La concepción de la guerra de Norberto Bobbio

A lo largo de la historia una incógnita que ha estado rondando el pensamiento de los hombres ha sido el problema de la guerra, pues siempre fue uno de los mayores desafíos de la humanidad hallar la clave de su extinción y con ella el triunfo de la paz. En el presente trabajo analizaremos las diferentes formas de afrontar este gran problema de nuestro tiempo y concretamente el punto de vista del excepcional jurista y filósofo Norberto Bobbio, con una de las ideas centrales de su pensamiento como es la guerra y las vías para alcanzar la paz. Identificaremos los distintas formas de considerar tanto la guerra como la paz más importantes del siglo XX, pasando por el pacifismo jurídico de Bobbio, pues confiaba en el Derecho como mecanismo para resolver los conflictos entre Estados, hasta llegar a analizar uno de los mayores miedos del autor italiano en el pasado siglo como fue el posible conflicto armado a mayor escala de la historia, identificado como guerra nuclear e imperado por su teoría del equilibrio del terror y su estrategia de la disuasión.Grado en Derech

Estimulación sensorial en personas con alzheimer desde terapia ocupacional. Revisión sistemática

Introducción: la Enfermedad de Alzheimer es una patología que provoca más de un millón de muertes al año. El tratamiento de estas patologías se basa en tratamieneos farmacológicos y no farmacológicos, destacando en los no farmacológicos la estimulación cognitiva y la sensorial. La estimulación cognitiva ha sido más estudiada, mientras que la estimulación sensorial menos, creando de esta manera una brecha de conocimiento y por ello, para cubrirla, se propone esta revisión, cuyo objetivo es realizar una revisión sistemática sobre los efectos que tiene la estimulación sensorial en las personas con Alzheimer.Metodología: se realizó una búsqueda en las siguientes bases de datos: Pubmed, Cochrane, Dialnet, Web of Science y Scopus, obteniéndose un total de 228 artículos que, tras aplicar los criterios de inclusión y exclusión, se redujeron a un total de 9 artículos. Los criterios de inclusión y exclusión se basaban en que no tuvieran una antigüedad superior a 10 años y estuvieran escritos en inglés o español.Resultados: encontramos que se usan existen distintos tipos de estimulación sensorial como la musical, aromaterapia, visual y las multisensoriales obteniéndose en cada una un efecto distinto, sobre todo en la cognición y el estado de ánimo de las personas con EA.Conclusión: las intervenciones de estimulación sensorial obtienen una mejora del estado de ánimo del paciente, consiguiendo una mejora en la atención de la persona y relajación y disminuyendo la ansiedad y comportamientos agresivos que poseen las personas con EA. Se necesita continuar investigando ya que actualmente, los beneficios que se consiguen son a corto plazo, desapareciendo si la persona deja de asistir a las intervenciones.<br /

Ground-based detection of an extended helium atmosphere in the Saturn-mass exoplanet WASP-69b

Hot gas giant exoplanets can lose part of their atmosphere due to strong stellar irradiation, affecting their physical and chemical evolution. Studies of atmospheric escape from exoplanets have mostly relied on space-based observations of the hydrogen Lyman-{\alpha} line in the far ultraviolet which is strongly affected by interstellar absorption. Using ground-based high-resolution spectroscopy we detect excess absorption in the helium triplet at 1083 nm during the transit of the Saturn-mass exoplanet WASP-69b, at a signal-to-noise ratio of 18. We measure line blue shifts of several km/s and post transit absorption, which we interpret as the escape of part of the atmosphere trailing behind the planet in comet-like form. [Additional notes by authors: Furthermore, we provide upper limits for helium signals in the atmospheres of the exoplanets HD 209458b, KELT-9b, and GJ 436b. We investigate the host stars of all planets with detected helium signals and those of the three planets we derive upper limits for. In each case we calculate the X-ray and extreme ultraviolet flux received by these planets. We find that helium is detected in the atmospheres of planets (orbiting the more active stars and) receiving the larger amount of irradiation from their host stars.]Comment: Submitted to Science on 14 March 2018; Accepted by Science on 16 November 2018; Published by Science on 6 December 2018. This is the author's version of the work. It is posted here by permission of the AAAS for personal use. The definitive version was published in Science, on 6 December 2018 - Report: pages 21 (preprint), 4 figures - Supplementary materials: 22 pages, 10 figures, 3 table

