M-Theory on S^1/Z_2 : New Facts from a Careful Analysis

We carefully re-examine the issues of solving the modified Bianchi identity, anomaly cancellations and flux quantization in the S^1/Z_2 orbifold of M-theory using the boundary-free "upstairs" formalism, avoiding several misconceptions present in earlier literature. While the solution for the four-form G to the modified Bianchi identity appears to depend on an arbitrary parameter b, we show that requiring G to be globally well-defined, i.e. invariant under small and large gauge and local Lorentz transformations, fixes b=1. This value also is necessary for a consistent reduction to the heterotic string in the small-radius limit. Insisting on properly defining all fields on the circle, we find that there is a previously unnoticed additional contribution to the anomaly inflow from the eleven-dimensional topological term. Anomaly cancellation then requires a quadratic relation between b and the combination lambda^6/kappa^4 of the gauge and gravitational coupling constants lambda and kappa. This contrasts with previous beliefs that anomaly cancellation would give a cubic equation for b. We observe that our solution for G automatically satisfies integer or half-integer flux quantization for the appropriate cycles. We explicitly write out the anomaly cancelling terms of the heterotic string as inherited from the M-theory approach. They differ from the usual ones by the addition of a well-defined local counterterm. We also show how five-branes enter our analysis.Comment: 32 pages, version to appear in Nucl. Phys. B, no figures, uses PHYZZ

An Assessment of Strengthening Minority Student Education Through Global Competence and Experiential Learning

Abstract A three-year study abroad training program with experiential learning opportunities was provided to students to better understand the processes that shape the global agricultural and environmental systems. Thirty-six students from Tuskegee University, Alabama, Delaware State University, Delaware, and Alabama A&M University, Alabama, were provided an opportunity to visit EARTH University and the Tropical Agricultural Research and Higher Education Center in Costa Rica; two well-known institutions for their hands-on training in sustainable agricultural and environmental systems. The students were involved in classroom discussions, case studies, and field activities under the supervision of specialists in solving real life problems. These exercises were in several areas of agriculture, environmental sustainability, and community engagement. Students were surveyed after the three-week program for each of three years, 2016-2018. In general, the students reported that they were positively impacted through their experiences, especially the multidimensional perspectives of problem solving, hands-on learning, global awareness, and community engagement. Keywords: Global Competence, Experiential Learning, Study Abroad Program, Minority Students, Agriculture and Related Science

Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi.

The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA. This pathway is distributed in diverse anaerobes and is used for both energy conservation and assimilation of C1 compounds. Genome annotations for all sequenced strains of Dehalococcoides mccartyi, an important bacterium involved in the bioremediation of chlorinated solvents, reveal homologous genes encoding an incomplete Wood-Ljungdahl pathway. Because this pathway lacks key enzymes for both C1 metabolism and CO2 reduction, its cellular functions remain elusive. Here we used D. mccartyi strain 195 as a model organism to investigate the metabolic function of this pathway and its impacts on the growth of strain 195. Surprisingly, this pathway cleaves acetyl-CoA to donate a methyl group for production of methyl-tetrahydrofolate (CH3-THF) for methionine biosynthesis, representing an unconventional strategy for generating CH3-THF in organisms without methylene-tetrahydrofolate reductase. Carbon monoxide (CO) was found to accumulate as an obligate by-product from the acetyl-CoA cleavage because of the lack of a CO dehydrogenase in strain 195. CO accumulation inhibits the sustainable growth and dechlorination of strain 195 maintained in pure cultures, but can be prevented by CO-metabolizing anaerobes that coexist with D. mccartyi, resulting in an unusual syntrophic association. We also found that this pathway incorporates exogenous formate to support serine biosynthesis. This study of the incomplete Wood-Ljungdahl pathway in D. mccartyi indicates a unique bacterial C1 metabolism that is critical for D. mccartyi growth and interactions in dechlorinating communities and may play a role in other anaerobic communities

First Observation of Coherent π0\pi^0 Production in Neutrino Nucleus Interactions with Eν<E_{\nu}< 2 GeV

The MiniBooNE experiment at Fermilab has amassed the largest sample to date of $\pi^0$s produced in neutral current (NC) neutrino-nucleus interactions at low energy. This paper reports a measurement of the momentum distribution of $\pi^0$s produced in mineral oil (CH$_2$) and the first observation of coherent $\pi^0$ production below 2 GeV. In the forward direction, the yield of events observed above the expectation for resonant production is attributed primarily to coherent production off carbon, but may also include a small contribution from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino flux, the sum of the NC coherent and diffractive modes is found to be (19.5 $\pm$1.1 (stat) $\pm$2.5 (sys))% of all exclusive NC $\pi^0$ production at MiniBooNE. These measurements are of immediate utility because they quantify an important background to MiniBooNE's search for $\nu_{\mu} \to \nu_e$ oscillations.Comment: Submitted to Phys. Lett.

Response of methanogenic microbial communities to desiccation stress in flooded and rain-fed paddy soil from Thailand

Rice paddies in central Thailand are flooded either by irrigation (irrigated rice) or by rain (rain-fed rice). The paddy soils and their microbial communities thus experience permanent or arbitrary submergence, respectively. Since methane production depends on anaerobic conditions, we hypothesized that structure and function of the methanogenic microbial communities are different in irrigated and rain-fed paddies and react differently upon desiccation stress. We determined rates and relative proportions of hydrogenotrophic and aceticlastic methanogenesis before and after short-term drying of soil samples from replicate fields. The methanogenic pathway was determined by analyzing concentrations and δ13C of organic carbon and of CH4 and CO2 produced in the presence and absence of methyl fluoride, an inhibitor of aceticlastic methanogenesis. We also determined the abundance (qPCR) of genes and transcripts of bacterial 16S rRNA, archaeal 16S rRNA and methanogenic mcrA (coding for a subunit of the methyl coenzyme M reductase) and the composition of these microbial communities by T-RFLP fingerprinting and/or Illumina deep sequencing. The abundances of genes and transcripts were similar in irrigated and rain-fed paddy soil. They also did not change much upon desiccation and rewetting, except the transcripts of mcrA, which increased by more than two orders of magnitude. In parallel, rates of CH4 production also increased, in rain-fed soil more than in irrigated soil. The contribution of hydrogenotrophic methanogenesis increased in rain-fed soil and became similar to that in irrigated soil. However, the relative microbial community composition on higher taxonomic levels was similar between irrigated and rain-fed soil. On the other hand, desiccation and subsequent anaerobic reincubation resulted in systematic changes in the composition of microbial communities for both Archaea and Bacteria. It is noteworthy that differences in the community composition were mostly detected on the level of operational taxonomic units (OTUs; 97% sequence similarity). The treatments resulted in change of the relative abundance of several archaeal OTUs. Some OTUs of Methanobacterium, Methanosaeta, Methanosarcina, Methanocella and Methanomassiliicoccus increased, while some of Methanolinea and Methanosaeta decreased. Bacterial OTUs within Firmicutes, Cyanobacteria, Planctomycetes and Deltaproteobacteria increased, while OTUs within other proteobacterial classes decreased

Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer

Aberrant transcriptional activity of androgen receptor (AR) is one of the dominant mechanisms for developing of castration-resistant prostate cancer (CRPC). Analyzing AR-transcriptional complex related to CRPC is therefore important towards understanding the mechanism of therapy-resistance. While studying its mechanism, we observed that a transmembrane protein called neuropilin-2 (NRP2) plays a contributory role in forming a novel AR-transcriptional complex containing nuclear pore proteins. Using immunogold electron microscopy, high-resolution confocal microscopy, chromatin immunoprecipitation, proteomics, and other biochemical techniques, we delineated the molecular mechanism of how a specific splice variant of NRP2 becomes sumoylated upon ligand stimulation and translocates to the inner nuclear membrane. This splice variant of NRP2 then stabilizes the complex between AR and nuclear pore proteins to promote CRPC specific gene expression. Both full-length and splice variants of AR have been identified in this specific transcriptional complex. In vitro cell line-based assays indicated that depletion of NRP2 not only destabilizes the AR-nuclear pore protein interaction but also inhibits the transcriptional activities of AR. Using an in vivo bone metastasis model, we showed that the inhibition of NRP2 led to the sensitization of CRPC cells toward established anti-AR therapies such as enzalutamide. Overall, our finding emphasize the importance of combinatorial inhibition of NRP2 and AR as an effective therapeutic strategy against treatment refractory prostate cancer

InfoSyll: A Syllabary Providing Statistical Information on Phonological and Orthographic Syllables

here is now a growing body of evidence in various languages supporting the claim that syllables are functional units of visual word processing. In the perspective of modeling the processing of polysyllabic words and the activation of syllables, current studies investigate syllabic effects with subtle manipulations. We present here a syllabary of the French language aiming at answering new constraints when designing experiments on the syllable issue. The InfoSyll syllabary provides exhaustive characteristics and statistical information for each phonological syllable (e.g. /fi/) and for its corresponding orthographic syllables (e.g. fi, phi, phy, fee, fix, fis). Variables such as the type and token positional frequencies, the number and frequencies of the correspondences between orthographic and phonological syllables are provided. As discussed, such computations should allow precise controls, manipulations and quantitative descriptions of syllabic variables in the field of psycholinguistic research.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Sensitivity of the IceCube Detector to Astrophysical Sources of High Energy Muon Neutrinos

We present the results of a Monte-Carlo study of the sensitivity of the planned IceCube detector to predicted fluxes of muon neutrinos at TeV to PeV energies. A complete simulation of the detector and data analysis is used to study the detector's capability to search for muon neutrinos from sources such as active galaxies and gamma-ray bursts. We study the effective area and the angular resolution of the detector as a function of muon energy and angle of incidence. We present detailed calculations of the sensitivity of the detector to both diffuse and pointlike neutrino emissions, including an assessment of the sensitivity to neutrinos detected in coincidence with gamma-ray burst observations. After three years of datataking, IceCube will have been able to detect a point source flux of E^2*dN/dE = 7*10^-9 cm^-2s^-1GeV at a 5-sigma significance, or, in the absence of a signal, place a 90% c.l. limit at a level E^2*dN/dE = 2*10^-9 cm^-2s^-1GeV. A diffuse E-2 flux would be detectable at a minimum strength of E^2*dN/dE = 1*10^-8 cm^-2s^-1sr^-1GeV. A gamma-ray burst model following the formulation of Waxman and Bahcall would result in a 5-sigma effect after the observation of 200 bursts in coincidence with satellite observations of the gamma-rays.Comment: 33 pages, 13 figures, 6 table

The nature of trauma memories in acute stress disorder in children and adolescents

Background: There is increasing theoretical, clinical and research evidence for the role of trauma memory in the aetiology of acute pathological stress responses in adults. However, research into the phenomenology of trauma memories in young people is currently scarce. Methods: This study compared the nature of trauma narratives to narratives of unpleasant non-traumatic events in young people (aged 8-17) who sought emergency medical attention following an assault or road traffic accident. Data were collected within 2-4 weeks of the index event. Symptom severity was assessed by child self-report and face-to-face diagnostic interviews. Comparisons of narrative indices were made between those children with acute stress disorder (ASD) and those without ASD. Results: Among participants (n = 50), those with ASD (38%) had significantly elevated levels of disorganisation in their trauma narrative, compared both to trauma-exposed controls and to their unpleasant comparative narrative. This effect was not accounted for by age. Regardless of ASD diagnostic status, trauma narratives had significantly higher sensory content and significantly lower positive emotion content compared to the unpleasant comparative narrative. These effects were not significant when age was included as a covariate. Acute symptom severity was significantly predicted by the level of disorganisation in the trauma narrative and the child's cognitive appraisals of the event. Conclusions: These data provide the first empirical evidence that disorganisation is not only directly linked to symptom severity, but also specific to the trauma memory. In addition, it provides support for the adaptation of adult cognitive models to acute pathological stress reactions in children and adolescents

Unbinned maximum-likelihood estimators for low-count data: Applications to faint X-ray spectra in the Taurus Molecular Cloud

Traditional binned statistics such as $\chi^2$ suffer from information loss and arbitrariness of the binning procedure. We point out that the underlying statistical quantity (the log likelihood $L$) does not require any binning beyond the one implied by instrumental readout channels, and we propose to use it for low-count data. The performance of $L$ in the model classification and point estimation problems is explored by Monte-Carlo simulations of Chandra and XMM X-ray spectra, and is compared to the performances of the binned Poisson statistic ($C$), Pearson's $\chi^2$ and Neyman's $\chi^2_N$, the Kolmogorov- Smirnov, and Kuiper' statistics. It is found that the unbinned log likelihood $L$ performs best with regard to the expected chi-square distance between true and estimated spectra, the chance of a successful identification among discrete candidate models, the area under the receiver-operator curve of reduced (two-model) binary classification problems, and generally also with regard to the mean square errors of individual spectrum parameters. The $\chi^2$ ($\chi^2_{\rm N}$) statistics should only be used if more than 10 (15) predicted counts per bin are available. From the practical point of view, the computational cost of evaluating $L$ is smaller than for any of the alternative methods if the forward model is specified in terms of a Poisson intensity and normalization is a free parameter. The maximum-$L$ method is applied to 14 observations from the Taurus Molecular Cloud, and the unbinned results are compared to binned XSPEC results, and found to generally agree, with exceptions explained by instability under re-binning and by background fine structures. The maximum-$L$ method has no lower limit on the available counts, and allows to treat weak sources which are beyond the means of binned methods.Comment: accepted for publication in A&