Suitability of vaccinia virus and bovine viral diarrhea virus (BVDV) for determining activities of three commonly-used alcohol-based hand rubs against enveloped viruses

BACKGROUND: A procedure for including activity against enveloped viruses in the post-contamination treatment of hands has been recommended, but so far no European standard is available to implement it. In 2004, the German Robert Koch-Institute (RKI) and the German Association for the Control of Virus Disease (DVV) suggested that vaccinia virus and bovine viral diarrhea virus (BVDV) should be used as test viruses in a quantitative suspension test to determine the activity of a disinfectant against all enveloped viruses. METHODS: We have studied the activities of three commonly-used alcohol-based hand rubs (hand rub A, based on 45% propan-2-ol, 30% propan-1-ol and 0.2% mecetronium etilsulfate; hand rub B, based on 80% ethanol; hand rub C, based on 95% ethanol) against vaccinia virus and BVDV, and in addition against four other clinically relevant enveloped viruses: herpes simplex virus (HSV) types 1 and 2, and human and avian influenza A virus. The hand rubs were challenged with different organic loads at exposure time of 15, 30 and 60 s. According to the guidelines of both BGA/RKI and DVV, and EN 14476:2005, the reduction of infectivity of each test virus was measured on appropriate cell lines using a quantitative suspension test. RESULTS: All three alcohol-based hand rubs reduced the infectivity of vaccinia virus and BVDV by ≥ 4 log(10)-steps within 15 s, irrespective of the type of organic load. Similar reductions of infectivity were seen against the other four enveloped viruses within 15 s in the presence of different types of organic load. CONCLUSION: Commonly used alcohol-based hand rubs with a total alcohol concentration ≥ 75% can be assumed to be active against clinically relevant enveloped viruses if they effectively reduce the infectivities of vaccinia virus and BVDV in a quantitative suspension test

Laboratory assessment of cold weather clothing

An overview of laboratory tests for cold weather clothing is provided starting from physical measurements on fabrics, and physical measurements on whole garments using thermal manikins. This is extended to human wear trials and climatic chamber experimentation. Insulation and vapour resistance are considered the most relevant parameters followed by wind and water proofness and moisture absorption properties. The use of test participants in wear trials is considered regarding the information provided by such tests. Tests for innovative fabrics (heated, variable insulation, phase change materials) are discussed. Finally testing of sleeping bags is considered

Seismic analysis of a tall metal wind turbine support tower with realistic geometric imperfections

The global growth in wind energy suggests that wind farms will increasingly be deployed in seismically active regions, with large arrays of similarly designed structures potentially at risk of simultaneous failure under a major earthquake. Wind turbine support towers are often constructed as thin-walled metal shell structures, well known for their imperfection sensitivity, and are susceptible to sudden buckling failure under compressive axial loading. This study presents a comprehensive analysis of the seismic response of a 1.5-MW wind turbine steel support tower modelled as a near-cylindrical shell structure with realistic axisymmetric weld depression imperfections. A selection of 20 representative earthquake ground motion records, 10 ‘near-fault’ and 10 ‘far-field’, was applied and the aggregate seismic response explored using lateral drifts and total plastic energy dissipation during the earthquake as structural demand parameters. The tower was found to exhibit high stiffness, although global collapse may occur soon after the elastic limit is exceeded through the development of a highly unstable plastic hinge under seismic excitations. Realistic imperfections were found to have a significant effect on the intensities of ground accelerations at which damage initiates and on the failure location, but only a small effect on the vibration properties and the response prior to damage. Including vertical accelerations similarly had a limited effect on the elastic response, but potentially shifts the location of the plastic hinge to a more slender and, therefore, weaker part of the tower. The aggregate response was found to be significantly more damaging under near-fault earthquakes with pulse-like effects and large vertical accelerations than far-field earthquakes without these aspects

Topology optimisation of lattice telecommunication tower and performance-based design considering wind and ice loads

With increasing demand of infrastructure to support power transmission and telecommunication systems, the need of erecting more towers has also been rising significantly. For many years, these towers were designed by using a conservative approach and the opportunities lying in the design optimisation of the towers were not leveraged. This paper presents the application of structural topology optimisation to lattice self-supported telecommunication towers in developing an improved solution in terms of weight-to-stiffness ratio. 2D and 3D topology optimisation studies were performed with highly optimised bracing systems reducing the amount of steel material used, thus its carbon footprint. The new exoskeleton structure is representing a lattice tower composed of ‘high-waisted’ bracing type and elliptical hollow sections (EHS). Comparative modal analyses demonstrated the structural performance of the optimised tower models. In addition, a research-led design was carried out for optimising the geometric cross-sectional properties of the optimised lattice tower subjected to quasi-static analysis followed by regression analysis. The cross-sectional parameters were progressively changed; explicitly the diameter and thickness of the members. The performance-based analysis and design of a topologically optimised lattice tower present alternatives to onerous approaches such as wind tunnel testing or finite element modelling. The results were further analysed to understand their viability in different loading design cases and the effect of cross-sections. Conclusions highlighted the benefits gained by introducing the structural topology optimisation process in the design of slender support structures

Measurement of the W±Z boson pair-production cross section in pp collisions at √s=13TeV with the ATLAS detector

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