Comportamento visual e desenvolvimento motor de recém-nascidos prematuros no primeiro mês de vida

OBJETIVO: Caracterizar o comportamento visual e o desenvolvimento motor de RNPT com um mês de idade corrigida, nascidos na maternidade de um hospital escola. MÉTODO: Estudo descritivo, seccional no primeiro mês de idade corrigida em uma coorte de recém-nascidos prematuros, utilizando-se como instrumentos de avaliação o Método de Avaliação da Conduta Visual de Lactentes e o Alberta Infant Movement Scale (AIMS). RESULTADOS: Observou-se que os recém-nascidos prematuros apresentaram respostas esperadas para as provas que avaliam o comportamento oculomotor e com frequências inferiores para a prova do sorriso, conforme o método de avaliação utilizado no estudo. Na avaliação motora, 25% apresentaram percentil abaixo de 5; 8,3% com percentil 5; 8,3% com percentil 10; 25% com percentil 25; 8,3% com percentil 50 e 25% com percentil 75. CONCLUSÕES: Os resultados deste estudo demonstraram que mesmo em pequena amostra é possível observar atraso típico no desenvolvimento motor de lactentes prematuros quando se utiliza instrumento de avaliação adequado. Evidenciou-se que a idade gestacional pode ter influenciado o desempenho dos lactentes e que os recém-nascidos prematuros, mesmo com a idade corrigida, ainda estão aquém dos bebês a termo no que se refere às aquisições do desenvolvimento motor, indicando a necessidade de alerta ao desenvolvimento no percentil 10 ou abaixo, mesmo apresentando desempenho satisfatório no comportamento visual. A correção da idade foi um importante fator que norteou a compreensão das aquisições visuais e motoras de lactentes prematuros.OBJECTIVE: To characterize the visual behavior and the motor development of premature newborns (RNPT) with one month of age corrected, born in the maternity of a school hospital. METHOD: Descriptive study, sectional in the first month of age corrected in a cohort of a premature newborn, by using as instruments the Evaluation Method of the Visual behavior in newborns and the Alberta Infant Movement Scale (AIMS). RESULTS: It was observed that the premature newborns presented expected answers for the tests that evaluate the oculomotor behavior and with lower frequencies for the test of smile, in agreement with the method of evaluation utilized in the study. In the motor evaluation (AIMS), 25% presented below the percentage 5; 8.3% had percentage 5; 8.3% had percentage 10; 25% had percentage 25; 8.3% had percentage 50 and 25% had percentage 75. CONCLUSION: The results obtained in this study showed that in despite of the small sample it was possible to observe a typical delay in the motor development in RNPT through an adequate instrument of evaluation. It was evident that the gestational age influenced the performance of the newborns and that the premature newborns even with the corrected age are still behind the full term babies regarding the acquisition of motor development, indicating the need of alert to the development at the percentile 10 or below, even presenting satisfactory performance in the visual behavior. Age correction was a significant factor facilitating in the understanding of the visual and motor acquisitions in RNPT

Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Leaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil as "cajuzinho do cerrado", have been used in folk medicine as an alternative treatment for ulcers and gastritis. This study evaluated the gastroprotective activity of an ethyl acetate extract of the leaves of A. humile (AcF) and the mechanism involved in this gastroprotection. Pretreatment concentrations (50, 100, 200 mg.kg(-1)) were administered by gavage. Following a 60 min. period, all the rats were orally administered 1 mL of absolute ethanol. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated. Prostaglandin PGE(2) concentration, gastric adherent mucous, and the participation of nitric oxide (NO) and sulfhydryl compounds in the gastroprotection process were also analyzed using the most effective tested dose (50 mg.kg(-1)). A histological study of the glandular stomach for the evaluation of the epithelial damage and mucus content was also performed. AcF significantly reduced the gastric damage produced by ethanol. This effect was statistically significant for the 50 mg.kg(-1) group compared to control. Also, it significantly increased the PGE(2) (by 10-fold) and mucous production, while pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) or N-ethylmaleimide (NEM) completely abolished the gastroprotection. AcF has a protective effect against ethanol, and this effect, might be due to the augmentation of the protective mechanisms of mucosa.151071537166Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Dengue Virus Infection of the Aedes aegypti Salivary Gland and Chemosensory Apparatus Induces Genes that Modulate Infection and Blood-Feeding Behavior

The female Aedes aegypti salivary gland plays a pivotal role in bloodmeal acquisition and reproduction, and thereby dengue virus (DENV) transmission. It produces numerous immune factors, as well as immune-modulatory, vasodilatory, and anti-coagulant molecules that facilitate blood-feeding. To assess the impact of DENV infection on salivary gland physiology and function, we performed a comparative genome-wide microarray analysis of the naïve and DENV infection-responsive A. aegypti salivary gland transcriptomes. DENV infection resulted in the regulation of 147 transcripts that represented a variety of functional classes, including several that are essential for virus transmission, such as immunity, blood-feeding, and host-seeking. RNAi-mediated gene silencing of three DENV infection-responsive genes - a cathepsin B, a putative cystatin, and a hypothetical ankyrin repeat-containing protein - significantly modulated DENV replication in the salivary gland. Furthermore, silencing of two DENV infection-responsive odorant-binding protein genes (OBPs) resulted in an overall compromise in blood acquisition from a single host by increasing the time for initiation of probing and the probing time before a successful bloodmeal. We also show that DENV established an extensive infection in the mosquito's main olfactory organs, the antennae, which resulted in changes of the transcript abundance of key host-seeking genes. DENV infection, however, did not significantly impact probing initiation or probing times in our laboratory infection system. Here we show for the first time that the mosquito salivary gland mounts responses to suppress DENV which, in turn, modulates the expression of chemosensory-related genes that regulate feeding behavior. These reciprocal interactions may have the potential to affect DENV transmission between humans