Архетип влюблённого в поэзии крымских ханов

<p>This article is focused on the seasonal variation in the contents of 5-methoxycanthin-6-one from the leaves of <i>Zanthoxylum chiloperone</i> (Rutaceae). Based on the pharmacological interest presented by 5-methoxycanthin-6-one, its seasonal variation in <i>Z. chiloperone</i> leaves was analysed in order to determine the best time for harvesting, optimising the 5-methoxycanthin-6-one content. The seasonal dynamics of canthinone alkaloids can be the key to improve the isolation from natural sustainable sources, such as leaves. Complementarily, this study describes the phytochemistry of leaf from this Ruraceae species.</p

Mecânica da fratura aplicada em juntas soldadas do aço astm A672 GR B em tubulações de processo / Fracture mechanics applied to welded joints in astm A672 GR B steel in process pipes

Este trabalho avaliou a geração de trincas internas em juntas soldadas em tubulações industriais de aço ASTM A672 grau B. Nessa abordagem foi utilizado o Diagrama de Falhas – FAD, que avaliou descontinuidades planares da estrutura da solda através de ensaios não destrutivos. Foram estudados parâmetros envolvendo mecânica da fratura e os efeitos micro estruturais que contribuem para a avaliação da integridade estrutural. As amostras foram obtidas do Sistema de Flare Geral da Unidade de Hidrotratamento de Diesel localizada no Complexo Petroquímico do Estado do Rio de Janeiro – COMPERJ. Os resultados mostraram que, em juntas soldadas, novos critérios podem ser inseridos na avaliação de defeitos em relação às propriedades mecânicas do material. Após analisar as tensões por difração de raios X, foi possível se avaliar as condições de operação da tubulação, posição, geometria da trinca e as tensões atuantes que contribuem para a análise de peças que seriam reprovadas em testes. Os resultados mostraram também que as tensões geradas sempre relacionam as condições operacionais na linha, envolvendo pressão e temperatura, resultou em posicionamento no diagrama de falhas, em regiões seguras que demonstraram a inexistência de probabilidade de falha do material. 

Health program for elders at primary health care centers

INTRODUCTION: Ageing is a process of irreversible changes, both physical and physiological. According to WHO, health programs directed to the elders must promote and encourage them to have a routine based on their goals. The number of senior citizens in Brazil is on the rise, and studies show that in 2020 they will represent about 12.5% of the country's population; therefore, health policies must meet the needs of this age group. OBJECTIVES: To create a health program for elders that can be applied at primary health care centers. METHODOLOGY: The project was initially applied at "Centro de Saúde Escola Barra Funda Dr. Alexandre Vranjac". Using both bibliographic and field research, we were able to create a profile of elders in the area and, thus, understand the needs of this age group, which enabled us to map the different activities directed to senior citizens that are available in the area and suggest new activities that appeal to this public. RESULTS: Several centers offer activities to senior citizens; however, few citizens attend them, which shows that more effective ways to advertise them must be used to attract more elders. After analyzing the data, a guidebook was created to help professionals when dealing with elders. In it, there is a bibliographic review about the ageing process, a flowchart with the ideal management of elder patients, a summary of activities available in the area and a schedule with such activities. This guidebook aims to help the professionals offer their patients a better orientation.INTRODUÇÃO: Envelhecer é um processo de mudanças irreversíveis na estrutura e no funcionamento de um organismo, que ocorre como resultado da passagem do tempo. Segundo a OMS, programas voltados à saúde dos idosos devem promover, estimular e potencializar situações que os levem a organizar sua rotina de acordo com o próprio planejamento e metas pessoais. No Brasil, a população de idosos aumenta significativamente; estima-se que representará 12,5% em 2020. Nesse contexto, justifica-se a criação de programas de saúde particularizados a esse grupo populacional. OBJETIVO: Elaborar programa de saúde para o idoso aplicável em Unidades Básicas de Saúde. METODOLOGIA: O projeto foi aplicado no Centro de Saúde Escola Barra Funda "Dr. Alexandre Vranjac". Com revisão bibliográfica, conhecimento da população local e das demandas regionais quanto a novas atividades e mapeamento das atividades existentes no terrritório, formulou-se uma apostila direcionada aos profissionais da saúde visando elucidar dúvidas e orientar o manejo do paciente idoso. RESULTADOS: A Unidade é referência na organização dos projetos existentes em sua área de abrangência; muitos, atualmente, com potencial subutilizado. Foram encontrados diversos centros que oferecem atividades aos idosos, no entanto há necessidade de aprimorar a divulgação desses projetos através de meios que atinjam efetivamente essa população. Elaborou-se apostila composta de revisão bibliográfica, fluxograma de atendimento médico, roteiro para personalizar o atendimento do idoso, banco de dados com os principais projetos da região e calendário com as atividades existentes permitindo centralizar informações e torná-las acessíveis, para que atividades específicas a cada paciente possam ser indicadas de maneira objetiva

Socio-economic inequalities in physical activity practice among Italian children and adolescents: a cross-sectional study

