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Attachment Stories: The Attachment Experiences Of Special Needs Adoptive Families
- Publication venue
- ScholarWorks@UMass Amherst
- Publication date
- 08/04/2011
- Field of study
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
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- I Burn
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- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
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- Immacolata Andolfo
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- J Allan
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- J Bradley-Potts
- J Brown
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- J Camsooksai
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- J Cockerill-Taylor
- J Cole
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- J Cuttler
- J Daglish
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- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
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- J Finn
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- J Frankham
- J Gaylard
- J Gill
- J Godden
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- J Gregory
- J Greig
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- J Harris
- J Hatton
- J Hawes
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- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
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- J Kenneth Baillie
- J Keshet-Price
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- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
- S Donlon
- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
- S Gurung Rai
- S Henderson
- S Hierons
- S Hope
- S Humphreys
- S Hussain
- S Jenkins
- S Jhanji
- S Jones
- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
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Openness in Adoptions from Foster Care:
- Publication venue
- ScholarWorks@UMass Amherst
- Publication date
- 11/04/2013
- Field of study
In search of innovation: A national qualitative analysis of child welfare recruitment and retention efforts
- Publication venue
- Publication date
- Field of study
This national qualitative study explores recruitment and retention strategies within state child welfare agencies and the perceived effectiveness of these strategies. The study includes a national review of 50 state child welfare websites, and qualitative interviews with 18 individuals in 13 states. The findings highlight agencies' identification and investment of similar types of recruitment and retention efforts; yet agencies still grapple with elevated turnover rates despite continued efforts. This article comprehensively explored national utilized and underutilized strategies that have been employed to help alleviate child welfare recruitment and retention challenges. Further, mechanisms for overcoming and promoting innovation to understand the effectiveness of child welfare recruitment and retention strategies are addressed.Child welfare Recruitment Retention Organizational innovation
Disparities in Counseling for Lifestyle Modification Among Obese Adults: Insights from the Dallas Heart Study
- Author
- (CDC) CfDCaP
- American Diabetes Association.
- Amit Khera
- Arnlöv
- Artinian
- Bish
- Bleich
- Colby R. Ayers
- Darren K. McGuire
- Durant
- Felix
- Flegal
- Flegal
- Flegal
- Forman-Hoffman
- Galuska
- Glasgow
- Jackson
- James A. de Lemos
- Jarett D. Berry
- Kamakki Banks-Richard
- Klein
- Ko
- Kuk
- Lagakos
- Lin
- Lopez-Quintero
- Ma
- Mack
- McTigue
- Ogden
- Poirier
- Post
- Sandeep R. Das
- Sciamanna
- Sidorov
- Simkin-Silverman
- Susan G. Lakoski
- Tiffany M. Powell-Wiley
- Victor
- Wilson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Agency-Related Barriers Experienced by Families Seeking to Adopt From Foster Care
- Author
- AdoptUSKids
- AdoptUSKids
- AdoptUSKids
- AdoptUSKids
- AdoptUSKids
- Amy Chanmugam
- Berry M.
- Casey Family Services
- Center for Adoption Support and Education
- Courtney M.
- Elissa E. Madden
- Emlen A.
- Evan B. Donaldson Institute.
- Flower C.
- Freundlich M.
- Hollingsworth L. D.
- Interactive Harris
- Kathleen J. Ledesma
- Lodermeier J.
- Macomber J. E.
- McMurtry S. L.
- McRoy R.
- Michele D. Hanna
- Patricia A. Cody
- Pecora P. J.
- Pecora P. J.
- Ruth G. McRoy
- Sankaran V.
- Smith S.
- Sullivan D.
- Susan J. Ayers-Lopez
- U.S. Department of Health and Human Services
- U.S. Department of Health and Human Services
- U.S. Department of Health and Human Services
- U.S. Department of Health and Human Services
- U.S. General Accounting Office
- U.S. General Accounting Office
- U.S. General Accounting Office
- Wilson J. B.
- Young L.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Life-Threatening and Non-Life-Threatening Complications Associated With Coughing
- Author
- Aaronson
- Abd Moain Abu Dabrh
- Abid
- Abigail Moore
- Abu-Gazala
- Adam T. Hill
- Ahn
- Alan F. Barker
- Alex Molasoitis
- Ali A. El Solh
- Aliyev
- Altman
- Alves
- Anderton
- Andrew P. Lane
- Anne B. Chang
- Anne E. Vertigan
- Annunziata
- Anthony Harnden
- Ariturk
- Asenjo
- Awad
- Ayers
- Bahra
- Baiardini
- Banyai
- Baron
- Bartel
- Bayram
- Begley
- Ben Safta
- Benditt
- Benedict
- Berciano
- Bilir
- Birring
- Bodenheimer
- Boulet
- Braido
- Brendan Canning
- Bruce Rubin
- Bundy
- Butensky
- Butman
- Buzzi
- Cameron Grant
- Candas
- Castelnuovo
- Ceponis
- Chaar
- Chadda
- Chen
- Cherian
- Chiba
- Cho
- Choi
- Christopher Brightling
- Chua
- Cogbill
- Comroe
- Cordenier
- Cosgun
- Curley
- Cynthia L. French
- Cynthia T. French
- Daniel
- De Luca
- De Maeseneer
- Dean
- Dearlove
- Derbes
- Derbes
- Deslee
- Dickinson
- Dina Fisher
- Donald C. Bolser
- Dubey
- Ducatman
- el-Hammady
- Elango
- Elie Azoulay
- Enamorado
- Ertsey
- Fajgenbaum
- Fein
- Fenig
- Field
- Fitzsimons
- Francis
- Franco
- Franco
- French
- French
- French
- French
- Gelisse
- George
- Glaspole
- Glauser
- Gradwohl
- Grant
- Gupta
- Habib
- Hamid
- Hamilton
- Han
- Hart
- Haslam
- Heckman
- Herr
- Hillenbrand
- Hillman
- Hjalmarsson
- Horsburgh
- Hrisanfow
- Irani
- Ireland
- Irwin
- Irwin
- Irwin
- Irwin
- Irwin
- Irwin
- Irwin
- Irwin
- Irwin
- Ishii
- Ishizuka
- J. Mark Madison
- Jabr
- Jaclyn Smith
- Jacobs
- Jang
- Jay H. Ryu
- Jenkins
- Joanne Kavanagh
- John Oppenheimer
- Kaiser Lim
- Kallay
- Kao
- Kapoor
- Kara
- Karabulut
- Karina A. Keogh
- Kashani
- Katrancioglu
- Katz
- Kau
- Kawahara
- Kefang Lai
- Kenneth W. Altman
- Kerr
- Kerr
- Khan
- Khayer
- Kodama
- Kopcsanyi
- Kosalka
- Kravitz
- Krediet
- Kreitmann
- Kuczkowski
- Kusuyama
- Kwong
- Laitinen
- Larson
- Lee
- Lee
- Lee
- Lee
- Leung
- Lewis
- Lin
- Lindegaard
- Lindsley
- Linzer
- Litch
- Littmann
- LoMauro
- Long
- Lopez-Candales
- Lorcan McGarvey
- Lord
- Lorin
- Louis-Philippe Boulet
- Love
- M. Hassan Murad
- Ma
- Macedo
- Macias-Robles
- Macklin
- Mahawish
- Mao
- Maqsood
- Marimuthu
- Marinella
- Mark A. Malesker
- Marous
- Mary Parks
- Mattle
- Maury
- Maznyczka
- McCann
- McCarthy
- McCorry
- McIntosh
- McIntyre
- Mereu
- Migeot
- Moncada
- Morgan-Hughes
- Musher
- Naggar
- Nakanishi
- Natasha Dudiki
- Natelson
- Nelwan
- Nensa
- Nerurkar
- Newcombe
- Nomura
- Oertel
- Omori
- Oostendorp
- Oren
- Ozge
- Ozlu
- O’Doherty
- O’Shea
- Papadimos
- Papanikitas
- Pareja Lopez
- Park
- Park
- Pascual
- Pascual
- Patel
- Paterson
- Patolia
- Patricio Escalante
- Paul Davenport
- Paulley
- Pavao Martins
- Perini
- Peter J. Kahrilas
- Peter Newcombe
- Peters
- Peters
- Petsios
- Pollack
- Polley
- Prasad
- Prasad
- Puetz
- Ramneesh
- Rao
- Reichman
- Reid
- Reisin
- Reper
- Richard J. Russell
- Richard S. Irwin
- Richard S. Irwin
- Rieger
- Rivara
- Roberge
- Roe
- Rogers
- Roh
- Romano
- Rousie
- Ruckdeschel
- Runciman
- Rydell
- Sala
- Salameh
- Sandford
- Sands
- Sanjay
- Sano
- Sansur
- Santarpino
- Sanyal
- Sayhan
- Schen
- Sengar
- Shaikh
- Sharpey-Schafer
- Sharpey-Schafer
- Sheka
- Shirai
- Shugar
- Shutsha
- Siclari
- Sidney S. Braman
- Sivam
- Skolnick
- Sloth-Nielsen
- Smith
- Sonal Singh
- Stephen K. Field
- Stern
- Sternfeld
- Stillman
- Strauss
- Stuart Mazzone
- Stupnik
- Styczynski
- Sulaiman
- Surinder S. Birring
- Susan M. Harding
- Susan M. Tarlo
- Swenson
- Symonds
- Tack
- Takazawa
- Tanaka
- Tashkin
- Terrie Cowley
- Torrington
- Toubia
- Tricco
- Tsai
- Tseng
- Tsuji
- Ulla
- Ulyatt
- Vasquez
- Vaya
- Vincent
- Viticchi
- Vivek Iyer
- Waldmann
- Wang
- Wang
- Warmington
- Weaver
- Wehbe
- Wei
- Weinberger
- Weissberg
- Wergowske
- White
- Williams
- Wolman
- Won
- Wu
- Wurm Johansson
- Yagi
- Yeh
- Yirerong
- Young
- Young
- Yu
- Zeng
- Zlab
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
- Author
- Abboud Shérine
- Abecasis Gonçalo
- Abraham Gad
- Adams Hieab H. H.
- Akiyama Masato
- Alg Varinder S.
- Almgren Peter
- Amin Najaf
- Amort Margareth
- Amouyel Philippe
- Anttila Verneri
- Arfan Ikram M.
- Arking Dan E.
- Arnold Marie-Luise
- Aromaa Arpo J.
- Artto Ville
- Attia John R.
- Ayers Kristin L.
- Bakker Mark K.
- Barbieri Caterina M.
- Batini Chiara
- Belin Andrea C.
- Beretta Simone
- Berrandou Takiy
- Bersano Anna
- Bijlenga Philippe
- Bis Joshua C.
- Blake Tineka
- Bochud Murielle
- Bodenant Marie
- Boehnke Michael
- Boerwinkle Eric
- Bonati Leo
- Boomsma Dorret I.
- Boomsma Dorret I.
- Borck Guntram
- Bottinger Erwin P.
- Bouatia-Naji Nabila
- Bourcier Romain
- Boutin Thibaud
- Bown Matthew
- Brandt Tobias
- Braund Peter S.
- Broderick Joseph P.
- Brown Morris J.
- Brumat Marco
- Brumpton Ben M.
- Brumpton Ben M.
- Buring Julie E.
- Butterworth Adam S.
- Byrnes Andrea E.
- Béjot Yannick
- Børte Sigrid
- Børte Sigrid
- Cader Zameel
- Campbell Archie
- Campbell Harry
- Canaple Sandrine
- Caria Filomena
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chasman Daniel I.
- Chasman Daniel I.
- Chauhan Ganesh
- Cherkas Lynn
- Ciullo Marina
- Cocca Massimiliano
- Cole John
- Collins Francis
- Conen David
- Connell John
- Cordell Heather J.
- Crozier Sophie
- Cucca Francesco
- Cuenca-Leon Ester
- Dallongeville Jean
- Daly Mark J.
- Danesh John
- Dauvillier J. rôme
- Davey Smith George
- Davies Gail
- de Borst Martin H.
- de Geus Eco J.
- de Giuli Valeria
- de Mutsert Renée
- Deary Ian J.
- Debette Stéphanie
- Decavel Pierre
- Deelen Joris
- del Greco M Fabiola
- Deltour Sandrine
- Desal Hubert
- Dichgans Martin
- Dichgans Martin
- Dimou Niki
- Dina Christian
- Ding Jun
- Doney Alex S. F.
- Dos Santos Michael
- Dörr Marcus
- Ehret Georg B.
- Ellekjær Hanne
- Elliott Paul
- Elosua Roberto
- Engelter Stefan
- Enroth Stefan
- Eriksson Johan G.
- Eriksson Nicholas
- Esko Tonu
- Esko Tonu
- Esserlind Ann-Louise
- Evangelou Evangelos
- Farh Kai-How
- Farrall Martin
- Ferrarese Carlo
- Ferrari Michel D.
- Ferreira Teresa
- Fluri Felix
- Folkmann Hansen Thomas
- Francke Christensen Anne
- Franco Oscar H.
- Franke Lude
- Freilinger Tobias M.
- Friedrich Christoph M.
- Fritsche Lars G.
- Frånberg Mattias
- Furlotte Nicholas A.
- Färkkilä Markus
- Gabrielsen Maiken E.
- Gandin Ilaria
- Ganesh Santhi K.
- Gao He
- Gasparini Paolo
- Gaál-Paavola EmÃlia I.
- Gensicke Henrik
- Gentric Jean-Christophe
- Giacolone Giacomo
- Giedraitis Vilmantas
- Gieger Christian
- Girotto Giorgia
- Giroud Maurice
- Gisler Dominique
- Giulianini Franco
- Godefroy Olivier
- Goel Anuj
- Gordon Scott G.
- Gormley Padhraig
- Gow Alan J.
- Grau Armin
- Grond-Ginsbach Caspar
- Gudlaug Hrafnsdottir Maria
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf
- Göbel Hartmut
- Hagen Knut
- Hamsten Anders
- Harris Sarah E.
- Harris Tamara B.
- Hartman Catharina A.
- Hatz Florian
- Havulinna Aki S.
- Hayward Caroline
- Heath Andrew C.
- Hege Aamodt Anne
- Heidi Skogholt Anne
- Heikkilä Kauko
- Heuch Ingrid
- Hicks Andrew A.
- Hinds David A.
- Hirsch Sven
- Hofer Edith
- Hofman Albert
- Hofman Albert
- Holliday Elizabeth G.
- Holmen Oddgeir L.
- Hostettler Isabel C.
- Hottenga Jouke-Jan
- Hottenga Jouke-Jan
- Houlden Henry
- Howson Joanna M. M.
- Huang Hailiang
- Huang Jie
- Huffman Jennifer E.
- Hveem Kristian
- Hveem Kristian
- Hwang Shih-Jen
- Hämäläinen Eija
- Ingason Andres
- Ingelsson Erik
- Jackson Anne U.
- James Alan
- Jansen Rick
- Jarvelin Marjo-Riitta
- Joehanes Roby
- Johansson Ã…sa
- Johnsen Marianne Bakke
- Johnson Andrew D.
- Jones Gregory
- Joshi Peter K.
- Jousilahti Pekka
- Jula Antti
- Järvelin Marjo-Riitta
- Jääskeläinen Juha E.
- Kallela Mikko
- Kals Mart
- Kamatani Yoichiro
- Kanning Jos P.
- Kaprio Jaakko
- Kathiresan Sekar
- Kaunisto Mari
- Keavney Bernard D.
- Khaw Kay-Tee
- Kittner Steven
- Kloss Manja
- Knekt Paul
- Knight Joanne
- Koido Masaru
- Koiranen Markku
- Kolcic Ivana
- Kooner Jaspal S.
- Koskinen Seppo
- Kristiansson Kati
- Kristoffersen Espen S.
- Kubisch Christian
- Kurki Mitja I.
- Kurth Tobias
- Kutalik Zoltan
- Kähönen Mika
- Laakso Markku
- Laan Maris
- Lakatta Edward G.
- Lanfranconi Silvia
- Langenberg Claudia
- Larson Marty
- Launer Lenore J.
- Leder Sara
- Lee Phil H.
- Lehne Benjamin
- Lehtimäki Terho
- Lehtimäki Terho
- Levy Daniel
- Leys Didier
- Li Liming
- Li-Gao Ruifang
- Lichy Christoph
- Liewald David C. M.
- Ligthart Lannie
- Lin Kuang
- Lin Li
- Lin Wei-Yu
- Lind Lars
- Lindgren Antti
- Lindgren Cecilia M.
- Liu YongMei
- Loehrer Elizabeth
- Loos Ruth J. F.
- Lopez Lorna M.
- Louillet Fabien
- Lu Yingchang
- Luan Jian'an
- Lyrer Philippe
- Lyytikäinen Leo-Pekka
- Léger Anne
- Madden Pamela A. F.
- Mahajan Anubha
- Majersik Jennifer
- Malik Rainer
- Mamasoula Chrysovalanto
- Mangino Massimo
- Markus Hugh
- Marrugat Jaume
- Marten Jonathan
- Martin Nicholas G.
- Martin Olivier
- Martinsen Amy E.
- Mas Jean-Louis
- Matsuda Koichi
- Mcmahon George
- Medeiros Elizabeth
- Meitinger Thomas
- Melander Olle
- Menni Cristina
- Mesut Erzurumluoglu A.
- Metso Antti J.
- Metso Tiina
- Metspalu Andres
- Metspalu Andres
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Millwood Iona Y.
- Montgomery Grant W.
- Montiel Paola
- Mook-Kanamori Dennis O.
- Morel Sandrine
- Morgan Anna
- Morris Andrew D.
- Morris Andrew P.
- Morrison Alanna C.
- Moulin Thierry
- Muller-Myhsok Bertram
- Munroe Patricia B.
- Munson Peter J.
- Muona Mikko
- Mägi Reedik
- Mägi Reedik
- Männikkö Minna
- Méresse Isabelle
- Naggara Olivier
- Nalls Mike A.
- Nandakumar Priyanka
- Neale Benjamin M.
- Nelson Christopher P.
- Newton-Cheh Christopher
- Nielsen Christopher S.
- Nielsen Jonas B.
- Niemelä Mika
- Niiranen Teemu
- Nolte Ilja M.
- Noordam Raymond
- Ntritsos Georgios
- Nutile Teresa
- Nyholt Dale R.
- O'reilly Paul F.
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Olesen Jes
- Oostra Ben A.
- Org Elin
- Padmanabhan Sandosh
- Padovani Alessandro
- Palmas Walter
- Palmer Colin N. A.
- Palotie Aarno
- Palotie Aarno
- Palta Priit
- Pandolfo Massimo
- Paolucci Stefano
- Paré Guillaume
- Pattie Alison
- Pedersen Linda M.
- Pedersen Linda M.
- Penninx Brenda W. J. H.
- Pera Joanna
- Perola Markus
- Pers Tune H.
- Peter Prins Bram
- Peters Annette
- Pezzini Alessandro
- Polasek Ozren
- Poli Loris
- Poulter Neil R.
- Pramstaller Peter P.
- Psaty Bruce M.
- Pärn Kalle
- Qian Yong
- Quaye Lydia
- Raitakari Olli
- Raitakari Olli T.
- Ran Caroline
- Redon Richard
- Rettig Rainer
- Rice Kenneth
- Ridker Paul M.
- Ridker Paul M.
- Ried Janina S.
- Riese Harriëtte
- Ring Susan M.
- Rinkel Gabriel J. E.
- Ripatti Samuli
- Risch Lorenz
- Robino Antonietta
- Rose Lynda M.
- Rotter Jerome I.
- Rouleau Guy A.
- Rudan Igor
- Ruggiero Daniela
- Ruigrok Ynte M.
- Saba Yasaman
- Sala Cinzia F.
- Salomaa Veikko
- Salomaa Veikko
- Samani Nilesh J.
- Samson Yves
- Sandor Cynthia
- Sandset Else C.
- Sandvei Marie S. fteland
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarin Antti-Pekka
- Sawada Tomonobu
- Schilling Sabine
- Schmidt Helena
- Schmidt Reinhold
- Schreiber Stefan
- Schürks Markus
- Scott Robert A.
- Scott Rodney J.
- Sever Peter
- Shah Nabi
- Shields Denis C.
- Shotar Eimad
- Shrine Nick
- Siscovick David
- Slowik Agnieszka
- Smith Albert V.
- Snieder Harold
- Sorice Rossella
- Southerland Andrew
- Spector Tim
- Spector Tim D.
- Stam Anine H.
- Stanton Alice
- Starr John M.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stergiakouli Evie
- Stott David J.
- Strachan David P.
- Strachan David P.
- Strawbridge Rona J.
- Stubhaug Audun
- Sundström Johan
- Surendran Praveen
- Swertz Morris A.
- Sõber Siim
- Tatlisumak Turgut
- Taylor Kent D.
- Terao Chikashi
- Terwindt Gisela M.
- Teumer Alexander
- Thijs Vincent
- Thom Simon
- Thomas Laurent F.
- Thomas-Feles Constanze
- Thériault S. bastien
- Tobin Martin D.
- Tomaszewski Maciej
- Toniolo Daniela
- Touzé Emmanuel
- Traglia Michela
- Tri Nguyen Quang
- Trompet Stella
- Tuomilehto Jaakko
- Tzourio Christophe
- Uitterlinden Andre G.
- Uitterlinden André G.
- Vaez Ahmad
- van den Maagdenberg Arn M. J. M.
- van der Harst Pim
- van der Most Peter J.
- van Duijn Cornelia M.
- van Duijn Cornelia M.
- Veldink Jan H.
- Vepsäläinen Salli
- Verschuren W. M. Monique
- Verweij Niek
- Verwoert Germaine C.
- Vitart Veronique
- Vollenweider Peter
- Vuckovic Dragana
- Vuillier Fabrice
- Völker Uwe
- Wain Louise V.
- Walters Robin G.
- Wareham Nicholas J.
- Warren Helen R.
- Watkins Hugh
- Webber Caleb
- Weber Ralf
- Wedenoja Juho
- Werge Thomas
- Werner Inge
- Werring David J.
- Wessman Maija
- Wild Sarah H.
- Willems Sara M.
- Willemsen Gonneke
- Willer Cristen J.
- Willer Cristen J.
- Wilson James F.
- Winsvold Bendik S.
- Wjh Penninx Brenda
- Woo Daniel
- Worrall Bradford
- Worrall Bradford B.
- Wouter Jukema J.
- Wright Alan F.
- Yao Jie
- Yusuf Demirkale Cumhur
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhao Jing-Hua
- Zhou Sirui
- Zhou Wei
- Zwart John-Anker
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2023
- Field of study
Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. Methods: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. Results: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20-1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01-1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59-0.67) to 0.65 (95% CI, 0.62-0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=-4.82×10-3per year [95% CI, -6.49×10-3to -3.14×10-3]; P=1.82×10-8), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86-0.98]; P=0.0041). Conclusions: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
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- Alghamdi B.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease