Quality evaluation of minoxidil topical solutions obtained from magistral pharmacies

The objective of this study was to evaluate quality parameters of magistral topical solutions containing minoxidil (A, B and C), comparing the results with the ones obtained for the industrial formulation. Organoleptic tests, evaluation of the pH and density, centrifuge test, drug content determination, comparison of indicated dosages and in vitro follicular penetration of minoxidil were performed. Regarding the organoleptic properties, differences in color and viscosity were observed between the magistral (composed of minoxidil sulfate) and the industrial formulations (composed of minoxidil base). For pH values, the magistral solutions presented considerably more acidic pH, compared to the industrial sample. For the density test, the samples with the highest ethanol percentages (B and C) presented lower density. In the centrifuge test, none of the samples showed changes. Considering the drug content test, only the industrial sample and the magistral sample C showed drug percentage within the expected (90-110%), indicating lack of correction factor determination by the magistral pharmacies. Furthermore, it was observed that the dosage indicated by the magistral pharmacies do not correspond to the dose indicated by the industry, being significantly lower. All topical solutions tested presented hair follicle penetration of minoxildil, without statistical difference. The results indicate that there is a failure in the magistral pharmacies regarding the production and the indication of dosage of minoxidil topical solutions

Functional traits reveal coastal vegetation assembly patterns in a short edaphic gradient in southern Brazil

The relationship between plant functional traits and soil variables is useful for understanding plant community composition and circumscribing plant functional groups to highlight their adaptations to environmental conditions. The principal aim of this study was to explain assembly patterns of coastal vegetation using functional traits along a short edaphic gradient. The work was carried out on the pioneer zone in the coastal lowland vegetation (foredune) in southern Brazil. We selected 40 functional traits related to the morphology and anatomy of leaves, stems and roots for 60 species recorded in 25 vegetation plots positioned along three transects from the shoreline to slacks. In each plot, floristic and soil data were collected, and functional traits measured. We analysed the relationships between species functional traits and soil factors through RLQ and fourth-corner analyses. Salinity and organic matter content were the most significant edaphic factors in the differentiation of foredune vegetation, while the most significant traits to explain plant adaptations to coastal environments were plant height, sclerenchyma, spongy parenchyma and reserves of inulin in the root. Two functional groups of plants were circumscribed: a conservative group formed by trees and shrubs dominated the Woody Community, with low values of SLA (specific leaf area), thick cuticles, high frequencies of phenolic compounds and crystals, woody stems and great plant heights, which tended to invest in permanent aerial organs; and a more heterogeneous group of herbaceous plants (found in Beach Community, Non-floodable, and Wet Communities) with acquisitive characteristics (high SLA values) or conservative strategy (rhizome and xylopodium). Finally, our results suggested that root and stem functional traits, which are infrequently taken into consideration, were useful to differentiate subtropical coastal plants and, in general, to study plant adaptations to environmental conditions in depth

Charged-Higgs phenomenology in the Aligned two-Higgs-doublet model

The alignment in flavour space of the Yukawa matrices of a general two-Higgs-doublet model results in the absence of tree-level flavour-changing neutral currents. In addition to the usual fermion masses and mixings, the aligned Yukawa structure only contains three complex parameters, which are potential new sources of CP violation. For particular values of these three parameters all known specific implementations of the model based on discrete Z_2 symmetries are recovered. One of the most distinctive features of the two-Higgs-doublet model is the presence of a charged scalar. In this work, we discuss its main phenomenological consequences in flavour-changing processes at low energies and derive the corresponding constraints on the parameters of the aligned two-Higgs-doublet model.Comment: 46 pages, 19 figures. Version accepted for publication in JHEP. References added. Discussion slightly extended. Conclusions unchange

Observation of CP violation in B+ to DK+ decays

An analysis of B+ to DK+ and B+ to Dpi+ decays is presented where the D meson is reconstructed in the two-body final states: K+pi-, K+K-, pi+pi- and pi+K-. Using 1.0 fb-1 of LHCb data, measurements of several observables are made including the first observation of the suppressed mode B+ to DK+, D to pi+K-. CP violation in B+ to DK+ decays is observed with 5.8 sigma significance

Measurement of CP observables in B± → D(⁎)K± and B± → D(⁎)π± decays

Measurements of CP observables in B ± →D (⁎) K ± and B ± →D (⁎) π ± decays are presented, where D (⁎) indicates a neutral D or D ⁎ meson that is an admixture of D (⁎)0 and D¯ (⁎)0 states. Decays of the D ⁎ meson to the Dπ 0 and Dγ final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± π ∓ , K + K − and π + π − final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb −1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± →D ⁎ K ± and B ± →D ⁎ π ± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± →DK ± and B ± →Dπ ± decays is an update of previous LHCb measurements. The B ± →DK ± results are the most precise to date

Measurement of the B0–B0 oscillation frequency Δmd with the decays B0→D−π+ and B0→ J/ψK∗0

The B 0 –B 0 oscillation frequency Δmd is measured by the LHCb experiment using a dataset corresponding to an integrated luminosity of 1.0 fb−1 of proton–proton collisions at √ s = 7 TeV, and is found to be Δmd =0.5156±0.0051 (stat.)±0.0033 (syst.) ps−1 . The measurement is based on results from analyses of the decays B 0 → D −π + (D − → K +π −π −) and B 0 → J/ψK ∗0 (J/ψ →μ +μ −,K ∗0 → K +π −) and their charge conjugated modes

Determination of gamma and-2 beta(s) from charmless two-body decays of beauty mesons

Using the latest LHCb measurements of time-dependent CP violation in the B^0_s -> K^+K^- decay, a U-spin relation between the decay amplitudes of B^0_s -> K^+K^- and B^0 -> \pi^+\pi^- decay processes allows constraints to be placed on the angle gamma of the unitarity triangle and on the B^0_s mixing phase -2\beta_s. Results from an extended approach, which uses additional inputs on B^0 -> \pi^0\pi^0 and B^+ -> \pi^+\pi^0 decays from other experiments and exploits isospin symmetry, are also presented. The dependence of the results on the maximum allowed amount of U-spin breaking is studied. At 68% probability, the value \gamma = ( 63.5 +7.2 -6.7 ) degrees modulo 180 degrees is determined. In an alternative analysis, the value -2\beta_s = -0.12 +0.14 -0.16 rad is found. In both measurements, the uncertainties due to U-spin breaking effects up to 50% are included.Comment: updated to v2 with minor changes after journal revie

Measurement of CP observables in B± → DK± and B± → Dπ± with two- and four-body D decays

Measurements of CP observables in B± → D K ± and B± → Dπ± decays are presented where the D meson is reconstructed in the final states K ±π∓, π± K ∓, K + K −, π+π−, K ±π∓π+π−, π± K ∓π+π− and π+π−π+π−. This analysis uses a sample of charged B mesons from pp collisions collected by the LHCb experiment in 2011 and 2012, corresponding to an integrated luminosity of 3.0 fb−1. Various CP-violating effects are reported and together these measurements provide important input for the determination of the unitarity triangle angle γ . The analysis of the four-pion D decay mode is the first of its kind

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació