6 research outputs found
A multiscalar methodology for holistic analysis of prehistoric rock carvings in Scotland
- Author
- Publication venue
- Springer
- Publication date
- 12/03/2024
- Field of study
Prehistoric rock carvings are one of Scotlandâs most enigmatic and poorly understood monument types. This article discusses the pioneering approach used by Scotlandâs Rock Art Project to enhance understanding of the abstract motifs through multiscalar computational analyses of a large dataset co-produced with community teams. The approach can be applied to suitable rock art datasets from other parts of the world and has international relevance for rock art reserach. Our analysis incorporates data from across Scotland in order to investigate inter-regional differences and similarities in the nature and contexts of the carvings. Innovative application of complementary analytical methods identified subtle regional variations in the character of the rock art and motif types. This variability suggest an understanding of the rock art tradition that was widely shared but locally adapted, and reflects connections and knowledge exchange between specific regions
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
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- Prabhakaran Dorairajan
- Pramstaller Peter P
- Prentice Ross
- Prezelj Janez
- Price Jackie F
- Prince Richard L
- Prior Sarah
- Probst-Hensch Nicole M
- Prokopenko Inga
- Province Michael
- Province Michael A
- Psaty Bruce
- PĂ©russe Louis
- Qi Lu
- Quertermous Thomas
- Quibrera Miguel
- Rader Daniel J
- Rafelt Suzanne
- Raffel Leslie J
- Rafnar Thorunn
- Raitakari Olli
- Ralston Stuart H
- Randall Joshua C
- Rankinen Tuomo
- Rao D C
- Rao Dabeeru C
- Rao Madhumathi
- Rasheed Asif
- Rasmussen-Torvik Laura J
- Rathmann Wolfgang
- Rauramaa Rainer
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Redline Susan
- Reeve Jonathan
- Rehnberg Emil
- Reid David M
- Reid Ian R
- Reilly Muredach
- Reinmaa Eva
- Renstrom Frida
- Reppe Sjur
- Restrepo Nicole
- Rettig Rainer
- Riancho José A
- Ricceri Fulvio
- Rice John P
- Rice Kenneth
- Rice Kenneth M
- Rice Treva K
- Rich Stephen S
- Richards J Brent
- Richards John Brent
- Ridker Paul
- Ried Janina S
- Rigalleau Vincent
- Ring Susan M
- Ripatti Samuli
- Ritchie Marylyn
- Rivadeneira Fernando
- Robbins John
- Roberts Robert
- Robertson Neil
- Robino Antonietta
- Roman Tamara S
- Rose Lynda M
- Roseman Fenella
- Rosengren Annika
- RosengÄrd-BÀrlund Milla
- Rosinger Silke
- Rosmalen Judith G M
- Rosse Stephanie
- Rossing Peter
- Rotimi Charles
- Rotter Jerome I
- Rousseau François
- Roussel Ronan
- Rubin Diana
- Rudan Igor
- Rudock Megan E
- Ruggiero Daniela
- Rumpf Moritz P
- Ruokonen Aimo
- Rybin Denis
- RÀikkönen Katri
- Saaristo Timo E
- Sadlier Denise M
- Sala Cinzia
- Salako Tunde
- Saleheen Danish
- Salem Rany M
- Salo Perttu
- Salomaa Veikko
- Salumets Andres
- Samani Nilesh
- Sambrook Philip N
- Sandholm Niina
- Sandhu Manjinder S
- Sanghera Dharambir K
- Sanna Serena
- Saraheimo Markku
- Saramies Jouko
- Sarti Cinzia
- Sarzynski Mark A
- Sattar Naveed
- Savage David A
- Saxena Richa
- Schadt Eric
- Scharnagl Hubert
