History biases reveal novel dissociations between perceptual and metacognitive decision-making

Human decision-making and self-reflection often depend on context and internal biases. For instance, decisions are often influenced by preceding choices, regardless of their relevance. It remains unclear how choice history influences different levels of the decision-making hierarchy. We used analyses grounded in information and detection theories to estimate the relative strength of perceptual and metacognitive history biases and to investigate whether they emerge from common/unique mechanisms. Although both perception and metacognition tended to be biased toward previous responses, we observed novel dissociations that challenge normative theories of confidence. Different evidence levels often informed perceptual and metacognitive decisions within observers, and response history distinctly influenced first- (perceptual) and second- (metacognitive) order decision-parameters, with the metacognitive bias likely to be strongest and most prevalent in the general population. We propose that recent choices and subjective confidence represent heuristics, which inform first- and second-order decisions in the absence of more relevant evidence

Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

Funding Information: The University of Stavanger supported M.C.G. The CamPaIGN study has received funding from the Wellcome Trust, the Medical Research Council, the Patrick Berthoud Trust, and the NIHR Cambridge Biomedical Research Centre (BRC‐1215‐20014). The ICICLE‐PD study was funded by Parkinson's UK (J‐0802, G‐1301, G‐1507) and supported by the Lockhart Parkinson's Disease Research Fund, National Institute for Health Research (NIHR) Newcastle Biomedical Research Unit and Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. The PICNICS study was funded by the Cure Parkinson's Trust, the Van Geest Foundation, the Medical Research Council, Parkinson's UK, and the NIHR Cambridge Biomedical Research Centre (BRC‐1215‐20014). The NYPUM study was supported by grants from the Swedish Medical Research Council, Erling‐Persson Foundation, the Swedish Brain Foundation (Hjärnfonden), Umeå University, Västerbotten County Council, King Gustaf V and Queen Victoria Freemason Foundation, Swedish Parkinson Foundation, Swedish Parkinson Research Foundation, Kempe Foundation, Swedish PD Association, the European Research Council, and the Knut and Alice Wallenberg Foundation. The PINE study was funded by Parkinson's UK (grant numbers G0502, G0914, and G1302), the Scottish Chief Scientist Office (CAF/12/05, PCL/17/10), Academy of Medical Sciences, NHS Grampian endowments, the BMA Doris Hillier award, RS Macdonald Trust, the BUPA Foundation, and SPRING. The PARKWEST study was supported by the Research Council of Norway (grant# 177966), the Western Norway Regional Health Authority (grant# 911218 and # 911949), Reberg legacy and the Norwegian Parkinson's Research Foundation. The PICC collaboration has been supported by The Chief Scientist Office of the Scottish Government (PCL/17/10), the Academy of Medical Sciences, Parkinson's UK (initial collaborator meeting) and the Norwegian Association for Public Health. The DEMVEST Study was supported by the regional health authorities of Western Norway, Helse‐Vest (grant# 911973). Motol University Hospital's Czech Brain Aging Study was supported by the National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107)—Funded by the European Union—Next Generation EU and by Charles University grant PRIMUS 22/MED/011. The Sant Pau Initiative on Neurodegeration (SPIN) cohort was supported by the Fondo de Investigaciones Sanitario (FIS), Instituto de Salud Carlos III (PI14/01126, PI17/01019 and PI20/01473 to JF, PI13/01532 and PI16/01825 to RB, PI18/00335 to MCI, PI18/00435 and INT19/00016 to DA, PI17/01896 and AC19/00103to AL) and the CIBERNED program (Program 1, Alzheimer Disease to AL), jointly funded by Fondo Europeo de Desarrollo Regional, Unión Europea, “Una manera de hacer Europa”. It was also supported by the National Institutes of Health (NIA grants 1R01AG056850‐01A1; R21AG056974; and R01AG061566), by Generalitat de Catalunya (2017‐SGR‐547, SLT006/17/125, SLT006/17/119, SLT002/16/408) and “Marató TV3” foundation grants 20141210, 044412 and 20142610. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The sponsors were not involved in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. The authors declare that there are no conflicts of interest relevant to this work. Funding Sources and Conflicts of Interest:Peer reviewedPublisher PD

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

`You must make it the fashion:' selling utopia in Roycroft and Arden, 1895-1915

The arts and crafts movement, a design style and reform movement in the late nineteenth century, formed as a reaction to the socio-economic inequities of industrialized labor in Britain before appearing in America at the turn of the century. The arts and crafts embraced simplicity and solid craftsmanship, however, the American marketplace forced the movement into a paradox when consumers demanded cheap, widely available goods. Wrapped in the ideology developed by John Ruskin and William Morris, arts and crafts goods present a unique opportunity to study the paradox between consumer dreams and realities. In the United States, Elbert Hubbard and Frank Stephens formed the arts and crafts utopian colonies of Roycroft, in East Aurora, New York, and Arden, Delaware, respectively. A comparative study of these communities is merited because the former focused on commercial endeavors while the latter preferred to follow political and educational pursuits over the production of goods. Furthermore, the managerial styles of Elbert Hubbard and Frank Stephens determined each community's subsequent relationship with middle-class consumers as they took their goods to market. Roycroft and Arden both used the discourse of the arts and crafts movement to financially support their goals; at the same time, they contributed to the discourse by modifying its language to meet consumer desires, and expanded it to include a greater body of adherents who used, accepted, or assimilated the movement as they so chose. The framework developed by Roycroft and Arden familiarized the public with the design style, while putting tools into place that would allow consumers to attempt a lifestyle of authenticity if they so wished it. The arts and crafts movement, as presented by the colonies, allowed consumers to embrace or discard the ideological tenets, and therefore claim or reject the sense of authenticity that perceivably accompanied the goods.</p

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1

'If Michael Owen drinks it, why can't I?' - 9 and 10 year olds' perceptions of physical activity and healthy eating

Objective - To explore the perceptions of physical activity and healthy eating among children from two north west of England primary schools, with the ultimate aim of improving healthy lifestyle choices. Design - A qualitative study in which each child participated in two focus groups. Setting Two primary schools in a deprived ward of Warrington, chosen to contrast with the focus of earlier research on relatively affluent communities. Method - A sample of 32 9 and 10 year olds was randomly selected from two Year 5 classes. Four focus groups were held in total; two in each school. The first explored perceptions of physical activity and the second examined views on food and eating. Discussions were recorded, transcribed verbatim and findings emerged through a process of thematic analysis. Results - Children reported being involved in a range of physical activities and recognized the health benefits associated with being active. Boys and girls differed in their attitude towards physical activity, with boys appearing competitive about sport while girls enjoyed a wider range of activities. Children were able to distinguish between healthy and unhealthy foods, but there was uncertainty over the healthiness of foods containing multiple ingredients (for example, salad in burgers). Children also identified the impact of the local environment, parents, school, the food industry and their peers on their diet and involvement in physical activity. Conclusions - Children receive contradictory messages about food and diet, which they make sense of through their social interactions. The development of obesity prevention strategies and weight management programmes must take into account children's perspectives. Children should be given the opportunity to contribute to the development of initiatives that are set up to prevent and treat obesity