128 research outputs found

    An Exploratory Study on the Antecedents of Occupational Commitment among Hospitality Educators in Hong Kong

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    In recent years, the growth in hospitality management programmes and the demand for hospitality educators in Hong Kong has increased dramatically. The hospitality industry, educational institutions and hospitality students also have high expectations of hospitality educators. Due to an increased need to recruit and retain qualified hospitality educators, this research seeks to understand the occupational commitment of hospitality educators in Hong Kong. Occupational commitment is an important indicator of a number of factors. It is found that occupational commitment is closely related to work-related stress, job satisfaction and occupational retention (Jamal, 1990; Borg et al., 1991; Jepson and Forrest, 2006; Klassen and Chiu, 2010). However, there is lack of research investigating the occupational commitment or its antecedents of hospitality educators. Therefore the study aims to gain an insight into the occupational commitment of hospitality educators in Hong Kong. This research identifies the key antecedents affecting occupational commitment and investigates which of these antecedents influence the occupational commitment of hospitality educators in Hong Kong. It also explores the reasons why hospitality educators are committed to hospitality education profession in Hong Kong. The research presented in this paper is one element of wider study. For this part, a qualitative research method and purposive sampling is adopted. Four focus groups comprised of twenty hospitality educators currently working in Hong Kong have been conducted. The results found that the flexibility of hospitality education work, non-shift work pattern, the self-actualization needs in education, career opportunities and occupational image are the key antecedents of occupational commitment of hospitality educators in Hong Kong

    Migrant networks, language learning and tourism employment

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    This paper examines the relationship between migrants’ social networks, the processes of language acquisition and tourism employment. Data collected using netnography and interviews are used to identify the strategies that Polish workers in the UK use to develop their language skills. The paper highlights the roles played by co-workers, co-nationals and customers in migrants’ language learning, both in the physical spaces of work and the virtual spaces of internet forums. It also shows how migrant workers exchange knowledge about the use of English during different stages of their migration careers: prior to leaving their country of origin and getting a job, during their employment and after leaving their job. Implications for academic inquiry and human resource management practice are outlined

    Adult-type granulosa cell tumor of the ovary : a FOXL2-centric disease

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    Adult-type granulosa cell tumors (aGCTs) account for 90% of malignant ovarian sex cord-stromal tumors and 2-5% of all ovarian cancers. These tumors are usually diagnosed at an early stage and are treated with surgery. However, one-third of patients relapse between 4 and 8 years after initial diagnosis, and there are currently no effective treatments other than surgery for these relapsed patients. As the majority of aGCTs (>95%) harbor a somatic mutation in FOXL2 (c.C402G; p.C134W), the aim of this study was to identify genetic mutations besides FOXL2 C402G in aGCTs that could explain the clinical diversity of this disease. Whole-genome sequencing of 10 aGCTs and their matched normal blood was performed to identify somatic mutations. From this analysis, a custom amplicon-based panel was designed to sequence 39 genes of interest in a validation cohort of 83 aGCTs collected internationally. KMT2D inactivating mutations were present in 10 of 93 aGCTs (10.8%), and the frequency of these mutations was similar between primary and recurrent aGCTs. Inactivating mutations, including a splice site mutation in candidate tumor suppressor WNK2 and nonsense mutations in PIK3R1 and NLRC5, were identified at a low frequency in our cohort. Missense mutations were identified in cell cycle-related genes TP53, CDKN2D, and CDK1. From these data, we conclude that aGCTs are comparatively a homogeneous group of tumors that arise from a limited set of genetic events and are characterized by the FOXL2 C402G mutation. Secondary mutations occur in a subset of patients but do not explain the diverse clinical behavior of this disease. As the FOXL2 C402G mutation remains the main driver of this disease, progress in the development of therapeutics for aGCT would likely come from understanding the functional consequences of the FOXL2 C402G mutation.Peer reviewe

    Neuromyopathy with congenital cataracts and glaucoma: A distinct syndrome caused by POLG variants

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    We identified three non-related patients manifesting a childhood-onset progressive neuromyopathy with congenital cataracts, delayed walking, distal weakness and wasting, glaucoma and swallowing difficulties. Electrophysiology and nerve biopsies showed a mixed axonal and demyelinating neuropathy, while muscle biopsy disclosed both neurogenic and myopathic changes with ragged red fibers, and muscle MRI showed consistent features across patients, with a peculiar concentric disto-proximal gradient of fatty replacement. We used targeted next generation sequencing and candidate gene approach to study these families. Compound biallelic heterozygous variants, p.[(Pro648Arg)]; [(His932Tyr)] and p.[(Thr251Ile),(Pro587Leu)]; [(Arg943Cys)], were found in the three patients causing this homogeneous phenotype. Our report on a subset of unrelated patients, that showed a distinct autosomal recessive childhood-onset neuromyopathy with congenital cataracts and glaucoma, expands the clinical spectrum of POLG-related disorders. It also confirms the association between cataracts and neuropathy with variants in POLG. Early onset cataract is otherwise rare in POLG-related disorders and so far reported only in a few patients with the clinical pattern of distal myopathy or neuromyopathy

    Evaluation of Allelic Expression of Imprinted Genes in Adult Human Blood

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    Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults
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