Casos de dengue em Fortaleza: um estudo epidemiológico documental/ Dengue cases in Fortaleza: a documentary epidemiological study

A dengue é uma doença febril aguda sistêmica de origem viral, transmitida pelo mosquito Aedes aegypti, o qual está presente em todas as regiões do Brasil, e o estado do Ceará apresentou períodos endêmicos e epidêmicos ao longo dos anos. Teve-se como objetivo verificar os casos de dengue confirmados no município de Fortaleza-Ceará. Estudo epidemiológico, documental, de natureza quantitativa dos casos de dengue confirmados em Fortaleza, no período de 2014 a 2017. Os dados foram obtidos por meio do Sistema de Monitoramento Diário de Agravos (SIMDA), organizados em tabelas e gráficos no programa Excel. A capital do estado, Fortaleza, é a responsável pelo maior número de casos. Os resultados mostraram que no período do estudo Fortaleza apresentou um total de (67.357) casos de dengue confirmados, sendo o ano de 2015 o responsável pelo maior quantitativo com 26.816 casos, seguido do ano de 2016 (21.853), 2017 (13.561) e 2014 (5.127). No período do estudo, a Secretária Regional VI teve o maior número de casos confirmados (22.185). O mês que mais se destacou foi maio com uma média anual de 4.772 casos. A faixa etária mais acometida foi de 19 a 59 anos (43.041). O estabelecimento de saúde com o maior número de casos foram as Unidades de Pronto Atendimento com (37.017). Torna-se evidente que Fortaleza apresentou um número elevado de casos confirmados de dengue ao longo dos anos, sendo necessário a construção de ações eficazes de combate ao vetor da doença.

FLUTTER ATRIAL EM PACIENTE PORTADORA DE SÍNDROME DE EBSTEIN SUBMETIDA À ANESTESIA GERAL ENDOVENOSA: UM RELATO DE CASO

RESUMO A anomalia de Ebstein (AE) é uma cardiopatia congênita rara. Caracteriza-se pela implantação anormal da valva tricúspide. Ocasionando fenômenos de sobrecarga de volume e disfunção ventricular direitas, o que aumenta o risco operatório e a morbidade pós-operatória com advento de arritmias de difícil controle, além de deterioração da função ventricular. O presente relato de caso tem por objetivo relatar uma ocorrência médica rara: estímulo mecânico servindo como gatilho arritmogênico para Flutter Atrial após indução anestésica em paciente portadora da Síndrome de Ebstein e meduloblastoma volumoso em linha mediana de fossa posterior, associados a hipertensão intracraniana, que necessitou de derivação ventrículo-peritoneal de urgência. O procedimento foi realizado e paciente seguiu internada em tratamento intensivo por 4 dias, quando evoluiu a óbito em decorrência de complicações cardioembólicas. Palavras-chave: Anomalia de Ebstein; Arritmias Cardíacas; Flutter Atrial; Anestesia Geral; Meduloblastoma; Hipertensão Intracraniana. ABSTRACT Ebstein's anomaly (EA) is a rare congenital heart disease. It is characterized by abnormal implantation of the tricuspid valve. Causing phenomena of volume overload and right ventricular dysfunction, which increases the operative risk and postoperative morbidity with the advent of difficult to control arrhythmias, in addition to deterioration of ventricular function. The present case report aims to report a rare medical occurrence: mechanical stimulus serving as an arrhythmogenic trigger for Atrial Flutter after anesthetic induction in a patient with Ebstein Syndrome and large medulloblastoma in the midline of the posterior fossa, associated with intracranial hypertension, which required emergency ventriculo-peritoneal shunt. The procedure was performed and the patient remained in intensive care for 4 days, when she died due to cardioembolic complications. Keywords: Ebstein Anomaly, Arrhythmias, Cardiac; Atrial Flutter; Anesthesia, General; Medulloblastoma; Intracranial Hypertension

Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 $< p_{\rm{T}, assoc} < p_{\rm{T}, trig} <$ 5.0 GeV/$c$ is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range $|\eta|<0.9$. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161

Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multi-particle azimuthal correlations (cumulants) for charged particles in p-Pb and Pb-Pb collisions are presented. They help address the question of whether there is evidence for global, flow-like, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a $|\Delta \eta|$ gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high-multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of $v_{2}\{4\}$ to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find $v_{2}\{4\} \simeq v_{2}\{6\}\neq 0$ which is indicative of a Bessel-Gaussian function for the $v_{2}$ distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a $|\Delta\eta| > 1.4$ gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87

Database Survey of Anti-Inflammatory Plants in South America: A Review

Inflammation is a complex event linked to tissue damage whether by bacteria, physical trauma, chemical, heat or any other phenomenon. This physiological response is coordinated largely by a variety of chemical mediators that are released from the epithelium, the immunocytes and nerves of the lamina propria. However, if the factor that triggers the inflammation persists, the inflammation can become relentless, leading to an intensification of the lesion. The present work is a literature survey of plant extracts from the South American continent that have been reported to show anti-inflammatory activity. This review refers to 63 bacterial families of which the following stood out: Asteraceae, Fabaceae, Euphorbiaceae, Apocynaceae and Celastraceae, with their countries, parts used, types of extract used, model bioassays, organisms tested and their activity

International Society of Human and Animal Mycology (ISHAM)-ITS reference DNA barcoding database - the quality controlled standard tool for routine identification of human and animal pathogenic fungi

Human and animal fungal pathogens are a growing threat worldwide leading to emerging infections and creating new risks for established ones. There is a growing need for a rapid and accurate identification of pathogens to enable early diagnosis and targeted antifungal therapy. Morphological and biochemical identification methods are time-consuming and require trained experts. Alternatively, molecular methods, such as DNA barcoding, a powerful and easy tool for rapid monophasic identification, offer a practical approach for species identification and less demanding in terms of taxonomical expertise. However, its wide-spread use is still limited by a lack of quality-controlled reference databases and the evolving recognition and definition of new fungal species/complexes. An international consortium of medical mycology laboratories was formed aiming to establish a quality controlled ITS database under the umbrella of the ISHAM working group on "DNA barcoding of human and animal pathogenic fungi." A new database, containing 2800 ITS sequences representing 421 fungal species, providing the medical community with a freely accessible tool at http://www.isham.org and http://its.mycologylab.org/ to rapidly and reliably identify most agents of mycoses, was established. The generated sequences included in the new database were used to evaluate the variation and overall utility of the ITS region for the identification of pathogenic fungi at intra-and interspecies level. The average intraspecies variation ranged from 0 to 2.25%. This highlighted selected pathogenic fungal species, such as the dermatophytes and emerging yeast, for which additional molecular methods/genetic markers are required for their reliable identification from clinical and veterinary specimens.This study was supported by an National Health and Medical Research Council of Australia (NH&MRC) grant [#APP1031952] to W Meyer, S Chen, V Robert, and D Ellis; CNPq [350338/2000-0] and FAPERJ [E-26/103.157/2011] grants to RM Zancope-Oliveira; CNPq [308011/2010-4] and FAPESP [2007/08575-1] Fundacao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants to AL Colombo; PEst-OE/BIA/UI4050/2014 from Fundacao para a Ciencia e Tecnologia (FCT) to C Pais; the Belgian Science Policy Office (Belspo) to BCCM/IHEM; the MEXBOL program of CONACyT-Mexico, [ref. number: 1228961 to ML Taylor and [122481] to C Toriello; the Institut Pasteur and Institut de Veil le Sanitaire to F Dromer and D Garcia-Hermoso; and the grants from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and the Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG) to CM de Almeida Soares and JA Parente Rocha. I Arthur would like to thank G Cherian, A Higgins and the staff of the Molecular Diagnostics Laboratory, Division of Microbiology and Infectious Diseases, Path West, QEII Medial Centre. Dromer would like to thank for the technical help of the sequencing facility and specifically that of I, Diancourt, A-S Delannoy-Vieillard, J-M Thiberge (Genotyping of Pathogens and Public Health, Institut Pasteur). RM Zancope-Oliveira would like to thank the Genomic/DNA Sequencing Platform at Fundacao Oswaldo Cruz-PDTIS/FIOCRUZ [RPT01A], Brazil for the sequencing. B Robbertse and CL Schoch acknowledge support from the Intramural Research Program of the NIH, National Library of Medicine. T Sorrell's work is funded by the NH&MRC of Australia; she is a Sydney Medical School Foundation Fellow.info:eu-repo/semantics/publishedVersio

K0S and Λ production in Pb-Pb collisions at sNN−−−−√=2.76 TeV

The ALICE measurement of K0S and Λ production at midrapidity in Pb-Pb collisions at sNN−−−√=2.76  TeV is presented. The transverse momentum (pT) spectra are shown for several collision centrality intervals and in the pT range from 0.4  GeV/c (0.6  GeV/c for Λ) to 12  GeV/c. The pT dependence of the Λ/K0S ratios exhibits maxima in the vicinity of 3  GeV/c, and the positions of the maxima shift towards higher pT with increasing collision centrality. The magnitude of these maxima increases by almost a factor of three between most peripheral and most central Pb-Pb collisions. This baryon excess at intermediate pT is not observed in pp interactions at s√=0.9  TeV and at s√=7  TeV. Qualitatively, the baryon enhancement in heavy-ion collisions is expected from radial flow. However, the measured pT spectra above 2  GeV/c progressively decouple from hydrodynamical-model calculations. For higher values of pT, models that incorporate the influence of the medium on the fragmentation and hadronization processes describe qualitatively the pT dependence of the Λ/K0S ratio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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