679 research outputs found
Minimizing Use of Aquaculture Ponds by Double-Crested Cormorants Phalacrocorax Auritus and Other Fish-Eating Birds
- Publication venue
- DigitalCommons@USU
- Publication date
- 06/04/2003
- Field of study
Methods used to minimize abundance of double-crested cormorant (Phalacrocorax auritus), great blue herons (Ardea herodias), and great egrets (Arded alba) at aquaculture facilities have limited success because of the birds\u27 ability to habituate to the applied technique. The primary objectives of this study were to evaluate and quantify the effects of overhead lines on minimizing number of cormorants, egrets and herons. We measured the long-term (01 December 2000 to 14 April 2001) effectiveness of exclusion barriers positioned every 30 m at 8 aquaculture ponds in southeastern Arkansas and the post-removal of the barrier effects from 15 April to 31 May 2001. The exclusion barrier limited the number of cormorants landing on treatment ponds significantly (P \u3c 0.001, by 10-fold), had a greater effect on herons (P \u3c 0.001, by 19-fold), and completely excluded egrets. Over 200 hours of observations with the barriers installed and an additional 90 hours of post-treatment observation resulted in 23,200 cormorant observations at the site. Eight treatment ponds averaged 429 cormorant landings (1.9 birds per hour) compared to 4,240 cormorant s landings (15.6 birds per hour) on 8 control ponds. Although the physical barrier did not exclude all cormorants and other fish-eating birds from a pond, this technique offers a nonlethal, cost-efficient, easy installation and removal, and low maintenance method to minimize depredation at aquaculture ponds
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J.L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Curb J. David
- Dahgam Santosh
- Danesh John
- Day Ian N.M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo P.
- Dreisbach Albert W.
- Dries Daniel L.
- Dörr Marcus
- Eaton Charles B.
- Ehret Georg B.
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Eyheramendy Susana
- Fabsitz Richard R.
- Farlow Deborah N.
- Farrall Martin
- Fava Cristiano
- Ferrucci Luigi
- Forrester Terrence
- Fowkes Gerald R.
- Fox Ervin R.
- Franceschini Nora
- Frayling Timothy M.
- Galan Pilar
- Ganesh Santhi
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Goel Anuj
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Hernandez Dena
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hirschorn Joel N.
- Hoffman Bolton Judith A.
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- JinGo Min
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kang Sun J.
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.R.
- Kathiresan Sekar
- Keating Brendan J.
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M.J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kutlar Abdullah
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Li Yali
- Liu Kiang
- Liu Yongmei
- Lohman Kurt K.
- Longstreth Will T.
- Loos Ruth J.F.
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lyon Helen N.
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- MariaCorsi Anna
- Marmot Michael G.
- Martin Lisa W.
- Mattace-Raso Francesco U.S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Miki Tetsuro
- Milaneschi Yuri
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Musani Solomon K.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nilsson Peter
- Nyberg Fredrik
- O'Connell Jeffrey R.
- O'Donnell Chris
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ongen Halit
- Oostra Ben A.
- Org Elin
- Orru Marco
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Penman Alan D.
- Perola Markus
- Pihur Vasyl
- Platou Carl G.P.
- Plump Andrew
- Polak Josef F.
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Prokopenko Inga
- Psaty Bruce M.
- Radha Mani K.
- Raffel Leslie J.
- Raitakari Olli
- Ramachandran Vasan S.
- Rao Dabeeru C.
- Rasheed Asif
- Redline Susan
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rosengren Annika
- Rotimi Charles N.
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schwartz Steven M.
- Schwarz Peter E.H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shrine Nick R.G.
- Shriner Daniel
- Shuldiner Alan R.
- Shyong Tai E.
- Sijbrands Eric J.G.
- Sim Xueling
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- SolerArtigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Taylor Herman A.
- Tayo Bamidele O.
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Townsend Raymond R.
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Twee-Hee Ong Rick
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S.P.M.
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D.G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H.-Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C.M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Wyatt Sharon B.
- Würz Peter
- Yajnik Chittaranjan S.
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexit
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J.L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Curb J. David
- Dahgam Santosh
- Danesh John
- Day Ian N.M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo P.
- Dreisbach Albert W.
- Dries Daniel L.
- Dörr Marcus
- Eaton Charles B.
- Ehret Georg B.
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Eyheramendy Susana
- Fabsitz Richard R.
- Farlow Deborah N.
- Farrall Martin
- Fava Cristiano
- Ferrucci Luigi
- Forrester Terrence
- Fowkes Gerald R.
- Fox Ervin R.
- Franceschini Nora
- Frayling Timothy M.
- Galan Pilar
- Ganesh Santhi
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Goel Anuj
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Hernandez Dena
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hirschorn Joel N.
- Hoffman Bolton Judith A.
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- JinGo Min
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kang Sun J.
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.R.
- Kathiresan Sekar
- Keating Brendan J.
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M.J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kutlar Abdullah
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Li Yali
- Liu Kiang
- Liu Yongmei
- Lohman Kurt K.
- Longstreth Will T.
- Loos Ruth J.F.
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lyon Helen N.
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- MariaCorsi Anna
- Marmot Michael G.
- Martin Lisa W.
- Mattace-Raso Francesco U.S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Miki Tetsuro
- Milaneschi Yuri
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Musani Solomon K.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nilsson Peter
- Nyberg Fredrik
- O'Connell Jeffrey R.
- O'Donnell Chris
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ongen Halit
- Oostra Ben A.
- Org Elin
- Orru Marco
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Penman Alan D.
- Perola Markus
- Pihur Vasyl
- Platou Carl G.P.
- Plump Andrew
- Polak Josef F.
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Prokopenko Inga
- Psaty Bruce M.
- Radha Mani K.
- Raffel Leslie J.
- Raitakari Olli
- Ramachandran Vasan S.
- Rao Dabeeru C.
- Rasheed Asif
- Redline Susan
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rosengren Annika
- Rotimi Charles N.
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schwartz Steven M.
- Schwarz Peter E.H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shrine Nick R.G.
- Shriner Daniel
- Shuldiner Alan R.
- Shyong Tai E.
- Sijbrands Eric J.G.
- Sim Xueling
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- SolerArtigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Taylor Herman A.
- Tayo Bamidele O.
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Townsend Raymond R.
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Twee-Hee Ong Rick
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S.P.M.
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D.G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H.-Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C.M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Wyatt Sharon B.
- Würz Peter
- Yajnik Chittaranjan S.
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- Hum Mol Genet
- Publication date
- 01/01/2011
- Field of study
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity
Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Adrienne Cupples L.
