Laser Ablation Applied for Synthesis of Thin Films: Insights into Laser Deposition Methods

This chapter will focus on laser ablation applied for thin film deposition. The first thin films deposition method based upon laser ablation was pulsed laser deposition (PLD), that could produce thin films out of metals, ceramics and even temperature resistant organics. The need of depositing increasingly complex and delicate materials, lead to radical modifications of PLD and allowed other laser ablation methods to develop. If complex libraries are to be synthesized two or more plasmas will be mixed and the thin films will have a variable composition over surface. This technique is called Combinatorial PLD (CPLD)

Unresonant interaction of laser beams with microdroplets

The interaction of distilled water microdroplets (volumes of 3-4μl) with pulsed laser beams emitted at 532nm is described. At 532nm the distilled water absorption is very low and the interaction of a water bead with the laser radiation is dominated by unresonant phenomena. Following the collision of the laser beam with a microdroplet in suspended/ hanging/pendant position in air, deformations and mechanical vibrations of the droplets are produced. The conditions in which the droplets lose material as a consequence of the impact with laser beams are also explored. The effects produced on the droplet were studied pulse by pulse and depend on: droplet’s content, beam wavelength, power and focusing conditions, irradiation geometry and adhesion of the bead to the capillary on which it is suspended. The laser pulses energies were varied in four steps: 0.25mJ, 0.4mJ, 0.7mJ and 1mJ. The pulse full time width was 5ns and the typical focus diameter on the droplet was 90μm; the beam had a relatively low divergence around the focus point. The microdroplets and the modification/evolution of their shapes are visualised by recordings performed at 10kframes/second. Following a microdroplet interaction with the laser beam one may also produce at a controlled moment in time nanodroplets propagating at high (probably supersonic) speeds and microdroplets propagating at slower speeds. One may also produce pendant droplets of smaller dimensions than the initial one as well as micro/nano gas bubbles in the pendant droplet’s material/volume. In a second set of experiment was recorded at high speed the behaviour of the microdroplets of Rhodamine 6G in distilled water at resonant interaction with similar laser pulses, at the same power levels. The optical phenomena considering that the microdroplets contents are Newtonian liquids which dominate the beads behaviour at interaction with the laser beams, are discussed

Lassoing and corraling rooted phylogenetic trees

The construction of a dendogram on a set of individuals is a key component of a genomewide association study. However even with modern sequencing technologies the distances on the individuals required for the construction of such a structure may not always be reliable making it tempting to exclude them from an analysis. This, in turn, results in an input set for dendogram construction that consists of only partial distance information which raises the following fundamental question. For what subset of its leaf set can we reconstruct uniquely the dendogram from the distances that it induces on that subset. By formalizing a dendogram in terms of an edge-weighted, rooted phylogenetic tree on a pre-given finite set X with |X|>2 whose edge-weighting is equidistant and a set of partial distances on X in terms of a set L of 2-subsets of X, we investigate this problem in terms of when such a tree is lassoed, that is, uniquely determined by the elements in L. For this we consider four different formalizations of the idea of "uniquely determining" giving rise to four distinct types of lassos. We present characterizations for all of them in terms of the child-edge graphs of the interior vertices of such a tree. Our characterizations imply in particular that in case the tree in question is binary then all four types of lasso must coincide

Treatment of axial spondyloarthritis patients with biologic disease-modifying anti-rheumatic drugs in 2022 - data from the Romanian Registry of Rheumatic Diseases

Objective. The objective of this cross-sectional study was to analyze data available in the Romanian Registry of Rheumatic Diseases (RRBR) in 2022 for axial spondyloarthritis (axSpA) patients treated with biologic disease modifying anti-rheumatic drugs (bDMARDs). Methods. From the RRBR electronic database were collected multiple variables, including patient’s demographic and clinical characteristics, treatment characteristics, patterns of treatment use (initiations, continuations, switching, tapering), and treatment efficacy data of axSpA patients, from 1 January 2022 to 31 December 2022. Results. In 2022, a total of 4315 axSpA patients were registered in the RRBR database: 70% were men, 48.4 years mean age, 13.3 years mean disease duration, 90% with radiographic axSpA, with high prevalence of extra-musculoskeletal manifestations and cardiovascular comorbidities. Most patients (88%) were treated with a tumor necrosis factor inhibitor (TNFi), usually in monotherapy. The most frequently prescribed bDMARDs were adalimumab (36%), etanercept (32%) and secukinumab (12%). The uptake of biosimilars reached one third of patients from molecules with available biosimilars in 2022. Most patients had a good clinical response, irrespective of clinical form, disease duration, type of medication or line of treatment. Medication switching was needed in 10% of patients, the main reason for switching was secondary loss of efficacy. Medication tapering was implemented in 11% of patients, and it was successful in 90% of cases. Conclusion. Data from RRBR provide a valuable real-world view of clinical practice at the national level regarding biologic treatment of axSpA patients

CONSIDERATIONS ON THE IMPORTANCE OF CULTIVATING SORGHUM TO THE BIOFUEL INDUSTRY FOR PRODUCING BIOETHANOL

Energy crops are crops suitable for the production of products such as biofuels (biodiesel, ecological diesel) and electric or thermal energy. Plants suitable for such energy crops are: woody (energy willow, poplar, paulownia) and grasses (annual crops such as corn, wheat, rapeseed, soybeans, sweet sorghum or perennials: pampas grass, elephant grass). The article presents a series of arguments for growing sugar sorghum on large areas in order to obtain the bioethanol used in the biofuel industry

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde