Impact of a dexmedetomidine intravenous infusion in septic dogs: preliminary study

Sepsis represents an increasing health emergency both in human and veterinary medicine Dexmedetomidine is an alpha-2 agonist drug with sedative and analgesic properties recently used critically ill patient in human ICU. The purpose of this work was to evaluate hemodynamics effects of a continuous infusion of dexmedetomidine in septic dogs

Chiasma

Newspaper reporting on events at the Boston University School of Medicine in the 1960s

AN INFORMATIVE CONTENT 3D MODEL FOR THE HALL HOLDING THE RESURRECTION OF CHRIST BY PIERO DELLA FRANCESCA MURAL PAINTING AT SANSEPOLCRO, ITALY

The Resurrection of Christ by Piero della Francesca (about 1460) at Sansepolcro (Italy) is a masterpiece in the development of painting. The painting is located in a hall of the city government building, which today holds the Civic Museum of Sansepolcro. This mural painting was realized on a brick wall (15&thinsp;cm thick) located in a different place as it is today. Shortly later, the painting was moved by means of a transport to solid-wall and placed against a pre-existing wall (60&thinsp;cm thick), where it is today, erecting against this wall a counter wall (15&thinsp;cm thick) where the mural painting wall-panel (225&thinsp;&times;&thinsp;200&thinsp;cm) had been inserted.Within the studies aimed at restoration and conservation of the painting, the type and characteristics of the walls of the museum hall and of the wall where the painting is located have been defined through different types of diagnostic surveys. Geometric, physical, mechanical and material data from surveys are knowledge that must be archived and made accessible for future maintenance operations. Building Information Modeling (BIM) is a valid methodology that allows to build a three-dimensional database in which to collect information about diagnostics and conservation of the historical building. The aim of this paper is digitalization through the HBIM methodology of the hall of Resurrection, in order to create a “3D informative model” that describes the geometry with objects linking them the information related to knowledge of cultural heritage and it can represent a technical and organizational support for future conservation operations.</p

Spontaneous polarization and piezoelectric field in G a N / A l 0.15 Ga 0.85 N quantum wells: Impact on the optical spectra

We have investigated the effects of the built-in electric field in ${\mathrm{G}\mathrm{a}\mathrm{N}/\mathrm{A}\mathrm{l}}_{0.15}{\mathrm{Ga}}_{0.85}\mathrm{N}$ quantum wells by photoluminescence spectroscopy. The fundamental electron heavy-hole transition redshifts well below the GaN bulk gap for well widths larger than 3 nm for the specific quantum wells investigated and exhibits a concomitant reduction of the intensity with increasing well thickness. The experimental data are quantitatively explained by means of a self-consistent tight-binding model that includes screening (either dielectric or by free-carriers), piezoelectric field and spontaneous polarization field. The impact of the built-in field on the exciton stability is discussed in detail. We demonstrate that the exciton binding energy is substantially reduced by the built-in field, well below the values expected from the quantum size effect in the flat band condition

Conductive Cooling of SDD and SSD Front-End Chips for ALICE

We present analysis, technology developments and test results of the heat drain system of the SDD and SSD front-end electronics for the ALICE Inner Tracker System (ITS). Application of super thermoconductive carbon fibre thin plates provides a practical solution for the development of miniature motherboards for the FEE chips situated inside the sensitive ITS volume. Unidirectional carbon fibre motherboards of 160 -300 micron thickness ensure the mounting of the FEE chips and an efficient heat sink to the cooling arteries. Thermal conductivity up to 1.3 times better than copper is achieved while preserving a negligible multiple scattering contribution by the material (less than 0.15 percent of X/Xo)

Test and commissioning of the CARLOS control boards for the ALICE Silicon Drift Detectors

This paper presents the test strategy employed during the installation of the CARLOS end ladder boards developed for the Silicon Drift Detectors (SDD) of ALICE. Each CARLOS board compresses the data provided by the front-end electronics of one SDD and sends them via an optical link of 800 Mbit/s to the data concentrator card (CARLOSrx) located in the counting room. The paper describes the integration of the CARLOS boards in the final SDD system, including its cooling and mechanical support, the power supply distribution and the optical interconnections. The results of the tests performed after each step of the installation sequence are reported

Study of cosolvent-induced α-chymotrypsin fibrillogenesis: Does protein surface hydrophobicity trigger early stages of aggregation reaction?

The misfolding of specific proteins is often associated with their assembly into fibrillar aggregates, commonly termed amyloid fibrils. Despite the many efforts expended to characterize amyloid formation in vitro, there is no deep knowledge about the environment (in which aggregation occurs) as well as mechanism of this type of protein aggregation. Alpha-chymotrypsin was recently driven toward amyloid aggregation by the addition of intermediate concentrations of trifluoroethanol. In the present study, approaches such as turbidimetric, thermodynamic, intrinsic fluorescence and quenching studies as well as chemical modification have been successfully used to elucidate the underlying role of hydrophobic interactions (involved in early stages of amyloid formation) in α-chymotrypsin-based experimental system. © 2009 Springer Science+Business Media, LLC

Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets

This document is the Technical Design Report covering the two large spectrometer magnets of the PANDA detector set-up. It shows the conceptual design of the magnets and their anticipated performance. It precedes the tender and procurement of the magnets and, hence, is subject to possible modifications arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski, Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy), Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy

Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR

Simulation results for future measurements of electromagnetic proton form factors at \PANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel $\bar p p \to e^+ e^-$ is studied on the basis of two different but consistent procedures. The suppression of the main background channel, $\textit{i.e.}$ $\bar p p \to \pi^+ \pi^-$, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. However, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance

Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV

We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (|$\eta$|<0.8) and transverse momentum range 0.2< $p_{\rm T}$< 5.0 GeV/$c$. The elliptic flow signal v$_2$, measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 $\pm$ 0.002 (stat) $\pm$ 0.004 (syst) in the 40-50% centrality class. The differential elliptic flow v$_2(p_{\rm T})$ reaches a maximum of 0.2 near $p_{\rm T}$ = 3 GeV/$c$. Compared to RHIC Au-Au collisions at 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.Comment: 10 pages, 4 captioned figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/389