CSI-Microbes-identification

<p>CSI-Microbes-identification (v1.0.0) with PathSeq database files for reproducibility. </p&gt

ruppinlab/CSI-Microbes-analysis with intermediate files needed for reproducibility

<p>CSI-Microbes-analysis (v1.0.0) with intermediate files (generated by CSI-Microbes-identification) for reproducibility. This code reproduces figures from the bioRxiv paper "scRNA-seq analysis of colon and esophageal tumors uncovers abundant microbial reads in myeloid cells undergoing proinflammatory transcriptional alterations".</p&gt

Ecomorphology of plesiosaur flipper geometry

The Plesiosauria is an extinct group of marine reptiles once common in mesozoic seas. Previous work on plesiosaur hunting styles has suggested that short-necked, large-headed animals were pursuit predators, whereas long-necked, small-headed animals were ambush predators. This study presents new data on the aspect ratios (ARs) of plesiosaur flippers, and interprets these data via comparison with AR in birds, bats and aircraft. Performance trade-offs implicit in AR variation are well-understood in the context of aircraft design, and these trade-offs have direct ecomorphological analogues in birds and bats. Knowledge of these trade-offs allows interpretation of variation in plesiosaur AR. By analogy, short-necked taxa were specialized for manoeuvrability and pursuit, whereas long-necked taxa were generally specialized for efficiency and cruising. These interpretations agree with previous assessments of maximum swimming speed

No contribution of lifestyle and environmental exposures to gender discrepancy of liver disease severity in chronic hepatitis b infection: Observations from the Haimen City cohort.

BACKGROUND:Previous studies have noted significant gender difference in the risk of liver cancer among hepatitis B chronic infection patients. Some indicated that it might be due to lifestyle-related differences. This paper tests whether or not such a gender discrepancy among the chronic hepatitis B population is confounded by lifestyle and environment related exposures. METHODS:We retrieved a sample of 1863 participants from a prospective cohort in Haimen City, China in 2003. Liver disease severity was categorized as "normal", "mild", "moderate", and "severe" based on a clinical diagnosis. Lifestyle and environmental exposures were measured by questionnaires. We used factor analysis and individual variables to represent lifestyle and environmental exposures. We applied the cumulative logit models to estimate the effect of gender on liver disease severity and how it was impacted by lifestyle and environmental exposures. RESULTS:Gender and HBeAg positivity were independent risk factors for more severe liver disease. Compared to females, males were 2.08 times as likely to develop more severe liver disease (95% CI: 1.66-2.61). Participants who were HBeAg positivite were 2.19 times (95% CI: 1.61-2.96) as likely to develop more severe liver disease compared to those who were negative. Controlling for lifestyle and environmental exposures did not change these estimations. CONCLUSIONS:Males in the HBV infected population have an increased risk of severe liver disease. This gender effect is independent of the lifestyle and environmental exposures addressed in this study. Our findings support the hypothesis that gender discrepancies in HCC risk are attributable to intrinsic differences between males and females