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72 research outputs found

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

Author: BD Brown
BD Brown
D Barnes
D Kirn
E Ylosmaki
EJ Kelly
EJ Small
Fionnadh Carroll
G Karber
Hannah H. Chen
J Chang
Klaus Früh
Leonard W. Seymour
M Bazan-Peregrino
M Lagos-Quintana
M Lagos-Quintana
M Vignuzzi
Miriam Bazan-Peregrino
N Mittereder
N Van Rooijen
Nico van Rooijen
NK Green
RM Zinkernagel
RS Pillai
Ryan Cawood
S Deng
SJ Duncan
SM Frisch
TC Liu
TW Nilsen
Publication venue
Publication date: 01/01/2009
Field of study

Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective microRNA expression now affords the possibility of engineering replicating viruses that are attenuated at the RNA level in sites of potential pathology, but retain wild-type replication activity at sites not expressing the relevant microRNA. To assess the usefulness of this approach for the DNA virus adenovirus, we have engineered a hepatocyte-safe wild-type adenovirus 5 (Ad5), which normally mediates significant toxicity and is potentially lethal in mice. To do this, we have included binding sites for hepatocyte-selective microRNA mir-122 within the 39 UTR of the E1A transcription cassette. Imaging versions of these viruses, produced by fusing E1A with luciferase, showed that inclusion of mir-122 binding sites caused up to 80-fold decreased hepatic expression of E1A following intravenous delivery to mice. Animals administered a ten-times lethal dose of wild-type Ad5 (5610 10 viral particles/mouse) showed substantial hepatic genome replication and extensive liver pathology, while inclusion of 4 microRNA binding sites decreased replication 50-fold and virtually abrogated liver toxicity. This modified wild-type virus retained full activity within cancer cells and provided a potent, liver-safe oncolytic virus. In addition to providing many potent new viruses for cancer virotherapy, microRNA control of virus replication should provide a new strategy for designing safe attenuated vaccines applied across a broad range of viral disease

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Oxford University Research Archive

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
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Aderombi A.
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Adiamah A.
Adishesh M.
Agapov M.
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Agnes A.
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Agoston P.
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Ahmeidat A.
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Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Institutional Research Information System University of Turin

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

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Abad-Motos A.
Abate E.
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Aboelkassem Ibrahim A.
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Videira J. F.
Videria J. F.
Vidya R.
Vieira A.
Vieira B.
Vieira Caroco T.
Vieira P.
Vieira Paiva Lopes A. C.
Vignali A.
Vigorita V.
Vijayan D.
Vilatoba M.
Vilendecic Z.
Villalabeitia Ateca I.
Vimalachandran D.
Vinayagam R.
Violante T.
Visgauss J.
Viswambaram P.
Viswanath Y.
Vitali A.
Vitone L.
Vives R. V.
Vo U. G.
Vogel J.
Vollkommer T.
Von Papen M.
Vovola F.
Vucic N.
Vujanac V.
Wade R.
Wadham B.
Waheed S.
Wai K.
Wali A.
Walker C.
Walker D.
Walkes K.
Wallwork K.
Walton G.
Walton T.
Waqar S. H.
Warburton H.
Ward D.
Ward S.
Waris Farooka M.
Warren O.
Waseem S.
Wasim T.
Watson D.
Watson L. J.
Watson N.
Weaver H.
Webber L.
Weitz J.
Welsch T.
Wensley F.
Werner J.
West C.
West D.
Westwood E.
Whelan M.
Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
Wilson M.
Wimberger P.
Wimmer A.
Winnand P.
Winter D.
Winter S.
Wolfer S.
Wong M. P. K.
Wong S.
Wong W. J.
Woodham A.
Woodun H.
Worku D.
Wright G.
Wullschleger M.
Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Author: Aawsaj Yousif
Abayomi Michael
Acharya Vikas
Aggarwal Smeer Kumar
Ahmad Anwar
Ahmed Irfan
Ahmed Jamil
Ahmed Javed
Ahmed Talat
Ainley Paul
Akhtar Mansoor
Al Amari Khalid
Al-Abed Yahya A.
Al-Akash Musallam
Al-Bahrani Ahmed Z.
Al-Khyatt Waleed
Al-Muhktar Ahmed
Al-Sarireh Bilal
Al-Taan Omer
Alagaratnam Swethan
Alam Imran
Alberts Justin
Alderson Derek
Aldridge Roland C.
Aleksandrov Danail
Ali Haythem
Ali Shahda
Amin Khalid
Andrew David R.
Appleton Shaun
Arhi Chanpreet
Aroori Somaiah
Aryal Kamal
Asad Mehek
Aseem Rabiya
Asprou Fotini M.
Awan Altaf
Ayaani Soofiyah
Aymon null
Babu Benoy I.
Bajwa Dalvir S.
Bajwa Farrukh M.
Baker Andrew L.
Balfe Paul
Ball William R.
Ballance Laura
Banwell Victoria
Barnes James
Barrie Jenifer
Bartlett Francis
Basheer Mohammed
Bashir Gareth
Basra Melvinder
Basu Sanjoy
Basynat Pradeep
Batt Jeremy
Bausbacher Harald
Bawa Sadiq
Beasley William D.
Belding Rowena
Bellini Maria Irene
Bennett Stephen P.
Bhandari Santosh
Bharamgoudar Reshma
Bhattacharya Vish
Blane Christine
Blazeby Jane M.
Boal Matthew
Boddy Alexander
Boland Michael
Bond-Smith Giles
Booth Michael I.
Borowski David W.
Bowen Laura
Boyce Kathryn M.
Boyd Alan T.
Bradley Donal
Bradley Neil
Brennan Stephen
Brett Daniel
Broadhurst Jack
Brooke Eleanor
Brown Timothy H.
Bryant Alice
Buchan Joanna
Bullen Naomi
Bunnell Catherine
Bunting David M.
Burke Paul
Byrne James P.
Byrnes Colman K.
Campbell William
Carney Kate
Carney Kate
Carroll Paul
Carter C. Ross
Carter Nicholas C.
Carty Nick
Cassidy John T.
Chambers Adam
Chambers Alice
Chambers Alice
Chan Wei Ming
Chang Jessica
Charalabopoulos Alexandros
Chauhan Neal
Cheung Melanie
Chhabra Alok
Chishti Imran A.
Chitre Vivek
Choy Alfred
Cieplucha Krzysztos
Clements Joshua M.
Coats Maria
Cockbain Andrew J.
Coe Peter O.
Connelly Martin
Cooke Fiachra
Courtney Michael J.
Cowley Jonathan B.
Cross Keith S.
Cuming Tamzin
Cunha Pedro
Dalgaty Faith
Dar Farooq
Date Ravindra
Dave Rajiv V.
Davey Phil
Davies James
Dawson Suzanne
De Marchi Joshua A.
de Siqueira Jonathan
Deguara Jean
Delisle Theo G.
Dennison A. R.
Derbyshire Laura
Devoto Laurence
Dhillon Ajit
Diamond Tom
Dickson-Lowe Richard
Digney Ruairi
Dindyal Shiva
Dobbins Brian
Doe Matthew
Dorrian Emmet
Doulias Triantafyllos
Downing Justine
Drake Benjamin
Driscoll Peter J.
Duke Diana
Durkin Damien
Dwerryhouse Simon J.
D’Costa Conrad
Ebdewi Hamdi
Ebied Husam
Eisawi Abdalla
El-Dhuwaib Yesar
El-Hasani Shamsi S.
Elkheir Natalie
Elmasry Mohamed
Elsayed Mohammed
Elshaer Mohamed
Emesih Sophie
Farag Sameh F.
Farooq Ansar
Farouk Marwan
Fasih Tani
Fawole Adeshina S.
Fenwick Stephen
Ferguson Graeme
Ferris Paul
Finch David
Finch J. G.
Finlay Ian
Fleming Katie
Fletcher Ted
Fordham Imogen J.
Forouzanfar Amir
Forrest Craig R.
Forster Luke
Fothergill Laura
Frame Richard J.
Francombe James
Frank Lucinda
Fusai Guiseppe
Galanopoulos Giorgios
Gallagher Paul V.
Garcea Giuseppe
Gardner-Thorpe James
Geoghegan Justin G.
Geogloma Ileana
Gerakopoulos Stratos
Ghareeb Essam
Ghazanfar Mudassar A.
Gibson Simon
Giles Mathew
Giovinazzo Francesco
Giwa Lola
Goh Yan Li
Gopalswamy Sivakumar
Goscimski Andrzej
Gossage James A.
Gough Martin
Gould Laura
Gould Laura
Grant Alan J.
Gravante Gianpiero
Griffiths Ewen
Griffiths Ewen A.
Gull Sadaf
Gunasekera Rohan T.
Gurung Kabita
Guthrie Graeme J. K.
Guy Finch J.
Hafiz Shazia
Halkias Constantine
Hall Claire
Hamady Zayed
Hamdan Alhafidz
Hamdan Mohammed F.
Hamilton Emma
Hancorn Kate
Haque Manzarul
Haque Samer Ul
Hardy Thomas J.
Hargreaves Anita
Harilingam Mohan
Harris Andrew
Harrison Ewen
Hawkins Helen
Heath Jonathan
Hebbar Madhusoodhana
Henderson Lucy T.
Henley Natasha
Heshaishi Mohamed
Hewes James
Hewes James C.
Heywood Nick
Higgs Simon M.
Hill Arnold D. K.
Hindley Caroline
Hirst Natalie A.
Hisham Elzanati
Ho Wei-Min
Hoban Jennifer R.
Hodgkins Kathryn A.
Hodson James
Holroyd David J.
Hooks Gareth
Hopwood Benjamin
Hornby Steve T.
Hornsby Jane
Hosie Kenneth B.
Hosie Kenneth B.
Hossack Martin R.
Hossain Tanvir
Hoti Emir
Hou David
Hrycaiczuk Alex
Hughes Michael
Hunter David I.
Hussain Abdulzahra A.
Hussain Adnan
Hussain Anwar
Hussain Najam
Iftikhar Syed Yusuf
Iqbal Nusrat
Iskandar Edrin
Issa Eyad
Ivanovski Ivan
Jackson Andrew
Jackson Claire
Jafferbhoy Sadaf F.
Jambulingam Periyathambi
Jamdar Saurabh
Jamel Sara
Janeczko Adam
Jaunoo Shameen
Jayanthi Naga V. G.
Jelley Clare
Jennings Neil A.
Joel Abraham
Johnpulle Michelle A.
Johnston Dorothy
Johnstone Marianne
Johnstone Marianne
Joji Nikita
Jones Claire
Jones Elinor
Jones Gareth H.
Jones M. Angharad
Jones Michael J.
Jones Robert P.
Jones Steven M.
Kadhim Abbas
Kadirkamanathan Sritharan
Kallaway Charlotte
Kanakala Venkatesh
Kanavati Osama
Kansal Nisheeth
Kaptanis Sarantos
Karavadra Babu
Karim Lawen
Karunakaran Priyadarssini
Kaur Parminder
Kausar Ambareen
Kelly Michael E.
Kendal Chris
Kennedy David
Kenny Ross
Keogh Ken
Khalil Ahmed M.
Khan Amarah
Khan Mohammad A.
Khan Muhammad A. S.
Khan Raja Basit
Khan Shabuddin
Khan Shahab
Khawaja Amir
Khawaja Zechan
Khogali Elmoataz
Kimble Adam
Kinghorn Alison
Kirkham Amanda J.
Knight Benjamin
Knight Katrina
Kourkulos Michail
Krysztopik Richard
Kumar Pradeep
Kynaston James
Kyriakidis Dimitrios
Lalla Kushik
Lambert Joel
Lammy Simon
Lane Risha
Larkin David
Law Jennifer
Lawther Roger
Lazim Taha
Lee Kathryn
Lee Matthew
Leeder Paul
Lennon Hannah
Lewis Michael
Lim Henry C. C.
Lim Pei J.
Lindsay David
Lloyd David
Lo Christina
Lodhia Joshil
Longbotham David A.
Loughlin Paula
Lovett Bryony
Luhmann Andreas
Luther Ali Alison
Lyons Emma M.
Macano Christina A. W.
MacArtney Matthew
Macdonald Andrew
Madanipour Suroosh
Madbak Khaliel
Madurska Marta
Magee Conor J.
Maguire Donal
Maharaj Geta
Majeed Ali
Malcolm Cathy
Malde Deep
Malik Nabeela S.
Mallik Mekhlola
Mansour Sami
Manu Mangta
Manzelli Antonio
Marriott Paul
Martin Jack
Martin Sean T.
Martin Serena
Marudanayagam Ravi
Mason Denise
Mathur Pawan
Mawhinney Abi
Mbuvi James
McAree Barry
McCain Stephen
McCallum Iain J. D.
McClarey Andrew
McCune Ken
McDermott Frank
McEntee Gerry P.
McGlone Emma R.
McGuigan Andrew
McIlmunn Colin
McKay Damian
McKenzie Stephen
McNair Angus G. K.
Mealy Ken
Menzies Donald
Mercer Stuart J.
Milburn James
Mirza Ahmed K.
Mirza Darius
Miu Victor
Mockford Justine Downing Katherine A.
Mohamed Sarah
Mohan Helen M.
Mok Kam Wa Jessica
Monk David
Morcous Paul
Morrison Tamsin E. M.
Mothe Bhavani Sidhartha
Mowbray Nicholas
Mozolowski Kirsty L.
Mukherjee Dipankar
Murphy James O.
Murtaza Ghulam
Nally Deirdre M.
Napetti Sara
Nassar Ahmad H.
Naumann David
Nedujchelyn Yuwaraja
Needham Paul J.
Newton Katy
Newton Richard C.
Ngu Wee Sing
Nicholson Gary A.
Nicholson James
Nicholson James A.
Nicol Laura
Nicolay Christopher R.
Nieto Tom
Nijjar Rajwinder S.
Nilsen-Nunn April
Nilsson Frida
Noble Fergus
Nofal Emma
Noor Nigel
Nunes Quentin M.
Obeidallah Mohd Rami
Ogedegbe Arikoge
Old Oliver J.
Orchard Philippa
Orizu Mavis N.
O’Dwyer Patrick
O’Neill Maeve A.
O’Neill Stephen
O’Reilly Derek A.
O’shea Kathryn M.
O’Sullivan Adrian W.
Packer Jessica R.
Padwick Robert
Pannu Arslan
Panteleimonitis Sofoklis
Parappally Ciny P.
Parmar J.
Pasquali Sandro
Patel Abhilasha
Patel Krashna
Patel Shakira
Pati Pradeep
Pearce Belinda
Pearson Katherine L.
Peirce Colin
Pellen Mike
Peter Mark B.
Peterson Mark
Pezzuto Roberto
Photi Evangelos
Phull Manraj
Pinho-Gomes Ana C.
Pollock Sarah
Popplewell Matthew
Pore Naresh
Porter Jonathan
Prasad Abheesh R.
Prasad Raj
Preston Shaun R.
Preziosi Giuseppe
Prince Sarah
Psica Alicja
Puig Sonia
Puntis Daniel J.
Puri Yogesh
Qandeel Haitham
Rabie Mohamed
Radwan Rami
Rae David M.
Rahman Saquib
Rajaganeshan Rajasundaram
Rajendran Ilayaraja
Ramage Michael I.
Rao Sudhindra T. V.
Rate Anthony J.
Raza Soulat
Read Edward
Reddy Marcus
Reece-Bolton Obuobi
Reed Joanna
Reid Alistair
Rengifo Carla
Rhys Thomas
Richards Colin H.
Riera Manel
Ritchie Judith
Robb William
Roberts Geoffrey P.
Robinson Sarah
Robinson Steven J.
Robinson Stuart
Rodriguez Dan
Rodriguez Daniel Urriza
Roebuck Amanda
Rogers Paul N.
Rolph Rachel C.
Roy Sudipta
Rutherford Claire L.
Sadat Mohammed M.
Sakai Naomi
Sampat Keerthika
Samuel Nehemiah
Sarmah Piyush B.
Sarvananthan Kas
Sarveswaran Janahan
Satheesan Steve
Saunders Michael
Sayegh Mazin
Segaran Ashvina
Sekhar Hema
Sen Gourab
Seymour Keith
Shabo Wael
Shah Nayab
Shah Reena
Shahin Yousef
Sheel Andrea R. G.
Shenoy Hrishikesh
Shetty Vinutha
Shier David
Shingler Guy M.
Shiwani Muhammad Hanif
Shrestha Ashish Kiran
Siddiqi Najaf
Siddiqui Midhat N.
Siddiqui Zohaib
Sillo Toritseju O.
Silva Michael
Simpson Duncan J.
Singh Shailendra
Singh-Ranger Deepak
Sinha Sidhartha
Skelly Brendan L.
Slavin John P.
Slawinski Corinna
Sloane Jake
Smith Stella R.
Smith Stella R.
Sonsale Aniket
Spearman John
Spence Gary
Spreadborough Philip
Spreadborough Philip
Starmer Benjamin Z.
Stevenson Thomas E. J.
Stewart Duncan J.
Stirland E.
Subramanium Dhivya
Sufi Pratik A.
Sukha Anisha
Sutcliffe Robert
Suttie Stuart
Sutton Cherith M. L. R.
Szentpali Karoly
Tang Cheuk-Bong
Tanner Nicola
Tate Sophie
Tayeh Salim
Taylor Christopher
Taylor Greg W.
Teasdale Rebecca L.
Templeton Alexa
Terrace John
Thakkar Rohan
Thomas George
Thompson Ronald L. E.
Tilston Michael P.
Toh Simon K. C.
Tolofari Sotonye
Tomlinson Mark A.
Trevatt Alexander E. J.
Trotter Martin
Tsang Andrew
Tsavellas George
Tuck Liz
Turner Paul
Tutton Matthew G.
Ullah Muhammad Fahad
Upchurch Emma A.
Urbonas Tomas
Varghase Joseph
Vass David G.
Vaughan Elizabeth M.
Vijay Vardhini
Vijayan Deepak
Vijayanand Dhakshinamoorthy
Villatoro Eduardo
Virupaksha Suvi
Vitone Louis J.
Vohra Ravinder S.
Wadley Martin
Wainwright Denise
Wajed Saj
Wallace Tom
Wardle Stacy
Warren Conor
Watkin Helen
Watson Angus J. M.
Watson Nicholas F.
Wayman John
Weaver Simon
Weber Beatrix
Weber Beatrix
Weerasinghe Chamindri
Welbourn Hannah
Wheatley Kevin
White Timothy J.
Wijetunga Imeshi
Wild Jonathan R. L.
Wilkinson Marc D.
Williams Sophie V.
Williamson Tracey K.
Willson Peter D.
Wilson Michael S. J.
Wilson Timothy R.
Winter Des C.
Winter Hannah
Wood Christopher P. J.
Wood Peter
Wood Simon
Woodman Thomas
Yahya Salama
Yao Caroline
Yeldham Geoffrey
Yoganathan Thusidaran
Youssef Haney
Zafar Sara
Zafrani Zakhi
Zarsadias Prizzi
Zeeshan Saquib
Zhang Catherine
Ziprin Paul
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2018
Field of study

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

University of Liverpool Repository

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University of Birmingham Research Portal

Edinburgh Research Explorer

Heart of England: HEFT Repository

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Archivio istituzionale della ricerca - Università di Padova

HEFT Repository

Family Communication in Inherited Cardiovascular Conditions in Ireland

Author: A Liede
A Metcalfe
A Smart
A Strauss
AF Koerner
AF Patenaude
Andrew Green
B Glaser
BJ Wilson
C Pope
C Shaw
CL Gaff
CL Gaff
CL Gaff
E Claes
E Ormondroyd
EMA Smets
F Ulph
Hannah Shipman
HW Nieuwenhoff Van Den
J Green
JL Weiner
JS Rolland
K Chivers-Seymour
K Finkler
K Forrest
K Forrest Keenan
KM Galvin
L D’Agincourt-Canning
L White
LM Koehly
M Mcallister
Marion McAllister
MM Farnsworth
R Kenen
R Parrott
R Schaffer
RB Dugan
RD Aatre
S Ashida
S Mccann
Sinead Whyte
SK Peterson
SK Sobel
V Braun
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2016
Field of study

Over 100,000 individuals living in Ireland carry a mutated gene for an inherited cardiac condition (ICC), most of which demonstrate an autosomal dominant pattern of inheritance. First-degree relatives of individuals with these mutations are at a 50 % risk of being a carrier: disclosing genetic information to family members can be complex. This study explored how families living in Ireland communicate genetic information about ICCs and looked at the challenges of communicating information, factors that may affect communication and what influence this had on family relationships. Face to face interviews were conducted with nine participants using an approved topic guide and results analysed using thematic analysis. The participants disclosed that responsibility to future generations, gender, proximity and lack of contact all played a role in family communication. The media was cited as a source of information about genetic information and knowledge of genetic information tended to have a positive effect on families. Results from this study indicate that individuals are willing to inform family members, particularly when there are children and grandchildren at risk, and different strategies are utilised. Furthermore, understanding of genetics is partially regulated not only by their families, but by the way society handles information. Therefore, genetic health professionals should take into account the familial influence on individuals and their decision to attend genetic services, and also that of the media.postprin

Crossref

HKU Scholars Hub

A Roadmap for HEP Software and Computing R&D for the 2020s

Author: Albrecht Johannes
Alves Antonio Augusto, Jr
Amadio Guilherme
Andronico Giuseppe
Anh-Ky Nguyen
Aphecetche Laurent
Apostolakis John
Asai Makoto
Atzori Luca
Babik Marian
Bagliesi Giuseppe
Bandieramonte Marilena
Banerjee Sunanda
Barisits Martin
Bauerdick Lothar A. T.
Belforte Stefano
Benjamin Douglas
Bernius Catrin
Bhimji Wahid
Bianchi Riccardo Maria
Bird Ian
Biscarat Catherine
Blomer Jakob
Bloom Kenneth
Boccali Tommaso
Bockelman Brian
Bold Tomasz
Bonacorsi Daniele
Boveia Antonio
Bozzi Concezio
Bracko Marko
Britton David
Buckley Andy
Buncic Predrag
Calafiura Paolo
Campana Simone
Canal Philippe
Canali Luca
Carlino Gianpaolo
Castro Nuno
Cattaneo Marco
Cerminara Gianluca
Cervantes Villanueva Javier
Chang Philip
Chapman John
Chen Gang
Childers Taylor
Clarke Peter
Clemencic Marco
Cogneras Eric
Coles Jeremy
Collier Ian
Colling David
Corti Gloria
Cosmo Gabriele
Costanzo Davide
Couturier Ben
Cranmer Kyle
Cranshaw Jack
Cristella Leonardo
Crooks David
Crépé-Renaudin Sabine
Currie Robert
Dallmeier-Tiessen Sünje
De Cian Michel
De Roeck Albert
De Kaushik
Delgado Peris Antonio
Derue Frédéric
Di Girolamo Alessandro
Di Guida Salvatore
Dimitrov Gancho
Doglioni Caterina
Dotti Andrea
Duellmann Dirk
Duflot Laurent
Dykstra Dave
Dziedziniewicz-Wojcik Katarzyna
Dziurda Agnieszka
Egede Ulrik
Elmer Peter
Elmsheuser Johannes
Elvira V. Daniel
Eulisse Giulio
Farrell Steven
Ferber Torben
Filipcic Andrej
Fisk Ian
Fitzpatrick Conor
Flix José
Formica Andrea
Forti Alessandra
Foundation HEP Software
Franzoni Giovanni
Frost James
Fuess Stu
Gaede Frank
Ganis Gerardo
Gardner Robert
Garonne Vincent
Gellrich Andreas
Genser Krzysztof
George Simon
Geurts Frank
Gheata Andrei
Gheata Mihaela
Giacomini Francesco
Giagu Stefano
Giffels Manuel
Gingrich Douglas
Girone Maria
Gligorov Vladimir V.
Glushkov Ivan
Gohn Wesley
Gonzalez Lopez Jose Benito
González Caballero Isidro
González Fernández Juan R.
Govi Giacomo
Grandi Claudio
Grasland Hadrien
Gray Heather
Grillo Lucia
Guan Wen
Gutsche Oliver
Gyurjyan Vardan
Hanushevsky Andrew
Hariri Farah
Hartmann Thomas
Harvey John
Hauth Thomas
Hegner Benedikt
Heinemann Beate
Heinrich Lukas
Heiss Andreas
Hernández José M.
Hildreth Michael
Hodgkinson Mark
Hoeche Stefan
Holzman Burt
Hristov Peter
Huang Xingtao
Ivanchenko Vladimir N.
Ivanov Todor
Iven Jan
Jashal Brij
Jayatilaka Bodhitha
Jones Roger
Jouvin Michel
Jun Soon Yung
Kagan Michael
Kalderon Charles William
Kane Meghan
Karavakis Edward
Katz Daniel S.
Kcira Dorian
Keeble Oliver
Kersevan Borut Paul
Kirby Michael
Klimentov Alexei
Klute Markus
Komarov Ilya
Konstantinov Dmitri
Koppenburg Patrick
Kowalkowski Jim
Kreczko Luke
Kuhr Thomas
Kutschke Robert
Kuznetsov Valentin
Lampl Walter
Lancon Eric
Lange David
Lassnig Mario
Laycock Paul
Leggett Charles
Letts James
Lewendel Birgit
Li Teng
Lima Guilherme
Linacre Jacob
Linden Tomas
Livny Miron
Lo Presti Giuseppe
Lopienski Sebastian
Love Peter
Lyon Adam
Magini Nicolò
Marshall Zachary L
Martelli Edoardo
Martin-Haugh Stewart
Mato Pere
Mazumdar Kajari
McCauley Thomas
McFayden Josh
McKee Shawn
McNab Andrew
Mehdiyev Rashid
Meinhard Helge
Menasce Dario
Mendez Lorenzo Patricia
Mete Alaettin Serhan
Michelotto Michele
Mitrevski Jovan
Moneta Lorenzo
Morgan Ben
Mount Richard
Moyse Edward
Murray Sean
Nairz Armin
Neubauer Mark S
Norman Andrew
Novaes Sérgio
Novak Mihaly
Oyanguren Arantza
Ozturk Nurcan
Pacheco Pages Andres
Paganini Michela
Pansanel Jerome
Pascuzzi Vincent R.
Patrick Glenn
Pearce Alex
Pearson Ben
Pedro Kevin
Perdue Gabriel
Perez-Calero Yzquierdo Antonio
Perrozzi Luca
Petersen Troels
Petric Marko
Petzold Andreas
Piedra Jónatan
Piilonen Leo
Piparo Danilo
Pivarski Jim
Pokorski Witold
Polci Francesco
Potamianos Karolos
Psihas Fernanda
Puig Navarro Albert
Quast Günter
Raven Gerhard
Reuter Jürgen
Ribon Alberto
Rinaldi Lorenzo
Ritter Martin
Robinson James
Rodrigues Eduardo
Roiser Stefan
Rousseau David
Roy Gareth
Rybkine Grigori
Sailer Andre
Sakuma Tai
Santana Renato
Sartirana Andrea
Schellman Heidi
Schovancová Jaroslava
Schramm Steven
Schulz Markus
Sciabà Andrea
Seidel Sally
Sekmen Sezen
Serfon Cedric
Severini Horst
Sexton-Kennedy Elizabeth
Seymour Michael
Sgalaberna Davide
Shapoval Illya
Shiers Jamie
Shiu Jing-Ge
Short Hannah
Siroli Gian Piero
Skipsey Sam
Smith Tim
Snyder Scott
Sokoloff Michael D
Spentzouris Panagiotis
Stadie Hartmut
Stark Giordon
Stewart Gordon
Stewart Graeme
Sánchez Arturo
Sánchez-Hernández Alberto
Taffard Anyes
Tamponi Umberto
Templon Jeff
Tenaglia Giacomo
Tsulaia Vakhtang
Tunnell Christopher
Vaandering Eric
Valassi Andrea
Vallecorsa Sofia
Valsan Liviu
Van Gemmeren Peter
Vernet Renaud
Viren Brett
Vlimant Jean-Roch
Voss Christian
Votava Margaret
Vuosalo Carl
Vázquez Sierra Carlos
Wartel Romain
Watts Gordon T.
Wenaus Torre
Wenzel Sandro
Williams Mike
Winklmeier Frank
Wissing Christoph
Wuerthwein Frank
Wynne Benjamin
Xiaomei Zhang
Yang Wei
Yazgan Efe
Publication venue
Publication date: 18/12/2017
Field of study

Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe

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Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Author: Liza
- AP-HP) Bertrand Dousset (H\uf4pital Cochin
- APHP) Anne Thomin (H\uf4pital Trousseau
- ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
/ Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
3 University Hospital) Bridget Egan (Tallaght
4 Lapolla Pierfrancesco
5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
6 G\uf3mez Marcos
\u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
\u2013 Italy) 20089 Rozzano (MI)
\uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
A Aaraj Mahmoud
A Ayeni Funbi
A Bass Gary
A Benson Ruth
A Bozkurt Mehmet
A Breen Kerry
A Breen Kerry
A Breen Kerry
A Callcut Rachael
A Chung Eric
A Coughlin Patrick
A de Gheldere Charles
A De Marchi Joshua
A Elliott Jessie
A Fahey Brian
A Griffiths Ewen
A Griffiths Ewen
A Griffiths Ewen
A Guariglia Claudio
A Hirji Sameer
A Khalefa Mohamed
A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
A Nguyen (Frankfurt University Hospital Truong
A Olson (Duke University Medical Center) Steven
A Raptis Dimitri
A Rollett Rebecca
A Saeed Samerah
A Salama Hiba
A Salamah Abdulrauf
A Schnitzbauer Andreas
A Schnitzbauer Andreas
A Singh Aminder
A Stevens Kent
A Stylianides Nicholas
A Thaha Mohamed
A Vega (12 de Octubre University Hospital) Viviana
A Vivas Alfredo
A Zappa Marco
Abate Emmanuele
Abdalaziz (Gloucestershire Royal Hospital) Hossam
Abdelkarim Mostafa
Abdou Hossam
Aboelkassem-Ibrahim Ahmad
Abuown Ala
Acebes-Garcia Fernando
Acharya Metesh
Adamina Michel
Addae-Boateng Emmanuel
Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
Aftab Raiyyan
AG Moir John
Agarwal Arnav
AH Ibrahim Mohamed
Aitken (Queen Elizabeth University Hospital) Emma
Al-Azzawi Marwa
Al-Embideen Somya
Al-Sukaini Ahmad
Alakaloko Felix
Alam (Heartlands Hospital) Ruhina
Alameer Ehab
Alderson Derek
Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
Aljanadi Firas
Almasri Murad
Alonso Poza (Hospital Universitario del Sureste) Alfredo
Alonso-Ortu\uf1o Paula
Alser Osaid
Alser Osaid
Alser Osaid
Altintoprak (Sakarya University Faculty of Medicine) Fatih
Amalina Che Bakri Nur
Amjad Rabbia
Anania Gabriele
and Westminster Hospital NHS FT and Imperial College London) Chelsea
Andabaka Tatjana
Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
Angelou Dimitrios
Anita Volpe (New York Presbyterian Queens) Stephen Merola
Annamalai Seethalakshmi
Annessi Valerio
Anthoney James
Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
Anwar Sibtain
Aragon-Chamizo Juan
Ardito Antonella
Arigoni Michele
Armao Teodora
Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
Armstrong Lara
Asaad Peter
Ashcroft James
Ashmore Christopher
Asqalan Ahmad
Asti (IRCCS Policlinico San Donato Emanuele
Aubry Emmanuelle
Aytac Erman
Ayuso-Herrera Esther
Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
B Avellana Rocio
B Catton Andrew
B Fonsi Giovanni
B Hing Caroline
B O'Meara Lindsay
B Schaffer Kathryn
B Yousuf (Tobruk Medical Center) Farhat
B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
Baldi Caterina
Baldini Edoardo
Baldo (Ospedale Santa Corona Stefano
Ballabio Michele
Baloyiannis Ioannis
Baltazar Gerard
Bandiera Alessandro
Barlow Emma
Barmasse (Ospedale Regionale Umberto Parini) Roberto
Barmpagianni Christina
Baronio (Policlinico San Pietro) Gianluca
Barra Fabio
Bartholomew's Hospital) St
Bartsch Anne-Marie
Basgaran Amedra
Basha Amr
Bashkirova (North Middlesex University Hospital) Varvara
Bastazza Marco
BB Sullivan (The Royal London Hospital) Tom
Beak Philip
Belcher Elizabeth
Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
Beltr\ue1n de Heredia Juan
Belvedere Angela
Ben\uedtez-Linero Inmaculada
Benjamin Franklin) Campus
Bergeat Damien
Bernasconi Matteo
Bhalla Ashish
Bhangu Aneel
Bianco Federica
Bisagni Pietro
BJ Borgstein Alexander
Blake (Southport and Formby District General Hospital) Iain
Blanco-Colino Ruth
Blazquez-Martin (Hospital Principe De Asturias) Alma
Boal Matthew
Bologna) Ausl
Bonavina Giulia
Bonavina Luigi
Bond-Smith Giles
Booth (Freeman Hospital) Karen
Borges Filipe
Borghi Felice
Borja De Lacy (Hospital Clinic Barcelona) F
Bourke Grainne
Boyle Emily
Brachini Gioia
Brain Jessie
Brar Amanpreet
Breckles Lisa
Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
Brianza) Carate
Brixton Genevieve
Bruzzaniti Placido
Bueser Teofila
Burnside Nathan
C Bosanquet David
C Brown (Manchester University NHS Foundation Trust Benjamin
C De Souza Anthony
C Glasbey James
C Glasbey James
C Hopkins James
C Lauscher Johannes
C McIntyre Robert
C Mckay Siobhan
C Neary Paul
C Nugent III William
C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
C Roslani April
C Tucker Sarah
C Velmahos (Massachusetts General Hospital) George
C Winter Stuart
Caballero Albert
Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
Calcerrada-Alises Enrique
Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
Camarero Enrique
Campagnaro Tommaso
Campanelli Michela
Candiani Massimo
Cannoletta (Royal Brompton Hospital) Marina
Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
Cao Han
Capizzi Vita
Carcano (Ospedale di Circolo Giulio
Carissimi Francesca
Carlini Massimo
Carlos Bernal-Sprekelsen Juan
Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
Carlucci Michele
Carmela Giuffrida Maria
Carmichael Heather
Carrasco Milagros
Carrillo Mariana
Carvello Michele
Casati Massimiliano
Castoro Carlo
Castro Ruiz Carolina
Catalan Vanesa
Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
Cavaleiro Salom\ue9
Cellerino Paola
Center Amsterdam) Cancer
Centinaio (Ospedale Maggiore di Lodi) Giovanna
Cernei Cristina
Cervellera Maurizio
Chakrabortee Sohini
Chamberlain Stephanie
Chan Jeffrey
Chang Grace
Chaudhry Daoud
Chebaro Alexandre
Chen (Jamaica Hospital) David
Chetty Govind
Chia (Royal Derby Hospital) Zoe
Chiappini Ambra
Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
Chidambaram Swathikan
Chiozza Matteo
Cholewa Hanna
Chong (Evelina London Children's Hospital) Clara
Choolani-Bhojwani Ekta
Christian Cotsoglou (ASST Vimercate) Stefano Granieri
Chui Karen
Chung Choyin
Cirillo Bruno
Citterio Davide
Clermidi Pauline
Coccolini Federico
Colletti Gaia
Compagnoni Bruno
Concepci\uf3n-Mart\uedn Vanesa
Confalonieri Marco
Connolly Hannah
Conso Christel
Conti Luigi
Cooper Zara
Corral Javier
Costa Marta
Costanzi Andrea
Cox Daniel
Cozza Valerio
CR Wormald Justin
Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
CS Clough Ethan
Cuming Tamzin
Cuneo)
Curtis Miles
Cuschieri Joseph
D Baron Ryan
D Bosch Karen
D Brown Oliver
D Bueno-Ca\uf1ones Alejandro
D Cato Liam
D Drake Thomas
D Jenkinson Michael
D Jenkinson Michael
D Liyanage Aloka S
D Pinkney Thomas
D Rajgor Amarkumar
D Stewart Grant
D Tebala Giovanni
D'Agruma Michele
D'Andrea Giancarlo
D\uedaz P\ue9rez David
D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
Da Roit Anna
da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
Dare Oliver
Darko Ebenezer
Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
Day Andrew
De Andr\ue9s-Asenjo Beatriz
de Medicina Facultad
De Miguel-Ardevines Maria-Carmen
De Nardi Paola
De Simone Veronica
De Toma Giorgio
Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
Dehart Dustin
Del Giudice Roberto
Delgado-Oliver Eduardo
Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
Denning Max
Desai Anant
Desender (Ghent University Hospital) Liesbeth
Dester (ASST Valcamonica Ospedale di Esine) Sara
Di Candido Francesca
Di Chiara Francesco
Di Franco Gregorio
Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Diaz-Pe\uf1a Patricia
Dieguez Fernandez Beatriz
Dissemination Committee: Michel Adamina Aneel Bhangu.
Dolores Del Toro M
Domodossola
Doussot Alexandre
Duff Sarah
Dunning Joel
Dunstan Matt
Duque-Mallen Victoria
Dziakova Jana
E Canova Michaela
e Carle Hospital Chiara Peluso (Santa Croce
e Carlo ASST Santi Paolo
E Dawson Brett
E Dickson Kathryn
E Hudson Victoria
E Jenny (Johns Hopkins Hospital) Hillary
E Lewis Sophia
E Nita George
e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
E P\ue9rez-S\ue1nchez Luis
E Rice Henry
E Ssentongo Anna
e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
E Xyda Souzana
Edward Fitzgerald J
EF Abbott Tom
EF Abbott Tom
Egan Richard
Egypt: Mohamed El Kassas University of Copenhagen).
El Youzouri Hanan
El-Ali (Queen's Hospital Abess
Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
Elfeki Hossam
Elhadi Muhammed
Eljareh (Aljalaa Hospital) Mohammed
Elkadi Hannah
Elkady Ramy
Elkhafeefi Fatimah
Elmore Ugo
Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
EM Bouhuwaish Ahmad
EM Brathwaite Collin
Emmerson (North Manchester General Hospital) Oliver
Enemosah Ibrahim
English Camilla
English William
Ereidge Simon
Escartin Jorge
Estaire-Gomez Mercedes
EuroSurg
Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
Exley Rebecca
F Bath Michael
F Cunha Miguel
F Cunha Miguel
F Davis Niall
F Ridgway Paul
Fabbri Nicol\uf3
Falco Giuseppe
Familiari Pietro
Fancellu (Cliniche San Pietro Alessandro
Fanjul G\uf3mez Mar\ueda
Farik Shebani
Farr\ue9 Font Roser
Farrell Tony
Fehervari Matyas
Fell Adam
Fern\ue1ndez- Mart\uednez Mar\ueda
Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
Fern\ue1ndez-Mar\uedn Reyes
Fernandez-Camu\uf1as Angel
Ferrara)
Ferrara Francesco
Ferrari Guglielmo
Ferrero Simone
FF Simoes Joana
FF Simoes Joana
Findlay Laura
Fiore Marco
Fiore Marco
Fiori Enrico
FJ Dunne Declan
Flatman Michael
Flindall Ian
Fontana (Vittorio Emanuele Tommaso
Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
Ford Samuel
Forlani Stefano
Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
Francisco de Vitoria Universidad
Francone Elisa
Frattaruolo Colomba
Frio (Institute of Neurological Sciences of Bologna Federico
Frosinone)
G Aoun Salah
G Barranquero Alberto
G Blazer III Dan
G Collins Chris
G Edwards John
G Edwards John
G Morton Dion
G Povey Meical
G Velopulos Catherine
G Wade Ryckie
Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
Gagliano Annalisa
Gagliardi Filippo
Gahunia Sukhpreet
Gala Tanzeela
Galfrascoli Elisa
Galimberti Luca
Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
Gallagher Phoebe
Galleano Raffaele
Gallo Gaetano
Gallo Gaetano
Gallo Gaetano
Galv\ue1n-P\ue9rez Armando
Gamal Amira Ibrahim Sallam
Gammeri Emanuele
Ganau Mario
Garc\ue9s-Garc\ueda Ra\ufal
Garcia Fernandez Andres
Garcia-Conde Delgado Maria
Garulli (Ospedale Infermi di Rimini) Gianluca
Gascon-Ferrer Isabel
Gattolin (Regina Montis Regalis Hospital Andrea
Gaujoux Sebastien
Gentilli Sergio
Georgiades Fanourios
Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
Ghanbari (Homerton University Hospital) Amir
Ghosh Dhruv
Giacometti Marco
Giblin Anna-Victoria
Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
Gim\ue9nez Clara
Giorgakis Emmanouil
Gipponi Manuel
Glen Paul
GlobalPaedSurg GlobalSurg
Goatly Giles
Gobatti (San Carlo Borromeo Hospital Davide
Godbole Chintamani
Gohil Kajal
Gomez-Rosado Juan-Carlos
Gonullu Emre
Gonzalez-De Miguel Melania
Gonzalez-Gonzalez Enrique
Gordini Luca
Gracia Isabel
Gracia-Roche Carlos
Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
Green Susanna
Grivon Manuela
Grove (Department of Colorectal Surgery Thomas
Guaglio Marcello
Guaitoli (Perrino) Eleonora
Guglielmi Alfredo
Guha Soumya
Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
Guti\ue9rrez Samaniego Mar\ueda
H Babu Bheemanakone
H Chowdhury Abeed
H Davidson Giana
H Davidson Giana
H Davidson Giana
H Elfallal Ahmed
H Emile Sameh
H Kirmani Bilal
H Liu Helen
H Murphy Suzanne
H van Ramshorst Gabrielle
H\uf6lzle Frank
Habeeb Amir
Hagger Robert
Hakmi Hazim
Halkias Constantine
Halkias Constantine
Hampton (Rotherham District General Hospital) Matthew
Handa Siddhartha
Haq Iram
Harky (Liverpool Heart and Chest Hospital) Amer
Harries (Morriston Hospital Rhiannon
Harrison Joseph
Hasan Raashad
Hawari Mohammad
Hawkin Paul
Hebblethwaite Bethany
Helier University Hospitals NHS Trust) St
Heritage Emily
Hernandez Garcia Miguel
Hernandez-Juara Pilar
Herrero-Lopez Maria
Hervieux Erik
Heyd Bruno
Higgs Simon
Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
Ho Beatrice
Hogan Aisling
Hospital of Varese University
Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
Hospital) Atakent
Hospital) Wythenshawe
Hossain Tanvir
Houston Roy
Hurt Libor
HV Byrne Matthew
i Pujol) Alba Zarate (Hospital Germans Trias
I Roxo (Brigham and Women's Hospital) Vanessa
I van Berge Henegouwen (Amsterdam UMC Mark
I Alessandro Di Bartolomeo (Policlinico Umberto
Iannone Immacolata
Ibrahim Sherif
Iovino Domenico
Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
Isik Arda
Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
J Abbott Sarah
J Baker Olivia
J Baldwin Alexander
J Beamish Andrew
J Carlos William
J Caruana Edward
J Caruana Edward
J Davies Emma
J Diaz Jose
J Doe Matthew
J Eardley Nicola
J Fern\ue1ndez Antonio
J G\uf3mez D\uedaz Carlos
J Hainsworth Alison
J Hall Bria
J Holme Thomas
J Hutchinson Peter
J Hutchinson Peter
J Kalkwarf Kyle
J Lin Daniel
J Lowery Aoife
J McCluney Simon
J Mehigan Brian
J Mills Sarah
J Pachl (Birmingham Children's Hospital) Max
J Rogers Luke
J Ryan \uc9anna
J Scurrah Rachel
J Shackcloth Michael
J Smart Neil
J Steinkamp Pieter
J Tejero-Pintor Francisco
J Thomas Amy
J Torres Antonio
J Warren Oliver
J Warren Oliver
J Williams Katherine
James RW Hall (Stepping Hill Hospital) Claire Hall
James's Hospital) Conor P Barry (St.
Jamil Tahir
Jayaraju (University Hospital of Wales) Ullas
Jenner Edward
JG Chase Thomas
Jha Shane Lester (James Cook University Hospital) Madan
Jimenez-Higuera Elisa
Jimeno Jaime
JM Dunne Naomi
JM Ferguson Henry
Jo\ue3o Lima Maria
Johnstone Jack
Jones Mark
Jordan: Mahmoud Al-Masri Gela).
JS Wall Joshua
Judkins Nicholas
JW Wilkin Richard
K Abou Chaar Mohamad
K Ambler Graeme
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Brown Allison
K Fusai Giuseppe
K Gill Charn
K Kamarajah Sivesh
K Patel Panna
K Ubhi Harmony
K Weerasinghe Chamindri
K\uf6nigsrainer Alfred
Kalidindi Venugopala
Kamal Mona
Kang Chong
Kara Yasin
Karam Edward
Karim Ahmed
Kashora Florence
KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
Kearney (Beaumont Hospital) David
Khajuria Apoorva
Khan Azam
Khan Umul
Khatri Chetan
Kinross James
Kler Aaron
Klimopoulos (Evangelismos General Hospital) Serafeim
Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
Kolias Angelos
Kolias Angelos
Kontovounisios Christos
Kourdouli (Leicester Royal Infirmary) Amar
Krishnan Emily
Kristinsson Sverrir
Kruijff Schelto
KS Viswanath Yirupaiahgari
Kudsk-Iversen S\uf8ren
Kufeji Dorothy
Kulkarni Rugved
Kurihara Hayato
L Biffl Walter
L Coleman Natasha
