Attached to the world: on the anchoring and strategy of Dutch foreign policy

Few other countries are so interrelated with the world around us in political, economic, and social respects as the Netherlands. This means that the Dutch government needs to be alert in its response to the risks and opportunities presented by a rapidly changing world. Addressing this issue, the Scientific Council for Government Policy (wrr) offers some reflections in this report, guided by the question how the Netherlands can develop a foreign policy strategy that matches the changing power relations in the world and the radically changed character of international relations. The answer to this question is a reorientation. This means making transparent choices, making smarter use of Europe as our dominant arena, and, finally, choosing an approach that makes better use of the growing role of non-state actors. The report's recommendations not only underline the necessity of reorientation but also show how this could be accomplished in practice

Attached to the World

Also available in Dutch "http://www.aup.nl/do.php?a=show_visitor_book&isbn=9789089643018">Aan het buitenland gehecht Few other countries are so interrelated with the world around us in political, economic, and social respects as the Netherlands. This means that the Dutch government needs to be alert in its response to the risks and opportunities presented by a rapidly changing world. Addressing this issue, the Scientific Council for Government Policy (wrr) offers some reflections in this report, guided by the question how the Netherlands can develop a foreign policy strategy that matches the changing power relations in the world and the radically changed character of international relations. The answer to this question is a reorientation. This means making transparent choices, making smarter use of Europe as our dominant arena, and, finally, choosing an approach that makes better use of the growing role of non-state actors. The report's recommendations not only underline the necessity of reorientation but also show how this could be accomplished in practice