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Andrade Mariza de
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Artigas Maria Soler
- Aspelund Thor
- Asselbergs Folkert W.
- Aulchenko Yurii
- Bakker Stephan J. L.
- Ballantyne Christie
- Bandinelli Stefania
- Barroso Inês
- Basu Saonli
- Baumert Jens
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bevan Steve
- Bielak Lawrence F.
- Bis Joshua C.
- Blankenberg Stefan
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burgess Stephen
- Burton Paul R.
- Cambien Francois
- Campbell Harry
- Carter Angela M.
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cheng Yu-Ching
- Chilukoti Ravi Kumar
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Corsi Anna Maria
- Couper David J.
- Cunningham Julie
- Cushman Mary
- D'Agostino Ralph B.
- Dahgam Santosh
- Danesh John
- Day Ian N. M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Demissie Serkalem
- Denniff Matthew
- Ding Jingzhong
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo
- Dreisbach Albert W.
- Duijn Cornelia van
- Dörr Marcus
- Ehret Georg B.
- Eicher John D.
- Eiriksdottir Gudny
- Elias-Smale Suzette E.
- Elliott Paul
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- Li Xia
- Li Yali
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- Liu Yongmei
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- Luan Jian'an
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- Matullo Giuseppe
- McArdle Wendy L.
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- Sigurdsson Sigurdur
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- Silbernagel Günther
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- Sim Xueling
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- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Smith Shelly
- Snieder Harold
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- Tripathy Vikal
- Truong Vinh
- Tukiainen Taru
- Tuomilehto Jaakko
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Umemura Satoshi
- Usala Gianluca
- van der Harst Pim
- van der Lugt Aad
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
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- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
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- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- White Charles C.
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild Philipp S.
- Wild Sarah H.
- Williams Frances M. K.
- Williams Scott M.
- Wilson James F.
- Winkelmann Bernhard R.
- Witteman Jacqueline
- Witteman Jacqueline C. M.
- Wolf Philip A.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yanek Lisa R.
- Yang Qiong
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler Andreas
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Öhrvik John
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2017
- Field of study
Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. Methods and Results--To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association studies. Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. In the systematic meta-analysis, the highest quantile of blood PAI-1 level was associated with higher CHD risk comparing with the lowest quantile (odds ratio=2.17; 95% CI: 1.53, 3.07) in an age- and sex-adjusted model. The effect size was reduced in studies using a multivariable-adjusted model (odds ratio=1.46; 95% CI: 1.13, 1.88). The Mendelian randomization analyses suggested a causal effect of increased PAI-1 level on CHD risk (odds ratio=1.22 per unit increase of log-transformed PAI-1; 95% CI: 1.01, 1.47). In addition, we also detected a causal effect of PAI-1 on elevating blood glucose and high-density lipoprotein cholesterol. Conclusions--Our study indicates a causal effect of elevated PAI-1 level on CHD risk, which may be mediated by glucose dysfunction
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
- Author
- Abecasis GR
- Abecasis Gonçalo R.
- Absher D
- Adair Linda S.
- Adeyemo Adebowale
- Aherrahrou Z
- Ahmadi KR
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Aragam J
- Arfan Ikram M.
- Arking DE
- Arking Dan E.
- Arnett D
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes TL
- Atkinson EJ
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
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- Bakker SJ
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- Balmforth AJ
- Bandinelli Stefania
- Barbalic M
- Barroso Inês
- Beckmann J
- Beckmann Jacques S.
- Beilby John P.
- Benjamin E
- Benjamin EJ
- Bergman Richard N.
- Bergmann Sven
- Bickel C
- Bilo HJ
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- Bochud Murielle
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Bolton Judith A Hoffman
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- Borecki I
- Bornstein Stefan R.
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- Scuteri Angelo
- Seelen MA
- Sehmi JS
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shlipak MG
- Shrine Nick R. G.
- Shriner Daniel
- Shuldiner AR
- Shuldiner AR
- Shuldiner Alan R.
- Shyong Tai E.
- Sidney S
- Sijbrands Eric J. G.
- Sim Xueling
- Singleton A
- Singleton Andrew
- Sinning C
- Siscovick D
- Siscovick DS
- Sjögren M
- Sjögren Marketa
- Smit JH
- Smith A
- Smith AV
- Smith N
- Smith NL
- Smith NL
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder H
- Snieder Harold
- Sober Siim
- Soininen Pasi
- Soranzo N
- Soranzo Nicole
- Spector TD
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Stark K
- Stefansson K
- Steinle Nanette I.
- Stenvinkel P
- Sternberg MJ
- Stewart AF
- Stojakovic T
- Strachan David P.
- Stricker B
- Stricker BH
- Stringham Heather M.
- Stritzke J
- Struchalin M
- Struchalin M
- Stumvoll M
- Sun Yan V.
- Swaminathan R
- Swift Amy J.
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka T
- Tanaka T
- Tanaka Toshiko
- Tang H
- Taylor KD
- Taylor Andrew
- Tayo Bamidele
- Terzic Janos
- Teumer A
- Teumer A
- Teumer Alexander
- Thelle Dag S.
- Thompson JR
- Thorgeirsson G
- Thorleifsson G
- Thorsteinsdottir U
- Tiret L
- Tobin Martin D.
- Tomaschitz A
- Tomaszewski Maciej
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Turne ST
- Twee-HeeOng Rick
- Tzoulaki Ioanna
- Tönjes A
- Ubink-Veltmaat LJ
- Uda M
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden A
- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst P
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn C
- van Duijn CM
- van Duijn CM
- van Duijn CM
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Vasan R
- Vasan RS
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D. G.
- Vineis Paolo
- Vitart V
- Vitart Veronique
- Voight BF
- Voight Benjamin F.
- Volcik K
- Vollenweider P
- Vollenweider Peter
- Völker U
- Völker U
- Völker Uwe
- Völzke H
- Völzke H
- Völzke Henry
- Waeber G
- Wagenknecht Lynne E.
- Wain Louise V.
- Waksman R
- Walker M
- Wallace C
- Wang TJ
- Wang TJ
- Wang W
- Wang YA
- Wang Thomas J.
- Wang Xiaoling
- Wareham NJ
- Wareham Nicholas J.
- Wass MN
- Waterworth D
- Waterworth DM
- Watkins Hugh
- Watzinger N
- Weder Alan B.
- Wells GA
- Werdan K
- Whincup Peter H.
- Whitteman J
- Wichmann HE
- Wichmann HE
- Wichmann HE
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild P
- Wild PS
- Wild PS
- Wild SH
- Wild Sarah H.