Aim: The aim of the study was to evaluate whether socio-economic inequalities in the practice of physical activity existed among children and adolescents, using different indicators of socio-economic status (SES). Subjects and methods: Data were derived from the Italian National Health Interview Survey carried out in 2004–2005, which examined a large random sample of the Italian population using both an interviewer-administered and a self-compiled questionnaire. This study was based on a sample of 15,216 individuals aged 6–17 years. The practice of physical activity was measured on the basis of questions regarding frequency and intensity of activity during leisure time over the past 12 months. Parents’ educational and occupational level, as well as family’s availability of material resource, were used as indicators of SES. Multivariable logistic regression analyses were performed to estimate the contribution of each SES indicator to the practice of physical activity, adjusting for potential confounding factors. The results of the regression models are expressed as odds ratio (OR) with 95% confidence intervals (95% CI). Results: About 64% of children and adolescents in the sample declared that they participated in moderate or vigorous physical activity at least once a week. After adjustment for gender, age, parental attitudes towards physical activity and geographical area, the practice of physical activity increased with higher parental educational and occupational level and greater availability of material resources. Children and adolescents whose parents held a middle or high educational title were 80% more likely to practice moderate or vigorous physical activity than subjects whose parents had a lower level of education (OR = 1.80, 95% CI: 1.40–2.33), while subjects with unemployed parents had an odds of practicing moderate or vigorous physical activity 0.43 times that of those children whose parents belonged to the top job occupation category (administrative/professionals). Socio-economic differences were about the same when the practice of vigorous physical activity only was considered instead of that of moderate or vigorous physical activity. Conclusion: Interventions that promote the practice of physical activity, and especially those aimed at the wider physical and social environment, are strongly needed to contrast socio-economic differences in physical activity among children and adolescents

The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital

<p>Abstract</p> <p>Background</p> <p>Vancomycin is an antibiotic of growing importance in the treatment of hospital infections, with particular emphasis on its value in the fight against methicillin-resistant <it>Staphylococcus aureus</it>. However its usage profile must be evaluated to assure maximum benefit and minimum risk.</p> <p>Findings</p> <p>A cross-sectional retrospective study was carried out among inpatients that received vancomycin in a Brazilian quaternary hospital. The occurrence of adverse reactions reported was evaluated in medical records relating to patients taking vancomycin during a one year period. Males comprised 52% (95% CI: 41.7-60.2%) of the sample population, with a mean age of 50.6 (95% CI: 47.2-54.0) years and mean treatment period of 9.7 (95% CI: 8.0-11.5) Days. It was verified that nephrotoxicity occurred in 18.4% (95% CI: 11.3-27.5) of patients, Red man syndrome occurred in 2% (95% CI 0.2-7.2), while the occurrence of thrombocytopenia was 7.1% (95% CI: 2.9-14.2).</p> <p>Conclusions</p> <p>It may be noted that even after 50 years of use, adverse reactions associated with vancomycin continue with high frequency, presenting a public health problem, especially considering its current use in cases of multidrug resistant infections. In this context, we emphasize the importance of intensive pharmacovigilance in hospital as a surveillance tool after drug approval by the sanitary authority.</p

Incentive or Habit Learning in Amphibians?

Toads (Rhinella arenarum) received training with a novel incentive procedure involving access to solutions of different NaCl concentrations. In Experiment 1, instrumental behavior and weight variation data confirmed that such solutions yield incentive values ranging from appetitive (deionized water, DW, leading to weight gain), to neutral (300 mM slightly hypertonic solution, leading to no net weight gain or loss), and aversive (800 mM highly hypertonic solution leading to weight loss). In Experiment 2, a downshift from DW to a 300 mM solution or an upshift from a 300 mM solution to DW led to a gradual adjustment in instrumental behavior. In Experiment 3, extinction was similar after acquisition with access to only DW or with a random mixture of DW and 300 mM. In Experiment 4, a downshift from DW to 225, 212, or 200 mM solutions led again to gradual adjustments. These findings add to a growing body of comparative evidence suggesting that amphibians adjust to incentive shifts on the basis of habit formation and reorganization

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Different neurodegenerative diseases are caused by aberrant elongation of repeated glutamine sequences normally found in particular human proteins. Although the proteins involved are ubiquitously distributed in human tissues, toxicity targets only defined neuronal populations. Changes caused by an expanded polyglutamine protein are possibly influenced by endogenous cellular mechanisms, which may be harnessed to produce neuroprotection. Here, we show that ataxin-3, the protein involved in spinocerebellar ataxia type 3, also known as Machado-Joseph disease, causes dendritic and synapse loss in cultured neurons when expanded. We report that S12 of ataxin-3 is phosphorylated in neurons and that mutating this residue so as to mimic a constitutive phosphorylated state counters the neuromorphologic defects observed. In rats stereotaxically injected with expanded ataxin-3–encoding lentiviral vectors, mutation of serine 12 reduces aggregation, neuronal loss, and synapse loss. Our results suggest that S12 plays a role in the pathogenic pathways mediated by polyglutamine-expanded ataxin-3 and that phosphorylation of this residue protects against toxicity

Compressed representation of a partially defined integer function over multiple arguments

In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one

Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy

A search for new physics is performed in events with two same-sign isolated leptons, hadronic jets, and missing transverse energy in the final state. The analysis is based on a data sample corresponding to an integrated luminosity of 4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of 7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of 140 increase in integrated luminosity over previously published results. The observed yields agree with the standard model predictions and thus no evidence for new physics is found. The observations are used to set upper limits on possible new physics contributions and to constrain supersymmetric models. To facilitate the interpretation of the data in a broader range of new physics scenarios, information on the event selection, detector response, and efficiencies is provided.Comment: Published in Physical Review Letter