33 research outputs found

    Gorilla Park: A Sustainable Space for All (Mobility pilot project)

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    This project explores urban design and urban systems solutions to address issues of shared mobility, accessibility and urban fragmentation. It is a pilot project to create a park and a shared mobility hub in the borough of Rosemont-La-Petite-Patrie in Montreal. This is to be a node of many in a metropolitan-wide shared mobility system. A shared mobility approach to city planning incorporates notions of Transportation Oriented Development (TOD) and Pedestrian Oriented Development (POD) and links it to notions of smart cities and autonomous transportation. The challenge at hand was to create a public space that incorporates these questions as well as notions of placemaking, community planning and open urbanisms. The project is part of an urban design studio taught in the Department of Geography Planning and Environment at Concordia University in Montreal, and it takes place in the context of the first edition of the CitéStudio Montreal program, which fosters collaborations between academics, students and the city government. The solutions explored in this project were conceived by the students of URBS333 - Urban Laboratory (class of 2019-2020) under the supervision of the instructor (S. De la Llata) and in collaboration with stakeholders and neighbours of Gorilla Park. The solutions are divided into five thematic axes (Sustainability, Mobility and Accessibility, Community Engagement, Hard Design and Soft Design)

    Thyroid hormone enhances transected axonal regeneration and muscle reinnervation following rat sciatic nerve injury.

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    Improvement of nerve regeneration and functional recovery following nerve injury is a challenging problem in clinical research. We have already shown that following rat sciatic nerve transection, the local administration of triiodothyronine (T3) significantly increased the number and the myelination of regenerated axons. Functional recovery is a sum of the number of regenerated axons and reinnervation of denervated peripheral targets. In the present study, we investigated whether the increased number of regenerated axons by T3-treatment is linked to improved reinnervation of hind limb muscles. After transection of rat sciatic nerves, silicone or biodegradable nerve guides were implanted and filled with either T3 or phosphate buffer solution (PBS). Neuromuscular junctions (NMJs) were analyzed on gastrocnemius and plantar muscle sections stained with rhodamine alpha-bungarotoxin and neurofilament antibody. Four weeks after surgery, most end-plates (EPs) of operated limbs were still denervated and no effect of T3 on muscle reinnervation was detected at this stage of nerve repair. In contrast, after 14 weeks of nerve regeneration, T3 clearly enhanced the reinnervation of gastrocnemius and plantar EPs, demonstrated by significantly higher recovery of size and shape complexity of reinnervated EPs and also by increased acetylcholine receptor (AChRs) density on post synaptic membranes compared to PBS-treated EPs. The stimulating effect of T3 on EP reinnervation is confirmed by a higher index of compound muscle action potentials recorded in gastrocnemius muscles. In conclusion, our results provide for the first time strong evidence that T3 enhances the restoration of NMJ structure and improves synaptic transmission
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