30 research outputs found
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection
- Author
- A Canepa
- A Gouzy
- A Gouzy
- AK Pandey
- AL Kullas
- Alexandre Gouzy
- Alexia Dumas
- AM Abdallah
- BY Lee
- C de Chastellier
- C Harper
- C Lechene
- C Recchi
- C Scotti
- CA Schneider
- Chantal de Chastellier
- CM Sassetti
- D Bottai
- D Bottai
- D Hofreuter
- D Leduc
- D Schnappinger
- D Schnappinger
- DA Cooney
- Daria Bottai
- DG Russell
- DG Russell
- Dirk Schnappinger
- DL Jack
- E Carlemalm
- F Kirchheimer
- Florence Levillain
- G Harth
- Gérald Larrouy-Maumus
- H Rachman
- H Song
- Irène Caire-Brandli
- J Amon
- J Marrero
- JC van Kessel
- JD McKinney
- JE Griffin
- Jean-Luc Guerquin-Kern
- JF Hainfeld
- JJ Pesek
- JL Guerquin-Kern
- JM Reyrat
- Joshua B. Wallach
- K Sendide
- K Shibayama
- KH Rohde
- KH Rohde
- KY Rhee
- L Tailleux
- LE Via
- LP de Carvalho
- Luiz Pedro Sório de Carvalho
- M Braunstein
- M Braunstein
- Marcel A. Behr
- MH Daleke
- MP Jennings
- MV Tullius
- N van der Wel
- Olivier Neyrolles
- P Brodin
- P Carroll
- R Appelberg
- R Simeone
- Renaud Poincloux
- RH Lyon
- RH Lyon
- Roland Brosch
- S Ehrt
- S Ehrt
- S Homolka
- S Woong Park
- ST Cole
- Ting-Di Wu
- UE Schaible
- V Reddy
- W Lin
- X Cai
- Yannick Poquet
- YJ Zhang
- YJ Zhang
- YN Srikhanta
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH is slightly acidic, and where access to nutrients is limited. Understanding how the bacillus extracts and incorporates nutrients from its host may help develop novel strategies to combat tuberculosis. Here we show that M. tuberculosis employs the asparagine transporter AnsP2 and the secreted asparaginase AnsA to assimilate nitrogen and resist acid stress through asparagine hydrolysis and ammonia release. While the role of AnsP2 is partially spared by yet to be identified transporter(s), that of AnsA is crucial in both phagosome acidification arrest and intracellular replication, as an M. tuberculosis mutant lacking this asparaginase is ultimately attenuated in macrophages and in mice. Our study provides yet another example of the intimate link between physiology and virulence in the tubercle bacillus, and identifies a novel pathway to be targeted for therapeutic purposes. © 2014 Gouzy et al
Structural studies of T4S systems by electron microscopy
- Author
- Abdallah AM Gey van Pittius NC, Champion PA, et a
- Backert S Meyer TF
- Bailey S Ward D, Middleton R, et al.
- Banta LM Kerr JE, Cascales E, et al.
- Cascales E
- Cascales E Christie PJ
- Cascales E Christie PJ
- Christie PJ Atmakuri K, Krishnamoorthy V, et al.
- Christie PJ Cascales E
- Clemens DL Ge P, Lee BY, et al.
- Cornelis GR Van Gijsegem F
- De Carlo S Harris JR
- de Jong MF Sun YH, den Hartigh AB, et al.
- Dubochet J
- Durand E Waksman G, Receveur-Brechot V
- Eisenbrandt R Kalkum M, Lai EM, et al.
- Filloux A
- Fronzes R Christie PJ, Waksman G
- Fronzes R Schafer E, Wang L, et al.
- Gomis-Ruth FX Moncalian G, Perez-Luque R, et al.
- Henderson IR Navarro-Garcia F, Desvaux M, et al.
- Hofreuter D Karnholz A, Haas R
- Jakubowski SJ Kerr JE, Garza I, et al.
- Jakubowski SJ Krishnamoorthy V, Cascales E, et al
- Judd PK Mahli D, Das A
- Kerr JE Christie PJ
- Kudryashev M Wang RY, Brackmann M, et al.
- Lederberg J Tatum EL
- Lessl M Lanka E
- Li X Mooney P, Zheng S, et al.
