95 research outputs found
Ultrasound-responsive gene-activated matrices (GAMs) for osteogenic gene therapy using matrix-assisted sonoporation (MAS)
Direct imaging of extra-solar planets in star forming regions: Lessons learned from a false positive around IM Lup
Most exoplanet imagers consist of ground-based adaptive optics coronagraphic
cameras which are currently limited in contrast, sensitivity and astrometric
precision, but advantageously observe in the near-IR (1- 5{\mu}m). Because of
these practical limitations, our current observational aim at detecting and
characterizing planets puts heavy constraints on target selection, observing
strategies, data reduction, and follow-up. Most surveys so far have thus
targeted young systems (1-100Myr) to catch the putative remnant thermal
radiation of giant planets, which peaks in the near-IR. They also favor systems
in the solar neighborhood (d<80pc), which eases angular resolution requirements
but also ensures a good knowledge of the distance and proper motion, which are
critical to secure the planet status, and enable subsequent characterization.
Because of their youth, it is very tempting to target the nearby star forming
regions, which are typically twice as far as the bulk of objects usually combed
for planets by direct imaging. Probing these interesting reservoirs sets
additional constraints that we review in this paper by presenting the planet
search that we initiated in 2008 around the disk-bearing T Tauri star IM Lup
(Lupus star forming region, 140-190pc). We show and discuss why age
determination, the choice of evolutionary model for the central star and the
planet, precise knowledge of the host star proper motion, relative or absolute
astrometric accuracy, and patience are the key ingredients for exoplanet
searches around more distant young stars. Unfortunately, most of the time,
precision and perseverance are not paying off: we discovered a candidate
companion around IM Lup in 2008, which we report here to be an unbound
background object. We nevertheless review in details the lessons learned from
our endeavor, and additionally present the best detection limits ever
calculated for IM Lup.Comment: 8 pages, 3 figures, 3 tables, accepted to A&
Unveiling the Structure of Pre-Transitional Disks
In the past few years, several disks with inner holes that are empty of small
dust grains have been detected and are known as transitional disks. Recently,
Spitzer has identified a new class of "pre-transitional disks" with gaps; these
objects have an optically thick inner disk separated from an optically thick
outer disk by an optically thin disk gap. A near-infrared spectrum provided the
first confirmation of a gap in the pre-transitional disk of LkCa 15 by
verifying that the near-infrared excess emission in this object was due to an
optically thick inner disk. Here we investigate the difference between the
nature of the inner regions of transitional and pre-transitional disks using
the same veiling-based technique to extract the near-infrared excess emission
above the stellar photosphere. We show that the near-infrared excess emission
of the previously identified pre-transitional disks of LkCa 15 and UX Tau A in
Taurus as well as the newly identified pre-transitional disk of ROX 44 in
Ophiuchus can be fit with an inner disk wall located at the dust destruction
radius. We also model the broad-band SEDs of these objects, taking into account
the effect of shadowing by the inner disk on the outer disk, considering the
finite size of the star. The near-infrared excess continua of these three
pre-transitional disks, which can be explained by optically thick inner disks,
are significantly different from that of the transitional disks of GM Aur,
whose near-infrared excess continuum can be reproduced by emission from
sub-micron-sized optically thin dust, and DM Tau, whose near-infrared spectrum
is consistent with a disk hole that is relatively free of small dust. The
structure of pre-transitional disks may be a sign of young planets forming in
these disks and future studies of pre-transitional disks will provide
constraints to aid in theoretical modeling of planet formation.Comment: Accepted for publication in ApJ on May 10, 2010; 29 page
Spatial and Spectral Coherent Control with Frequency Combs
Quantum coherent control (1-3) is a powerful tool for steering the outcome of
quantum processes towards a desired final state, by accurate manipulation of
quantum interference between multiple pathways. Although coherent control
techniques have found applications in many fields of science (4-9), the
possibilities for spatial and high-resolution frequency control have remained
limited. Here, we show that the use of counter-propagating broadband pulses
enables the generation of fully controlled spatial excitation patterns. This
spatial control approach also provides decoherence reduction, which allows the
use of the high frequency resolution of an optical frequency comb (10,11). We
exploit the counter-propagating geometry to perform spatially selective
excitation of individual species in a multi-component gas mixture, as well as
frequency determination of hyperfine constants of atomic rubidium with
unprecedented accuracy. The combination of spectral and spatial coherent
control adds a new dimension to coherent control with applications in e.g
nonlinear spectroscopy, microscopy and high-precision frequency metrology.Comment: 12 page
International variation in survival after out-of-hospital cardiac arrest : A validation study of the Utstein template
Introduction: Out-of-hospital cardiac arrest (OHCA) survival varies greatly between communities. The Utstein template was developed and promulgated to improve the comparability of OHCA outcome reports, but it has undergone limited empiric validation. We sought to assess how much of the variation in OHCA survival between emergency medical services (EMS) across the globe is explained by differences in the Utstein factors. We also assessed how accurately the Utstein factors predict OHCA survival. Methods: We performed a retrospective analysis of patient-level prospectively collected data from 12 OHCA registries from 12 countries for the period 1 Jan 2006 through 31 Dec 2011. We used generalized linear mixed models to examine the variation in survival between EMS agencies (n = 232). Results: Twelve registries contributed 86,759 cases. Patient arrest characteristics, EMS treatment and patient outcomes varied across registries. Overall survival to hospital discharge was 10% (range, 6% to 22%). Overall survival with Cerebral Performance Category of 1 or 2 (available for 8/12 registries) was 8%(range, 2% to 20%). The area-under-the-curve for the Utstein model was 0.85 (Wald CI: 0.85-0.85). The Utstein factors explained 51% of the EMS agency variation in OHCA survival. Conclusions: The Utstein factors explained 51%. of the variation in survival to hospital discharge among multiple large geographically separate EMS agencies. This suggests that quality improvement and public health efforts should continue to target modifiable Utstein factors to improve OHCA survival. Further study is required to identify the reasons for the variation that is incompletely understood.Peer reviewe
Optical and infrared flares from a transient Galactic soft gamma-ray repeater
Soft gamma-ray repeaters (SGRs) are a rare type of gamma-ray transient
sources that are ocasionally detected as bursts in the high-energy sky. They
are thought to be produced by magnetars, young neutron stars with very strong
magnetic fields of the order of 10^(14-15) G. Only three such objects are known
in our Galaxy, and a fourth one is associated with the supernova remnant N49 in
the Large Magellanic Cloud. In none of these cases has an optical counterpart
to either the gamma-ray flares or the quiescent source been identified. Here we
present multi-wavelength observations of a puzzling source, SWIFT
J195509+261406, for which we detected more than 40 flaring episodes in the
optical band over a time span of 3 days, plus a faint infrared flare 11 days
later, after which it returned to quiescence. We propose that SWIFT
J195509+261406 is a member of a subgroup of SGRs for which the long-term X-ray
emission is transient in nature. Furthermore, it is the first SGR for which
bursts have been detected in the optical and near-infrared bands and maybe the
link between the "persistent" SGRs and the dim isolated neutron stars.Comment: Version submitted to Nature on 31 Jan 2008. A substantially revised
version of this work has been published in Nature, vol. 455 issue 7212 pp
506-509 under the title "Flares from a Galactic magnetar suggest a missing
link to dim isolated neutron stars
Tissue engineering of functional articular cartilage: the current status
Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The results of joint-preserving treatment protocols such as debridement, mosaicplasty, perichondrium transplantation and autologous chondrocyte implantation vary largely and the average long-term result is unsatisfactory. One reason for limited clinical success is that most treatments require new cartilage to be formed at the site of a defect. However, the mechanical conditions at such sites are unfavorable for repair of the original damaged cartilage. Therefore, it is unlikely that healthy cartilage would form at these locations. The most promising method to circumvent this problem is to engineer mechanically stable cartilage ex vivo and to implant that into the damaged tissue area. This review outlines the issues related to the composition and functionality of tissue-engineered cartilage. In particular, the focus will be on the parameters cell source, signaling molecules, scaffolds and mechanical stimulation. In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its functionality
HIGH-RESOLUTION SUBMILLIMETER AND NEAR-INFRARED STUDIES OF THE TRANSITION DISK AROUND Sz 91
Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy
We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan- 1,3-dione. The molecule is a Γ-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (Β±160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (Β±10 ps) followed by decay (Β±390 ps) to the corresponding ground state. Β© 2015 Author(s)1561sciescopu
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