- Scherag André
- Schlessinger David
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholtens Salome
- Schork Nicholas J
- Schreiber Stefan
- Schumacher Fredrick
- Schunkert Heribert
- Schwartz Stephen M
- Schwarz Peter E H
- SchÀfer Arne
- Scollen Serena
- Scott James
- Scott Laura J
- Scott Robert A
- Scuteri Angelo
- Seeley Janet
- SegrĂš Ayellet V
- Sehmi Joban S
- Seielstad Mark
- Sekowska Magdalena
- Semple Robert
- Sengupta Sebanti
- Sennblad Bengt
- Serafinceanu Cristian
- Service Susan K
- Seshadri Sudha
- Seufferlein Thomas
- Shah Sonia
- Shah Svati H
- Sham Pak Chung
- Sharma Pankaj
- Shaw-Hawkins Sue
- Sheu Wayne H-H
- Shi Gang
- Shin So-Youn
- Shlipak Michael G
- Shohet Ralph
- Shrine Nick R G
- Shriner Daniel
- Shuldiner Alan R
- Shungin Dmitry
- Sidore Carlo
- Siegbahn Agneta
- Siggeirsdottir Kristin
- Sigurdsson Gunnar
- Sijbrands Eric J G
- Silander Kaisa
- Sim Xueling
- Singleton Andrew
- Sinisalo Juha
- Siscovick David S
- Sitlani Colleen M
- Sivananthan Mohan
- Sjögren Marketa
- Skorpen Frank
- Slaets Joris P
- Slagboom P Eline
- Small Kerrin
- Small Kerrin S
- Smit Johannes H
- Smith Albert
- Smith Erin N
- Smith George Davey
- Smith Jennifer A
- Smith Nicholas L
- Snider Harold
- Snieder Harold
- Soininen Pasi
- Song Ci
- Song Kijoung
- Soranzo Nicole
- Sorice Rossella
- Soro-Paavonen Aino
- Sovio Ulla
- Spector Tim D
- Spector Timothy D
- Speliotes Elizabeth K
- Spencer Kylee
- Srinivasan Sathanur R
- St Pourcain Beate
- Stacey Simon N
- Staessen Jan A
- StanÚåkovå Alena
- StanÄĂĄkovĂĄ Alena
- Stark Klaus
- Starr John M
- Stathopoulou Maria G
- Stavarachi Monica
- Stefansson Kari
- Steinle Nanette I
- Steinthorsdottir Valgerdur
- Stewart Alexandre F R
- Stirrups Kathleen
- Stolk Lisette
- Stolk Ronald P
- Strachan David P
- Stracke Sylvia
- Stram Daniel
- Strauch Konstantin
- Strawbridge Rona J
- Streeten Elizabeth A
- Stringham Heather M
- Struchalin Maksim
- Stumvoll Michael
- Styrkarsdottir Unnur
- Sulem Patrick
- Sun Yan V
- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
- SyvÀnen Ann-Christine
- SÔber Siim
- Söderlund Jenny
- Tabara Yasuharu
- Tai E Shyong
- Taliun Daniel
- Talmud Philippa J
- Tammesoo Mar-Liis
- Tan Sian-Tsung
- Tanaka Toshiko
- Tang Nelson L S
- Tarnow Lise
- Taylor Andrew
- Taylor Kira
- Tayo Bamidele
- Tenesa Albert
- Terzic Janos
- Teslovich Tanya M
- Teumer Alexander
- Thelle Dag S
- Thompson John R
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
- van Dam Rob M
- Van den Herik Evita G
- van der Harst Pim
- van der Klauw Melanie M
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
- van Meurs Joyce B J
- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber GĂ©rard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- WĂŒrtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo LoĂŻc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia MarĂa T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Team Effectiveness Theory from Industrial and Organizational Psychology Applied to Engineering Student Project Teams: A Research Review
- Author
- ABET
- Adams
- Adams
- Al-Ani
- Al-Rizzo
- Alcover
- Alexander
- Ardaiz-Villanueva
- Austin
- Baillie
- Barczak
- Berdahl
- Bermejo
- Bhandari
- Bierhals
- Booker
- Borg
- Borges
- Borrego
- Borrego
- Brodie
- Brodie
- Brodie
- Bromiley
- Burd
- Butler
- Cannon-Bowers
- Cardella
- Cerato
- Chao
- Chau
- Chen
- Chiocchio
- Cinar
- Cook
- Costa
- Costa
- Cramer
- Crede
- Crittenden
- Cross
- Dahm
- Dahm
- Daniels
- Davis
- Dederichs
- Di Marco
- Dinsmore
- Dirks
- Douglas-Mankin
- Dreu
- Dudley
- Edwards
- Eggermont
- Eisner
- Elizalde
- Ellis
- Ellis
- Ellis
- Fiegel
- Flinders
- Fredrick
- Froyd
- Gall
- Gary
- Ge
- Geske
- Gibbings
- Glier
- Gnanapragasam
- Goff
- Gough
- Gransberg
- Gruenther
- Gunderson
- Guzzo
- Hackman
- Hey
- Hirsch
- Hirst
- Huguet
- Ito
- Jaffe
- Jehn
- Johnson
- Johnson
- Johnson
- Kajfez
- Karau
- Karau
- Karn
- Keefe
- Kim
- Kirkman
- Knobbs
- Korkmaz
- Kozlowski
- Krippendorff
- Krishnan
- Kumar
- Langan-Fox
- Lau
- Layton
- Lee
- Leicht
- Linsey
- Louis
- Luechtefeld
- Luque Ruiz
- Manuel
- Marquez
- Martin
- Martin
- Martins
- Mat
- Mathieu
- Mathieu
- Mathieu
- Mayer
- McAllister
- McGourty
- McGrath
- McIntyre
- McNair
- McNair
- Mehalik
- Minocha
- Mitchell
- Mohammed
- Mohtar
- Muethel
- Mullen
- Naik
- Neal
- Oden
- Oehlberg
- Oladiran
- Oliva
- Onwuegbuzie
- Paletz
- Paretti
- Paretti
- Paretti
- Patil
- Petticrew
- Pieterse
- Pinder
- Polzner
- Pondy
- Price
- Pritchard
- Purzer
- Rahim
- Ramirez Cajiao
- Ras
- Rebollar
- Reid
- Richter
- Sahin
- Schaffer
- Schippers
- Schroeder
- SchÀfer
- Scott
- Sears
- Senge
- Serçe
- Serçe
- Sheppard
- Shuman
- Skilton
- Smith
- Soares
- Steiner
- Steiner
- Sundstrom
- Svihla
- Swigger
- Tafa
- Tesluk
- Thompson
- Tjosvold
- Tonso
- Tubaishat
- Turetken
- Vars
- Varvell
- Ven
- Wageman
- Walthall
- Webber
- Weingart
- Williams
- Wilson
- Wit
- Wodehouse
- Wodehouse
- Worthen
- Yakhno
- Yang
- Yang
- Zafft
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2013
- Field of study
Background
Engineering student team projects are frequently used to meet professional learning outcomes. Industrial and organizational psychologists study teams in the industry settings for which we prepare students, yet this research does not effectively inform engineering education. Purpose
This research review sought to demonstrate the relevance of literature on teams literature from industrial and organizational psychology to engineering education and to identify implications for practice and future directions for research. Scope/Method
Phase 1 systematically reviewed 104 articles published from 2007 to 2012 describing engineering and computer science student team projects and sought to answer the following questions: What professional learning outcomes have been met by team projects? What negative student team behaviors have faculty sought to minimize? What literature has been used to inform development of teamwork outcomes? Phase 2 reviewed five team effectiveness constructs selected according to the results of Phase 1: social loafing, interdependence, conflict, trust, and shared mental models. Examples from Phase 1 articles and our own work explain how this research informs facilitation and assessment of engineering student teams. Conclusions
Engineering faculty sought to achieve a variety of outcomes through team projects, including teamwork, communication, sustainability, and consideration of global/societal design context. They sought to avoid social loafing and conflict while building trust to ensure equal team effort. That few Phase 1 articles engaged the literature about team effectiveness indicates there is great opportunity to apply industrial and organizational psychology research to engineering education
Team Effectiveness Theory from Industrial and Organizational Psychology Applied to Engineering Student Project Teams: A Research Review
- Author
- ABET
- Adams
- Adams
- Al-Ani
- Al-Rizzo
- Alcover
- Alexander
- Ardaiz-Villanueva
- Austin
- Baillie
- Barczak
- Berdahl
- Bermejo
- Bhandari
- Bierhals
- Booker
- Borg
- Borges
- Borrego
- Borrego
- Brodie
- Brodie
- Brodie
- Bromiley
- Burd
- Butler
- Cannon-Bowers
- Cardella
- Cerato
- Chao
- Chau
- Chen
- Chiocchio
- Cinar
- Cook
- Costa
- Costa
- Cramer
- Crede
- Crittenden
- Cross
- Dahm
- Dahm
- Daniels
- Davis
- Dederichs
- Di Marco
- Dinsmore
- Dirks
- Douglas-Mankin
- Dreu
- Dudley
- Edwards
- Eggermont
- Eisner
- Elizalde
- Ellis
- Ellis
- Ellis
- Fiegel
- Flinders
- Fredrick
- Froyd
- Gall
- Gary
- Ge
- Geske
- Gibbings
- Glier
- Gnanapragasam
- Goff
- Gough
- Gransberg
- Gruenther
- Gunderson
- Guzzo
- Hackman
- Hey
- Hirsch
- Hirst
- Huguet
- Ito
- Jaffe
- Jehn
- Johnson
- Johnson
- Johnson
- Kajfez
- Karau
- Karau
- Karn
- Keefe
- Kim
- Kirkman
- Knobbs
- Korkmaz
- Kozlowski
- Krippendorff
- Krishnan
- Kumar
- Langan-Fox
- Lau
- Layton
- Lee
- Leicht
- Linsey
- Louis
- Luechtefeld
- Luque Ruiz
- Manuel
- Marquez
- Martin
- Martin
- Martins
- Mat
- Mathieu
- Mathieu
- Mathieu
- Mayer
- McAllister
- McGourty
- McGrath
- McIntyre
- McNair
- McNair
- Mehalik
- Minocha
- Mitchell
- Mohammed
- Mohtar
- Muethel
- Mullen
- Naik
- Neal
- Oden
- Oehlberg
- Oladiran
- Oliva
- Onwuegbuzie
- Paletz
- Paretti
- Paretti
- Paretti
- Patil
- Petticrew
- Pieterse
- Pinder
- Polzner
- Pondy
- Price
- Pritchard
- Purzer
- Rahim
- Ramirez Cajiao
- Ras
- Rebollar
- Reid
- Richter
- Sahin
- Schaffer
- Schippers
- Schroeder
- SchÀfer
- Scott
- Sears
- Senge
- Serçe
- Serçe
- Sheppard
- Shuman
- Skilton
- Smith
- Soares
- Steiner
- Steiner
- Sundstrom
- Svihla
- Swigger
- Tafa
- Tesluk
- Thompson
- Tjosvold
- Tonso
- Tubaishat
- Turetken
- Vars
- Varvell
- Ven
- Wageman
- Walthall
- Webber
- Weingart
- Williams
- Wilson
- Wit
- Wodehouse
- Wodehouse
- Worthen
- Yakhno
- Yang
- Yang
- Zafft
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
- Biello K
- Biello K
- Bii S
- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
- Bivol S
- Black D
- Blantari J
- Blick G
- Blumenthal S
- Bock N
- Boivin M
- Boleo C
- Boleo C
- Bolton-Moore C
- Bond V
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- Zablotska I
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- Zandamela A
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- Zerbe A
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- Zhang F
- Zhang H
- Zhang W
- Zhang Y
- Zhanpeisova A
- Zhao Y
- Zhu L
- Zieman B
- Zieman B
- Zulu C
- Zuma T
- Zurla C
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
Abstracts
- Author
- A. A. Al-Kaisy
- A. Berrill
- A. D. Krahn
- A. D. Krahn
- A. Fisher
- A. J. Baker
- A. Joel Dagnone
- A. Lagmiche
- A. Langer
- A. Lye
- A. M. Diemunsch
- A. Miniad
- A. Perlas
- A. Sandier
- Adrian W. Gelb
- Alan H. Menkis
- Alan H. Menkis
- Alan Sandier
- Aleksa Cenic
- Alexander J. Clark
- Alexander S. Clanachan
- Ananthan Krishnathas
- Andrew R. Claxton
- Anna Kinahan
- Anne C. P. Lui
- Anthony M. -H. Ho
- Avaleigh Milne
- Aznif Ozsolak Calikyan
- B. Evans
- B. Lockhart
- Barbra Krepski
- Barry A. Finegan
- Beruie Y. Mezon
- Beverley Guard
- Blair T. Henderson
- Brendan T. Finucane
- Brian Milne
- Brian P. Kavanagh
- Bruce Forster
- Buvanendran Asokumar
- C. Copplestone
- C. CrochetiĂšre
- C. D. Mazer
- C. McCudden
- C. Moote
- Caroline S. Grange
- Carolyn L. Giesinger
- Carolyne J. Montgomery
- Carolyne Montgomery
- Chantal Cambier
- Chris Eagle
- Christian Jodoin
- Clare Trachuk
- Claude A. Trépanier
- Cuong Ngo
- D. C. H. Cheng
- D. Cleave-Hogg
- D. Eckhoff
- D. J. Cuillerier
- D. J. McKnight
- D. K. Rose
- D. K. Rose
- D. Redelmeier
- D. Thiessen
- D. Wong
- Dan Viskari
- Dany L. CÎté
- Daren K. Heyland
- David E. Lacey
- David H. Wong
- David P. Archer
- David R. Grant
- David T. Wong
- David W. Fear
- David Wong
- Davy C. H. Cheng
- Davy Cheng
- Davy Cheng
- Dennis Reid
- Donal B. Downey
- Donald T. Jolly
- Doreen Cleave-Hogg
- Doreen Mashava
- E. Bernadska
- E. Coonan
- E. Coonan
- E. Troncy
- E. Villeneuve
- Edgar G. Chedrawy
- Edward R. Lazar
- Edward T. Crosby
- Edward V. Cushing
- Eleanor J. Reimer
- Elizabeth Ling
- Ernest Puil
- F. D. Rubens
- F. D. Rubens
- F. Neil McKenzie
- F. Walsh
- F. X. Reinders
- F. Yang
- Frances Chung
- François Bellemare
- Fredrick K. Orkin
- G. Blaise
- G. Czaika
- G. J. Klein
- G. Lefevre
- G. Scarth
- G. Volgyesi
- G. Webb
- Gabor Mezei
- Geeta R. Shetty
- Geoffrey Dunn
- Geoffrey S. Hawboldt
- Gilbert Blaise
- Gillian Dunn
- Gillian S. Dunn
- Gordon Wood
- Graham Smith
- Gregory M. T. Hare
- Guy R. Orlay
- GĂ©rard BĂ©gou
- H. I. Manson
- H. Nguyen
- H. Sampson
- H. Sandhu
- Heather Francis
- Herbert M. Chinyanga
- Hervé DeladriÚre
- Hilton Swan
- Himat Vaghadia
- Holly Muir
- Homer Yang
- Hossam El-Beheiry
- Ian R. Thomson
- Ian Thomson
- Imtiaz Hossain
- Ingrid S. Luchsinger
- Ireneusz Wachowski
- J. A. Robblee
- J. A. Robblee
- J. Bruce Smith
- J. Haughton
- J. Hugh Devitt
- J. I. M. Brown
- J. K. Lee
- J. Katz
- J. Kronberg
- J. L. Scholtes
- J. M. Karski
- J. Rucker
- J. Saunders
- J. Silverman
- J. Sleigh
- J. Watson
- Jacek Karski
- Jacek Karski
- Jacek Karski
- Jacqueline A. Doyle
- Jacques Couture
- Jamal A. Alhashemi
- James McCormack
- Jan-Ake I. Schultz
- Jason Lo
- Jean-Gilles Guimond
- Jean-Paul Collet
- Jean-Paul Viale
- Jean-Pierre TĂ©trault
- Jeff Cole
- Jennifer Raymond
- Jerrold Lerman
- Jerry Cox
- Jim Mohr
- Jo Carroll-Munro
- Joanne Carrier
- Joel L. Parlow
- Joel Parlow
- Joel Parlow
- John Bradley
- John G. Fuller
- John M. Murkin
- John M. Murkin
- John Weaver
- Johnson C. S. Ngan
- Jonathan Richards
- Juditli L. Kutt
- Julia A. Smith
- Julie M. Williams
- K. Armstrong
- K. Karkouti
- K. Sykora
- Kandiah P. Gnanendran
- Karen Raymer
- Karin M. Williamson
- Kathryn A. Hull
- Keith R. Mills
- Kelly Mayson
- Kenneth M. LeDez
- Kevin Boyle
- Kevin Teoh
- Kristine Wilson-Yang
- L. Doiron
- L. Errett
- L. Girling
- L. Hurst
- L. Lortie
- L. OâBrien-Pallas
- L. Roy
- L. Ryner
- L. Schlichtert
- L. Sommer
- L. Valiquette
- Line Gagnon
- Louis Blair
- Louis Scheepers
- Luc Frenette
- Luc Quintin
- Lucia E. O. Silva
- Luiz G. R. DeLima
- M. -Y. Arsenault
- M. Arnell
- M. Basta
- M. Basta
- M. D. Sharpe
- M. De Kock
- M. Jewett
- M. Joanne Douglas
- M. Kolton
- M. Kurrek
- M. M. Cohen
- M. Mezei
- Mahesh Mehta
- Mahesh Mehta
- Marc A. St-Amand
- Marc Charbonneau
- Marco Pozzi
- Mark D. Peterson
- Mark H. Gelula
- Mark Levine
- Marline Pirlet
- Marsha Cohen
- Marsha M. Cohen
- Martin FrancĆur
- Martin R. Lessard
- Mary Fletcher
- Mary Morris
- MaryLou Crossan
- Matt M. Kurrek
- Melissa Shaw
- Michael Curran
- Michael Moon
- Micheline Roy
- Mitchel B. Sosis
- Mohamed Ali
- Morley Rosenbloom
- N. Cregg
- Naheed S. Ali
- Nancy Sikich
- Narendra Vakharia
- Neal H. Badner
- Neal H. Badner
- Nicholas Cicutti
- Noreen Dowd
- Norman R. Searle
- O. R. Hung
- Osamu Nishida
- Oya Yilmaz
- P. Kozlowski
- P. McArdle
- P. Peng
- Pamela J. Morgan
- Pamela J. Morgan
- Pamela M. Merrick
- Patrick J. Davison
- Patty Boylen
- Paul Bragg
- Peter Cox
- Peter D. Booker
- Peter J. A. van der Starre
- Peter J. Duffy
- Peter J. Duffy
- Peter L. Carien
- Peter M. Sanderson
- Peter Sanderson
- Philip I. Robles
- Philip Peng
- Philippe Pendeville
- Phyllis Money
- Pierre Sagnard
- Pirjo Manninen
- Pirjo Manninen
- R. Gervais
- R. J. Byrick
- R. J. Moulton
- R. K. Warrian
- R. M. K. W. Lee
- R. Mian
- R. S. Labow
- R. S. Labow
- R. Wassermann
- R. Yee
- R. Yee
- Rafal Kustra
- Ramiro Arellano
- Ramiro Arellano
- René Martin
- Richard Hughson
- Richard I. Hall
- Richard Kolesar
- Richard W. Norman
- Robert Byrick
- Robert G. Green
- Robert J. Hudson
- Robert J. Tibshirani
- Robert J. Tibshirani
- Robert McTaggart Cowan
- Roger Franks
- Rosemary A. Craen
- Roy J. Maliakkal
- Russell Bourne
- S. Brian Lucas
- S. Bynon
- S. C. Whynot
- S. C. Whynot
- S. Dunington
- S. Edelstein
- S. Ganapathy
- S. Ganapathy
- S. Halpern
- S. J. Bignell
- S. Jones
- S. Katsiris
- S. Siu
- S. Spadafora
- Salvatore M. Spadafora
- Sandy Adams
- Sandy Adams
- Sandy Shysh
- Sara Rafuse
- Sheldon H. Roth
- Shirley L. W. Cheung
- Shokrollah S. Jahromi
- Sitaram Raman
- Soheir R. Tawfik
- Srigowri Vishnubala
- Stan Shapiro
- Stephan K. W. Schwarz
- Stephen Farmer
- Stephen H. Halpern
- Stephen Halpern
- Stéphan Langevin
- T. D. Wong
- Teresa Novick
- Terrance W. Breen
- Terri A. Betts
- Terri L. Paul
- Thiérry Ducruet
- Timothy J. Adams
- Ting-Yim Lee
- Todd Chedore
- Travis Beamish
- V. Chan
- Vincent Chan
- Vivian Nedelcu
- W. A. C. Mutch
- W. G. Williams
- W. Middleton
- W. Scott Beattie
- W. Snedden
- W. T. van Rooyen-Butijn
- Walter Snedden
- Warren L. May
- Wayne Chamberlain
- Wendy Komar
- Wilfred DeMajo
- William J. Wall
- William Nantau
- Wlodzimierz Grodecki
- Wojciech B. Dobkowski
- Y. Fradet
- Yildiz Kose
- Yun K. Tarn
- Yves Claprood
- Ăric Troncy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study