L Collins Michelle
L Engel (Temple University Hospital) Jamie
L Fowler Amy
L Garcia Galocha Jose
L Hughes Jane
L J\uf6nsson (Bispebjerg Hospital Maria
L Labib Peter
L Marsh (Scripps Memorial Hospital) Christopher
L McKevitt Kevin
L Osorio Alexander
L Romera Jose
L Serevina Olivia
L Venn Mary
L Venn Mary
L Venn Mary
L Wright Franklin
L Young Alastair
L\ue1zaro Andr\ue9
La Torre Filippo
Laface (Ospedale Vittorio Emanuele III Letizia
Lami Mariam
Landaluce-Olavarria Aitor
Laura Hansen 9
Lawani Ismail
Lawday (Southmead Hospital) Samuel
Lawday Samuel
Le Roy Bertrand
Lecco) Asst
Lecolle Katia
Lederhuber Hans
Lederhuber Hans
Leeds)
Leicester)
Leventoglu Sezai
Li Elizabeth
Li Elizabeth
Li Zoe
Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
Liew Ignatius
Ligure (SV) Pietra
Lima Buarque Igor
Lisi Giorgio
Lizzi Vincenzo
Lo Terence
Lombardia) Regione
Lomiento Daniele
Longhi Marco
Lopez Antonanzas (Hospital Clinico San Carlos Leyre
Losada Ruiz Manuel
Lostis Emilie
Lostoridis Eftychios
Loubani Mahmoud
Lowy- Benoliel Alejandro
Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
luis Blas Laina Juan
Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
Luke Louis
Lunevicius Raimundas
Luraghi Marco
Lye George
M Alrahawy (Menofiya University Hospital) Mahmoud
M Andreani Stefano
M Ashoush Fouad
M Bajomo Oreoluwa
M Blundell Chris
M Cicerchia Pierfranco
M Connolly Tara
M Diez-Alonso Manuel
M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
M Emslie Katy
M Harrison Ewen
M Holbrook Charlotte
M Isolani Simone
M Keatley James
M Leite-Moreira Andr\ue9
M Mithany Reda H
M Mohan Helen
M Mohan Helen
M Monteiro Joana
M Morgom (Tripoli Central Hospital) Marwa
M Muguerza Jose
M Nunes Quentin
M Nygaard Rachel
M Omar Aneel Bhangu Omar
M Philp Matthew
M Pollok Joerg
M Rooney Siobhan
M Sampietro Gianluca
M Sewards Joseph
M Tang Alethea
M Trout Isobel
M Walters (Harborview Medical Center Andrew
MA Kaafarani Haytham
MA Kaafarani Haytham
MA Kaafarani Haytham
Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
Mabrouk Islam
Macchi Alberto
MacDonald Luisa
Machairas (Royal Free Hospital) Nikolaos
Madonini Marco
Madrid)
Madrid)
Magalh\ue3es Maia Mariana
Magne Augestad Knut
Magowan Drew
Maha H Haqqani (Boston Medical Center) Frederick T Drake
Maisonneuve Emeline
Majkowska Agata
Majkowski (Northern General Hospital Lawrence
Mak (Queen Elizabeth Hospital Birmingham) Jason
Malabarba Stefano
Malerba Michele
Maninder Kalkat 7
Mannan Syed
Manson Joanna
Mansuri Ahmer
Mantoglu (Sakarya University Research and Educational Hospital) Baris
Manu Nichola
Manzoni 56 Via
Maqsood Afnan
Marano Alessandra
Marchbank Adrian
Marcos-Santos Pablo
Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
Marqueta De Salas Maria
Marrano Enrico
Mart\uedn-Rom\ue1n Lorena
Mart\uednez P\ue9rez Carolina
Mart\uednez-dePaz Fernando
Martel Lozano Saida
Martin (St Mary's Hospital) Guy
Martin Emmeline
Martin Janet
Martin-Albo Lorena
Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
Martinelli Fabio
Martinez-German Antonio
Martinez-Pinedo Carlos
Martins Ricardo
Marwan Hisham
Marzi Federica
MAS Baig Mirza
Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
Mater Studiorum University of Bologna) Alma
Mathieu (CHU Besan\ue7on) Pierre
Matute-Najarro Maria-Soledad
Maw Andrew
Mazingi Dennis
Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
McCanny (Antrim Area Hospital) Andrew
McKenzie Katherine
McLarty (Northumbria NHS Hospital Trust) Nicola
McPherson Iain
Medina Esther
Mediratta Saniya
Medone Marzia
Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
Mele Simone
Melero-Cort\ue9s Lidia
Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
Mendon\ue7a Ata\uedde Gomes Gustavo
Mendoza-Moreno Fernando
Meneghini Simona
Merate
Mercante Giuseppe
Merdrignac (Rennes University Hospital) Aude
Metallidis Symeon
Michel (Pinderfields Hospital) Martin
Migliore Marco
Milan)
Milan)
Milan)
Miller Douglas
Minaya- Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Mingoli Andrea
Minto Gary
Mirabella Antonello
Misra Nikhil
Mitrasinovic Stefan
Miu Victor
Moawad (Royal Victoria Hospital) Nader
Mochet Sylvie
Modabber Ali
Mohammad Adam
Mohan Midhun
Moliner-S\ue1nchez Carmen
Mondov\uec)
Mongelli Francesco
Monteleone (Ospedale San Leopoldo Mandic Michela
Montuori Mauro
Moore Rachel
Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
Morales Dieter
Morales Xavier
Morelli Luca
Morelli Lucia
Morgan Richard
Morris Chris
Mortini Pietro
Mosca Angelo
Moszkowicz David
Moszkowicz David
Motter Dema
Moug Susan
Mukherjee Samrat
Munoz Rivas Ana
Murcia)
N Bence Matthew
N Hopkinson David
N Mashbari Hassan
N Mashbari Hassan
N Mashbari Hassan
N Naumann David
N Rao Jagan
N Townshend David
N\ufa\uf1ez Jordi
Najdy Manhal
Nakas (Glenfield Hospital Apostolos
Namazov Ilgar
Naredla Pradyumna
Nasef Emmhamed
Nassa Heeam
Nath Rahul
Navarro-S\ue1nchez Antonio
Nazarian (Bupa Cromwell Hospital) Scarlet
Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
Negri Giampiero
Nehra Deepika
Neil-Dwyer Jason
Nepogodiev Dmitri
Nepogodiev Dmitri
Nepogodiev Dmitri
Neri Jacopo
Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
Newton (Manchester Royal Infirmary) Katy
Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
Niquen Milagros
Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
Nogueiro Jorge
Nogues Pevidal (Royo Villanova) Ana
Novara)
Ntirenganya Faustin
Nugent Michael
O Ademuyiwa Adesoji
O Kavanagh Dara
O Larkin John
Oca\uf1a Juan
of Amsterdam University
of Ferrara) University
of Insubria University
of Milan) University
of Surgeons in Training (ASiT) Association
of Surgery) Department
of Washington) University
Okafor Barbara U.
Okechukwu Valentine
Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
Oliveira Ana
OM Abdalla Mutwakil
Omar M Omar
OO Ayorinde John
Osagie-Clouard (Epsom &amp
Osman (Walsall Manor Hospital) Khabab
Ottolina Jessica
Ourieff (Mount Sinai Hospital) Jared
Outani Oumaima
Oyewole Bankole
P Arnaud Alexis
P Arnaud Alexis
P Arnaud Alexis
P Baker Markus
P Belgaumkar Ajay
P Boddy Alexander
P Duffy (Nottingham City Hospital) John
P Evans Jonathan
P Hazelton Joshua
P Jones Andrew
P Jones Robert
P Joyce Doireann
P Kisiel Aaron
P Pezzuto Anna
P Singh Rabindra
P\ue9rez-Gonz\ue1lez Marta
P\ue9rez-Saborido Baltasar
Pacheco-Sanchez David
Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
Pai (Hammersmith Hospital) Madhava
Paiella Salvatore
Paisley (Brighton and Sussex NHS Trust Samuel
Palermo)
Palini Gianmarco
Palmeri Matteo
Parente Alessandro
Parlanti Daniele
Parmar Chetan
Pascual Angela
Pata Francesco
Pata Francesco
Patel Mahul
Pathak Abhijit
Patil Sangram
Pattyn Piet
Peckham- Cooper Adam
Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
Pedrazzani Corrado
Pellino Gianluca
Pereira Andr\ue9
Pereira-Neves Ant\uf3nio
Perez-Diaz Md
Perivoliotis (General University Hospital of Larissa) Konstantinos
Perkins Clare
Perotto (CHU Saint Etienne) Ornella
Perra Teresa
Petrone Patrizio
Phenix George
Piacenza)
Picazo Sara
Picon-Rodriguez Rafael
Piloni Martina
Pingarr\uf3n-Mart\uedn Lorena
Pinotti Enrico
Pizzini Paolo
PM de Vries Jean-Paul
Pockney Peter
Podolsky Dina
Poggioli Gilberto
Pompili Cecilia
Pontari Michael
Porcu Alberto
Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
Potter (Royal Bournemouth Hospital) Ryan
Price Claire
Prita Daliya 8
Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
PTSurg ItSURG
Pujol-Muncunill Roger
Puppo Andrea
Q Mehdi (University of Texas Medical Branch) Mohammad
Quante Markus
Quintana-Villamandos Bego\uf1a
Qureshi Ali
R Burke Joshua
R Davidson Brian
R Dixon Jan
R Fretwell Kenneth
R Gujjuri Rohan
R Gujjuri Rohan
R Kowal Mikolaj
R O\u2019Neill John
R Sarma Diwakar
R Spalding Duncan
R Springford Laurie
Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
Radenkovic Dejan
Rahman Saad (Medway Maritime Hospital) Abdel
Rakvin Ivan
Ramallo-Sol\ueds Irene
Ramcharan Sean
Ramos Diego
Ramos-Bonilla Antonio
Ramos-De la Medina Antonio
Ramzi Joussi
Rathinam Sridhar
Rausa Emanuele
Ravaioli Matteo
Ravindran Sharanya
Raymond (Royal Lancaster Infirmary) Thomas
Razik Aisha
Redfern (Furness General Hospital) Jennifer
Reguera-Rosal Julio
Rey-Biel Juan
Rey-Valcarcel Cristina
RG Sheel Andrea
Ribolla Marta
Richards Tomos
Richmond (University of Maryland Medical Center) Michael
Righini (Ospedale del Delta Erminio
Rio-Gomez Javier
Riuniti Villa Sofia-Cervello Ospedali
Riyat Harjoat
Rizvi Sana
Roberts Keith
Roberts Matthew
Robertson (University Hospitals Coventry and Warwickshire) Stuart
Robertson (University of Arkansas for Medical Sciences) Ronald
Robin-Valle Alvaro
Rochon Melissa
Rojo Mikel
Rolli Luigi
Romano Silvio
Rome)
Romford)
Ross Elizabeth
Ross Howard
Rottoli Matteo
Royal Hospital) Princess
Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
Ruiz- Grande Fernando
Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
Ruzzenente Andrea
Ryska Ondrej
S Abdelaal (Alexandria Main University Hospital) Ahmed
S Al Maadany Faraj
S Faria Carlos
S Hammond John
S Hossain Fahad
S Jeyaretna Deva
S Jones Conor
S Khan (Queen Alexandra Hospital) Jim
S Moura Francisco
S Ng-Kamstra Joshua
S Sica Giuseppe
S Tamimy Muhammad
S Wadley Martin
S\ue1nchez- Arteaga Alejandro
SA Taher Ahmed
Saez Carlos
Sahnan Kapil
Sahni Arun
Salim Ali
Salvia Roberto
Sammarco Giuseppe
Sampaio-Alves Mafalda
San Miguel-Mendez Carlos
Sanchez del Pueblo Cristina
Sanchez-Fuentes Maria-Nieves
Sanchez-Pelaez Daniel
Sanchez-Perez Coral
Sanchez-Rubio Maria
Sancho-Muriel Jorge
Sanchon Fructuoso Lorena
Sanders Julie
Santero-Ramirez Maria-Pilar
Santora Thomas
Santoro Antonio
Santos Irene
Sapienza Paolo
Sartarelli (Sant\u2019Orsola Hospital Lodovico
Sarveswaran Janahan
Sasia Diego
Sassari) A. O. U.
Saudemont Alain
Saudi-Moro Sef
Saxena Dolly
Saxena Shobhit
Sayasneh Ahmad
Scalabre Aurelien
Schache Andrew
Schiavina Riccardo
Schineis (Charit\ue9 University Medicine Christian
Schreckenbach Teresa
Scorza Antonella
Scott Lucy
Seegert (ProMedica Toledo Hospital) Sara
Seguin-Givelet Agathe
Senent-Boza Ana
Serrano Gonz\ue1lez Javier
Sette Laghi Asst
Seymour Keith
Shabana Amanda
Shah (The Whittington Hospital) Sujay
Shah Jigar
Shah Karishma
Shah Preena
Shakir Taner
Shalaby (Mansoura University Hospital) Mostafa
Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
Shaw Richard
Sheffield)
Shehata Sameh
Shelley Hwang E.
Shen Ban Vin
Shenfine Amy
Sheridan Kelda
Sherief Ahmed
Sherif Mohamed
Shinkwin Michael
Shu Sebastian
Siaw-Acheampong Kwabena
Sileri (San Raffaele Scientific Institute Pierpaolo
Singh Abhinav
Singh Shailendra
Sinha Sanjay
Siragusa (Policlinico Tor Vergata Hospital Leandro
Sivaprakasam Rajesh
Sivayoganathan Sriharan
SJ Ledesma Frances
Smillie Robert
Smith (Countess of Chester Hospital) Claire
Smith Andrew
Smith Christopher
Sochorova (Royal Liverpool University Hospital) Dana
Society of Coloproctology (ESCP) European
Society of Colorectal Surgery (SICCR) Italian
Soggiu Fiammetta
Sohrabi (St Bartholomew's Hospital) Catrin
Sohrabi (Whipps Cross University Hospital) Catrin
Sohrabi Catrin
Solari (Royal Gwent Hospital) Francesca
Solli Piergiorgio
Soreide Kjetil
Soto Montesinos Cristina
SpainSurg
Spinelli Antonino
Spinelli Antonino
Spoletini (Sant'Eugenio Hospital) Domenico
Spriano Giuseppe
Sravanam Sanskrithi
Ssentongo (Pennsylvania State University) Paddy
Stanger Sophie
Stavroulias Dionisios
Steel (Sunderland Royal Hospital) Ben
Stella Marco
Stewart Robbie
Stringer Sally
Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
Sulen Nina
Sundar Sudha
Sundhu (Aintree University Hospital) Matthew
Surgical Research Collaborative (ISRC) Irish
Suri (University of California Davis Health Avni
Swansea)
Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
Syed Arooj
Szatmary Peter
T Colonna Emily
T Enjuto Diego
T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
TA Neely David
Tabiri Stephen
Tadross Daniel
Taglietti Lucio
Tansey (Princess Alexandra Hospital) Rosamond
Tartaglia Dario
Tawheed (Endemic Medicine Department Ahmed
Tayeh Salim
Testa Valentina
Tewari Nilanjana
Thoenissen Philipp
Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
Thrush Jessica
Tierney Sean
Tiwari Abhinav
Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
Toledo Enrique
Tonini Valeria
Torkington Jared
Torzilli Guido
Totty Joshua
Tousidonis Manuel
Townend Philip
Townsend Catherine
Trompeter (St George's Hospital) Alex
Trotta Francesco
Truant St\ue9phanie
Trujillo-D\uedaz Jeancarlos
Tsoulfas George
Tsoulfas Georgios
Turco Celia
Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
Turrado- Rodriguez Victor
Turri Giulia
Tustin (Cumberland Infirmary) Harry
Tyler Jayne
Tzedakis Stylianos
Tzovaras George
Ullah Ramzan
Unit\ue0 Sanitaria Locale di Ferrara Azienda
United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
University Hospitals NHS Trust) Nottingham
University of Rome) Sapienza
University) Goethe
University) Helwan
Urban (University of Colorado Hospital) Shane
Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
Usai Antonella
V Bhavaraju Avi
V Comini Lara
V Feo Carlo
V Marino Marco
V Shaw Abigail
V\ue1zquez- Fern\ue1ndez Andrea
Vaccarella (Azienda Ospedaliera Gianpaolo
Valdes- Hernandez Javier
Valsecchi Luca
Vashisht Rajiv
VCO) Asl
Venkatesan (Glan Clwyd Hospital) Gowtham
Vera-Mansilla Cristina
Vergari (Ospedali Riuniti di Ancona) Roberto
Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
Vidya Raghavan
Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
Vijay Vardhini
Vimalachandran Dale
Vimalachandran Dale
Violante Tommaso
Vovola Fernanda
Vulliamy Paul
W Endorf (Hennepin Healthcare) Frederick
W Etchill Eric
W L\uf6ffler Markus
W L\uf6ffler Markus
Wall Rosemary
Wallwork Kate
Ward Alex
Warwick (University Hospital Southampton) David
Waseem Saima
Weaver Helen
Wells Fiona
Wen Jiaxin
West Raha
Whitehall Emma
Wild Laura
Wilkins Alex
Williams Gethin
Williams Matthew
Winnand (University Hospital Aachen) Philipp
Wong (Addenbrooke's Hospital) Ken
Worku (Queen\u2019s Medical Centre Dawit
Wright Naomi
WS Ho (Leeds Teaching Hospitals NHS Trust Michael
WT Ngu Albert
y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
Y Oo (Department of Cardiothoracic Surgery Aung
y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
Y van der Plas Willemijn
Yalamanchili Seema
Yershov (South Warwickshire NHS Foundation Trust) Danylo
Young Richard
Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
Yurttas Can
Zadegan Frederic
Zafar (Northwick Park Hospital) Noman
Zakaria Rasheed
Zambon Martina
Zanini Nicola
ZE Durst Alexander
Zerbib Philippe
Zonta (Ospedale San Biagio Sandro
Publication venue: 'Elsevier BV'
Publication date: 01/01/2020
Field of study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

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Affleck Julia
Agno Sathianathan Ronan
Ahmad Norfaizan
Ahmed Iram
Ainscough Kate
Al Qasim Eman
Al Swaidan Lolowa
Al-Bassam Wisam
Al-Beidh Farah
Al-Beidh Farah
Albert Martin
Alegria Ana
Alexander Brian
Alexander Peter
Allan Angela
Allan Elizabeth
Allen Louise
Allibone Suzanne
Amaro dos Santos Catorze Teodoro
Anderson Tom
Andric Zdravko
Angus Derek
Angus Derek C
Anjum Aisha
Ankert Juliane
Annane Djillali
Annane Djillali
Anstey Matthew
Antcliffe David
Aparicio Christelle
Appelt Peter
Arabi Yaseen
Arabi Yaseen
Arbane Gill
Archer Simon
Aref Noah
Arias Ana-Marie
Arishi Hatim
Arnold Donald
Asghar Adeeba
Ashelford Angela
Attwood Ben
Austin Karen
Aysel Florescu Simin
Azaiz Amine
Babel Jakša
Babio-Galan Maite
Badie Julio
Bagshaw Sean
Baillie Kenneth
Baker Evelyn
Bakthavatsalam Dhanalakshmi
Bamford Peter
Banach Dorota
Bannard-Smith Jonathan
Barbazza Leanne
Barber Russell
Barge Deborah
Barnes Nicky
Baršić Bruno
Bashyal Archana
Basile Kim
Bass Frances
Bates Michelle
Bauchmuller Kris
Bean Sarah
Beane Abigail
Beane Abigail
Beasley Richard
Begin Phillipe
Bellemare David
Benettaib Fatna
Benzekri Dalila
Berdaguer Fernando Daniel
Bergin Colin
Berry Lindsay
Berry Lindsay
Berry Scott
Berry Scott
Bhimani Zahra
Bhimani Zahra
Bihari Shailesh
Bihari Shilesh
Binnie Alexandra
Bion Julian
Biradar Vishwanath
Birch Janine
Birch Jenny
Birchall Katie
Birkinshaw Isobel
Black Ethel
Bloos Frank
Board Jasmin
Bone Allsion
Bonner Stephen
Bonten Marc
Bonten Marc
Borgatta Barbara
Borrill Zoe
Bosch Ziekenhuis Jeroen
Boschert Catherine
Bossard Isabelle
Boumahni Dounia
Bourgoin Charlotte
Bourne Michelle
Bourne Richard
Bouwman Wietske
Bowler Helen
Boyd Craig
Bracke Stephanie
Bradbury Charlotte
Bradbury Charlotte
Bradley-Potts Joanne
Brailsford Jane
Brain Matthew
Brant Emily
Breen Patrick
Brett Stephen
Brewer Chris
Brickell Kathy
Brightling Chris
Brillinger Nicole
Brimfield Lutece
Brinkerhoff Gail
Brochard Laurent
Brohi Farooq
Browne Troy
Brunkhorst Frank
Brunkhorst Frank
Budd Joanna
Buehner Ulrike
Buhr Heidi
Bullman Laetitia
Burns Karen
Burt Karen
Buscher Hergen
Butler Amelia
Butler M
Buxton Meredith
Buxton Meredith
Buzgau Adrian
Byrne Deborah
Byrne Kathleen
Bélteczki János
Cabreros Leilani
Calfee Carolyn
Callender Owen
Campbell Andy
Campbell Hilary
Campbell Lewis
Camsooksai Julie
Caplin Cecile
Carbonneau Elaine
Carmona Flores Rosario
Carr-Knott Lisa
Carrier François Martin
Carrier Marc
Cartner Brittney
Casey Ruth
Casey Siobhan
Castro Ferreira Ricardo Manuel
Cate Heidi
Cathcart Susanne
Cavayas Alexandros
Cawley Kathryn
Cazzola Federica
Centofanti John
Chablani Manish
Chamara Warnapura Loku
Chan Carmen
Chan Charles
Chan Peter
Charlewood Richard
Charron Cyril
Chartier Delphine
Chasse Michael
Chassé Michaël
Chen Yan
Cheng Allen
Cheng Allen C
Cherian Shiney
Cheung Winston
Chhablani Manish
Chudeau Nicolas
Cirstea Emanuel
Clarey Emma
Claridge Helen
Clark Michele
Clark Sarah
Claxton Andrew
Clermont Giles
Cloutier Ève
Coburn Susan
Codreanu Daniel
Coghlan Phoebe
Cole Jade
Coles Holly
Coles Jennifer
Colin Gwenhael
Collier Dawn
Collins Daniel
Collins Emma
Collins Joanne
Connor Jason
Cooke Jill
Cooper Jamie
Cooper Melanie
Cornell Sarah
Cort Jon
Courtin Laura
Cowdrey Keri-Anne
Cowley Nicholas
Cowton Amanda
Coyne Mark
Craner Michelle
Craven Thomas
Creagh-Brown Ben
Crisp Nikki
Croft Maria
Cusack Rebecca
Cutler Sean
Cviljevic Sabina
Cárcel Fernández Sheila
Daly James
Daly Zoe
Daneman Nick
Dark Paul
Darreau Cédric
Dasgin Joanne
Davey Miriam
Davidson Neil
Davies Gwyneth
Davies Louisa
Davies Michelle
Dawda Ashlish
Day Christopher
De Beaux Fiona
De Bus Liesbet
de Courcy-Golder Kim
de Jager P
de Jong Menno
De Jong Menno
de Jonge E
de la Fuente Martos Carmen
de Lima Pereira Tiago Nuno Alfaro
de Man Angelique
De Waele Jan
Dearden Joy
Dechert William
Deelchand Vashish
Dela Rosa Arnold
Dell Amanda
Demetriou Carrie
Depante Maria Theresa
Depuydt Pieter
Dequin PierreFrançois
Derde Lennie
Derde Lennie
Detry Michelle
Detry Michelle
Deye Nicolas
Digby Stephen
Distler Michael
Doble Patricia
Donnelly Adrian
Donnison Phil
Doran Peter
Dragija Lidija
Driscoll Alana
Drummond Andrew
Duan Erick
Duffy Eamon
Duke Graeme
Duncan Tracey
Duplaix Mathilde
Dushianthan Ahilanandan
Dyas Sarah
D’Aragon Frédérick
D’Souza Ramsy
Effelaar Evelien
Elhassan Munzir
Elin Hall Rebecca
Ellis Christine
Elmahi Einas
Elsefi Tarek
English Shane
Estcourt Lise
Estcourt Lise
Estensen Kristen
Everitt Robert
Evers Mirjam
Farahi Neda
Fartoukh Muriel
Faulkner Beverley
Faulkner Maria
Fazekas Ágnes
Felton Tim
Ferguson Niall
Ferguson Susan
Fergusson Dean
Fernández de Pinedo Artaraz Ziortza
Ferrier Janet
Fierens Jan
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Fischer Roy
Fitzgerald Mark
Fitzgerald Mark
Fletcher Simon
Flint Neil
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Forton Daniel
Fortune Louise
Fottrell-Gould Deirdre
Fowler Rob
Fowler Robert
Fox Claire
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Francoeur Charles
Frey Anna
Friedrich Hinrichs Carl
Frohlich Stephen
Fysh Ed
Gallagher Linda Jude
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Garcia Rebecca
Gardiner-Hill Caroline
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Gattas David
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Gendall Emma
Genetu Roman Mary
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Ghamraoui Ali
Ghosh Alison
Gibson Charly
Girard Timothy
Girijadevi Dinu
Gledhill Lisa
Godement Mathieu
Golden David
Goligher Ewan
Gomm Linda
Goodson Jennifer
Goodwin Jayne
Goossens Herman
Goossens Herman
Gopal Shameer
Gopinath Amitha
Gordon Anthony
Gordon Anthony C
Gordon Elizabeth
Gosbell Iain
Gould Richard
Grecu Irina
Green Cameron
Green Cameron
Gregory Jane
Gresha Rebecca
Grimmer Lisa
Grimwade Kate
Guilder E
Guitton Christophe
Hacking Danielle
Hadebe Bernard
Hagel Stefan
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Hall Andrew
Hall Kathryn
Hamilton David Oliver
Hamilton-Davies Colin
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Haniffa Rashan
Haniffa Rashan
Hanson Jane
Harford Rachel
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Hart Ciaran
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Harward Meg
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Hay Sophie Kennedy
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Henning Jeremy
Henry Joanne
Heritier Stephane
Hickey Naomi
Higgins Alisa M
Higgins Lisa
Hill Helen
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Hird Clare
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Hoff Uwe
Hoiting Oscar
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Hope David
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Horvat Christopher
Horvat Christopher
Howcroft Clare
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Huckle Abby
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Hugill Keith
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Hullegie Sebastiaan J
Hulley Amanda
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Hunter Stephanie
Hutter Joanne
Hutton Paula
Innes Richard
Ireland Jane
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Ivatt Helen
Jackson Matthew
Jackson Shane
Jackson Susan
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Janin Pierre
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Jeblaoui Asma
Jeffrey Helen
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Jones Jo
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Karlikowski Michal
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Kruger Peter
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Landais Mickaël
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Lankester Liana
Laver Russell
Lawler Patrick
Lawler Patrick R
Lawless Patrick
Lazaro Juan Martin
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Leblond Julie
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Lesona Eden
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Lewis Roger
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Linstrum Kelsey
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Mart Emma
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McWilliam Stephen
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Menzies Daniel
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Mercier Romain
Meredith Megan
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Millen Tina
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Moore Lorraine
Morel Guillaume
Moreno Cuesta Jeronimo
Morgan Matt
Morpeth Susan
Morris Sheila
Morrison Lynette
Mouncey Paul
Mouncey Paul
Moviat M
Mullan Dee
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Munt Sheila
Murphy Sheenagh
Murray Lauren
Murthy Srinivas
Murthy Srinivas
Music Edvin
Muñoz-Bermúdez Rosana
Mwaura Esther
Myers Erina
Naiker Kevin
Nair Priya
Nay Mai-Anh
Neal Matthew
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Newby Lynette
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Orford Neil
Oritz-Ruiz de Gordoa Laura
Orr Katrina
Oza Deepali
O’Brien Julie
O’Dywer Michael
O’Kane Cecilia
O’Kane Sinéad
O’Malley Laura
O’Neill Aisling
Page Valerie
Paling A
Panwar Rakshit
Paramasivam Elankumaran
Parekh Dhruv
Parke Rachael
Parke Rachael
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Pletz Mathias
Plumb Benjamin
Pogreban Tatiana
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Polderman F
Polgarova Petra
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Pourcine Franck
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Powell Matthew
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Rad Laura
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Rae Nicola
Raithatha Ajay
Ramali Mohamed
Ramanan Mahesh
Ramos Lidia
Randell Georgina
Rauniyar Rashmi
Raymakers Kik
Reddy Amie
Reddy Harsha
Rees Tabitha
Reeve Brenda
Regli Adrian
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Rengers Els
Reschreiter Henrik
Reynolds Claire
Reynolds John
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Richards-Belle Alvin
Ricketts Daniel
Rietveld Ilse
Ristimäki Sanna
Ritzema Carter Jay
Robert Alain
Roberts David
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Robinson Matt
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Roynon-Reed Anna
Rozendaal Wim
Russell Robert
Ryalls Kim
Ryan Lucy
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Salazar Degracia Anna
Salerno Tania
Salet A
Salisbury Sarah
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Salmon Charlotte
Sandhu Gyan
Sanil Ashish
Sanil Ashish
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Santos Filipa
Santos Marlene
Santos Marlene
Saull Michelle
Saunders Christina
Saunders Christina
Schischka Livia
Schneider Francis
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Schuster-Bruce Martin
Schutgens Roger
Schweikert Sacha
Schütze Bianka
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Sellers Katharine
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Senya Ho Jan
Seppelt Ian
Serri Karim
Sever Helena
Seymour Christopher
Seymour Christopher
Shah Asim
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Shaw David
Shaw Joanne
Shearer Audrey
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Shehabi Yahya
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Siami Shidasp
Silversides Jon
Sim Malcolm
Simmonds Catherine
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Simpson Scott
Singh Vanessa
Singleton Jo
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Small Charlotte
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Smith John
Smith Judith
Smith Julie
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Song Rima
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Spittle Nick
Spivey Michael
Stanciu Delia
Stanworth Simon
Sterba Martin
Stevenson Hannah
Stewart Richard
Strzelecka Anna
Sundara Raman Ajay
Sundaran Dhinesh
Sutherland Helen
Sutterlin Laetitia
Sutu Mihaela
Sweet Katie
Szakmany Tamas
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Szőke Viktória
Tallott Mandy
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Templeton Maie
Thomas Amy
Thomas Helen
Thomas Matt
Thomas Matthew
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Thomson Nicola
Thrush Jessica
Tilney Emma
Tinmouth Alan
Tong Steve
Tooley Joe
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Trask Kara
Triulzi Darrell
Trodd Dawn
Tsang Jennifer
Tully Redmond
Turgeon Alexis
Turki Salah
Turner Anne
Turner Anne
Turner-Bone Ian
Turns Margaret
Uddin Ruzena
Udy Andrew
Uyeki Tim
Vaara Suvi
Vahtera Annukka
Vamplew Luke
van Bentum Puijk Wilma
van Bentum-Puijk Wilma
van Bentum-Puijk Wilma
van Beurden Marloes
van de Veerdonk Frank
van de Veerdonk Frank
Van Der Heyden Kym
van der Poll Tom
van’t Hoff Willian
Vates Jennifer
Vautier Sarah
Vazquez-Grande Gloria
Venkatesh Bala
Venkatesh Balasubramanian
Venz Ellen
Verlander Mark
Verrier Nathalie
Victor Saji
Vieillard-Baron Antoine
Voicu Sebastian
Vowell Emma
Vujaklija Brajković Ana
Vuylsteke Alain
Wagh Atul
Walden Andrew
Walker Rachel
Walsh Joanne
Walsh Tim
Walsham James
Ward Kathryn
Warnock Majella
Waterson Sharon
Watkins Claire
Watpool Irene
Watters Malcolm
Waugh Victoria
Webb Steve
Webb Steven A
Wedd Steve
Weismann Dirk
Weissman Alexandra
Wells Colin
Welters Ingeborg
Wetherill Bill
Whelan Ruth
Whileman Amanda
Whitbread Jennifer
White Hayden
White Ian
White Katie
Whitehead Christina
Wibrow Bradley
Wigbers J
Wilby Elizabeth
Wild Laura
Wild Laura
Wilding Laura
Wiley Daisy
Wilhelmsen Elva
Wilkinson Dean
Willams Felicity
Williams Alexandra
Williams Erin
Williams Hannah
Williams Karen
Williams Patricia
Williams Patricia
Williams Penny
Williams Tony
Williams Virginie
Williamson Dawn
Williamson James
Wilson Karen
Wilson Maggie
Wiseman Sophie
Wong Helen
Wood Erica
Wood Hannah
Wood Tracy
Woods Jane
Woods Lindsey
Worner Ruth
Wren Jess
Wren Lynn
Wrey Brown Caroline
Writing Committee for the REMAP-CAP Investigators
Xavier Kugan
Xia Le Tai Charlotte
Yarad Elizabeth
Yates David
Young Chelsea
Young Ian
Young Meredith
Young Paul
Yusuff Hakeem
Zaharia Miahela Florentina
Zaidi Abbas
Zaki Ahmed
Zaman Mohsin
Zammit Claire
Zapalac Marija
Zarychanski Ryan
Zarychanski Ryan
Zhao Xiao Bei
Zinzoni Vanessa
Zitter Letizia
Đimoti Renata
Publication venue: JAMA: Journal of the American Medical Association
Publication date: 06/10/2020
Field of study

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Apollo (Cambridge)

Finishing the euchromatic sequence of the human genome

Author: . Haifeng
. Magner
. Yin
Abbott Scott
Abbott-Ozersky Amanda
Abdellah Zahra
Abouelleil Amr
Abrajano Anne
Adachi Tamami
Adam Catherine
Adams Charles Q.
Adamson Aaron
Adekoya Emmanuel
Adio-Oduola Babajide
Aerts Andrea
Aggarwal Arun
Ahmadi Alireza
Ahmed Shahana
Aimable Matthew
Ainscough Rachael
Ait-Zahra Mostafa
Aizu Tomoyuki
Alcivare Dana
Alegria Michelle
Ali Alla
Ali Johar
Allegria-hartmann Michelle
Alleman Jennifer
Allen Carlana C.
Allen Heather
Allen Nicole R.
Allen Susan
Allen Thaddeus
Almeida Jeff
Almond Claire
Alsbrooks Stephen L.
Altherr Michael R.
Amaratunge Harshinie C.
Ambler Andrew
Ambrose Karen
Ambrose Kerrie
Amemiya Chris
Amico-Keller Gina
Amin Amita G.
Anderson Mechele
Anderson Scott
Anderson Scott
Andora Janice
Andredesz Carol
Andrew Robert
Andrews Dan
Andrews Daniel
Andrews Neil
Andrews Stephanie
Andriese Tim
Anthouard Véronique
Antonarakis Stylianos E.
Anyalebechi Vivian
Aoki Norie
Apostolou Sinoula
Apweiler Eva
Arachchi Harindra
Arai Rie
Arbery Hazel
Arcaina Marlon
Arcaina Terisita
Archer Beth
Arellano Andre
Arellano-Jones Perry
Armbruster Jeff
Armstrong Jon
Arredondo Dilrukshi P.
Arredondo Heather Hope
Artiguenave François
Asakawa Shuichi
Asakawa Teruyo
Ash Gareth
Ashcroft Kevin
Ashurst Jennifer
Ashwell Robert
Ashworth Linda K.
Aslanidis Cara
Asomugha Chinwe O.
Asuncion Lawreen
Atkin Deborah
Atkinson Andrea
Atkinson Barry
Attix Cristina
Attwood John
Aubin Keith
Auger Katherine
Austin Shannon Michelle
Avila Aaron
Avis Terry
Ayele Mulu
Babayan Primo
Babbage Anne
Babbage Sarah
Bach Phil
Bachatsang Pasang
Bacon Joanne
Badri Hummy
Baertsch Robert
Bagguley Claire
Bailey Jonathan
Bajorek Eva
Baker Andrew
Baker Dan
Baker M.
Baker Richard
Bakis Michele
Baldwin Jennifer
Banda Michael
Banerjee Ruby
Bao Jingyue
Bao Qiyu
Bao Weidong
Bao Weidong
Baptiste Pertrice
Barbaria Joseph A.
Barbe Valérie
Bardill Simon
Barker Daniel
Barker Darren
Barker Gary
Barlow Karen
Baron Laurent
Barrett Anika
Bartlett Rebecca
Basham Victoria
Bashman David
Basu Suba
Bateman Alex
Bates Karen
Battles John
Batzer Mark
Baumgart Cornelia
Baumohl Jason
Baynes Caroline
Bayul Tashi
Beall Keith
Beard Lisa
Beard Susan
Beare David
Beasley Alastair
Beasley Helen
Beasley Oliver
Beaucham Leslie
Beaudet Arthur
Beck Alfred
Beck Stephen
Becker Michael
Bell Emma
Bell George I.
Bellard Terell M.
Bellerby Damian
Bellerby Tristram
Belter Edward A., Jr.
Bemrose Richard
Benard Michael Anthony
BenKahla Alia
Benke J
Benner William
Bennett James
Bensasson Douda
Bentley Andrew
Bentley Dan
Bentley David
Berardinis Véronique de
Bercovitz John
Berghoff Amy
Bergmann Anne
Berkowicz Nicolas
Berks Mary
Berks Michael
Bethel Graeme
Beugelsdijk Tony J.
Bhakta Rita
Bhuchar Venita
Bi Shihua
Bian Xuemeng
Bieri Tamberlyn
Bimage Kesha E.
Bird Christine
Birditt Brian
Birney Ewan
Birney Ewan
Birren Bruce
Bissell Helen
Biswalo Kaneza
Bituin Aleksandr
Black Stacey
Blackburne-Maze Suzanne
Blair Jessica Anne
Blakey Sarah
Blanks Tia
Blasiar Darin
Blazej Robert
Blitshsteyn Berta
Blomstrom David B.
Bloom Scott
Bloom Toby
Blumer Heather
Blye Jason
Blyth Peter R.
Blöcker Helmut
Boatright Elizabeth
Boehm John
Boen Juanan
Boguslavskiy Leonid
Bolton Christel
Bolund Lars
Bondoc Marnel
Bonfield James
Bonnett Ralph
Bonnin David
Border Richard
Borowsky Mark
Borzym Katja
Boukhgalter Boris
Bowen Eric
Bradley Amanda
Bradshaw-Cordum Holly
Brady Nicola
Brandriff Brigitte F.
Brannon Wade
Branscomb Elbert
Bray Jason
Bray-Allen Sarah
Brettin Thomas
Bridgeman Anne
Bridgers Michael
Brimhall Angela K.
Brokstein Peter
Brook Jonathan
Brooking Shane
Brottier Philippe
Brown Andrew
Brown Clive
Brown Jacqui
Brown Margaret
Brown Mary
Brown Mary J.
Brown Michael
Brown Nancy C.
Bruce David D.
Bruce Robert
Bruno William J.
Bruskiewich Richard
Bryant Jackie
Bryant Jennifer E.
Bryant Nathaniel P.
Brüls Thomas
Buatsi Delali
Buck David
Buckingham Judith M.
Buckle Veronica
Buczek Donald
Budd Claire
Buhay Christian J.
Bulbul Kerem
Buller Sarah
Bunker Nathan
Burberry Jill
Burch Paula Ellen
Burford Deborah
Burgess Joanne
Burgin Matt
Burkett Carrie E.
Burkhart-Schultz Karolyn
Burrell Kevin L.
Burrill Wayne
Burrows Christine
Burton Christine
Burton John
Butcher Phil
Butler Adam
Butler Jon
Butler Paul
Caenepeel Sean
Cahill Patrick
Cai Tianjing
Cai Zhen
Cairns Murray
Calderon Eliana
Callen David F.
Camarata Jody
Camire David
Camm Nick
Campbell Christopher
Campbell Connie S.
Campbell Evelyn W.
Campbell Mary I.
Campbell Mary L.
Campo Kevin
Canning Bruno
Cao Ting
Cao Yuzhu
Caoile Chenier
Cardenas Faviola
Cardenas Lolo
Cardenas Veronica
Carder Carol
Carder Paul
Carpenter Kelly
Carrano Anthony V.
Carriere Jason
Carter Jason
Carter Kelvin
Carter Nigel
Caruso Lauren
Casias Kristal
Cattolico Laurence
Cavanna Tamara
Cavazos Iracema
Cavazos Sandra R.
Ceasar Heather
Cedroni Maria
Cepeda Mario
Chacko Joseph
Chain Patrick
Chalk Shani
Challacombe Jean F.
Chan Ka
Chan Sheryl N.
Chan Yee Man
Chang Jean L.
Chapman Jarrod
Chapman Joanna
Chapple Jeffrey
Charles Rachel
Chasteen Leslie A.
Chavarria Simeon
Chazaro Bruno
Chen Baoxian
Chen Bin
Chen Chira
Chen Chong
Chen Chong
Chen Chun-Nan
Chen Cong
Chen Ellson
Chen Hsiu-Chuan
Chen Jianlong
Chen Jie
Chen Jin
Chen Junbao
Chen Lihong
Chen Lixia
Chen Ray
Chen Shu
Chen Tong
Chen Xiaoyun
Chen Xinyi
Chen Yanjiong
Chen Yiyu
Chen Zhu
Chen Zhu
Chen Zhu
Cheng Jan-Fang
Cheng Zhihua
Chertkov Olga
Cheshatsang Yama
Chi Cheng
Chi Han C.
Chillingworth Neil
Chin Sylvia
Chinn Corey
Chinwalla Asif
Chissoe Stephanie
Chiu Sally
Chothia Tom
Christensen Mari
Christopoulos Constantine
Chu Joseph
Chui Connie
Chung A
Cinkowsky Michael J.
Citroen Mieke
Clack Rob
Clamp Michele
Clark Anthea
Clark Graham
Clark Kevin
Clark Lynn
Clark Lynn M.
Clark Richard
Clark Sarah
Clark Sue
Clarke Adrian
Clarke Betty
Clarke Eddie
Clarke Kay
Clarke Laura
Clawson Hiram
Clee Chris
Clegg Shelia
Clerc Blankenburg Kerstin Petra
Cleveland David
Clifford Karen
Clifton Sandra W.
Coates Julia
Cobley Victoria
Cockrell Raynard
Coffey Alison
Cofield Jackie
Coggill Penelope
Cohn Judith D.
Colayco Rick
Cole Lotte
Collier Rachael
Collings Simon
Collins Francis S.
Collins John
Collins Philip
Collymore Al
Colman Louise
Combs Jessie
Comstock Robin
Cong Bin
Conner Richard
Connolly Anthony
Connolly Karen
Conquer Jennie
Conrad Ansgar
Conroy Donald
Considine Tony
Constance Doug
Cook April
Cook Leanna
Cooke Patrick
Cooper Jonathan
Cooper Rachel
Cooper Robert
Copeland Alex
Coppola Maria
Copsey Teresa
Corby Nicole
Cordes Matt
Cordray Rebecca
Cornell Christine
Cornell Earl
Cornell Linda
Cornell Ruth
Corum Ben
Cottage Amanda
Cotton Sara
Coulson Alan
Couronne Olivier
Courtney Laura P.
Coville Gez
Cox Anthony
Cox Caroline D.
Cox Tony
Coxhill Robert
Coyle Marcus D.
Craig Matthew
Crane Tom
Crawford Amanda L.
Crawley Matt
Cree Andrew
Crespeau Hervé
Crew Victor
Critchlow Terrance
Critz Paul
Cruaud Corinne
Cuff James
Cui Hongjuan
Cui Jinhui
Cui Peng
Cui Peng
Culley Karl
Cummings Auli
Cummings Kirsti
Cummings Paul
Cummings Stephanie
Cuomo Christina A.
Curran Adam
Curwen Valery
Cutts Jeffrey
Czubayko Martin
D\u27Souza Lisa Marie
Da Silva Corinne
Dai Li
Dalin Eillen
Dang Michelle
Danganan Linda
Daniels Rachael
Dathorne Stephanie R.
Daum Christopher
David Robert
Davidson Lucy
Davidson Stuart
Davies Jonathon
Davies Joy
Davies Nicholas
Davies Robert
Davila Mary Louise
Davis Candi Mon\u27et
Davis Cheryl
Davis Clay
Davis Jayne
Davis John
Davis Matthew
Davy-Carroll Latarsha
Dawoe Tenzin
Dawson Elisabeth
De Anda Claudia
De Latorre Andrea
Deadman Rebecca
Dean Peter
Dear Simon
Dearden Frances
DeArellano Kurt
Deaven Larry I.
Deaven Larry L.
Deere Kerry
DeGray Stewart
Degusta David
Deguzman Maria
Dehal Paramvir
Delgado Marcos
Delgado Oliver
Delhaunty Kimberley
Deloukas Panos
Deng Yajun
Dennis Janet
Denson Shawn
Denys Mirian
Deramo Christine
Desai Anu
Detter John C.
Devlin Laurie
Dewar Ken
Dhami Pawandeep
Dhongsar Chemey
Dias Jennifer
Dias Victoria
Dibartolo Genevieve
Dibling Catherine
Dickson Mark
Diekhans Mark
Dietz-Band Jeanne
Digennaro Richard
Dilts Karen
Dimitrijevic-Bussod Mira
Ding Hao
Ding Keyue
Ding Li
Ding Yan
Dinh Huyen H.
Dixon Kami
Do Long
Dobbs Ruth
Dobson Richard
Dockree Catherine
Doddington Daniel
Dodsworth Steven
Doggett Norman
Doggett Norman A.
Dong Hui
Dong Kimberly
Dong Wei
Dong Wei
Dong Xiaojia
Donlin Jeremy E.
Dooley Kathy
Dooling David
Dorje Passang
Dorjee Kunsang
Dorris Lester
Dorsett Victor
Doucette-Stamm Lynn
Douthwaite Karen J.
Down Thomas
Draper Heather
Du Feiyu
Du Hui
Du Yutao
Duarte Suzanne
Dubchak Inna
Duffy Noah
Dugan-Rocha Shannon
Dunham Andrew
Dunham Ian
Dunn Adam M.
Dunn Anne
Dunn Matthew
Dunwell Erin
Dupes Alan
Durbin Kenneth J.
Durbin Richard
Durham Jillian
Dutta Ireena
Dwyer Ruth
Dyer Lauren
Dziuda Darius
Earnhardt Christopher D.
Earthrowl Mark
Eastham Emma
Eastham Timothy
Eaves Kristy A.
Eckenberg Ralph
Edgar Darren
Edionwe Susan Omwanghe Osayanro
Edwards Carol
Edwards Jennifer
Edwards Karen
Egan Amy
Eichler Evan
Eichler Evan
Ejima Fumio
Elkin Chris
Ellington Andrew
Elliot David
Elliot Glendoria
Elliot Jeffrey
Ellwood Matthew
Emberson Becky
Emelianenko Natalia
Emery-Cohen Alexandra J.
Endrizzi Matthew
Engh Ger van den
Engle David
Erickson Jeffery
Erler Anne Marie
Errington Helen
Escobar Julio
Escotto Michael
Eugene Craig S.
Evans Gareth
Evans John
Evans Katie
Evans Richard
Eveleth Gerald
Eyras Eduardo
Fan Hongyuan
Fan Keke
Fang Jianqiu
Farina Abderrahim
Faro Susan
Faulkner Louisa
Fawcett Joseph J.
Fechtel Kim
Fellingham Charlotte
Felming Claire
Felsenfeld Adam
Feltwell Theresa
Feng Guodong
Feng Haiyan
Feng Jie
Feng Xiaoli
Fennell Stephen
Ferguson Alicia
Fernandez Sonia
Fernandez-Suarez Xose
Fernando Pushpa Ranjani
Ferriera Pat
Fertitta Anne
Fey Jim
Fidel Patrick
Fields Elizabeth
Fink Marie
Finley Maria C.
Finn Robert
Fischer Heather
Fischer Laurice
Fisher Shelia
Fitch Pat
Fitzgerald Mike
Flack Tina
Flagg Nicole
Flanagan J.
Fleming Kerry
Flint Jonathan
Flint Mark
Flowers Dave
Floyd Yvonne
Foley Karen
Folta Peg
Fong Jonathan
Fonknechten Núrua
Footman Simon
Forbes Lisa D.
Ford Amanda F.
Foster Myre J.
Fotopulos Dea
Fourcade Matthew
Fowler John
Fox Jessica
Frame Deborah
Francis Matthew
Francis Stephen
Frankel Ken
Frankish Adam
Frankland John
Fraser Audrey
Fraser David
Frazier Marvin
French Lisa
Fricker David
Fridlyand Jane
Fronick Catrina
Frost Carole
Frost Daniel
Frost Jackie
Frost Lorna
Fu Gang
Fu Gang
Fu Gang
Fu Qiushi
Fujioka Michiru
Fujiyama Asao
Fukawa Rintaro
Fuller Liam
Fuller Sharin
Fullerton Kathryn
Fulton Lucinda A.
Fulton Robert S.
Furey Terrence S.
Furuhashi Mie
Förste Silke
Gabisi Abdul M.
Gage Diane
Gaige Tony
Galgoczy Petra
Gallegos Celsa
Galvez Michael
Gammon Stuart
Gao Anwu
Gao Jimei
Gao Quan
Gao Yang
Gao Yimei
Garcia Carmen
Garcia Emilio
Garcia Marvin
Garcia Ricardo M, III
Garcia-Martinez Antonio
Gardner Alison
Gardner Alison
Garduno Consuelo
Gardyna Steph
Garner Patrick
Garner Toni T.
Garnes Jeffrey A.
Garnett Jane
Garza Melissa
Gatewood Joseph M.
Gatland Leigh
Gatland Lindsay
Gattung Stacie
Gay Laura
Gearin Gary
Gebreyesus Binyam
Gelein Cynthia
Gelpke Maartin
Gench Stephanie L.
Geng Jianing
Georgescu Anca
Geotina Amy
Ghori Jilur
Ghose Sayantan
Gibbs Ben
Gibbs Richard A.
Gibson Diane
Gibson Elizabeth
Gifford Mary
Gil Isaias
Gilbert James
Gilby Lisa
Gill Rachel
Gillet Will
Gillson Christopher
Gilna Paul
Gimmel Verena
Gingrich Jeff
Giovanelli Kira
Glavina Tijana
Glithero Rebecca
Glöckner Gernot
Gnerre Sante
Gnirke Andreas
Gold Darren
Golinveaux Kristen
Gomez Maria
Gong Guanghui
Gong Jinying
Gonzales Eidelyn
Gonzalez Guillermo B.
Gooderham April
Goodstadt Leo
Goodstein David
Goodwin Lynne A.
Gordon Catherine
Gordon Laurie A.
Gordon Seth
Gorton Matthew
Gorvad Ann
Gould Christine
Goyea Ernest
Goyette Audra
Grady Deborah I.
Grady Michelle L.
Grafham Darren
Graham Joe
Grandbois Edward
Grant Jennifer
Grant Michael
Grant Susan
Graves Tina A.
Gray Bruce
Gray Emma
Gray Lain
Green Lisa
Greenhalgh James
Greenhill Joe
Gregg Philippa
Gregory Simon
Grewal Nennu
Gribble Susan
Griffith Jeffrey K.
Griffiths Coline
Griffiths Ed
Griffiths Mark
Griffiths-Jones Sam
Grigoriev Igor
Grimwood Jane
Grocock Russell
Groza Matthew
Gu Jingli
Gu Jun
Gu Jun
Gu Wenyi
Gu Wenyi
Gu Xiaochang
Guan Qiaoning
Guarin Hannibal
Guel Metzalli
Guerra William
Guevara Whitney V.
Gui Qi
Gunaratne Preethi
Gunning Kate
Guo Daorong
Guo Jane
Guo Lili
Gustafson Erik
Guthrie Ian
Guyer Mark
Gwilliam Rhian
Gyaltsen Kunsang
Gyapay Gábor
Görlich Yvonne
Ha Chi
Hafez Nabil
Haglund Krista
Hagopian Daniel
Hagos Birhane
Haim Allen
Hajek Patrick
Hall Brett Lynn
Hall Brittany
Hall Jennifer
Hall Rebekah
Hall-Tamly Gretta
Halls Karen
Hallsworth-Pepin Kym
Hamada Junko
Hamilton Cerissa
Hamilton Keelan A.
Hamilton Matt
Hamlett John
Hamlett John
Hammon Nancy
Hammond Martin
Hammond Sha
Hammond Sian
Hamza Khalid
Han Guiqing
Han Shunsheng
Han Xurong
Hanak Vincent A.
Hancock Julie
Harbes Brandy A.
Harding Adam
Harkins C. Richard
Harley Joanne
Harper David
Harper Georgina
Harper Patrik
Harradence Grant
Harris Anthony
Harrison Charlene-Lou
Harrison Elliot
Harrison Ruth
Hart Elizabeth
Hasegawa Tomoko
Hashimoto Etsuko
Hashimoto Wakako
Hassan Daniel
Hatcher Beath
Hattori Masahira
Haugen Eric
Haussler David
Havlak Paul
Hawes Alicia C.
Hawkins Ebere Sylvia Onyirioha
Hawkins Natalie
Hawkins Trevor
Hawley Kellie
Haydu Lauren
Hayes Kerry
He Fengying
He Jiaying
He Lin
Heaford Andrew
Heath Paul
Heathcott Rosemary
Heilig Roland
Heiner Cheryl
Heinze Ivonne
Heitmann Katja
Helfenbein Keven
Heller Andrew
Hellsten Uffe
Hembry Cathy
Henderson Carl
Henderson Nicholas
Henderson Nina
Hendrix David
Hennig Steffen
Henning Karla
Hepa Victor
Herd Tim
Herman Charles
Hernandez Judith
Hernandez Omar
Herseim Allyson
Hewitt Stephen
Heyen Joshua
Higgs Douglas
Hildebrand Carl E.
Hillier LaDeana
Hillyard Guy
Hines Sandra
Hinkins Russell
Hinrichs Angela S.
Hitchens Matthew Edward
Ho Issac
Ho Sara-Jane
Hodgson Anne V.
Hodgson David
Hoffman Susan M.G.
Hoffs Michael
Hogues Marilyn E.
Holden Jane
Holdgate Janet
Hollaway Mara
Hollins Barbara
Holloway Ele
Holmes Andrea
Holmes Ian
Holmes Sarah
Holroyd Simon
Holtz Ann
Holtzer Caleb
Homsi Deana K.
Homsi Farah J.
Honan Tracy
Hood Leroy
Hooper Alison
Hopewell Lucy
Hopkins Ben
Horne Jennifer
Hornett Gary
Hornischer Klaus
Hornsby Amber
Hornsby Geoff
Hornsby Tony
Horsley Sharon
Horton Roger
Hosage-Norman Catherine
Hosoda Kei
Hosono Katsuhiro
Hosseini Roya
Hou Shunfang
Hou Xiaodi
Houde Nathan
Howard Philip
Howard Stephanie R.
Howden Philip
Howe Kevin
Howell Gareth
Howell Latoya Lynette