- Llosa M de la Cruz F
- Low HH Gubellini F, Rivera-Calzada A, et al.
- McMullan G Faruqi AR, Henderson R, et al.
- Mossey P Hudacek A, Das A
- Ninio S Roy CR
- Orlova EV Saibil HR
- Pansegrau W Lanka E
- Pena A Matilla I, Martin-Benito J, et al.
- Ripoll-Rozada J Zunzunegui S, de la Cruz F, et al
- Rivera-Calzada A Fronzes R, Savva CG, et al.
- Savvides SN Yeo HJ, Beck MR, et al.
- Schraidt O Marlovits TC
- Schroder G Krause S, Zechner EL, et al.
- Sivanesan D Baron C
- Terradot L Bayliss R, Oomen C, et al.
- Trokter M Felisberto-Rodrigues C, Christie PJ, et
- Wallden K Williams R, Yan J, et al.
- Yeo HJ Savvides SN, Herr AB, et al.
- Yeo HJ Yuan Q, Beck MR, et al.
- Yuan Q Carle A, Gao C, et al.
- Zechner EL Lang S, Schildbach JF
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Abstract: Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein organisation and lack of overall global symmetry. Nonetheless the last decade demonstrated an amazing progress achieved by X-ray crystallography and cryo-electron microscopy. In this review we present a structural analysis of this dynamic complex based on recent advances in biochemical, biophysical and structural studies
Oxygen Effect on Structural and Optical Properties of ZnO Thin Films Deposited by RF Magnetron Sputtering
- Author
- Abdallah B
- Abdul Kader Jazmati
- Al-Khawaja S
- Ayouchi R
- Bassam Abdallah
- Basu PK
- Ben-Yaacov T
- Bensmaine S
- Bi Z
- Fu YQ
- Fujimura N
- Gao W
- Hoffman RL
- Hong JI
- Ismail A
- Ismail IM
- Jiang YJ
- Khelladi MR
- Kumar R
- Kushiya K
- Laidoudi S
- Lee JB
- Mentar L
- Oh BY
- Park TE
- Pearton SJ
- Prathap P
- Raeda Refaai
- Rahmane S
- Sahay PP
- Scherrer P
- Shinde VR
- Shishiyanu ST
- Suchea M
- Sundaram KB
- Ting CC
- Vishnoi S
- Wang JM
- Wang YG
- Wang ZA
- Wu KY
- Zhu H
- Zhu J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Determination of the ratio of b-quark fragmentation fractions fs/fd in pp collisions at √s = 7 TeV with the ATLAS Detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Alkire SP
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amadio BT
- Amako K
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov AV
- Anjos N
- Annovi A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Aranda CP
- Araque JP
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Atkinson M
- Atlay NB
- Augsten K
- Aurousseau M
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baak MA
- Baas AE
- Baca MJ
- Bacci C
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bain T
- Baines JT
- Baker OK
- Baldin EM
- Balek P
- Balestri T
- Balli F
- Banas E
- Banerjee S
- Bannoura AAE
- Bansil HS
- Barajas CAC
- Barak L
- Barberio EL
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- Barbero M
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska Z
- Baroncelli A
- Barone G
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- Bartoldus R
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- Beacham JB
- Beattie MD
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- Beauchemin PH
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- Berlingen JM
- Bernard C
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- Bernius C
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- Berta P
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- Bertolucci F
- Bertsche C
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- Besana MI
- Besjes GJ
- Bessner M
- Besson N
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- Bethke S
- Bevan AJ
- Bhimji W
- Bianchi RM
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- Biebel O
- Biedermann D
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- Biglietti M
- Bilokon H
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- Blanchard J-B
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- Bobbink GJ
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- Buda SI
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- Zhemchugov A
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- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
With an integrated luminosity of 2.47 fb−1 recorded by the ATLAS experiment at the LHC, the exclusive decays B 0s→J/ψϕ and B0d→J/ψK*0 of B mesons produced in pp collisions at √s=7 TeV are used to determine the ratio of fragmentation fractions fs/fd. From the observed B0s→J/ψϕ and B0d→J/ψK*0 yields, the quantity (fs/fd)[B(B0s→J/ψϕ)/B(B 0d→J/ψK*0)] is measured to be 0.199±0.004(stat)±0.008(syst). Using a recent theory prediction for [B(B0s→J/ψϕ)/B(B0d→J/ψK*0)] yields (fs/fd)=0.240±0.004(stat)±0.010(syst)±0.017(th). This result is based on a new approach that provides a significant improvement of the world average
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
- Author
- A Bhattacharyya
- A Musacchio
- A Saadatpour
- AA Alizadeh
- Aaron Taudt
- AD Silk
- Allan Bradley
- AM Laughney
- Anke van den Berg
- B Bakker
- Bjorn Bakker
- BR Williams
- BY Abdallah
- David Porubsky
- Diana C. J. Spierings
- DJ Baker
- DJ Baker
- DJ Baker
- E Falconer
- EM Torres
- Eveline S. J. M. de Bont
- F Foijer
- F Foijer
- F Foijer
- Floris Foijer
- GJPL Kops
- HHQ Heng
- Hinke G. Kazemier
- IC Macaulay
- J Simon
- JJ Siegel
- JM Nicholson
- JM Sheltzer
- K Knouse
- Karina Hoekstra-Wakker
- L Baum
- M Gerlinger
- M Giam
- M Vleugel
- Maria Colomé-Tatché
- Mirjam E. Belderbos
- N McGranahan
- N Navin
- N Navin
- Nancy Halsema
- NJ Ganem
- Peter M. Lansdorp
- R Jinadasa
- R Sotillo
- SL Thompson
- T Garvin
- Tristan V. de Jong
- Victor Guryev
- WT Silkworth
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The thermodynamics of protein interactions with essential first row transition metals
- Author
- A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry
- Abajian
- Alterio
- Banci
- Berg
- Berg
- Bertini
- Bordbar
- Bou-Abdallah
- Bou-Abdallah
- Bou-Abdallah
- Bou-Abdallah
- Bou-Abdallah
- Bou-Abdallah
- Bounds
- Bradley
- Burdach
- Burnouf
- Chasteen
- Cláudio
- Cox
- Crichton
- Crichton
- Crow
- Damo
- Dörnyei
- Ebrahimi
- Emsley
- Fadi Bou-Abdallah
- Font
- Freyer
- Gagnon
- Gray
- Grossoehme
- Harris
- Hayden
- Hirose
- Holm
- Huffman
- Hunt
- Hunt
- Irving
- Kaim
- Karsten
- Kehl-Fie
- Kiss
- Kiss
- Klug
- Korndörfer
- Krishnamurthy
- Li
- Liboiron
- Lippard
- Lucia Bianconi
- Lyons
- Lyons
- Maret
- Maret
- McCall
- Miller
- Olsen
- Palm-Espling
- Palm-Espling
- Papp-Wallace
- Potter
- Rich
- Roe
- SEDPHAT
- Smith
- Song
- Terpstra
- Theil
- Theil
- Thomas R. Giffune
- Todd
- Transtruma
- Valentine
- Wernimont
- Whittaker
- Wilcox
- Xiao
- Yatsunyk
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Theory of the time dependent transferred nuclear Overhauser effect: Applications to structural analysis of ligand-protein complexes in solution
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- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Determination of sensitivity of some food pathogens to spice extracts
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
What Is the Future of Circulating Tumor Cells in Colorectal Cancer?
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- A Lyberopoulou
- A Matikas
- A-W Lee
- AG Vaiopoulos
- B Mostert
- BL Khoo
- BY Oh
- C Aggarwal
- C Welinder
- D Nesteruk
- DA Haber
- E Denève
- EA Abdallah
- EA Abdallah
- F Grillet
- F Vecchio Del
- G Steinert
- Hui Zhang
- J Barbazan
- J Barbazan
- JT Kaifi
- JY Tseng
- K Sugimachi
- K Tan
- KC Andree
- L Chen
- LT Seeberg
- M Pesta
- MF Santos
- MG Krebs
- MJ Sotelo
- N Hao
- OA Martin
- P Eliasova
- R Divella
- S Hinz
- S Hinz
- S Katoh
- S Matsusaka
- T Hillig
- T Yokobori
- TR Church
- V Musella
- WS Tsai
- Yun Deng
- Z Bielčiková
- Zhen Zhang
- ZS Lalmahomed
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study