An algorithm for Monte-Carlo time-dependent radiation transfer

A new Monte-Carlo algorithm for calculating time-dependent radiative-transfer under the assumption of LTE is presented. Unlike flux-limited diffusion the method is polychromatic, includes scattering, and is able to treat the optically thick and free-streaming regimes simultaneously. The algorithm is tested on a variety of 1-d and 2-d problems, and good agreement with benchmark solutions is found. The method is used to calculate the time-varying spectral energy distribution from a circumstellar disc illuminated by a protostar whose accretion luminosity is varying. It is shown that the time lag between the optical variability and the infrared variability results from a combination of the photon travel time and the thermal response in the disc, and that the lag is an approximately linear function of wavelength.Comment: 10 pages, 10 figures, accepted for publication by MNRA

Ponatinib in patients with refractory acute myeloid leukaemia: findings from a phase 1 study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99099/1/bjh12382.pd

Modelling massive star feedback with Monte Carlo radiation hydrodynamics: photoionization and radiation pressure in a turbulent cloud (article)

This is the final version of the article. Available from Oxford University Press via the DOI in this record.The dataset associated with this article is located in ORE at: https://doi.org/10.24378/exe.1163We simulate a self-gravitating, turbulent cloud of 1000 M⊙ with photoionization and radiation pressure feedback from a 34 M⊙ star. We use a detailed Monte Carlo radiative transfer scheme alongside the hydrodynamics to compute photoionization and thermal equilibrium with dust grains and multiple atomic species. Using these gas temperatures, dust temperatures, and ionization fractions, we produce self-consistent synthetic observations of line and continuum emission. We find that all material is dispersed from the (15.5 pc)3 grid within 1.6 Myr or 0.74 free-fall times. Mass exits with a peak flux of 2 × 10−3 M⊙ yr−1, showing efficient gas dispersal. The model without radiation pressure has a slight delay in the breakthrough of ionization, but overall its effects are negligible. 85 per cent of the volume, and 40 per cent of the mass, become ionized – dense filaments resist ionization and are swept up into spherical cores with pillars that point radially away from the ionizing star. We use free–free emission at 20 cm to estimate the production rate of ionizing photons. This is almost always underestimated: by a factor of a few at early stages, then by orders of magnitude as mass leaves the volume. We also test the ratio of dust continuum surface brightnesses at 450 and 850 µm to probe dust temperatures. This underestimates the actual temperature by more than a factor of 2 in areas of low column density or high line-of-sight temperature dispersion; the HII region cavity is particularly prone to this discrepancy. However, the probe is accurate in dense locations such as filaments.We thank the referee, Alejandro Raga, for helpful comments. We also thank Thomas Haworth and David Acreman for useful discussions. AA is funded by an STFC studentship. TJH and TAD are funded by STFC Consolidated Grant ST/M00127X/1. The calculations for this paper were performed on the DiRAC Complexity system at the University of Leicester and the DiRAC Data Centric system at Durham University. These form part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). Complexity is funded by BIS National E-Infrastructure capital grant ST/K000373/1 and STFC DiRAC Operations grants ST/K0003259/1 and ST/M006948/1. Data Centric is funded by a BIS National E-infrastructure capital grant ST/K00042X/1, STFC capital grants ST/K00087X/1 and ST/P002307/1, DiRAC Operations grant ST/K003267/1, and Durham University. We also used the University of Exeter Supercomputer, Zen, a DiRAC Facility jointly funded by STFC, the Large Facilities Capital fund of BIS, and the University of Exeter

The Unusually Long Duration Gamma-ray Burst GRB 000911: Discovery of the afterglow and host galaxy

Of all the well-localized gamma-ray bursts, GRB 000911 has the longest duration (T90 = 500 s) and ranks in the top 1% of BATSE bursts for fluence. Here we report the discovery of the afterglow of this unique burst. In order to simultaneously fit our radio and optical observations, we are required to invoke a model involving a hard electron distribution, p ∼ 1.5, and a jet-break time less than 1.5 days. A spectrum of the host galaxy taken 111 days after the burst reveals a single emission line, interpreted as [011] at a redshift z = 1.0585, and a continuum break that we interpret as the Balmer limit at this redshift. Despite the long 790, the afterglow of GRB 000911 is not unusual in any other way when compared to the set of afterglows studied to date. We conclude that the duration of the GRB plays little part in determining the physics of the afterglow.P. A. P. gratefully acknowledges an Alex Rodgers Travelling Scholarship. J. S. B. gratefully acknowledges the fellowship support from the Fannie and John Hertz Foundation. K. H. is grateful for Ulysses support under JPL contract 958056, and for IPN support under the NEAR Participating Scientist program, NAG 5-9503, and under the LTSA, NAG 5-3500. The Konus/Wind experiment was supported by RFBR grant 99-02-017031 and CRDF grant RPI-2260

The Faint Optical Afterglow and Host Galaxy of GRB 020124: Implications for the Nature of Dark Gamma-ray Bursts

We present ground-based optical observations of GRB 020124 starting 1.6 hr after the burst, as well as subsequent Very Large Array and Hubble Space Telescope (HST) observations. The optical afterglow of GRB 020124 is one of the faintest afterglows detected to date, and it exhibits a relatively rapid decay, Fv ∝ t-1.60±0.04, followed by further steepening. In addition, a weak radio source was found coincident with the optical afterglow. The HST observations reveal that a positionally coincident host galaxy must be the faintest host to date, R ≳ 29.5 mag. The afterglow observations can be explained by several models requiring little or no extinction within the host galaxy, AVhost ≈ 0-0.9 mag. These observations have significant implications for the interpretation of the so-called dark bursts (bursts for which no optical afterglow is detected), which are usually attributed to dust extinction within the host galaxy. The faintness and relatively rapid decay of the afterglow of GRB 020124, combined with the low inferred extinction, indicate that some dark bursts are intrinsically dim and not dust obscured. Thus, the diversity in the underlying properties of optical afterglows must be observationally determined before substantive inferences can be drawn from the statistics of dark bursts.F. A. H. acknowledges support from a Presidential Early Career award. S. R. K. and S. G. D. thank the NSF for support. R. S. is grateful for support from a NASA ATP grant. R. S. and T. J. G. acknowledge support from the Sherman Fairchild Foundation. J. C. W. acknowledges support from NASA grant NAG 59302. K. H. is grateful for Ulysses support under JPL contract 958056 and for IPN support under NASA grants FDNAG 5-11451 and NAG 5-17100. Support for Proposal HST-GO-09180.01-A was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years

ATLAS flavour-tagging algorithms for the LHC Run 2 pp collision dataset

The flavour-tagging algorithms developed by the ATLAS Collaboration and used to analyse its dataset of √s = 13 TeV pp collisions from Run 2 of the Large Hadron Collider are presented. These new tagging algorithms are based on recurrent and deep neural networks, and their performance is evaluated in simulated collision events. These developments yield considerable improvements over previous jet-flavour identification strategies. At the 77% b-jet identification efficiency operating point, light-jet (charm-jet) rejection factors of 170 (5) are achieved in a sample of simulated Standard Model tt¯ events; similarly, at a c-jet identification efficiency of 30%, a light-jet (b-jet) rejection factor of 70 (9) is obtained

Collision activity during training increases total energy expenditure measured via doubly labelled water

Purpose: Collision sports are characterised by frequent high intensity collisions that induce substantial muscle damage, potentially increasing the energetic cost of recovery. Therefore, this study investigated the energetic cost of collision-based activity for the first time across any sport. Methods: Using a randomised crossover design, six professional young male rugby league players completed two different five-day pre-season training microcycles. Players completed either a collision (COLL; 20 competitive one-on-one collisions) or non-collision (nCOLL; matched for kinematic demands, excluding collisions) training session on the first day of each microcycle, exactly seven days apart. All remaining training sessions were matched and did not involve any collision-based activity. Total energy expenditure was measured using doubly labelled water, the literature gold standard. Results: Collisions resulted in a very likely higher (4.96 ± 0.97 MJ; ES = 0.30 ±0.07; p=0.0021) total energy expenditure across the five-day COLL training microcycle (95.07 ± 16.66 MJ) compared with the nCOLL training microcycle (90.34 ± 16.97 MJ). The COLL training session also resulted in a very likely higher (200 ± 102 AU; ES = 1.43 ±0.74; p=0.007) session rating of perceived exertion and a very likely greater (-14.6 ± 3.3%; ES = -1.60 ±0.51; p=0.002) decrease in wellbeing 24h later. Conclusions: A single collision training session considerably increased total energy expenditure. This may explain the large energy expenditures of collision sport athletes, which appear to exceed kinematic training and match demands. These findings suggest fuelling professional collision-sport athletes appropriately for the "muscle damage caused” alongside the kinematic “work required”. Key words: Nutrition, Recovery, Contact, Rugb

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans. Susceptibility loci have been described on the X chromosome and chromosome 20, but these loci explain a minority of its heritable variance. We conducted a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ancestry. While replicating the two AGA loci on the X chromosome and chromosome 20, six novel susceptibility loci reached genome-wide significance (p = 2.62×10−9–1.01×10−12). Unexpectedly, we identified a risk allele at 17q21.31 that was recently associated with Parkinson's disease (PD) at a genome-wide significant level. We then tested the association between early-onset AGA and the risk of PD in a cross-sectional analysis of 568 PD cases and 7,664 controls. Early-onset AGA cases had significantly increased odds of subsequent PD (OR = 1.28, 95% confidence interval: 1.06–1.55, p = 8.9×10−3). Further, the AGA susceptibility alleles at the 17q21.31 locus are on the H1 haplotype, which is under negative selection in Europeans and has been linked to decreased fertility. Combining the risk alleles of six novel and two established susceptibility loci, we created a genotype risk score and tested its association with AGA in an additional sample. Individuals in the highest risk quartile of a genotype score had an approximately six-fold increased risk of early-onset AGA [odds ratio (OR) = 5.78, p = 1.4×10−88]. Our results highlight unexpected associations between early-onset AGA, Parkinson's disease, and decreased fertility, providing important insights into the pathophysiology of these conditions