All Roads Lead to Rome: Results of Non-Invasive Respiratory Therapies Applied in a Tertiary-Care Hospital Without an Intermediate Care Unit During the COVID-19 Pandemic

Introducción. Las terapias respiratorias no invasivas (TRNI) fueron ampliamente utilizadas en la primera ola de la pandemia de COVID-19, en escenarios distintos según los medios disponibles. El objetivo fue presentar la supervivencia a 90 días y los factores asociados a esta de los pacientes tratados con TRNI en un centro de tercer nivel sin Unidad de Cuidados Respiratorios Intermedios. Como objetivo secundario comparar los resultados obtenidos de las distintas terapias. Métodos. Estudio observacional de pacientes tratados con TRNI fuera de un ambiente de Cuidados Intensivos o Unidad de Cuidados Respiratorios Intermedios, diagnosticados de COVID-19 y con síndrome de distrés respiratorio agudo por criterios radiológicos y de ratio SpO2/FiO2. Se desarrolló un modelo multivariante de regresión logística para determinar las variables independientemente asociadas, y se compararon los resultados de la terapia de alto flujo con cánula nasal y la presión positiva continua en la vía aérea. Resultados. Se trataron 107 pacientes y sobrevivieron 85 (79,4%) a los 90 días. Antes de iniciar la TRNI el ratio medio de SpO2/FiO2 fue de 119,8±59,4. Un mayor score de SOFA se asoció significativamente a la mortalidad (OR 2,09; IC95% 1,34 – 3,27), mientras que la autopronación fue un factor protector (OR 0,23; IC95% 0,06 – 0,91). La terapia de alto flujo con cánula nasal fue utilizada en 63 sujetos (58,9%), y la presión positiva continua en la vía aérea en 41 (38,3%). No se encontraron diferencias entre ellas. Conclusión. Aproximadamente cuatro de cada cinco pacientes tratados con TRNI sobrevivieron a los 90 días, y no se encontraron diferencias significativas entre la terapia de alto flujo con cánula nasal y la presión positiva continua en la vía aérea.S

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Broad-Scale Patterns of Late Jurassic Dinosaur Paleoecology

There have been numerous studies on dinosaur biogeographic distribution patterns. However, these distribution data have not yet been applied to ecological questions. Ecological studies of dinosaurs have tended to focus on reconstructing individual taxa, usually through comparisons to modern analogs. Fewer studies have sought to determine if the ecological structure of fossil assemblages is preserved and, if so, how dinosaur communities varied. Climate is a major component driving differences between communities. If the ecological structure of a fossil locality is preserved, we expect that dinosaur assemblages from similar environments will share a similar ecological structure.This study applies Ecological Structure Analysis (ESA) to a dataset of 100+ dinosaur taxa arranged into twelve composite fossil assemblages from around the world. Each assemblage was assigned a climate zone (biome) based on its location. Dinosaur taxa were placed into ecomorphological categories. The proportion of each category creates an ecological profile for the assemblage, which were compared using cluster and principal components analyses. Assemblages grouped according to biome, with most coming from arid or semi-arid/seasonal climates. Differences between assemblages are tied to the proportion of large high-browsing vs. small ground-foraging herbivores, which separates arid from semi-arid and moister environments, respectively. However, the effects of historical, taphonomic, and other environmental factors are still evident.This study is the first to show that the general ecological structure of Late Jurassic dinosaur assemblages is preserved at large scales and can be assessed quantitatively. Despite a broad similarity of climatic conditions, a degree of ecological variation is observed between assemblages, from arid to moist. Taxonomic differences between Asia and the other regions demonstrate at least one case of ecosystem convergence. The proportion of different ecomorphs, which reflects the prevailing climatic and environmental conditions present during fossil deposition, may therefore be used to differentiate Late Jurassic dinosaur fossil assemblages. This method is broadly applicable to different taxa and times, allowing one to address questions of evolutionary, biogeographic, and climatic importance

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe