Assessment of multipath and shadowing effects on UHF band in built-up environments

Ultra-high frequency (UHF) bands are radio frequencies in the range of 300 MHz and 3 GHz. These bands are used for television broadcasting, mobile cellular systems, Wi-Fi, satellite communications and many others. Effective communication link in the UHF band requires direct line of sight between the transmitters and receivers. However, this is not always the case in built-up areas where diverse obstacles such as large buildings, trees, moving objects and hills are present along the communication path. These obstacles result in signal degradation as a result of shadowing (blockages) and multi-path, which are two major causes of signal losses. Path loss models are used in predicting signal losses but, the accuracy of these models depend on the fitness between the model's predictions and measured loses. In this work, the multi-path and shadowing effects on signal impairment were investigated through the use of empirical and semi-empirical path loss models analysis in built-up environments. Electromagnetic field strength measurements were conducted using four television transmitters at UHF bands along four major routes of Osun State, Nigeria. Experimental and simulation results indicated that the empirical models provide a better fit than the semi-empirical models. It was also found that the poor performance of the Knife Edge Model which is a semi-empirical model was traced to the bases of its formulation, which assumed point like knife edge for all obstacles on the path of radio propagation. The work therefore recommends that network planners employ empirical models found suitable for their kind of terrain when faced with coverage planning and optimization.Keywords: Path loss models, Radio propagation,  Terrain feature

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths in the GBD. The present iteration of the GBD, GBD 2017, improves on previous assessments and provides timely estimates of the mortality experience of populations globally. METHODS: The GBD uses all available data to produce estimates of mortality rates between 1950 and 2017 for 23 age groups, both sexes, and 918 locations, including 195 countries and territories and subnational locations for 16 countries. Data used include vital registration systems, sample registration systems, household surveys (complete birth histories, summary birth histories, sibling histories), censuses (summary birth histories, household deaths), and Demographic Surveillance Sites. In total, this analysis used 8259 data sources. Estimates of the probability of death between birth and the age of 5 years and between ages 15 and 60 years are generated and then input into a model life table system to produce complete life tables for all locations and years. Fatal discontinuities and mortality due to HIV/AIDS are analysed separately and then incorporated into the estimation. We analyse the relationship between age-specific mortality and development status using the Socio-demographic Index, a composite measure based on fertility under the age of 25 years, education, and income. There are four main methodological improvements in GBD 2017 compared with GBD 2016: 622 additional data sources have been incorporated; new estimates of population, generated by the GBD study, are used; statistical methods used in different components of the analysis have been further standardised and improved; and the analysis has been extended backwards in time by two decades to start in 1950. FINDINGS: Globally, 18·7% (95% uncertainty interval 18·4–19·0) of deaths were registered in 1950 and that proportion has been steadily increasing since, with 58·8% (58·2–59·3) of all deaths being registered in 2015. At the global level, between 1950 and 2017, life expectancy increased from 48·1 years (46·5–49·6) to 70·5 years (70·1–70·8) for men and from 52·9 years (51·7–54·0) to 75·6 years (75·3–75·9) for women. Despite this overall progress, there remains substantial variation in life expectancy at birth in 2017, which ranges from 49·1 years (46·5–51·7) for men in the Central African Republic to 87·6 years (86·9–88·1) among women in Singapore. The greatest progress across age groups was for children younger than 5 years; under-5 mortality dropped from 216·0 deaths (196·3–238·1) per 1000 livebirths in 1950 to 38·9 deaths (35·6–42·83) per 1000 livebirths in 2017, with huge reductions across countries. Nevertheless, there were still 5·4 million (5·2–5·6) deaths among children younger than 5 years in the world in 2017. Progress has been less pronounced and more variable for adults, especially for adult males, who had stagnant or increasing mortality rates in several countries. The gap between male and female life expectancy between 1950 and 2017, while relatively stable at the global level, shows distinctive patterns across super-regions and has consistently been the largest in central Europe, eastern Europe, and central Asia, and smallest in south Asia. Performance was also variable across countries and time in observed mortality rates compared with those expected on the basis of development. INTERPRETATION: This analysis of age-sex-specific mortality shows that there are remarkably complex patterns in population mortality across countries. The findings of this study highlight global successes, such as the large decline in under-5 mortality, which reflects significant local, national, and global commitment and investment over several decades. However, they also bring attention to mortality patterns that are a cause for concern, particularly among adult men and, to a lesser extent, women, whose mortality rates have stagnated in many countries over the time period of this study, and in some cases are increasing

