discussed.Comment: 20 pages, 6 figures, TeX file, to appear in Journal of Russian Laser
Researc
Reduction of the secondary structure topological space through direct estimation of the contact energy formed by the secondary structures
WNT signalling in prostate cancer
Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-resistant prostate cancer. WNT signalling is also important in the prostate tumour microenvironment, in which WNT proteins secreted by the tumour stroma promote resistance to therapy, and in prostate cancer stem or progenitor cells, in which WNT-ÎČ-catenin signals promote self-renewal or expansion. Preclinical studies have demonstrated the potential of inhibitors that target WNT receptor complexes at the cell membrane or that block the interaction of ÎČ-catenin with lymphoid enhancer-binding factor 1 and the androgen receptor, in preventing prostate cancer progression. Some WNT signalling inhibitors are in phase I trials, but they have yet to be tested in patients with prostate cancer
Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study
TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities.
The redox state of the neural progenitors regulates physiological processes such as neuronal differentiation and dendritic and axonal growth. The relevance of endoplasmic reticulum (ER)-associated oxidoreductases in these processes is largely unexplored. We describe a severe neurological disorder caused by bi-allelic loss-of-function variants in thioredoxin (TRX)-related transmembrane-2 (TMX2); these variants were detected by exome sequencing in 14 affected individuals from ten unrelated families presenting with congenital microcephaly, cortical polymicrogyria, and other migration disorders. TMX2 encodes one of the five TMX proteins of the protein disulfide isomerase family, hitherto not linked to human developmental brain disease. Our mechanistic studies on protein function show that TMX2 localizes to the ER mitochondria-associated membranes (MAMs), is involved in posttranslational modification and protein folding, and undergoes physical interaction with the MAM-associated and ER folding chaperone calnexin and ER calcium pump SERCA2. These interactions are functionally relevant because TMX2-deficient fibroblasts show decreased mitochondrial respiratory reserve capacity and compensatory increased glycolytic activity. Intriguingly, under basal conditions TMX2 occurs in both reduced and oxidized monomeric form, while it forms a stable dimer under treatment with hydrogen peroxide, recently recognized as a signaling molecule in neural morphogenesis and axonal pathfinding. Exogenous expression of the pathogenic TMX2 variants or of variants with an in vitro mutagenized TRX domain induces a constitutive TMX2 polymerization, mimicking an increased oxidative state. Altogether these data uncover TMX2 as a sensor in the MAM-regulated redox signaling pathway and identify it as a key adaptive regulator of neuronal proliferation, migration, and organization in the developing brain
Habilidades funcionais de crianças com deficiĂȘncias em inclusĂŁo escolar: barreiras para uma inclusĂŁo efetiva
An effective multisource informed consent procedure for research and clinical practice: an observational study of patient understanding and awareness of their roles as research stakeholders in a cancer biobank
Search for anomalous couplings in the W tb vertex from the measurement of double differential angular decay rates of single top quarks produced in the t-channel with the ATLAS detector
The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper uses 4.6 fbâ1 of proton-proton collision data at âs =7 TeV collected with the ATLAS detector at the LHC. Two parameters are measured simultaneously in this analysis. The fraction f 1 of decays containing transversely polarised W bosons is measured to be 0.37 ± 0.07 (stat.âsyst.). The phase ÎŽ â between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be â0.014Ï Â± 0.036Ï (stat.âsyst.). The correlation in the measurement of these parameters is 0.15. These values result in two-dimensional limits at the 95% confidence level on the ratio of the complex coupling parameters g R and V L, yielding Re[g R /V L] â [â0.36, 0.10] and Im[g R /V L] â [â0.17, 0.23] with a correlation of 0.11. The results are in good agreement with the predictions of the Standard Model
Modelling Z â ÏÏ processes in ATLAS with Ï-embedded Z â ΌΌ data
This paper describes the concept, technical realisation and validation of a largely data-driven method to model events with ZâÏÏ decays. In ZâΌΌ events selected from proton-proton collision data recorded at âs=8 TeV with the ATLAS experiment at the LHC in 2012, the Z decay muons are replaced by Ï leptons from simulated ZâÏÏ decays at the level of reconstructed tracks and calorimeter cells. The Ï lepton kinematics are derived from the kinematics of the original muons. Thus, only the well-understood decays of the Z boson and Ï leptons as well as the detector response to the Ï decay products are obtained from simulation. All other aspects of the event, such as the Z boson and jet kinematics as well as effects from multiple interactions, are given by the actual data. This so-called Ï-embedding method is particularly relevant for Higgs boson searches and analyses in ÏÏ final states, where ZarrowÏÏ decays constitute a large irreducible background that cannot be obtained directly from data control samples. In this paper, the relevant concepts are discussed based on the implementation used in the ATLAS Standard Model HâÏÏ analysis of the full datataset recorded during 2011 and 2012
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