Development of a single‐cell X‐ray fluorescence flow cytometer

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/122448/1/jsy2pp5083.pd

Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.

Reference ranges provide a powerful tool for diagnostic decision-making in clinical medicine and are enormously valuable for understanding normality in pre-clinical scientific research that uses in vivo models. As yet, there are no published reference ranges for electrocardiography (ECG) in the laboratory mouse. The first mouse-specific reference ranges for the assessment of electrical conduction are reported herein generated from an ECG dataset of unprecedented scale. International Mouse Phenotyping Consortium data from over 26,000 conscious or anesthetized C57BL/6N wildtype control mice were stratified by sex and age to develop robust ECG reference ranges. Interesting findings include that heart rate and key elements from the ECG waveform (RR-, PR-, ST-, QT-interval, QT corrected, and QRS complex) demonstrate minimal sexual dimorphism. As expected, anesthesia induces a decrease in heart rate and was shown for both inhalation (isoflurane) and injectable (tribromoethanol) anesthesia. In the absence of pharmacological, environmental, or genetic challenges, we did not observe major age-related ECG changes in C57BL/6N-inbred mice as the differences in the reference ranges of 12-week-old compared to 62-week-old mice were negligible. The generalizability of the C57BL/6N substrain reference ranges was demonstrated by comparison with ECG data from a wide range of non-IMPC studies. The close overlap in data from a wide range of mouse strains suggests that the C57BL/6N-based reference ranges can be used as a robust and comprehensive indicator of normality. We report a unique ECG reference resource of fundamental importance for any experimental study of cardiac function in mice

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Headquarters for Consumer Council

published_or_final_versionArchitectureMasterMaster of Architectur

Epiphany.

Epiphany is a short film produced by a student group, Raison d'être Productions, as their Final Year Project. Raison d'être Productions is made up of 4 final year students from the Wee Kim Wee School of Communication and Information. The duration of the entire project took approximately nine months, under the supervision of Ms. Nikki Draper. This report aims to document the full process of our final year project, from the conceptualization of our film’s theme to the filming process to post-production. It also describes some of the difficulties faced and decisions made throughout the journey. Most importantly, this report is a personal reflection of what we have done.Bachelor of Communication Studie

Deep Learning Methods for Remote Heart Rate Measurement: A Review and Future Research Agenda

Heart rate (HR) is one of the essential vital signs used to indicate the physiological health of the human body. While traditional HR monitors usually require contact with skin, remote photoplethysmography (rPPG) enables contactless HR monitoring by capturing subtle light changes of skin through a video camera. Given the vast potential of this technology in the future of digital healthcare, remote monitoring of physiological signals has gained significant traction in the research community. In recent years, the success of deep learning (DL) methods for image and video analysis has inspired researchers to apply such techniques to various parts of the remote physiological signal extraction pipeline. In this paper, we discuss several recent advances of DL-based methods specifically for remote HR measurement, categorizing them based on model architecture and application. We further detail relevant real-world applications of remote physiological monitoring and summarize various common resources used to accelerate related research progress. Lastly, we analyze the implications of research findings and discuss research gaps to guide future explorations

Sense of place, subjective well-being, and the influence of housing and neighbourhood: A comparative study of two marginalised districts in Hong Kong

This paper investigates the associations between the multiple dimensions of individuals’ sense of place and subjective well-being. The impact of objective and subjective housing and neighbourhood attributes on sense of place was also examined. Using a questionnaire and government spatial datasets, data were collected from residents of two marginalised communities in Hong Kong, Sham Shui Po and Tin Shui Wai. The results reveal positive relationships between various facets of sense of place and subjective well-being that vary in strength in different urban forms. Among the attributes of housing and neighbourhood analysed, housing satisfaction is found to be the strongest predictor of sense of place. The study further verifies the use of a synthesised three-dimensional scale to measure sense of place. It also has important implications for urban planning policies and practices for high-density cities