Clutter Height Variation Effects on Frequency Dependen Path Loss Models at UHF Bands in Build-Up Areas

In this work, the performance of eight prominent empirical path loss models and a localized model, in predicting path losses in build up areas is investigated. Multi-transmitter electromagnetic field strength measurements were conducted, using a dedicated Agilent spectrum analyzer, along five predefined routes in Osun State, Nigeria. The measured data were compared with the model predictions. Path profile and terrain undulations effects have been observed on the received signal. For all the routes and transmitters, Okumura, SUI models over predicted the path losses, while Ericsson model under predicted the losses. However, Hata, Davidson, Cost 231 and ILORIN models generally show promising results with varying performance. The average mean error values of 55.11 dB, -8.53 dB, 46.72 dB, -9.81 dB, -28.16 dB, -8.93 dB, -30.59 dB, -22.95 dB and -12.57 dB are respectively obtained for NTAOSOGBO transmitter for Okumra, Hata, SUI, Cost 231, CCIR, Davidson, Ericsson, EEC-33 and ILORIN models. In terms of RMSE, the  average RMSE values of 9.24 dB, 9.08 dB and 9.18 dB were obtained for ILORIN, Hata and Davidson models respectively. This trend was found to be similar for other transmitters i.e. OSBC, NDTV and NTA Ile Ife with varying performances among the four contending models. We, further, examined the route performance for the two main contending models i.e. ILORIN and Hata models. Inconsistency in terms of the performance for each model were observed, however the localized model i.e. ILORIN was found to provide optimum path loss prediction with considerable accuracy, over the other models. With the aforementioned, we believe the results and observations presented would provide guide to radio system engineers in making informed choices on the applicability and predictability of such models in the terrain of Osun State and other similar build-up areas in Nigeria

Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398

The up-regulation of cyclooxygenase 2 (COX-2) expression is a frequent occurrence in a variety of different tumors. In this study, COX-2 protein expression was investigated in 50 glioma and 3 normal brain specimens by immunohistochemistry. Expression of COX-2 protein was observed in all normal brain and glioma specimens by immunohistochemistry, regardless of histological grade. The immunoreactive score was significantly higher in high-grade glioma than low-grade glioma and normal brain specimens. For a subset of these tumors (nine gliomas and three normal brain), Western blot analysis was also performed. COX-2 protein was detected in all specimens by Western blot analysis. The effect of the specific COX-2 inhibitor NS-398 on monolayer cell cultures and three-dimensional glioma spheroids was investigated using U-87MG and U-251MG human glioblastoma cell lines. The proliferation rate was assessed in monolayer cultures. In addition, a growth assay, a migration assay, an apoptosis assay, and a tumor invasion assay were performed in a three-dimensional spheroid culture system. NS-398 was able to reduce the proliferation of monolayer cell cultures, as well as the growth of spheroids and tumor cell migration, in a dose-dependent manner. There was also a moderate increase in the number of apoptotic cells in the treated spheroids. NS-398 did not have an inhibitory effect on tumor invasion in the coculture spheroid system. Our study provides evidence that COX-2 is up-regulated in the majority of high-grade gliomas and that a potential role of COX-2 inhibitors as an adjuvant therapy for brain tumors may exist

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission. © 2019, The Author(s)