Aan het buitenland gehecht

Also available in English "http://www.aup.nl/do.php?a=show_visitor_book&isbn=9789089643285">Attached to the World Few other countries are so interrelated with the world around us in political, economic, and social respects as the Netherlands. This means that the Dutch government needs to be alert in its response to the risks and opportunities presented by a rapidly changing world. Addressing this issue, the Scientific Council for Government Policy (wrr) offers some reflections in this report, guided by the question how the Netherlands can develop a foreign policy strategy that matches the changing power relations in the world and the radically changed character of international relations. The answer to this question is a reorientation. This means making transparent choices, making smarter use of Europe as our dominant arena, and, finally, choosing an approach that makes better use of the growing role of non-state actors. The report's recommendations not only underline the necessity of reorientation but also show how this could be accomplished in practice.Ook verschenen in het Engels "http://www.aup.nl/do.php?a=show_visitor_book&isbn=9789089643285">Attached to the World De Wetenschappelijke Raad voor het Regeringsbeleid (WRR) bepleit in zijn rapport Aan het buitenland gehecht een nieuwe aanpak van het buitenlandbeleid. De wereld om ons heen is onderhevig aan veranderende machtsverhoudingen, wordt bevolkt door andere spelers dan in het verleden, en wordt gekenmerkt door een sterkere verknoping van nationale en internationale vraagstukken. Dit vraagt om nieuwe antwoorden, om een heroriëntatie op het buitenlandbeleid. Het rapport wordt op 30 november namens de regering in ontvangst genomen door de minister van Buitenlandse Zaken, dr. U. Rosenthal. Het rapport stelt vast dat de internationale betrekkingen radicaal van karakter zijn veranderd. De vertrouwde afbakening tussen binnen- en buitenland vervaagt steeds verder, met name in Europa. Een groot deel van de Nederlanders ervaart dit evenwel nog anders. Tegelijkertijd neemt hun onzekerheid over de positie van Nederland in de wereld toe, mede door de recente financiële crisis. Het WRR-rapport bepleit een strategischer aanpak van de buitenlandpolitiek en schetst daarvoor een afwegingskader. Hiermee kunnen duidelijke keuzes worden gemaakt. Bijvoorbeeld door de nadruk te leggen op beleidsterreinen waarop Nederland sterk is en zich langere tijd wil profileren, zoals water, voedsel, of internationaal recht. De keuzes moeten ertoe bijdragen dat het profiel, de zichtbaarheid en de invloed van Nederland worden vergroot. Door in het buitenlandbeleid de samenhang tussen nationale en internationale belangen sterker te benadrukken, zal dat beleid in eigen land op ruimere steun kunnen rekenen, verwacht de WRR. De nieuwe aanpak zal er volgens de WRR toe leiden dat de algemene buitenlandstrategie een zaak van de gehele ministerraad wordt. Deze aanpak impliceert geen herijking of ontkokering van het buitenlandbeleid. Het vraagt een andere benadering, een andere houding. De Europese Unie is en blijft voor Nederland de meest dominante arena voor internationale samenwerking. Wie zijn doelen in het buitenlandbeleid wil bereiken, moet juist hier invloed uitoefenen, juist hier excelleren om zijn nationale belangen te realiseren. Volgens de WRR vergt dit een antwoord op de vragen: in wat voor Europa willen wij leven en hoe kunnen we onze invloed aanwenden om dit Europa naar vermogen mee vorm geven? Daarbij zou het passen wanneer ons land de praktijk van de ons omringende landen volgt en de minister-president daadwerkelijk tot eerstverantwoordelijke voor het EU-beleid aanwijst, aan het hoofd van het 'ministerie van Algemene en Europese Zaken'. Een strategischer buitenlandbeleid vraagt om een adequate uitvoering. Naast organisatorische aanscherpingen, kunnen bestaande instrumenten beter worden benut. Zo meent de WRR dat het postennet van diplomatieke vertegenwoordigingen in de wereld niet gebaseerd moet zijn op vaste reflexen, maar een afgeleide dient te zijn van een heldere strategie. Tevens zijn nieuwe vormen van samenwerking met andere landen noodzakelijk, waarbij ook nadrukkelijk ruimte en erkenning ontstaan voor samenwerking met niet-statelijke actoren zoals bedrijven, ngo's en belangenorganisaties. Kortom: de WRR bepleit in de buitenlandse politiek strategisch-inhoudelijk scherp te kiezen, te streven naar excellentie binnen Europa en een faciliterend medespeler te worden in de wereld van niet-statelijke actoren. Tevens zijn in het kader van dit onderzoek gepubliceerd: "http://www.wrr.nl/content.jsp?objectid=5464">WRR-webpublicatie nr. 43, Internationalisering en Europeanisering van strafrechtelijke rechtshandhaving in Nederland, dr.mr. A. van den Brink "http://www.wrr.nl/content.jsp?objectid=5302">WRR-webpublicatie nr. 42, Het Nederlandse veiligheidsbeleid in een veranderende wereld, drs. M.H. Kle

Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown

The coronavirus disease 2019 (COVID-19) outbreak introduced unprecedented health-risks, as well as pressure on the economy, society, and psychological well-being due to the response to the outbreak. In a preregistered study, we hypothesized that the intense experience of the outbreak potentially induced stress-related brain modifications in the healthy population, not infected with the virus. We examined volumetric changes in 50 participants who underwent MRI scans before and after the COVID-19 outbreak and lockdown in Israel. Their scans were compared with those of 50 control participants who were scanned twice prior to the pandemic. Following COVID-19 outbreak and lockdown, the test group participants uniquely showed volumetric increases in bilateral amygdalae, putamen, and the anterior temporal cortices. Changes in the amygdalae diminished as time elapsed from lockdown relief, suggesting that the intense experience associated with the pandemic induced transient volumetric changes in brain regions commonly associated with stress and anxiety. The current work utilizes a rare opportunity for real-life natural experiment, showing evidence for brain plasticity following the COVID-19 global pandemic. These findings have broad implications, relevant both for the scientific community as well as the general public

Estudio y edición de una versión sefardí aljamiada del Ma‘asé Yehudit

The proposal of the present contribution is to present the critical edition of the oldest Sephardic version known of the Ma‘asé Yehudit. It was published in Constantinople in 1758 included in the booklet Lúaḥ areź, published by Nisim ben Yoná Aškenaźí. The translator of this story (from Hebrew), Yiŝḥac Valero, says in the cover that he copied it in ladino. Effectively, the translation from the numerous biblical quotations and fragments of prayers follow the style from the translations of the Bible in ladino at that time and in the previous centuries. The story follows the textual tradition of the one content in Ḥemdat yamim (Izmir 1731-1732), but it is far from being literal. So, after considering some clues, we think that this is an eclectic version, because doesn’t trace none of those known until know.El propósito de esta contribución es presentar la edición crítica de la más antigua versión sefardí aljamiada del Ma‘asé Yehudit que conocemos. Apareció en Constantinopla en 1758 incluida en el libro Lúaḥ areź, publicada por Nisim ben Yoná Aškenaźí. El traductor de esta historia (del hebreo), Yiŝḥac Valero, dice en la portada que la copió en ladino. Efectivamente, la traducción de las numerosas citas bíblicas y de fragmentos de plegarias, lo son al estilo de los ladinamientos aljamiados en boga en la época y en los siglos precedentes. El relato sigue la tradición textual del contenido en la obra Ḥemdat yamim (Esmirna 1731-1732), pero no es literal, lo que después de algunos indicios nos lleva a pensar que se trata de una versión ecléctica, ya que no calca ninguna de las hasta ahora conocidas

AUXIN RESPONSE FACTOR3 Regulates Compound Leaf Patterning by Directly Repressing PALMATE-LIKE PENTAFOLIATA1 Expression in Medicago truncatula

[EN] Diverse leaf forms can be seen in nature. In Medicago truncatula, PALM1 encoding a Cys(2) His(2) transcription factor is a key regulator of compound leaf patterning. PALM1 negatively regulates expression of SGL1, a key regulator of lateral leaflet initiation. However, how PALM1 itself is regulated is not yet known. To answer this question, we used promoter sequence analysis, yeast one-hybrid tests, quantitative transcription activity assays, ChIP-PCR analysis, and phenotypic analyses of overexpression lines and mutant plants. The results show that M. truncatula AUXIN RESPONSE FACTOR3 (MtARF3) functions as a direct transcriptional repressor of PALM1. MtARF3 physically binds to the PALM1 promoter sequence in yeast cells. MtARF3 selectively interacts with specific auxin response elements (AuxREs) in the PALM1 promoter to repress reporter gene expression in tobacco leaves and binds to specific sequences in the PALM1 promoter in vivo. Upregulation of MtARF3 or removal of both PHANTASTICA (PHAN) and ARGONAUTE7 (AGO7) pathways resulted in compound leaves with five narrow leaflets arranged in a palmate-like configuration. These results support that MtARF3, in addition as an adaxial-abaxial polarity regulator, functions to restrict spatiotemporal expression of PALM1, linking auxin signaling to compound leaf patterning in the legume plant M. truncatula.Funding of this work was provided in part by The Samuel Roberts Noble Foundation and by grants from the Oklahoma Center for Advancement of Science and Technology (OCAST; PS12-036 and PS16-034) and the National Science Foundation (IOS-1127155). The laboratory of FM was funded by the Spanish Ministerio de Economia y Competitividad and FEDER (BIO2015-64307-R) and the Generalitat Valenciana (ACOMP2012-099).Peng, J.; Berbel Tornero, A.; Madueño Albi, F.; Chen, R. (2017). 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Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

The noise-lovers: cultures of speech and sound in second-century Rome

This chapter provides an examination of an ideal of the ‘deliberate speaker’, who aims to reflect time, thought, and study in his speech. In the Roman Empire, words became a vital tool for creating and defending in-groups, and orators and authors in both Latin and Greek alleged, by contrast, that their enemies produced babbling noise rather than articulate speech. In this chapter, the ideal of the deliberate speaker is explored through the works of two very different contemporaries: the African-born Roman orator Fronto and the Syrian Christian apologist Tatian. Despite moving in very different circles, Fronto and Tatian both express their identity and authority through an expertise in words, in strikingly similar ways. The chapter ends with a call for scholars of the Roman Empire to create categories of analysis that move across different cultural and linguistic groups. If we do not, we risk merely replicating the parochialism and insularity of our sources.Accepted manuscrip