Approximate Bayesian computation in large-scale structure: constraining the galaxy-halo connection

FWN – Publicaties zonder aanstelling Universiteit Leide

Flavor Changing Neutral Currents involving Heavy Quarks with Four Generations

We study various FCNC involving heavy quarks in the Standard Model (SM) with a sequential fourth generation. After imposing $B\to X_s\gamma$, $B\to X_sl^+l^-$ and $Z\to b\bar{b}$ constraints, we find ${\cal B}(Z\to s\bar{b}+\bar{s}b)$ can be enhanced by an order of magnitude to $10^{-7}$, while $t\to cZ, cH$ decays can reach $10^{-6}$, which are orders of magnitude higher than in SM. However,these rates are still not observable for the near future.With the era of LHC approaching, we focus on FCNC decays involving fourth generation $b^\prime$ and $t^\prime$ quarks. We calculate the rates for loop induced FCNC decays $b^\prime\to bZ, bH, bg, b\gamma$, as well as t^\prime\to tZ,\tH, tg, t\gamma. If $|V_{cb'}|$ is of order $|V_{cb}| \simeq 0.04$, tree level $b^\prime\to cW$ decay would dominate, posing a challenge since $b$-tagging is less effective. For $|V_{cb'}| \ll |V_{cb}|$, $b'\to tW$ would tend to dominate, while $b'\to t^\prime W^*$ could also open for heavier $b'$, leading to thepossibility of quadruple-$W$ signals via $b'\bar b'\to b\bar b W^+W^-W^+W^-$. The FCNC $b'\to bZ, bH$ decays could still dominate if $m_{b'}$ is just above 200 GeV. For the case of $t'$, ingeneral $t^\prime\to bW$ would be dominant, hence it behaves like a heavy top. For both $b'$ and $t'$, except for the intriguing light $b'$ case, FCNC decays are in the $10^{-4} -10^{-2}$ range, and are quite detectable at the LHC.For a possible future ILC, we find the associated production of FCNC $e^+e^-\to b\bar s$, $t\bar c$ are below sensitivity, while $e^+e^-\to b^\prime\bar b$ and$t^\prime\bar t$ can be better probed.Tevatron Run-II can still probe the lighter $b'$ or $t'$ scenario. LHC would either discover the fourth generation and measure the FCNC rates, or rule out the fourth generation conclusively.Comment: 31 pages, 15 eps figures, version to appear in JHE

Survival, pathologic response, and genomics in CALGB 40601 (Alliance), a neoadjuvant Phase III trial of paclitaxel-trastuzumab with or without lapatinib in HER2-positive breast cancer

PURPOSE CALGB 40601 assessed whether dual versus single human epidermal growth factor receptor 2 (HER2) -targeting drugs added to neoadjuvant chemotherapy increased pathologic complete response (pCR). Here, we report relapse-free survival (RFS), overall survival (OS), and gene expression signatures that predict pCR and survival. PATIENTS AND METHODS Three hundred five women with untreated stage II and III HER2-positive breast cancer were randomly assigned to receive weekly paclitaxel combined with trastuzumab plus lapatinib (THL), trastuzumab (TH), or lapatinib (TL). The primary end point was pCR, and secondary end points included RFS, OS, and gene expression analyses. mRNA sequencing was performed on 264 pretreatment samples. RESULTS One hundred eighteen patients were randomly allocated to THL, 120 to TH, and 67 to TL. At more than 7 years of follow-up, THL had significantly better RFS and OS than did TH (RFS hazard ratio, 0.32; 95% CI, 0.14 to 0.71; P 5.005; OS hazard ratio, 0.34; 95% CI, 0.12 to 0.94; P 5.037), with no difference between TH and TL. Of 688 previously described gene expression signatures, significant associations were found in 215 with pCR, 45 with RFS, and only 22 with both pCR and RFS (3.2%). Specifically, eight immune signatures were significantly correlated with a higher pCR rate and better RFS. Among patients with residual disease, the immunoglobulin G signature was an independent, good prognostic factor, whereas the HER2-enriched signature, which was associated with a higher pCR rate, showed a significantly shorter RFS. CONCLUSION In CALGB 40601, dual HER2-targeting resulted in significant RFS and OS benefits. Integration of intrinsic subtype and immune signatures allowed for the prediction of pCR and RFS, both overall and within the residual disease group. These approaches may provide means for rational escalation and de-escalation treatment strategies in HER2-positive breast cancer