- Wilde S
- Wilensky R
- Willenborg C
- Willerson JT
- Wilson JF
- Wilson James F.
- Winkelmann BR
- Winkler K
- Witteman JC
- Witteman JC
- Witteman JC
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
- Wright AF
- Wright BJ
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Q
- Yao Jie
- Zaboli G
- Zelenika Diana
- Zeller T
- Zeller T
- Zeller T
- Zemunik T
- Zerres K
- Zgaga L
- Zhai Guangju
- Zhang W
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler A
- Ziegler A
- Ziegler A
- Zillikens MC
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Zweiker R
- Publication venue
- Nature
- Publication date
- 01/01/2011
- Field of study
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention
A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J. L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beckmann Jacques S.
- Beilby John P.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Carstensen Maren
- Casas Juan P.
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Brian H.
- Chen Ming-Huei
- Clarke Robert
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Courchesne Paul
- Dahgam Santosh
- Danesh John
- Davey Smith George
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo
- Dreisbach Albert W.
- Dörr Marcus
- Dörr Marcus
- Ehret Georg B.
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Esko Tõnu
- Eyheramendy Susana
- Fava Cristiano
- Felix Stephan B.
- Ferrucci Luigi
- Forrester Terrence
- Fowkes F. Gerald R.
- Fox Ervin R.
- Galan Pilar
- Ganesh Santhi K.
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Go Min Jin
- Goel Anuj
- Grallert Harald
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G.
- Hicks Andrew A.
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hoang Nguyen Khanh-Dung
- Hoffman Bolton Judith A.
- Hofman Albert
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Huan Tianxiao
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jafar Tazeen H.
- Janipalli Charles S.
- Joehanes Roby
- Johnson Andrew D.
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Järvelin Marjo-Riitta
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.
- Kathiresan Sekar
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M. J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Levy Daniel
- Li Yali
- Liu Chunyu
- Liu Poching
- Liu Yongmei
- Lohman Kurt K.
- Longstreth W. T.
- Loos Ruth J. F.
- Luan Jian’an
- Lucas Gavin
- Ludwig Barbara
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- Maria AnnaCorsi
- Mattace-Raso Francesco U. S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Meitinger Thomas
- Melander Olle
- Melzer David
- Meneton Pierre
- Meschia James F.
- Metspalu Andres
- Miki Tetsuro
- Milaneschi Yuri
- Milani Lili
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Munson Peter J.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nilsson Peter
- Nyberg Fredrik
- O'Donnell Christopher J.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ong Rick Twee-Hee
- Ongen Halit
- Onland-Moret N. Charlotte
- Oostra Ben A.
- Org Elin
- Orru Marco
- O’Connell Jeffrey R.
- O’Donnell Chris
- O’Reilly Paul F.
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Peltonen Leena
- Perola Markus
- Peters Annette
- Peters Marjolein J.
- Pihur Vasyl
- Pilling Luke C.
- Platou Carl G. P.
- Plump Andrew
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Pramstaller Peter P.
- Prokisch Holger
- Prokopenko Inga
- Psaty Bruce M.
- RadhaMani K.
- Raffel Leslie J.
- Raghavachari Nalini
- Raitakari Olli
- Rao Dabeeru C.
- Rasheed Asif
- Reinmaa Eva
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Roden Michael
- Rosengren Annika
- Rotimi Charles
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schramm Katharina
- Schurmann Claudia
- Schwartz Stephen M.
- Schwarz Peter E. H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shin Cho Yoon
- Shrine Nick R. G.
- Shriner Daniel
- Shuldiner Alan R.
- Sijbrands Eric J. G.
- Sim Xueling
- Singleton Andrew
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- Soler Artigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Tai E. Shyong
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Tayo Bamidele
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Tripathy Vikal
- Tukiainen Taru
- Tzoulaki Ioanna
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden Andre G.
- Uitterlinden André G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Meurs Joyce B. J.
- Vartiainen Erkki
- Vasan Ramachandran
- Vasan Ramachandran S.
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D. G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Waldenberger Melanie
- Wang Richard
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Xia
- Yao Chen
- Yao Jie
- Ying Sai-xia
- Young J. H.
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%–9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension
Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Ajaltouni Ziad
- Akar Simon
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr. Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Auriemma Giulio
- Baalouch Marouen
- Babuschkin Igor
- Bachmann Sebastian
- Back John
- Badalov Alexey
- Baesso Clarissa
- Baker Sophie
- Baldini Wander
- Barlow Roger
- Barschel Colin
- Barsuk Sergey
- Barter William
- Baszczyk Mateusz
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beaucourt Leo
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Bel Lennaert
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Benton Jack
- Berezhnoy Alexander
- Bernet Roland
- Bertolin Alessandro
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bifani Simone
- Billoir Pierre
- Bird Thomas
- Birnkraut Alex
- Bitadze Alexander
- Bizzeti Andrea
- Blake Thomas
- Blanc Frederic
- Blouw Johan
- Blusk Steven
- Bocci Valerio
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Bonivento Walter
- Bordyuzhin Igor
- Borgheresi Alessio
- Borghi Silvia
- Borisyak Maxim
- Borsato Martino
- Bossu Francesco
- Boubdir Meriem
- Bowcock Themistocles
- Bowen Espen Eie
- Bozzi Concezio
- Braun Svende
- Britsch Markward
- Britton Thomas
- Brodzicka Jolanta
- Buchanan Emma
- Burr Christopher
- Bursche Albert
- Buytaert Jan
- Cadeddu Sandro
- Calabrese Roberto
- Calvi Marta
- Calvo Gomez Miriam
- Camboni Alessandro
- Campana Pierluigi
- Campora Perez Daniel
- Campora Perez Daniel
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carson Laurence
- Carvalho Akiba Kazuyoshi
- Casse Gianluigi
- Cassina Lorenzo
- Castillo Garcia Lucia
- Cattaneo Marco
- Cauet Christophe
- Cavallero Giovanni
- Cenci Riccardo
- Charles Matthew
- Charpentier Philippe
- Chatzikonstantinidis Georgios
- Chefdeville Maximilien
- Chen Shanzhen
- Cheung Shu-Faye
- Chobanova Veronika
- Chrzaszcz Marcin
- Cid Vidal Xabier
- Ciezarek Gregory
- Clarke Peter
- Clemencic Marco
- Cliff Harry
- Closier Joel
- Coco Victor
- Cogan Julien
- Cogneras Eric
- Cogoni Violetta
- Cojocariu Lucian
- Collazuol Gianmaria
- Collins Paula
- Comerma-Montells Albert
- Contu Andrea
- Cook Andrew
- Coombs George
- Coquereau Samuel
- Corti Gloria
- Corvo Marco
- Costa Sobral Cayo Mar
- Couturier Benjamin
- Cowan Greig
- Craik Daniel Charles
- Crocombe Andrew
- Cruz Torres Melissa Maria
- Cunliffe Samuel
- Currie Robert
- D'Ambrosio Carmelo
- d'Argent Philippe
- Da Cunha Marinho Franciole
- Dall'Occo Elena
- Dalseno Jeremy
- David Pieter
- Davis Adam
- De Aguiar Francisco Oscar
- De Bruyn Kristof
- De Capua Stefano
- De Cian Michel
- De Miranda Jussara M.
- De Paula Leandro
- De Serio Marilisa
- De Simone Patrizia
- de Vries Jacco
- Dean Cameron Thomas
- Decamp Daniel
- Deckenhoff Mirko
- Del Buono Luigi
- Demmer Moritz
- Dendek Adam
- Derkach Denis
- Deschamps Olivier
- Dettori Francesco
- Dey Biplab
- Di Canto Angelo
- Dijkstra Hans
- Dordei Francesca
- Dorigo Mirco
- dos Reis Alberto C.
- Dosil Suárez Alvaro
- Dovbnya Anatoliy
- Dreimanis Karlis
- Dufour Laurent
- Dujany Giulio
- Dungs Kevin
- Durante Paolo
- Dzhelyadin Rustem
- Dziurda Agnieszka
- Dzyuba Alexey
- Déléage Nicolas
- Easo Sajan
- Ebert Marcus
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eisenhardt Stephan
- Eitschberger Ulrich
- Ekelhof Robert
- Eklund Lars
- Elsasser Christian
- Ely Scott
- Esen Sevda
- Evans Hannah Mary
- Evans Timothy
- Falabella Antonio
- Farley Nathanael
- Farry Stephen
- Fay Robert
- Fazzini Davide
- Ferguson Dianne
- Fernandez Prieto Antonio
- Ferrari Fabio
- Ferreira Rodrigues Fernando
- Ferro-Luzzi Massimiliano
- Filippov Sergey
- Fini Rosa Anna
- Fiore Marco
- Fiorini Massimiliano
- Firlej Miroslaw
- Fitzpatrick Conor
- Fiutowski Tomasz
- Fleuret Frederic
- Fohl Klaus
- Fontana Marianna
- Fontanelli Flavio
- Forshaw Dean Charles
- Forty Roger
- Franco Lima Vinicius
- Frank Markus
- Frei Christoph
- Fu Jinlin
- Furfaro Emiliano
- Färber Christian
- Gallas Torreira Abraham
- Galli Domenico
- Gallorini Stefano
- Gambetta Silvia
- Gandelman Miriam
- Gandini Paolo
- Gao Yuanning
- Garcia Martin Luis Miguel
- García Pardiñas Julián
- Garra Tico Jordi
- Garrido Lluis
- Garsed Philip John
- Gascon David
- Gaspar Clara
- Gavardi Laura
- Gazzoni Giulio
- Gerick David
- Gersabeck Evelina
- Gersabeck Marco
- Gershon Timothy
- Ghez Philippe
- Gianì Sebastiana
- Gibson Valerie
- Girard Olivier Göran
- Giubega Lavinia-Helena
- Gizdov Konstantin
- Gligorov V. V.
- Golubkov Dmitry
- Golutvin Andrey
- Gomes Alvaro
- Gorelov Igor Vladimirovich
- Gotti Claudio
- Grabalosa Gándara Marc
- Graciani Diaz Ricardo
- Granado Cardoso Luis Alberto
- Graugés Eugeni
- Graverini Elena
- Graziani Giacomo
- Grecu Alexandru
- Griffith Peter
- Grillo Lucia
- Gruberg Cazon Barak Raimond
- Grünberg Oliver
- Gushchin Evgeny
- Guz Yury
- Gys Thierry
- Göbel Carla
- Hadavizadeh Thomas
- Hadjivasiliou Christos
- Haefeli Guido
- Haen Christophe
- Haines Susan
- Hall Samuel
- Hamilton Brian
- Han Xiaoxue
- Hansmann-Menzemer Stephanie
- Harnew Neville
- Harnew Samuel
- Harrison Jonathan
- Hatch Mark
- He Jibo
- Head Timothy
- Heister Arno
- Hennessy Karol
- Henrard Pierre
- Henry Louis
- Hernando Morata Jose Angel
- Heß Miriam
- Hicheur Adlène
- Hill Donal
- Hombach Christoph
- Hopchev P. H.
- Hulsbergen Wouter
- Humair Thibaud
- Hushchyn Mikhail
- Hussain Nazim
- Hutchcroft David
- Idzik Marek
- Ilten Philip
- Jacobsson Richard
- Jaeger Andreas
- Jalocha Pawel
- Jans Eddy
- Jawahery Abolhassan
- Jiang Feng
- John Malcolm
- Johnson Daniel
- Jones Christopher
- Joram Christian
- Jost Beat
- Jurik Nathan
- Kandybei Sergii
- Kanso Walaa
- Karacson Matthias
- Kariuki James Mwangi
- Karodia Sarah
- Kecke Matthieu
- Kelsey Matthew
- Kenyon Ian
- Kenzie Matthew
- Ketel Tjeerd
- Khairullin Egor
- Khanji Basem
- Khurewathanakul Chitsanu
- Kirn Thomas
- Klaver Suzanne
- Klimaszewski Konrad
- Koliiev Serhii
- Kolpin Michael
- Komarov Ilya
- Koopman Rose
- Koppenburg Patrick
- Kosmyntseva Alena
- Kozachuk Anastasiia
- Kozeiha Mohamad
- Kravchuk Leonid
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- Wilkinson Michael
- Williams Mark Richard James
- Williams Matthew
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- Wimberley Jack
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wraight Kenneth
- Wright Simon
- Wyllie Kenneth
- Xie Yuehong
- Xing Zhou
- Xu Zhirui
- Yang Zhenwei
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Liming
- Zhang Yanxi
- Zhang Yu
- Zhelezov Alexey
- Zheng Yangheng
- Zhokhov Anatoly
- Zhu Xianglei
- Zhukov Valery
- Zucchelli Stefano
- Publication venue
- LexisNexis
- Publication date
- 01/01/2016
- Field of study
The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of tt, W+bb and W+cc is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 ± 0.02 \mbox{fb}^{-1}. The W bosons are reconstructed in the decays W→ℓν, where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
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- Bouatia-Naji Nabila
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- Bragg-Gresham Jennifer L
- Brambilla Paolo
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- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
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- Carlson Olga D
- Carty Cara
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- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
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- Cimponeriu Dan
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- Clarke Robert
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- Coassin Stefan
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- Cole Shelley
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- Coresh Josef
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- Dastani Zari
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- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
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- Deelen Joris
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- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
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- Devuyst Olivier
- di Meglio Paola
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- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
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- Dreisbach Albert W
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- Duggan David
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- Eastell Richard
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- Folkersen Lasse
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- Forrester Terrence
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- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
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- Franceschini Nora
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- Franke Andre
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- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
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- Giedraitis Vilmantas
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- Goessling Wolfram
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- Goodarzi Mark O
- Goodloe Robert
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- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
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- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
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- Gyllensten Ulf B
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- Hedblad Bo
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- Higashio Julia
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- Hovingh G Kees
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- Islam Muhammad
- Ittermann Till
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- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
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- Jameson Karen A
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- Jansen Hanneke
- Janssens A Cecile J W
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- Khusainova Rita
- Khusnutdinova Elza
- Kiel Douglas P
- Kiess Wieland
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- Kim Eric
- Kim Ghi Su
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- Wichmann H-Erich
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- Wiggins Kerri L
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- Wijnands-van Gent Colette J M
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- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
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- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
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- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
- Author
- Abban Dzifa
- Abdul Nasser
- Abelson Mark
- Ackermann Alan
- Adams Fran
- Adams Luthando
- Adrag\ue3o Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Aguilar Linares Julio Alberto
- Aguilar Francisco
- Aguinaga Luis
- Ahmad Zia
- Ainsworth Paul
- Al Dallow Raed
- Al Ghalayini Kamal
- Al Ismail Saad
- Al Joundi Tammam
- Al Mahameed Soufian
- Al Obaidi Mohamed
- Al Zoebi Ayham
- Alasfar Abdelfatah
- Alawwa Abdul
- Alderson Lisa
- Alexopoulos Dimitrios
- Ali Abdullah
- Ali Malik
- Aliyar Pareed
- Almassi Hossein
- Almuti Khalid
- Alshehri Mohamed
- Altmann Ute
- Alves Alvaro Rabelo
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrawis Nabil
- Angela Koh Su Mei
- Angoulvant Denis
- Annoni Giorgio
- Ansalone Gerardo
- Antonescu Sorin Alexandru
- Ariani Mehrdad
- Arias Juan Carlos
- Armero S\ue9bastien
- Arora Chander
- Arora Rohit
- Ashcraft William
- Aslam M. Shakil
- Astesiano Alfredo
- Audouin Philippe
- Augenbraun Charles
- Aydin S.
- Azar Rabih
- Azim Abul
- Aziz Shahid
- B\uf8hmer Ellen
- Backes Luciano Marcelo
- Baig Mirza
- Bains Suchdeep
- Bakbak Asaad
- Baker Seth
- Bakhtiar Karim
- Bala Richard
- Banayan Jonathan
- Bandh Stellan
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Bar\uf3n Gonzalo
- Barbarash Olga
- Barr Craig
- Barrera Carlos
- Bartels Dorothee B.
- Barton John
- Baula Giovanni
- Bayeh Hamid
- Bazargani Nooshin
- Behrens Steffen
- Bell Alan
- Benezet Mazuecos Juan
- Benhalima Bouziane
- Berdagu\ue9 Philippe
- Berg van den B. J.
- Bergen van P. F. M. M.
- Berngard Edvard
- Bernstein Richard
- Berrospi Percy
- Berti Sergio
- Bertomeu Vicente
- Berz Andrea
- Bettencourt Paulo
- Betzu Robert
- Beyer Westendorf Jan
- Bhagwat Ravi
- Black Toby
- Blanco Ibaceta Jorge Hugo
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bockisch Valerie
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Borret Mariano Ruiz
- Bosch Ralph
- Boswijk D. J.
- Bott Jochen
- Bottacchi Edo
- Brandes Axel
- Bratland Bj\uf8rn
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers P. J. A. M.
- Browne Kevin
- Bruguera Jordi
- Brunehaut Myriam
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Herv\ue9
- Buenostro Gabriel Contreras
- Buhl Aur\ue9lie
- Bullinga John
- Butcher Kenneth
- Cabrera Honorio Jose Walter
- Caccavo Alberto
- Cadinot Didier
- Cai Shanglang
- Caiedo Carolina Guevara
- Calin Podoleanu Cristian Gheorghe
- Calvi Valeria
- Camm John
- Candeias Rui
- Cao Phai G\ue9rald Phan
- Capo James
- Capucci Alessandro
- Cardoso Juliano Novaes
- Carlson Brian
- Carvalho Paula
- Cary Susanna
- Casanova Rene
- Casu Gavino
- Cattan Simon
- Cavallini Claudio
- Cayla Guillaume
- Cha Kwang Soo
- Cha Tae Joon
- Chaaban Said
- Chae Jei Keon
- Challappa Krishnan
- Chand Sunil
- Chandrashekar Harinath
- Chang Mark
- Charbel Paul
- Chartier Ludovic
- Chatterjee Kausik
- Cheema Aamir
- Chen Shih Ann
- Chevallereau Pierre
- Chiang Fu Tien
- Chiarella Francesco
- Chih Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Chouinard Guy
- Chow Hoi Fan
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cieza Lara Tomas
- Ciobotaru Vlad
- Cislowski David
- Citerne Olivier
- Claus Matthias
- Clay Anthony
- Clifford Piers
- Cocina Emilio Gonzalez
- Cohen Andrew
- Cohen Serge
- Colivicchi Furio
- Collins R\uf3n\ue1n
- Compton Steve
- Connors Sean
- Conti Alberto
- Coodley Gregg
- Cooper Martin
- Corbett Lynn
- Corey Oran
- Coronel Juli\ue1n
- Corrigan John
- Cotrina Pereyra Rosa Ysabel
- Cottin Yves
- Coutu Benoit
- Cracan Aurel
- Crean Peter
- Crenshaw James
- Crijns H. J. G. M.