Howells Sally Lucinda
Hsu Fan
Hu George
Hu Jie
Hu Songnian
Huang Fang
Huang Guyang
Huang Katherine
Huang Mei
Huang Wayne
Huang Wei
Huang Wei
Huang Wei
Huang Zhengping
Hubbard Timothy
Huber James W.
Huckle Elizabeth
Hue Heather
Hughes Jaime
Hughes Jennifer
Hughes Lee
Hughes-Hull Hillary
Hull Louisa
Hulme Bill
Hulyk Steven
Hume Jennifer
Hummeric Holger
Humphray Sean
Humphries David
Humphries Matthew
Hunt Adrienne
Hunt Michael
Hunt Paul
Hunt Sarah
Hunter Giselle
Hunter Rov, II
Hupman Matt
Huynh Sandy
Hyde David
Hynds Christopher
Idlebird Devincent G.
Iliev Ilian
Imbro Paula
Imo Kelvin C.
Inacio Nicole
Inagaki Naomi
Ince Michael
Ingram Drew
Inoue Shuuji
Isak Amber
Isherwood Judith
Ishibashi Akiko
Ishikawa Sabine K.
Ishizaki Hinako
Isozaki Emi
Israni Sanjay
Ito Fumiaki
Ito Noriko
Itoh Takehiko
Iwakawa Shinobu
Iwatate Mariko
Iwatsu Mikiko
Iyer Vivek
Izatt Janet
Izmajlowicz Monica
Izumiyama Tomohiro
Jacintho Mark
Jackson Laronda R.
Jackson Terri
Jacob Leni Susan
Jaeger Sara
Jaffe David B.
Jahn Niels
Jaklevic Joseph
Jaklevic Michael
James Kent W.
Jareborg Niclas
Jarek Michael
Jassal Bijay
Jeffery Grant
Jeffery Kim
Jeffrey Colin
Jekosch Kerstin
Jenkins Lee
Jett Jamie
Jewett Phillip E.
Jia Jia
Jia Jia
Jia Nan
Jia Xingchang
Jiang Lu
Jiang Yanrui
Jiang Ziyou
Jimenez Alberto
Jin Jian
Jin Yetao
Jin Yongsan
Johansen Tina
Johnson Bennie
Johnson Cheryl
Johnson Christopher
Johnson David
Johnson Douglas
Johnson Genevieve
Johnson Lori
Johnson Mark
Johnson Philip
Johnson Rudy
Johnson Stephanie
Jolivet Angela
Jolley Keith
Jones Abigail
Jones Charlien
Jones Claire
Jones Juliet
Jones Matthew
Jones Michael
Jones Micheil
Jones Myrna D.
Jones Steven
Jong Pieter De
Jordan Yun
Joseph Shirin
Joy Ann
Joy Linsey
Joy Victoria
Joyce Gillian
Jubb Mark
Jung Eugine
Järke Doris
Kadner Kristen
Kagan Ryan
Kahsai Orsalem
Kaida Kaoru
Kale Pat
Kalicki-Veizer Joelle
Kamal Michael
Kamat Asha
Kamholz Sandra
Kana Arnold
Kang Hui
Kang Kelie
Kang Ning
Kapur Hitesh
Karolchik Donna
Karunaratne Kanchi
Kasprzyk Arek
Katayama Takujiro
Kato Takako
Kauer Gerhard
Kaul Rajinder
Kaur Amardeep
Kawagoe Chiharu
Kawasaki Kazuhiko
Kay Michael
Kaye Danielle
Kearney Lyndal
Keefe Damian
Keen Gifford
Keenan Stephen
Kegelmeyer Laura
Kegg Lisa
Kelley Simon
Kells Cristyn
Kelly Shayna P.
Kelly Susan H.
Kershaw Joanna
Kettleborough Ross
Keys David
Khan Arsi
Khan Umer F.
Khan Ziad Mohid
Khine Susu
Khurama Divya
Kidd Cathy
Kierstan Peter
Kieu Alix
Kim Jennifer
Kim Joomyeong
Kim Kyung
Kimball Heather
Kimberley Andrew
Kimura Moe
King Andrew
King Laquisha Monique
King Mary-Clare
Kingsley Simon
Kingswood Colin
Kisamo Haika
Kisner Peter
Kitts Paul
Kiyooka Miho
Klages Sven
Klingle Gillian
Knights Andrew
Kobayashi Mai
Kodira Chinnappa
Kohlberg Sara
Kojima Kazuyasu
Kolbe William
Kong Yi
Korf Ian
Kosiura Anna
Kou Zhaohui
Kovar Christie L.
Krawczyk Marie-Claude
Kremitzki Colin
Kremmidiotis Gabriel
Krogh Anders
Kronmiller Brent
Kruchowski Scott S.
Kube Michael
Kubischta Duane
Kudoh Jun
Kuehl Jennifer
Kuharic Patrick
Kuhn Carol
Kulish Larissa
Kuroki Yoko
Kwan Chinnie
Kyle Amy
LaButti Kurt
Lacombe Anne
Lad Heena
Lafrades Melanie
Lagemann Dorothee
Lai Jianghua
Lai Teresa
Laidlaw Philip
Laing Michael
Laird Gavin
Lam Edward
Lam Marissa
Lama Dawa
Lamar Betty
Lambart Christine
Lamble Ralph
Lamerdin Jane E.
Lander Eric S.
Landers Tom
Langford Cordelia
Lansang Christine
Lao Victoria
Lapidus Alla
Larke Ben
Lato Bernadette
Latreille Phil
Lau Timun
Lawlor Stephanie
Layman Dan
Leal Belita
Leather Sampsa
Lebow Heather
Lee Byung-in
Lee Cherie Jenae
Lee Denise
Lee Hong-Mei
Lee Joon ho
Lee Kenneth
Lee Lisa
Lee Peter
Legall Fitzherbert Henderson, III
Leger Jean Pierre
Lehman Karl
Lehmann Rüdiger
Lehoczky Jessica
Lehrach Hans
Lehvaslaiho Minna
Lei Meng
Lemke Johannes
Lennon Gregory
Leonard Shawn
Leonard Steven
Leongamornlert Daniel
Lesar Kendra
Levan Jaclyn M.
Leversha Margaret
Levine Rosie
Levy Andrew
Levy Michaël
Lewis Doreen
Lewis Ernest K.
Lewis Keith
Lewis Lakeshia C.
Lewis Lora R.
Lewis Tammy
Leyba Tina
Li Changfeng
Li Chenji
Li Eryao
Li Feifei
Li Gang
Li Jane
Li Jiayang
Li Jiayang
Li Jihong
Li Jing
Li Jingfei
Li Jingxiang
Li Li
Li Lili
Li Lin
Li Ming
Li Nan
Li Ran
Li Shengbin
Li Shuangding
Li Shuangli
Li Shuping
Li Shuxia
Li Songgang
Li Tao
Li Wei
Li Zaiping
Li Zhangwan
Lieuallen Kim
Lightning Julia
Lim Meng K.
Lindblad-Toh Kerstin
Lindo Ken
Lindquist K.
Lindsay Sarah
Lindstrom Kirsten
LIne Matthew
Ling Wei
Linkowski Albert
Linsdell Sally
Little Peter
Liu Boyong
Liu Boyong
Liu Cong
Liu Dianwu
Liu Haili
Liu Jing
Liu Jing
Liu Jing Mei
Liu Jun
Liu Kai
Liu Ning
Liu Qian
Liu Siqi
Liu Stephanie
Liu Wei
Liu Wen
Liu Xiaohong
Liu Xinshe
Liu Yanhua
Liu Yannan
Liu Yih-Shin
Liu Yilin
Liu Ying
Liu Yu
Liu Yu
Liu Zhanwei
Liyanage Dhammika
Llewellyn-Silva Crystal
Lloyd Christine
Lloyd David
Lobb Rebecca
Lock Victoria
Lock William
Lodziak Anne
Lokyitsang Tashi
Lokyitsang Yeshi
London Darin
London Pamela
Longden Ian
Longmire Johnathan L.
Lopez Frederick
Lopez John
Lopez Jose
Lopez Lora
Loraine Howard
Lord Rachel
Lorensuhewa Lorna M.
Lou Yunian
Loulseged Hermela
Loveland Jane
Lovell Jamie
Lovett Demetria A.
Lowenstein Michael G.
Lowry Stephen
Lozado Ryan J.
Lu Lingfeng
Lu Tao
Lu Xiuhua
Lu Yongxiang
Lu Yontao T.
Lu Yue
Lucas Robert
Lucas Susan
Lucier Alice
Lucier Raymond L.
Ludeman Thom
Lui Annie
Lundgren Lyndsey
Luo Chunqing
Luo Chunqing
Lv Gang
Lv Gang
Lye Georgina
Lynch Daniel
Löhnert Tschong-Hun
Ma Cheng
Ma Gary
Ma Jiao
Ma Jie
Ma Peter
Ma Qingmei
Ma Xiaohui
Maas Jason
Mabbitt Richard
Macdonald Pendexter
Machrus Migdad
Macht Madison
Macken Catherine A.
MacLean Christine
Madabhushi Ramki
Madu Renita C.
Maeda Hideto
Maglott Donna
Maheshwari Manjula
Mahindartne Mathew
Mahmoodi Venus
Mahnke Ryan
Mailey Brian
Major John
Malfatti Stephanie
Malloy Kevin
Maltbie Mary I.
Mangum Brian
Manning Jonathan
Manohar Chitra
Mapua Patricia
Marabella Dick
Mardis Elaine R.
Mareth David
Mariano Marisa
Marinelli Lisa
Mark Graham A.
Marquis-Homeyer Catherine
Marr Thomas G.
Marra Marco
Marriott Neil
Marrone Anne
Marroquin Christian
Marsden Paul
Marsh Victoria
Martin Christopher
Martin Joel
Martin Kirt
Martin Matthew
Martin Sancha
Martindale Ashley D.
Martinez Diego
Martinez Evangelina
Martinez Michele
Martinka Scott
Maru Kebede
Maruyama Kayo
Maslen Gareth
Mason Debbie
Masood Hadi
Massey Elizabeth
Matsuda Fumihiko
Matsumoto Shuko
Matsushita Yoshitaka
Matthews Charles D.
Matthews Lucy
Matthews Nick
Matthews Paul
Matthews Sterling D.
Mauceli Evan
Maunes Cynthia
Maupin Rachel
Mawhiney Samantha
Maynard Madalynne
McCann Owen
McCarthy Megan
McClay Joseph
McCollum Craig
McConnachie Louise
McCormick Mary Kay
McCready Paula
McDonald Bill
McDonald Louise
McDowall Jennifer
McGhee Tina
McGuire Sarah
McGurn Phil
McKeown Carole
McLaren Stuart
McLay Kirsten
McLean James
McLellan Michael D.
McLeod Michael P.
McMurdo John
McMurray Amanda
McMurray Des
McMurray Kimberly
McMurray Kimberly L.
McNinch Jenny
McPherson John
McPherson John D.
McVicker Graham
McWilliams Natalie
Mead Kelly
Meador Michael G.
Medina Catherine
Mehta Nalini
Meidi Patrick
Meier Elke
Meincke Linda J.
Mejima Mio
Meldrim James
Melsopp Craig
Mendez Sylvia
Meneus Louis
Meng Shanshan
Menuge Noel
Mercado Christian
Mercado George
Mercado Iracema C.
Mercer Simon
Merritt Christina E.
Mesirov Jill P.
Metzker Michael Lee
Meyer Rekha
Meyer Rick
Miah Asab
Michaelis Evelyn
Micklem Gos
Mieczkowski Carl
Mier Maggie
Miguel Trini
Mihalev Atanas
Mihalkanin Danielle
Mihova Tanya
Miles Simon
Mileur Mason W.
Miller Christie
Miller Donald
Miller Nancy
Milne Sarah
Miner George R.
Miner Sheri
Miner Tracie
Minja Emmanuel
Minoshima Shinsei
Minx Patrick J.
Misra Monica
Mistry Dippica
Mistry Shailesh
Mitchell Jake
Mitchell Jeff
Mitchell Teresa
Mitina Sophia
Mitsui Aki
Mitsuyama Susumu
Miyazawa Akemi
Mlenga Val
Mohabbat Farida
Mohabbat Khatera
Mohammadi Maryam
Mohrenweiser Harvey
Molina Christophe
Monforte Joseph
Montemayor Julie
Montgomery Baize
Montgomery Mishelle
Mooney Paul
Moore Madeline
Moore Niki
Moreland Andrea
Morgan Jenna
Morgan Margaret B.
Morita Hiroko
Morris Sidney
Mortimore Beverly
Morton Jerry
Motoyama Ayuko
Mott Richard
Moyzis Robert K.
Mu Feng
Mukherjee Shibani
Mullenger Ian
Mullikin Jim
Mulrain Leon
Munday Brian
Munday Elaine
Mundt Mark O.
Mungall Andy
Munidasa Mala
Munk A. Christine
Munk Christie A.
Munson Glen
Murakami Katsuhiko
Murayama Yuji
Murnane Clare
Murphy Matthew B.
Murphy Michael
Murray Christine
Murray Debra Dianne
Murray Jennifer
Murrell Kerry
Muzny Donna Marie
Myers Alison
Myers Richard
Müller Ines
Nagamine Kentaro
Nagao Syunsuke
Nagaraja R.
Nair Latha
Nair Seema R.
Naka Maho
Nakagawa Masayo
Nakagawa Saori
Nakamura Etsuko
Nakato Eriko
Nanavati Amit N.
Nandkeshwar Richard
Nankervis Colin E.
Naranjo Cleo M.
Nash William
Naylor Jerome
Nazareth Lynne V.
Neal Dearl D.
Negus David
Nelson Catherine
Nelson David O.
Nelson Deborah A.
Nelson Joanne
Nelson Kathryn
Nelson Ward
Nesbitt Ryan
Neunkirch Jennifer
Newes Christian
Newman April
Ng Bee
Ng Terrance
Ngo Robin Ngoc
Nguyen Bao-Viet
Nguyen Christine
Nguyen Cindy
Nguyen Hoa
Nguyen Le-Thu Dinh
Nguyen Lisa
Nguyen Minh
Nguyen Na
Nguyen Natalie M.
Nguyen Ngoc Bich
Nguyen Thu
Nhan Mike
Ni Lin
Niblett David
Nicholson Jonathan
Nickerson Elizabeth
Nickerson Tim
Nicol Robert
Nijjar Sukhjit
Ning Zemin
Nisbet James
Nishida Aki
Niu Yuxin
Niu Yuxin
Nivens Amber
Noguchi Hideki
Nolan Matt
Norbu Chou Dolma
Norbu Nyima
Nordsiek Gabriele
Norris Sarah Louise
Novik Karen
Nowlin Larry
Nusbaum Chad
Nwaokelemeh Ogechi O.
Nwokenkwo Stanley
O\u27Donnell Paula
O\u27Donovan Daniel
O\u27Leary Sinead
O\u27Loughlin Jennifer
O\u27Neill Keith
Obayashi Izumi
Obregon Melissa
Oddone Paola
Oddone Pierre
Oddy Lachlan
Odell Christopher
Ogawara Etsuko
Ogbighele Francess
Oguh Maryann
Ohmori Kyoko
Ohno Saho
Ohta Nao
Ohtsubo Masafumi
Oinn Tom
Okoawo Ose
Okui Michiyo
Okumura Reina
Okwuonu Geoffrey O.
Okwuonu Kenneth C.
Olarnpunsagoon Alisa
Olivas Jason
Oliver Hayley
Oliver Karen
Olsen Anne S.
Olson Maynard V.
Omotosho Bamidele
Onoda Junko
Oomori Nobuhiro
Ooshima Kenshiro
Oragunye Njideka
Orantes Jerry
Orbell Helena
Osada Misuzu
Osborn Anthony
Osborne Joan
Osman Sahal
Ovcharenko Ivan
Overton-Larty Emma
Oviedo Rodolfo J.
Ow David
Ozawa Ritsuko
Ozersky Philip
Pace Araceli C.
Pack Elizabeth
Padki Anuradha
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Pan Sisu
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Parker David Neil
Parker Stephen
Parkin Christopher
Parkin Kim
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Parry-Brown Ginny
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Pasternak Shiran
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Patel Dina
Patel Jalpa N.
Patel Ritesh
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Patrick James
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Paul Shelia
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Peck Anna
Peck Richard
Pedan John
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Peng Vivian
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Peng Yi
Peng Ze
Peng Ze
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Pennacchio Len A.
Percy Chantel
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Perez Lesette M.
Perito Andrew
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Perrier Rene
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Un Chun
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White P. Scott
White Scott P.
White Simon
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Whittaker Adam
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Whittaker Pamela
Wickremasinghe Manosha I.
Widaa Sara
Wiegel Sarah
Wild Anna
Wilkinson Jane
Wilkinson Jane
Wilkinson Paul
Willey David
Williams Albert L.
Williams Andy
Williams Bill
Williams Gabrielle A.
Williams Leanne
Williamson Angela L.
Williamson Helen
Wills Patricia L.
Wills Richard
Wilmer Tamsin
Wilming Laurens
Wilson Brian
Wilson Gareth
Wilson Margaret
Wilson Nyree
Wilson Piers
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Wilson Siobhan
Wilson Steve
Wilson Wendy
Wincker Patrick
Window Philip
Winster Jenny
Winzar Claire
Witt James
Wleczyk Regina
Wobus Fred
Woessner Jeffrey
Wohldmann Patty
Wollard Jessica
Womack Andrew W.
Wong Benjamin
Wong Gane K-S
Wood Diane
Wood Emma
Wood Joe
Wooden Hailey S.
Wooden Steven H.
Woodeson Sharon
Woodfine Kathryn
Woodmansey Rebecca
Woods Eric
Woodwark Cara
Wooster Richard
Worley Kim Carlyle
Woyke Tanja
Wray Matthew
Wray Paul
Wright Charmain
Wright Debbie
Wright Kathrine
Wright Kristin
Wright Rita A.
Wu Chungen
Wu Dongying
Wu Jiaqian
Wu Jung-Rung
Wu Kevin
Wu Qingfa
Wu Qingfa
Wu Ruiming
Wu Xiao
Wu Xiaojing
Wu Zaining
Wyatt Julia
Wycoff-Montenegro Melissa
Wylie Kris
Wyman Dudley
Wyman Stacia
Xi Yan
Xi Yingying
Xie Fei
Xie Gary
Xie Jane
Xiong Hui
Xiong Yuqing
Xu Alex
Xu Jing
Xu Jing
Xu Ruqin
Xu Shuhua
Xu Wei
Xu Xinlai
Xu Yan
Xu Yuning
Xu Zhihong
Xu Zuyuan
Xuan Yali
Xuan Zhenyu
Xue Rui
Yada Tetsushi
Yadav Shailendra
Yakub Syed
Yamamoto Lynn
Yamamoto Noriko
Yamamoto Yuko
Yamashita Yasue
Yamazaki Satoru
Yang Hao
Yang Huanming
Yang Huanming
Yang Joan
Yang Shiaw-Pyng
Yang Shudong
Yang Xiaonan
Yang Xiaonan
Yang Xiaoping
Yang Yongkui
Yano Candance
Yao Zhijian
Yao Zhijian
Yaspo Marie-Laure
Ye Chen
Yeager Shane
Yeh Mimi
Yen Jennifer
Yeshitela Rahel Retta
Yoakum Martin
Yokobata Kathy
Yokoyama Jennifer
Yonezawa Miho
Yoon Lillienne
Yoon Vivienne
Yoshida Satoru
You Bo
Young Geneva
Young Louise
Young Shelia
Younger Ruth
Yu Bing
Yu Charles
Yu Fuli
Yu Jun
Yu Jun
Yu Jun
Yuan Kaiwen
Yuan Ye
Yuan Yida
Yue Shujie
Yumae Brian
Yun Rui
Zainoun Joanne
Zembeck Lisa
Zeng Yixin
Zhai Dong
Zhan Guoping
Zhang Bo
Zhang Caimin
Zhang Fengmei
Zhang Guangyu
Zhang Guohua
Zhang Guohua
Zhang Haiqing
Zhang Haiqing
Zhang Haiqing
Zhang Hongbo
Zhang Hongbo
Zhang Jingjing
Zhang Jingjing
Zhang Jingkun
Zhang Jiuchun
Zhang Jiuchun
Zhang Lanzhi
Zhang Li
Zhang Li
Zhang Meihua
Zhang Meng
Zhang Ming
Zhang Qing
Zhang Ruhua
Zhang Shaojie
Zhang Tiezhen
Zhang Wei
Zhang Wei
Zhang Xianglin
Zhang Xianglin
Zhang Xiaoliang
Zhang Xiuqing
Zhang Yan
Zhang Yi
Zhang Yilin
Zhang Yilin
Zhang Ying
Zhang Yuansen
Zhang Yuzhi
Zhang Zhengdong
Zhao Hongmei
Zhao Lijian
Zhao Shenru
Zhao Zhijing
Zhen Zhicheng
Zheng Haibo
Zhong Ming
Zhou Carol
Zhou Haixia
Zhou Jianling
Zhou Nannan
Zhou Xinfeng
Zhou Yan
Zhou Yang
Zhou Yi
Zhu Bingying
Zhu Bofeng
Zhu Fenghua
Zhu Genfeng
Zhu Genfeng
Zhu Miao
Zhu Ning
Zhu Yongge
Zhu Zhen
Zhuang Shitao
Zierten Deborah
Zimmer Andrew
Zody Michael C.
Zollo Massimo
Zorrilla Sara E.
Zuo Lin
Publication venue: LSU Digital Commons
Publication date: 21/10/2004
Field of study

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Louisiana State University

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Author: Aamir Ayesha
Abdelbadiee Sherif
Abdullah Saad
Abiola Oluwatosin O.
Abras Ahmed
Abu Emmy
Abu-Arafeh Hashem
Achara Amaka
Adam Muhammad
Adams Lawrence A. T.
Adams Phillipa
Aggarwal Nisha
Ahmad Asim
Ahmad Sarah
Ahmed Bilquis
Ahmed Hamza
Ahmed Jabed
Ahmed Rohan
Ain Qurrat Ul
Akintade Olugbenro
Alareed Ahmad
Alhadadi Baraa
Ali Jawad
Allain Theresa J.
Allen James
Alsahab Mustafa
Amarnani Raj
Amin Zarah
Anderson Clementine
Andrusca Ana
Annamalai Arunkumar
Ansell Matthew
Appiah-Odame Paapa
Arkle Thomas
Ashton Caroline
Astaire Emma
Austin Keziah
Babar Laxmi
Babb Laura
Bahsoon Farrah
Baillie Jonathan
Baldwin Jack B. G.
Ball Katie
Bargaoanu Imola
Barlow Ciaran
Baron Alexander
Basker Karthik
Batho Rachel
Bazaraa Amr
Bedi Simran
Beeley Laura J.
Beharry Karen
Behbahani Abolfazl
Behbahani Ayoub
Bei Zhao Xiao
Bell Charlotte
Bertagne Marc
Berwick L.
Beveridge Louise
Bhakta Shiv
Bhat Ganapathy
Bhattacharya Saurav
Bhatti Jamal
Bilton Edward
Blair Mairi
Bowden Helen
Bowen Emily
Bowman Mark A.
Box Emma
Bremakumar Sanojan
Briggs Laura
Broadhurst Karen
Brown Harriet
Browne Marylin
Bryant Catherine
Bullock Stuart
Bultynck Celine
Burton Jenni K.
Bygate Rachael
Byravan Swetha
Caines Laurence
Cairns Christopher
Cameron Ewen
Campbell Angela
Capek Eileen
Carter Sammy
Cavaliere Chiara
Chai Chung Sien
Chamberlain Helen
Chamboult Aimee-Louise
Champion Jennifer
Chapman George
Cheah Khai L.
Cheema Anum
Chevolleau Jasmine
Chilton Angharad
Chourot Christian
Christie Lorna
Christodoulides Natasha
Chuter Charlotte
Clayton Victoria
Cleaver Sarah L.
Clements Hollie A.
Coffey Farah
Cohen Samuel
Connell Laura
Connor Louise
Cook Alan
Cooper Freya
Cooper Olivia
Copeland Claire
Cox Natalie
Cricklow Tamsin
Croft Paul
Crofts Jodie
Cummings Laura
Cunningham Emma L.
Currie Hannah
Cushen Claire
Dama Sindhoora
Darko Sandra
Davies Rhianna
Davies-Morris Jayne
Davis Daniel
De Mucha Pedro Vila
Deacon Elizabeth
Debrah Kwasi
Deosaran Jordanna
Dhillon Amber
Doherty Cal
Dove James
Dovey Julie
Drozdowska Bogna
Durcan Rory
Durrant Sabrina K.
Edwards Sarah
Einarsson Alice
Elliott Emma
Elliott Marianne
Ellis Elizabeth J.
Enfield-Bance Amy
Evans Elizabeth
Evans Jenny
Evans Olivia
Evans Sarah
Faheem Waleed
Fancourt Sarah
Farah Rinata
Faruq Sana
Fenneley Grace
Ferguson Eilidh E. C.
Fergusson Niall
Ferreira Ana Silva
Fisken Emma
Foster Kate
Fraser Debbie
Frewen John
Furmedge Daniel
Gallagher Michael
Gaskell Natalie
Gaunt Victoria
Gaywood James
Giblin Eleanor
Giddings Jane
Giet Leeying
Giles Alexis
Giridharan Kumudhini
Glasser Martin
Glasser Martin
Gluck Ilan
Goujon Marie
Govindji Suriti
Grange Robert
Greaves Isabel
Green Jessica
Gregory Jemma
Griffiths Eliza
Grundmann Natalie
Gui Jonathan
Gupta Abhishek
Gurung Sneha
Hackett Beth
Haddad Nedaa
Haley Michael
Hall Giles
Hall Susan A.
Handley Olivia
Harbinson Alexander
Harkin Teresa
Hart Jasmine
Hayat Yasmeen
Headlam John
Healy Roisin
Henderson Neil
Henderson Sarah
Herbert Fiona
Hindley Esther
Hodhody Ghazal
Hoffman Katrin
Holmes Elizabeth A. M.
Horner Sarah
Hornsby Alex
Horton Robbie
Houldershaw Katie
House Shannelle
Hughes Clare
Hunt Clare
Hunt William
Hunter Elisabeth
Hussain Ambreen
Hussain Zainab
Ibanichuka Jacqueline
Ikhwan Wan Idoracaera C.
Ingamells Nathan
Iqbal Shoaib
Irvine James
Irwin Sophie J.
Iwu Chioma
Jackson Peter
Jackson Peter
Jackson Thomas A.
Jacques Holly
Jagdeo Sarah
Jakupaj Adriana
Janagal Sureena
Jatti Puja
Jay Emma
Jelley Benjamin
Jenkin Rodric
Jewell Emilia
Jones Howell T.
Jones Karen
Jones Laura
Jones Polly
Kabia Angela
Kadir Ismail
Kalyaani Vickneswaran
Kantczak Ada
Katz-Summercorn Charles
Kay Aaron
Kearney Matthew
Kelly Dominic
Khalid Abdullah B.
Khambay Ethan
Khan Ali
Khan Asma
Khizar Bushra
Khor Ming
Kiani Mahum
King Rachel
Kirrane Kimberley
Konda Nagarjun
Koshedo Sejlo
Krishan Anjli
Kuek Dorothy K. C.
Kumar Anusha
Kumbun Gary
Kunaselan Lleika
Lai Jo
Large Jamie
Laud Rose
Layton Georgia R.
Le Poideven Andre
Leah Eleanor
Lee Helena
Lee Tammy
Leishman Felicity
Lewis Anna
Lim Su Kwan
Lim Vee Han
Livesey Joanna
Lochlainn Mary Ni
Lonsdale-Eccles Elizabeth
Love Ryan
Lowes Olivia
Lucocq James E.
Lyon Emily
MacCuish Annabel Hentall
Macdonald Fiona E.
Macharouthu Ajay
Mackenzie Eilidh R.
Macrae Victoria
Madden Katy F.
Magill Laura
Mahmood Al Wakkass
Majid Zeinab
Makin Stephen
Mani Shama
Marshall John
Masoli Jane
Matheswaran Yathu
Matthews Natasha R.
Matthews Stephanie A.
Mayor Kara
Mazzoleni Antonella
McCauley Hannah
McClean Adam
McClelland Sarah B.
McCluskey Heather J.
McCluskey Lauren
McCormack Roisin
McCormack Vincent
McCready Jack
McCulloch Alison
McDonald Helen
McErlean Catherine M.
McGonigal Gerry
McKay Siobhan
McKeown William
McNicholas Emily
McQuillan Alex
McShane David
Menezes Reema
Meyer Caitlin
Miller Christopher J.
Miller Hazel
Millichamp Katie
Millner Helen
Mills Sam
Mishra Pranav
Mishra Rajeev
Mitchell Oliver
Mithrakumar Pryankaran
Moad Mohammad
Mohammedseid-Nurhussien Awolkhier
Moore Emily
Moore Kirsty
Moorey Hannah
Morgan Bethan
Morgan Hannah
Morrison Kirty
Morrow Abbie
Morrow Olivia
Mosley Alice
Mukundan Maya
Mullarkey Emma
Mumtaz Emma
Murphy-Ackroyd Emily
Murray Adam A.
Murthy Seema
Mustafa Zeeshan
Naeem Fariha
Nagumantry Shonit
Naish George
Nandra Taran
Naqvi Huma
Nashed Nader
Ng Liji
Ngan Esther E. Y.
Nicholls Isabelle
Nightingale Peter
Nneamaka Asiodu
Noble Jane
Norman Emma
Nwabufor Philip
Nynaes Olga
Obi Ijeoma T.
Offer Megan
Ofoche Gladys
Ostrowski Caroline
O’shea Kate
Page Valerie
Pailing Adam
Pang Norman
Parkinson Megan
Parry Frances
Parry Sarah
Patel Minal D.
Patel Riana
Patterson Katherine
Peck George
Pendleton Hannah
Perry Rita
Pettler Sophie
Pinkney Thomas
Pope Leo
Porter Lucy
Porter-Bent Sasha
Poynton Jack
Prasad Vishnu
Prendergast Emma L.
Pullen Rosamund
Pyc Wioletta
Quinn Sinead
Quinn Terrence
Radoja Stephanie
Rai Nisha
Ramakrishna Sharan
Rashid Shayan
Rayner Helen
Raza Mahrukh
Reay Anna
Reidm James
Rice Caroline
Richardson Sarah
Rickard Frances
Rimmer Lucy
Robinson Hannah J.
Robson Richard
Ronan Lindsay
Rose Emily C.
Ross Anekea
Rutter Steve
Ryan Aidan
Sahnan Kapil
Saliu David
Sami Fadi
Sampson Elizabeth L.
San Moe Su Su
Sarma Dhruv
Satharasinghe Lahiru
Scarlett Danielle
Scott Deborah
Sehmbi Gurpreet
Sen Michael
Seymour Elaine
Shah Hussun-Ara
Shahid Muhammad
Shakeel Sohail
Shaw Megan E.
Shepherd Alison
Sloan Gerrard W.
Smith Abigail
Smith Gemma M.
Smith Nina
Speed James
Sprosen Charles
Stambollouian Katharine
Stapley Simon M.
Stirling Adam
Stratton Emma
Straughan Jacqui
Studley Mark
Subhan Zahid
Sundara Srividya
Swietoslawski Adam
Syed Nihaad
Tan Felicia
Tantam Kate
Taranu Roxana
Taylor Abigail
Taylor Emily
Taylor Jemima
Taylor Joanne
Taylor-Rowan Martin
Tencheva Ani
Tetlow Simon
Thake Miriam
Thayabaran Darmiga
Thomas Philip
Thyn Thyn
Timperley Alex
Tinson Guy
Todd Oliver
Torsney Kelli
Traill Philippa K.
Treml Jonathan
Tse Connie
Tumi Ebrahiem
Turton Sophie
Tyagi Bhavyas
Usmani Kasim
Valentine Janine
Vardon Henry
Varghese Jessel
Vasudev Ashish
Vedutla Tarunya
Velusamy Karthika
Venkat Shabnam
Virk Jasmine
Visvaratnam Parrthiepan
Wahballa Afnan
Walker Amy
Walter Amy
Waraich Hana
Warwicker Sarah
Watson Hannah
Watt Nicola
Webb Hannah
Welch Carly
Wheeler Alice
Whyte Lindsay
Wilcockson James
Wilkes Claire
Williamson Emily
Williamson Katherine
Willott Ruth
Wilson Daisy
Wilson Daisy
Wilson Darcy S.
Wilson Faye
Wilson Joseph B.
Wilson Michael S. J.
Winearls Stuart
Wong Li
Wong Ting W.
Woodman Hannah
Woodward Beth L.
Wrathall Abigail
Wright Emily
Wright Sophie
Wu Chenxian
Wu Edward
Wynne Luke
Yap Zhi Jiun
Young Lesley J.
Yule Ollie
Yunus Aayenah
Publication venue: Springer
Publication date: 01/04/2023
Field of study

Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

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