Reliability based design optimization of a multi‐axial load cell using genetic algorithm

A construção de uma célula de carga multiaxial requer ferramentas robustas a fim de analisar o comportamento da mesma quando submetida a carregamentos estáticos e dinâmicos. Neste trabalho, é dada uma ênfase ao problema da otimização de um modelo de célula de carga multiaxial (6 componentes de força) do tipo Lywood, utilizando‐se do conceito de otimização baseada em confiabilidade. É tratado o problema da análise de confiabilidade estrutural, incluindo o efeito da variabilidade geométrica de suas propriedades físicas. A célula de carga foi analisada pelo método de elementos finitos e a restrição da confiabilidade é aplicada para o limite de falha do material. Por meio de mudanças em sua geometria objetivou‐se a maximização da primeira frequência natural e, ao mesmo tempo, a redução de massa e consequente aumento da deformação medida sem que a restrição de confiabilidade das tensões seja violada. São mostradas comparações entre o procedimento determinístico de otimização e o proposto, onde constatou‐se que a otimização determinística apresentou pontos com elevada probabilidade de falha, sendo justificada a aplicação da otimização baseada em confiabilidade para este tipo de problema. Também foram aplicados diferentes valores do fator de segurança ao modelo de otimização, onde foi possível analisar, a posteriori , a confiabilidade do resultado da otimização.The manufacturing process of a multi‐axial load cell requires robust tools to analyze the structural behavior when it is subjected to static and dynamic loads. In this work, it is given focus to the problem of optimizing a multi‐axial load cell model (6 load components) of Lywood type considering concepts of reliability‐based design optimization. The reliability structural analysis problem is handled including the variability effect of geometric and physical properties. The load cell is analyzed by finite element method and the reliability constraint is applied to the strength limit. The objective is the maximization of the first natural frequency and simultaneously reducing the mass and corresponding strains without violating reliability limit set as a limit. Comparisons between the deterministic optimization procedure and the proposed method are presented and it is found that the deterministic optimization points may have a high probability of failure so justifying in this type of problem the reliability‐based optimization. Different values of the safety factor were also tested with the optimization model, and it was possible to analyze, a posteriori, the reliability of the optimization results.La construcción de una célula de carga multiaxial requiere herramientas robustas para analizar el comportamiento de los mismos cuando se somete a cargas estáticas y dinámicas. En este trabajo se da un énfasis al problema de la optimización de un modelo de célula de carga multiaxial (6 componentes de fuerza) de tipo Lywood utilizando el concepto de optimización basado en la confiabilidad. Se abordó el problema de análisis de fiabilidad estructural incluyendo el efecto de la variabilidad geométrica de sus propiedades físicas. La célula de carga se analizó por el método de elementos finitos y la restricción de fiabilidad se aplica al límite de falla del material. A través de cambios en la geometría destinadas a aumentar al máximo la primera frecuencia natural, mientras que se viola la reducción de la masa y el consiguiente aumento de la deformación medido sin la fiabilidad de la restricción de tensiones sea violada. Las comparaciones se muestran entre el procedimiento de optimización determinista y propusieron, donde se encontró que los puntos de optimización deterministas con alta probabilidad de fallo. Fueron también aplicados diferentes valores del factor de seguridad para el modelo de optimización, donde fue posible analizar, retrospectivamente, la confiabilidad del resultado de la optimización.Peer Reviewe

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αVβ3

Herein we report the synthesis of three multimeric RGD peptidomimetic-paclitaxel conjugates featuring a number of \u3b1V\u3b23 integrin ligands ranging from 2 to 4 (compounds 7-9). These constructs were assembled by conjugation of the integrin \u3b1V\u3b23 ligand cyclo[DKP-RGD]-CH2NH2 (2) with paclitaxel (3) via a 2\u2019-carbamate with a self-immolative spacer, the lysosomally cleavable Val-Ala dipeptide linker, a multimeric scaffold, a triazole linkage, and finally a PEG spacer. Two monomeric conjugates (compounds 5-6) were also synthesized as reference compounds. Remarkably, the new multimeric conjugates showed a binding affinity for the purified integrin \u3b1V\u3b23 receptor which increased with the number of integrin ligands (reaching a minimum IC50 value of 1.2 nM for the trimeric), thus demonstrating that multivalency is an effective strategy to strengthen the ligand-target interactions

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Measurement of the inclusive isolated prompt photon cross-section in pp collisions at sqrt(s)= 7 TeV using 35 pb-1 of ATLAS data

A measurement of the differential cross-section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. The measurement covers the pseudorapidity ranges |eta|<1.37 and 1.52<=|eta|<2.37 in the transverse energy range 45<=E_T<400GeV. The results are based on an integrated luminosity of 35 pb-1, collected with the ATLAS detector at the LHC. The yields of the signal photons are measured using a data-driven technique, based on the observed distribution of the hadronic energy in a narrow cone around the photon candidate and the photon selection criteria. The results are compared with next-to-leading order perturbative QCD calculations and found to be in good agreement over four orders of magnitude in cross-section.Comment: 7 pages plus author list (18 pages total), 2 figures, 4 tables, final version published in Physics Letters

Measurement of D*+/- meson production in jets from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

This paper reports a measurement of D*+/- meson production in jets from proton-proton collisions at a center-of-mass energy of sqrt(s) = 7 TeV at the CERN Large Hadron Collider. The measurement is based on a data sample recorded with the ATLAS detector with an integrated luminosity of 0.30 pb^-1 for jets with transverse momentum between 25 and 70 GeV in the pseudorapidity range |eta| < 2.5. D*+/- mesons found in jets are fully reconstructed in the decay chain: D*+ -> D0pi+, D0 -> K-pi+, and its charge conjugate. The production rate is found to be N(D*+/-)/N(jet) = 0.025 +/- 0.001(stat.) +/- 0.004(syst.) for D*+/- mesons that carry a fraction z of the jet momentum in the range 0.3 < z < 1. Monte Carlo predictions fail to describe the data at small values of z, and this is most marked at low jet transverse momentum.Comment: 10 pages plus author list (22 pages total), 5 figures, 1 table, matches published version in Physical Review

Search for scalar top quark pair production in natural gauge mediated supersymmetry models with the ATLAS detector in pp collisions at sqrt(s) = 7 TeV

The results of a search for pair production of the lighter scalar partners of top quarks in 2.05 fb-1 of pp collisions at sqrt(s) =7 TeV using the ATLAS experiment at the LHC are reported. Scalar top quarks are searched for in events with two same flavour opposite-sign leptons (electrons or muons) with invariant mass consistent with the Z boson mass, large missing transverse momentum and jets in the final state. At least one of the jets is identified as originating from a b-quark. No excess over Standard Model expectations is found. The results are interpreted in the framework of R-parity conserving, gauge mediated Supersymmetry breaking `natural' scenarios, where the neutralino is the next-to-lightest supersymmetric particle. Scalar top quark masses up to 310 GeV are excluded for the lightest neutralino mass between 115 GeV and 230 GeV at 95% confidence level, reaching an exclusion of the scalar top quark mass of 330 GeV for the lightest neutralino mass of 190 GeV. Scalar top quark masses below 240 GeV are excluded for all values of the lightest neutralino mass above the Z boson mass.Comment: 7 pages plus author list (20 pages total), 4 figures, 1 table, matches published PLB versio

Measurement of the production cross section of prompt j/psi mesons in association with a W (+/-) boson in pp collisions root s=7 TeV with the ATLAS detector

The process pp → W±J/ψ provides a powerful probe of the production mechanism of charmonium in hadronic collisions, and is also sensitive to multiple parton interactions in the colliding protons. Using the 2011 ATLAS dataset of 4.5 fb-1 of p s = 7TeV pp collisions at the LHC, the first observation is made of the production of W± + prompt J/ events in hadronic collisions, using W± → μ and J/ψ → μ+μ-. A yield of 27.4±7.5 -6.5 W± + prompt J/ψ events is observed, with a statistical significance of 5.1. The production rate as a ratio to the inclusive W± boson production rate is measured, and the double parton scattering contribution to the cross section is estimated. Copyright CERN, for the benefit of the ATLAS Collaboration

Search for supersymmetry in final states with jets, missing transverse momentum and one isolated lepton in sqrt{s} = 7 TeV pp collisions using 1 fb-1 of ATLAS data

We present an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon, using 1.04 fb^-1 of proton-proton collision data at sqrt{s} = 7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011. The analysis is carried out in four distinct signal regions with either three or four jets and variations on the (missing) transverse momentum cuts, resulting in optimized limits for various supersymmetry models. No excess above the standard model background expectation is observed. Limits are set on the visible cross-section of new physics within the kinematic requirements of the search. The results are interpreted as limits on the parameters of the minimal supergravity framework, limits on cross-sections of simplified models with specific squark and gluino decay modes, and limits on parameters of a model with bilinear R-parity violation.Comment: 18 pages plus author list (30 pages total), 9 figures, 4 tables, final version to appear in Physical Review