- Crump Charles
- Cucher Fred
- Cudmore David
- Cui Lianqun
- Culp John
- D'Souza Anthony
- Daniel Oh Chia Theng
- Danny Null
- Darius Harald
- Dary Patrick
- Dascotte Olivier
- Dauber Ira
- Davee Thomas
- Davies Ruth
- Davis Gershan
- Davy Jean Marc
- Dayer Mark
- De La Briolle Axel
- de Los Rios Ibarra Manuel Odin
- de Mora Manuel
- de Souza Olga Ferreira
- De Teresa Eduardo
- De Wolf Luc
- Decoulx Eric
- Deepak Sasalu
- Defaye Pascal
- Del Carpio Munoz Freddy
- Deluche Laurent
- Destrac Sylvain
- Deumite N. Joseph
- Di Legge Silvia
- Dibon Olivier
- Diemberger Igor
- Diener Hans Christoph
- Dillinger Jean
- Dion\uedsio Pedro
- Dotani Imran
- Dotcheva Elena
- Duarte Vera Yan Carlos
- Dubner Sergio J.
- Dubrey Simon
- Ducrocq Xavier
- Dupljakov Dmitry
- Duthinh Vuong
- Dutra Oscar Pereira
- Dutta Dipankar
- Duvilla Nathalie
- Dy Johnny
- Dziewas Rainer
- Eaton Charles
- Eaves William
- Ebinger Matthew
- Eck van J. W. M.
- Edwards Tim
- Egocheaga Isabel
- Ehrlich Clifford
- Eisenberg Steven
- El Hallak Abdel
- El Hamdani Mehiar
- El Jabali Adnan
- El Mahmoud Rami
- El Sayed Hassan
- El Shahawy Mahfouz
- Eldadah Zayd
- Elghelbazouri Fouad
- Elhag Omar
- Elias Darlene
- Ellery Adam
- Elsaesser Amelie
- Elvan A.
- Erickson Bernard
- Espaliat Eric
- Essandoh Louis
- Everington Tamara
- Evonich Rudolph
- Ezhov Andrey
- F\ue1cila Lorenzo
- Farsad Ramin
- Fayard Maxime
- Fedele Francesco
- Ferreira Daniel
- Ferrier Anna
- Finsen Alexandra
- First Brian
- Fisher Raymond
- Floyd John
- Folk Thomas
- Fonseca Catarina
- Fonseca Luisa
- Fonteles Ritt Luiz Eduardo
- Forman Steven
- Forsgren Magnus
- Foster Malcolm
- Foster Nathan
- Frais Michael
- Frandsen Brad
- Frapp\ue9 Thierry
- Freixa Ramon
- French William
- Freydlin Marina
- Frickel Siegfried
- Fruntelata Ana Gabriela
- Fujii Shigeru
- Fujino Yusuke
- Fukunaga Hiroshi
- Furukawa Yutaka
- G\uf6tte Andreas
- Gabelmann Matthias
- Gabris Michael
- Gadsb\uf8ll Niels
- Galin Pavel
- Galinier Michel
- Ganim Ricky
- Garcia Ronnie
- Gartenlaub Olivier
- Genz Conrad
- Georger Fr\ue9d\ue9ric
- Georges Jean Louis
- Georgeson Steven
- Ghanbasha Ali
- Giedrimas Evaldas
- Gierba Mariusz
- Gillespie Eve
- Giniger Alberto
- Gkotsis Alexandros
- Gmehling Joachim
- Gniot Jacek
- Goethals Peter
- Goldberg Ronald
- Goldmann Britta
- Goldscher David
- Golitsyn Sergey
- Gomes Ferreira Luis Gustavo
- Gomez Lopez Efrain Alonso
- Gomez Mesa Juan Esteban
- Gonzalez Efrain
- Gorbunov Vladimir
- Gordon Brian
- Gorka Herv\ue9
- Gornick Charles
- Gorog Diana
- Goss Franz
- Goube Pascal
- Goudevenos Ioannis
- Goulden Dudley
- Gr\uf6nefeld Gerian
- Graham Brett
- Grande Angel
- Greco Cesare
- Green Martin
- Greer Gerald
- Gremmler Uwe
- Grena Paul
- Grinshstein Yuriy
- Grond Martin
- Gronda Edoardo
- Grondin Francois
- Groot de J. R.
- Guardigli Gabriele
- Guarnieri Thomas
- Guignier Alexandre
- Gulizia Michele
- Gumbley Michael
- Gupta Dhiraj
- Hack Terrence
- Haerer Winfried
- Hakas Joseph
- Hall Christian
- Halperin Jonathan L.
- Hampsey James
- Hananis Georgios
- Hanbali Basel
- Handel Franklin
- Hargrove Joe
- Hargroves David
- Harris Kenneth
- Hartley David
- Haruna Tetsuya
- Hata Yoshiki
- Hayek Emil
- Healey Jeff
- Hearne Steven
- Heggelund Geir
- Hemels M. E. W.
- Hemery Yann
- Henein Sam
- Henz Benhur
- Her Sung Ho
- Hermany Paul
- Hern\ue1ndez Norberto Matadamas
- Hernandes Mauro Esteves
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
- Hitchcock James
- Hoffer Etienne
- Hoghton Matthew
- Holmes Clare
- Hong Suk Keun
- Houppe Nousse Marie Paule
- Howard Victor
- Hsu Li Fern
- Huang Chi Hung
- Huckins David
- Huehnergarth Kier
- Huisman Menno V
- Huizenga A.
- Huntley Richard
- Hussein Gamal
- Hwang Gyo Seung
- Igbokidi Oyidie
- Iglesias Ignacio
- Ikpoh Margaret
- Imberti Davide
- Ince H\ufcseyin
- Indolfi Ciro
- Ionova Tatiana
- Ip John
- Irles Didier
- Iseki Harukazu
- Ismail Younus
- Israel Noah
- Isserman Steven
- Iteld Bruce
- Ivanchura Galina
- Iyer Ramakrishnan
- Iyer Venkat
- Iza Villanueva Ruben Omar
- J\ue4ger Frank
- Jackson Voyzey Ewart
- Jaffrani Naseem
- Jain Manish
- James Martin
- Jamon Yann
- Jang Sung Won
- Jarmukli Nabil
- Jeanfreau Robert
- Jenkins Ronald
- Jiang Heng
- Jiang Nan
- Jiang Tiemin
- Jiang Xianyan
- Jimenez Javier
- Jobe Robert
- Joffe Ian
- Johansson Bengt
- Jones Nick
- Jos\ue9 Roberto Chuquiure Valenzuela Eduardo Juli\ue1n
- Jouve Bernard
- Juanatey Carlos Gonzalez
- Jundi Mayar
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- K\uf6hrmann Martin
- K\ufcmler Thomas
- K\ufcppers Achim
- Kabbani Samer
- Kabour Ameer
- Kafkala Chrystalenia
- Kajiwara Koji
- Kalan Marica Bracic
- Kalinina Larisa
- Kampus Priit
- Kanda Junji
- Kapadia Shaival
- Karim Amin
- Karolyi Laszlo
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John
- Keeling Phil
- Kerfes Galal Ali
- Kerr Saraiva Jos\ue9 Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit
- Khalid Muhammad
- Khludeeva Elena
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kleinschnitz Christoph
- Kmetzo James
- Kneller G. Larsen
- Knezevic Aleksandar
- Koch Stanley
- Koenig Kai
- Koons Jay
- Korabathina Ravikiran
- Korennova Olga
- Koschutnik Martin
- Kosinski Edward
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kragten J. A.