Lepton Flavor Violation in Z and Lepton Decays in Supersymmetric Models

The observation of charged lepton flavor non-conservation would be a clear signature of physics beyond the Standard Model. In particular, supersymmetric (SUSY) models introduce mixings in the sneutrino and the charged slepton sectors which could imply flavor-changing processes at rates accessible to upcoming experiments. In this paper we analyze the possibility to observe Z --> lep_I lep_J in the GigaZ option of TESLA at DESY. We show that although models with SUSY masses above the current limits could predict a branching ratio BR(Z --> mu e) accessible to the experiment, they would imply an unobserved rate of mu --> e gamma and thus are excluded. In models with a small mixing angle between the first and the third (or the second and the third) slepton families GigaZ could observe Z --> tau mu (or Z --> tau e) consistently with present bounds on lep_J --> lep_I gamma. In contrast, if the mixing angles between the three slepton families are large the bounds from mu --> e gamma push these processes below the reach of GigaZ. We show that in this case the masses of the three slepton families must be strongly degenerated (with mass differences of order 10^{-3}). We update the limits on the slepton mass insertions delta_{LL,RR,LR} and discuss the correlation between flavor changing and g_mu-2 in SUSY models.Comment: 23 pages, 6 figures. Version to appear in Phys. Rev.

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio

Search for charginos in e+e- interactions at sqrt(s) = 189 GeV

An update of the searches for charginos and gravitinos is presented, based on a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by combining the chargino searches with neutralino searches at the Z resonance implies a limit on the mass of the lightest neutralino which, for a heavy sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure

Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP

Promptly decaying lightest neutralinos and long-lived staus are searched for in the context of light gravitino scenarios. It is assumed that the stau is the next to lightest supersymmetric particle (NLSP) and that the lightest neutralino is the next to NLSP (NNLSP). Data collected with the Delphi detector at centre-of-mass energies from 161 to 183 \GeV are analysed. No evidence of the production of these particles is found. Hence, lower mass limits for both kinds of particles are set at 95% C.L.. The mass of gaugino-like neutralinos is found to be greater than 71.5 GeV/c^2. In the search for long-lived stau, masses less than 70.0 to 77.5 \GeVcc are excluded for gravitino masses from 10 to 150 \eVcc . Combining this search with the searches for stable heavy leptons and Minimal Supersymmetric Standard Model staus a lower limit of 68.5 \GeVcc may be set for the stau mas

Hadronization properties of b quarks compared to light quarks in e+e- -> q qbar from 183 to 200 GeV

The DELPHI detector at LEP has collected 54 pb^{-1} of data at a centre-of-mass energy around 183 GeV during 1997, 158 pb^{-1} around 189 GeV during 1998, and 187 pb^{-1} between 192 and 200 GeV during 1999. These data were used to measure the average charged particle multiplicity in e+e- -> b bbar events, _{bb}, and the difference delta_{bl} between _{bb} and the multiplicity, _{ll}, in generic light quark (u,d,s) events: delta_{bl}(183 GeV) = 4.55 +/- 1.31 (stat) +/- 0.73 (syst) delta_{bl}(189 GeV) = 4.43 +/- 0.85 (stat) +/- 0.61 (syst) delta_{bl}(200 GeV) = 3.39 +/- 0.89 (stat) +/- 1.01 (syst). This result is consistent with QCD predictions, while it is inconsistent with calculations assuming that the multiplicity accompanying the decay of a heavy quark is independent of the mass of the quark itself.Comment: 13 pages, 2 figure

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter