1,387 research outputs found
Kinetics of substitution of cis-bis(malonato)diaquochromate(III) with glycine, DL-alanine and DL-phenylalanine
The kinetics of interaction between amino acids such as glycine, DL-alanine and DLphenylalanine and cis-bis(malonato)diaquochromate(III) has been studied spectrophotometrically as a function of [glycine], [DL-alanine] and [DL-phenylalanine]. The effect of pH, temperature and substrate is also studied. The substrate exists predominantly as the diaquospecies and amino acids (glycine, DL-alanine and DL-phenylalanine) as the zwitterion at the experimental conditions. The substitution reaction has been found to proceed via two steps: amino acid dependent and amino acid independent paths indicating that the substitution reaction occurs through associative interchange (Ia) mechanism in the amino acid dependent path and the dissociative mechanism in the independent path, showing the higher reactivity of single ended malonate complex
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The Relationship Between Stigma and Health-Related Quality of Life in People Living with HIV Who Have Full Access to Antiretroviral Treatment: An Assessment of Earnshaw and Chaudoir's HIV Stigma Framework Using Empirical Data.
The aim was to empirically test the tenets of Earnshaw and Chaudoir's HIV stigma framework and its potential covariates for persons living with HIV in Sweden. Partial least squares structural equation modelling was used on survey data from 173 persons living with HIV in Sweden. Experiencing stigma was reported to a higher extent by younger persons and by women who had migrated to Sweden. As expected, anticipated stigma was related to lower Physical functioning, and internalized stigma to lower Emotional wellbeing. In contrast to that hypothesized by the HIV stigma framework, enacted stigma was not related to Physical functioning and no relationships were found between HIV-related stigma and antiretroviral adherence. These results indicate that the HIV stigma framework may need to be revised for contexts where a very high proportion of persons living with HIV are diagnosed and under efficient treatment
Occult intraocular foreign body masquerading as panuveitis: inductively coupled mass spectrometry and electrophysiologic analysis
A Minimal Model of Metabolism Based Chemotaxis
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent studies have shown, however, that many metabolism-dependent chemotactic patterns occur in bacteria. We hereby present the simplest artificial protocell model capable of performing metabolism-based chemotaxis. The model serves as a proof of concept to show how even the simplest metabolism can sustain chemotactic patterns of varying sophistication. It also reproduces a set of phenomena that have recently attracted attention on bacterial chemotaxis and provides insights about alternative mechanisms that could instantiate them. We conclude that relaxing the metabolism-independent assumption provides important theoretical advances, forces us to rethink some established pre-conceptions and may help us better understand unexplored and poorly understood aspects of bacterial chemotaxis
Neutron Majorana mass from exotic instantons
We show how a Majorana mass for the Neutron could result from
non-perturbative quantum gravity effects peculiar to string theory. In
particular, "exotic instantons" in un-oriented string compactifications with
D-branes extending the (supersymmetric) standard model could indirectly produce
an effective operator delta{m} n^t n+h.c. In a specific model with an extra
vector-like pair of `quarks', acquiring a large mass proportional to the string
mass scale (exponentially suppressed by a function of the string moduli
fields), delta{m} can turn out to be as low as 10^{-24}-10^{-25} eV. The
induced neutron-antineutron oscillations could take place with a time scale
tau_{n\bar{n}} > 10^8 s, that could be tested by the next generation of
experiments. On the other hand, proton decay and FCNC's are automatically
strongly suppressed and are compatible with the current experimental limits.
Depending on the number of brane intersections, the model may also lead to the
generation of Majorana masses for R-handed neutrini. Our proposal could also
suggest neutron-neutralino or neutron-axino oscillations, with implications in
UCN, Dark Matter Direct Detection, UHECR and Neutron-Antineutron oscillations.
This suggests to improve the limits on neutron-antineutron oscillations, as a
possible test of string theory and quantum gravity.Comment: 35 pages, 11 figures. More comments on neutron-neutralino mixin
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N-learners problem: Fusion of concepts
We are given N learners each capable of learning concepts (subsets) of a domain set X in the sense of Valiant, i.e. for any c {element of} C {improper subset} 2{sup X}, given a finite set of examples of the form ; ;...; generated according to an unknown probability distribution P{sub X} on X, each learner produces a close approximation to c with a high probability. We are interested in combining the N learners using a single fuser or consolidator. We consider the paradigm of passive fusion, where each learner is first trained with the sample without the influence of the consolidator. The composite system is constituted by the fuser and the individual learners. We consider two cases: open and closed fusion. In open fusion the fuser is given the sample and the hypotheses of the individual learners; we show that the fusion rule can be obtained by formulating this problem as another learning problem. For the case all individual learners are trained with the same sample, we show sufficiency conditions that ensure the composite system to be better than the best of the individual: the hypothesis space of the consolidator (a) satisfies the isolation property of degree at least N, and (b) has Vapnik-Chervonenkis dimension less than or equal to that of every individual learner. If individual learners are trained by independently generated samples, we obtain a much weaker bound on the VC-dimension of the hypothesis space of the fuser. Second, in closed fusion the fuser does not have an access to either the training sample or the hypotheses of the individual learners. By suitable designing a linear threshold function of the outputs of individual learners, we show that the composite system can be made better than the best of the learners
A Genomic-Based Approach Combining In Vivo Selection in Mice to Identify a Novel Virulence Gene in Leishmania
Parasites of the genus Leishmania cause a variety of human diseases that range from destructive skin lesions caused by L. major to visceral infections of the liver and spleen caused by L. donovani that result in death. The Leishmania genes responsible for these different pathologies are not known. In the present study, we used a comparative genome-based approach to introduce and over-express L. donovani genes in L. major to determine whether this results in increased virulence of L. major in visceral organs of infected mice. Through this approach, a novel gene termed Li1040 was identified that is potentially involved in protein transport and was shown to increase pathogenesis in the visceral organs in mice. The Li1040 gene may therefore represent a Leishmania virulence gene that has the potential to regulate the pathology of infection in the mammalian host. These observations help to define how Leishmania causes fatal infections in humans and therefore provide a parasite-specific target for therapy
Kernel-based methods for combining information of several frame surveys
A sample selected from a single sampling frame may not represent adequatly the entire population. Multiple frame surveys are becoming increasingly used and popular among statistical agencies and private organizations, in particular in situations where several sampling frames may provide better coverage or can reduce sampling costs for estimating population quantities of interest. Auxiliary information available at the population level is often categorical in nature, so that incorporating categorical and continuous information can improve the efficiency of the method of estimation. Nonparametric regression methods represent a widely used and flexible estimation approach in the survey context. We propose a kernel regression estimator for dual frame surveys that can handle both continuous and categorical data. This methodology is extended to multiple frame surveys. We derive theoretical properties of the proposed methods and numerical experiments indicate that the proposed estimator perform well in practical settings under different scenarios.Ministerio de Economía y CompetitividadConsejería de Economía, Innovación, Ciencia y Emple
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
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