- Krause Lars Udo
- Kreidieh Imad
- Krenning B. J.
- Krishnaswamy Kannappan
- Krysiak Waldemar
- Kuck Karl Heinz
- Kumar Somnath
- Kuniss Malte
- Kuo Jen Yuan
- Kurrelmeyer Karla
- Kwan Tak
- Kyo Eisho
- L\uf3pez Send\uf3n Jos\ue9
- Labovitz Arthur
- Lacroix Alain
- Lam Andy
- Lanas Zanetti Fernando Tomas
- Landau Charles
- Landini Giancarlo
- Lang Wilfried
- Larsen Torben Bjerregaard
- Laske Volker
- Lavandier Karine
- Law Nicki
- Lawrence Wong Ka Sing
- Lee Daniel
- Lee Moon Hyoung
- Leit\ue3o Ana
- Lejay Dominique
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Leprince Patrick
- Lequeux Benoit
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Yansheng
- Li Zhanquan
- Li Zicheng
- Liang Jianqiu
- Lieber Ira
- Lillestol Michael
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Lip Gregory
- Lip Gregory Y. H.
- Litchfield Jennifer
- Liu Feng
- Liu Wenhui
- Liu Xuebo
- Liu Yalin
- Liu Zhitao
- Llamas Esperon Guillermo Antonio
- Llisterri Jose Luis
- Lo Eric
- Lo Ted
- Lobos Jose Maria
- Lodde Bernhard Paul
- Loiselet Philippe
- Lorga Filho Adalberto Menezes
- Lori Ido
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- M\ufcgge Andreas
- Ma Chang Sheng
- Ma Changsheng
- Ma Genshan
- Ma Hong
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Mahmood Shahid
- Mahood Karen
- Maid Gustavo
- Mainigi Sumeet
- Makaritsis Konstantinos
- Maldonado Villalon Jos\ue9 Arturo
- Malhotra Rohit
- Malik Amir
- Mallecourt Catherine
- Mallik Rajiv
- Manning Rickey
- Manolis Athanasios
- Mantas Ioannis
- Manzur Jattin Fernando Gabriel
- Mar\uedn Francisco
- Marcionni Niccolo'
- Marin Javier Aguila
- Martinez Jorge
- Martinez Luis
- Maskova Petra
- Matskeplishvili Simon
- Matsuda Katsuhiro
- Mavri Alenka
- May Erik
- Mayer Nolan
- Mazon Pilar
- Mcclure John
- Mccormack Terry
- Mcgarity William
- Mcguire Michael
- Mcintyre Hugh
- Mclaughlin Paul
- Mclaurin Brent
- Medina Palomino Feliz Alvaro
- Mehta Paresh
- Mehzad Reza
- Meinel Andreas
- Melandri Francesco
- Mena Amparo
- Meno Hirosi
- Menzies Dhananjai
- Metcalf Kneale
- Meyer Beat
- Miarka Jacek
- Mibach Frank
- Michalski Dominik
- Michel Patrik
- Mikdadi Ghiath
- Mikhail Magdy
- Mikus Milan
- Milicic Davor
- Militaru Constantin
- Miller Gary
- Milonas Christos
- Minescu Bogdan
- Mintale Iveta
- Miralles Aur\ue9lien
- Mirault Tristan
- Mistry Dinesh
- Mitchell George
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Moccetti Tiziano
- Mohammed Akber
- Molina de Salazar Dora Ines
- Molon Giulio
- Molony David
- Mondillo Sergio
- Mont Lluis
- Moodley Rajendra
- Moore Roger
- Morales Oscar Saenz
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschos Nikitas
- Mota Gomes Marco Ant\uf4nio
- Moura Jorge Jose Carlos
- Mousallem Nicolas
- Moya Angel
- Mulhearn Thomas
- Muller Jean Joseph
- Muresan Carmen Manuela
- Muse Derek
- Musial Wlodzimierz
- Musumeci Francesco
- Nadar Venkatesh
- Nageh Thuraia
- Nair Priya
- Nakagawa Hidemitsu
- Nakamura Yuichiro
- Nakayama Toru
- Nam Ki Byeong
- Napalkov Dmitry
- Natarajan Indira
- Nayak Hemal
- Naydenov Stefan
- Nechvatal Libor
- Neiman James
- Nerheim Pamela
- Neuenschwander Fernando Carvalho
- Nica Violeta Cindea
- Nishida Kunihiro
- Nizov Alexey
- Nor Azlisham Mohd
- Novikova Tatiana
- Novo Salvatore
- Nowalany Kozielska Ewa
- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nyvad Ole
- O'Donnell Martin
- O'Donnell Philip
- O'Hara Gilles
- Oh Dong Jin
- Oh Yong Seog
- Oikonomou Kostas
- Olalla Juan Jose
- Olivari Zoran
- Oliver Richard
- Olympios Christoforos
- Osborne John
- Osca Joaquin
- Osman Raed
- Osunkoya Abayomi
- Padanilam Benzy
- Panchenko Elizaveta
- Pandey A. Shekhar
- Paquette Miney
- Paraschos Alexander
- Pardell Herbert
- Park Hyung Wook
- Park Jong Sung
- Parkash Ratika
- Parker Ian
- Parrens Eric
- Parris Robert
- Pascual Carlos Rodr\uedguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Rajesh
- Pentz William H.
- Pereira Jardim Cesar Augusto
- Persic Viktor
- Perticone Francesco
- Peters Patrick
- Petkar Sanjiv
- Pezo Luis Felipe
- Pham David
- Phlaum Stephen
- Pineau Julien
- Pineda Velez Armando
- Pini Riccardo
- Pinter Arnold
- Pinto Fausto
- Pirelli Salvatore
- Pivac Nediljko
- Pizzini Attilia Maria
- Pocanic Darko
- Polanczyk Carisi Anne
- Polasek Petr
- Poljakovic Zdravka
- Pollock Stewart
- Polo Jose
- Poock James
- Poppert Holger
- Porro Yamile
- Pose Antonio
- Poulain Fran\ue7ois
- Poulard Jean Ernst
- Pouzar Joe
- Povolny Petr
- Pozzer Domingo
- Pras Athanasios
- Prasad Neeraj
- Prevot S\ue9bastien
- Protasov Konstantin
- Prunier Laurent
- Puleo John
- Pye Maurice
- Qaddoura Fatma
- Quedillac Jean Michel
- Quintana Antonio Garcia
- Raev Dimitar
- Rahimi Sidiqullah
- Raisaro Arturo
- Rama Bhola
- Ranadive Nandkishore
- Randall Katie
- Ranjith Naresh
- Raposo Nuno
- Rashid Haroon
- Raters Christa
- Rauch Kroehnert Ursula
- Rebane Thomas
- Regner Stefan
- Renzi Michael
- Reyes Rocha Miguel Agustin
- Reyes Humberto Rodriguez
- Reza Shabbir
- Ria Luigi
- Ribeiro Moreira Dalmo Antonio
- Richter Dimitrios
- Rickli Hans
- Rickner Kyle
- Rieker Werner
- Rigo Fausto
- Ripoll Tomas
- Roberts Douglas
- Roelke Marc
- Roman Mark
- Romeo Francesco
- Ronner E.
- Ronziere Thomas
- Rooyer F. A.
- Rosenbaum David
- Roth Sherryn
- Rothman Kenneth J.
- Rozkova Nadezda
- Rubacek Miroslav
- Rubalcava Frank
- Rubanenko Olesya
- Rubin Andrew
- Rybak Karin
- Sabbour Hani
- Sakai Tetsuo
- Salacata Abraham
- Salecker Ilsbe
- Salem Adrien
- Salfity Marwan
- Salguero Rafael
- Salvioni Alessandro
- Samson Mercedes
- Sanchez Gregorio
- Sandesara Chirag
- Santana Antonio Mart\uedn
- Santos Jos\ue9 Ferreira
- Saporito Wladmir Faustino
- Sasaoka Taishi
- Sattar Payman
- Savard Daniel
- Scala Pierre Jean
- Scemama Jacques
- Sch\uf6n Norbert
- Schaupp Thierry
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl Heinz
- Schmitz Lisa
- Schnitzler Robert
- Schnupp Steffen
- Schoeniger Peter
- Schuster Stefan
- Schwimmbeck Peter
- Seamark Clare
- Seebass Ruediger
- Seidl Karl Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Seko Yoshinori
- Sepulveda Varela Pablo Andres
- Sevilla Bego\uf1a
- Shah Aman
- Shah Anil
- Shah Neerav
- Shah Vinay
- Shanes Jeffrey
- Sharareh Ali
- Sharma Vijay Kumar
- Shaw Louise
- Shimizu Yutaka
- Shimomura Hideki
- Shin Dong Gu
- Shin Eun Seok
- Shite Junya
- Shoukfeh Mohammad
- Shoultz Charles
- Silver Frank
- Sime Iveta
- Simmers T. A.
- Singal Dinesh
- Singh Narendra
- Siostrzonek Peter
- Sirajuddin Mohiburrahman
- Skeppholm Mika
- Smadja Didier
- Smith David
- Smith Richard
- Soda Hassan
- Sofley C. Wilson
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex
- Stakos Dimitrios
- Steinberg Alon
- Steinwender Clemens
- Stergiou Georgios
- Stites H. William
- Stoikov Anastas
- Strasser Ruth
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Suarez Rafael Martin
- Sudnik Wanda
- Sueyoshi Atsushi
- Sukles Kai
- Sun Li
- Suneja Randeep
- Svensson Peter
- Szavits Nossan Janko
- Taggeselle Jens
- Takagi Yuichiro
- Takhar Amrit
- Tallet Julio
- Tamm Angelika
- Tanaka Katsumi
- Tanaka Shozo
- Tang Aylmer
- Tang Sherman
- Tassinari Tiziana
- Tayama Shinji
- Tayebjee Muzahir
- Tebbe Ulrich
- Teixeira Jose
- Tesloianu Dan Nicolae
- Tessier Pascal
- Teutsch Christine
- The S. H. K.
- Thevenin J\ue9rome
- Thomas Harold
- Timsit Serge
- Topkis Robert
- Torosoff Mikhail
- Touze Emmanuel
- Traissac Thalie
- Trendafilova Elina
- Troyan Barry
- Tsai Wenchi Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tsutsui Takashi
- Tuininga Y. S.
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Twiddy Shannon
- Tytus Richard
- Ukrainski Gerald
- Valdovinos Chavez Salvador Bruno
- Van De Graaff Eric
- Vanacker Peter
- Vardas Panagiotis
- Vargas Michael
- Vassilikos Vassilios
- Vazquez Juan
- Venkataraman Asok
- Verdecchia Paolo
- Vester Ernst G\ufcnter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Vinereanu Dragos
- Vlastaris Anthony
- Vogel Craig
- vom Dahl J\ufcrgen
- von Mering Matthias
- Vora Kishor
- Wakefield Paul
- Walia Jasjit
- Walter Thomas
- Wang Feng
- Wang Kuo Yang
- Wang Mingsheng
- Wang Ningfu
- Wang Xinhua
- Wang Zulu
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weinrich Renate
- Wen Ming Shien
- Wheelan Kevin
- Wicke Jens
- Wiemer Marcus
- Wild Beate
- Wilke Andreas
- Willems Stephan
- Williams David
- Williams Marcus
- Winkler Andreas
- Wirtz Jost Henner
- Witzenbichler Bernhard
- Wong Brian
- Wong Danny H. K.
- Wozakowska Kaplon Beata
- Wu Shulin
- Wu Zhaohui
- Wyatt Nell
- Xu Xiangdong
- Xu Yong
- Yamada Akira
- Yamamoto Kazuya
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yang Yanmin
- Yao Jing
- Yarlagadda Chakri
- Yeh Kuo Ho
- Yotov Yoto
- Yvorra Serge
- Zahn Ralf
- Zamorano Jos\ue9
- Zanini Roberto
- Zarich Stuart
- Zebrack James
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Dadong
- Zhang Donghui
- Zhang Huanyi
- Zhang Quansan
- Zhang Xingwei
- Zhao Shuiping
- Zhao Xinwen
- Zheng Qiangsun
- Zheng Yang
- Zhou Jian
- Zhou Jing
- Ziekenhuis Antonius
- Zimmermann Rainer
- Zimmermann Sergio Luiz
- Zint Kristina
- Zuhairy Hamed M.
- Zukerman L. Steven
- Zwaan van der C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
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- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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