Results in liver transplantation using grafts from donors after controlled circulatory death: a single-center experience comparing donor grafts harvested after controlled circulatory death to those harvested after brain death

[Abstract] Background: In recent years, interest in donation after cardiac death (DCD) has increased. Although DCD liver transplantation (LT) has demonstrated satisfactory long-term outcomes, different studies have shown poorer patient and graft survival after DCD than after donation after brain death (DBD). This study aimed to evaluate the results of LT using controlled DCD (cDCD) donors, specifically the incidence of primary non-function and ischemic cholangiopathy (IC), and to compare these results with those of LT using DBD in the same time period. Methods: Between June 2012 and July 2018, we performed 66 transplants using cDCD and 258 with DBD grafts. Results: The incidence of IC was similar in both groups (2% in DBD, 1.5% in DCD; P = .999). No significant differences were found for overall graft and patient survival rates between the groups at 1 and 2 years post-transplantation. Conclusions: This study provided evidence that cDCD donors exhibit excellent graft and patient survival outcomes. When the warm ischemia time is <30 minutes and cold ischemia time is <6 hours, the graft and patient survival rates and the incidence of IC in DCD are similar to those in DBD, even when using donors without age restrictions

Datos químico-oceanográficos de la Ría de Pontevedra en invierno. Parte II

Se presentan los resultados de luminosidad, clorofilas y materia orgánica particulada obtenidos en la Ría de Pontevedra en un estudio integral realizado en invierno de 1980. En base a los datos obtenidos se pueden apreciar en dicha Ría tres zonas bien diferenciadas: la parte más interna que presenta poca transparencia y un contenido bajo en clorofilas debido a la alta carga contaminante que incide sobre ella, una segunda zona con valores intermedios y la más externa que tiende a características oceánico-costeras.The results of the analyses of transparency, chlorophyll and particulate organic matter (P.O.M.) in winter 1980 in the Ría de Pontevedra are presented. From the data three different parts in the Ría are differenciated, the inner part with low levels of transparency and chlorophyll due to contaminant load; the medium, with intermediate values, and the external part with characteristics corresponding to coastal shelf waters.Versión del editor0,000

POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas

Background: Mutations in the POT1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas (CAS). However, the link between long telomeres and tumorigenesis is poorly understood. Methods and Results: Here, we have studied the somatic landscape of 3 different angiosarcoma patients with mutations in the POT1 gene to further investigate this tumorigenesis process. In addition, the genetic landscape of 7 CAS patients without mutations in the POT1 gene has been studied. Patients with CAS and nonfunctional POT1 did not repress ATR (ataxia telangiectasia RAD3-related)-dependent DNA damage signaling and showed a constitutive increase of cell cycle arrest and somatic activating mutations in the VEGF (vascular endothelial growth factor)/angiogenesis pathway (KDR gene). The same observation was made in POT1 mutation carriers with tumors different from CAS and also in CAS patients without mutations in the POT1 gene but with mutations in other genes involved in DNA damage signaling. Conclusions: Inhibition of POT1 function and damage-response malfunction activated DNA damage signaling and increased cell cycle arrest as well as interfered with apoptosis, which would permit acquisition of somatic mutations in the VEGF/angiogenesis pathway that drives tumor formation. Therapies based on the inhibition of damage signaling in asymptomatic carriers may diminish defects on cell cycle arrest and thus prevent the apoptosis deregulation that leads to the acquisition of driver mutations

Sickness presenteeism in Spanish-born and immigrant workers in Spain

<p>Abstract</p> <p><b>Background</b></p> <p>Previous studies have shown that immigrant workers face relatively worse working and employment conditions, as well as lower rates of sickness absence than native-born workers. This study aims to assess rates of sickness presenteeism in a sample of Spanish-born and foreign-born workers according to different characteristics.</p> <p>Methods</p> <p>A cross-sectional survey was conducted amongst a convenience sample of workers (Spanish-born and foreign-born), living in four Spanish cities: Barcelona, Huelva, Madrid and Valencia (2008-2009). Sickness presenteeism information was collected through two items in the questionnaire ("Have you had health problems in the last year?" and "Have you ever had to miss work for any health problem?") and was defined as worker who had a health problem (answered yes, first item) and had not missed work (answered no, second item). For the analysis, the sample of 2,059 workers (1,617 foreign-born) who answered yes to health problems was included. After descriptives, logistic regressions were used to establish the association between origin country and sickness presenteeism (adjusted odds ratios aOR; 95% confidence interval 95%CI). Analyses were stratified per time spent in Spain among foreign-born workers.</p> <p>Results</p> <p>All of the results refer to the comparison between foreign-born and Spanish-born workers as a whole, and in some categories relating to personal and occupational conditions. Foreign-born workers were more likely to report sickness presenteeism compared with their Spanish-born counterparts, especially those living in Spain for under 2 years [Prevalence: 42% in Spanish-born and 56.3% in Foreign-born; aOR 1.77 95%CI 1.24-2.53]. In case of foreign-born workers (with time in Spain < 2 years), men [aOR 2.31 95%CI 1.40-3.80], those with university studies [aOR 3.01 95%CI 1.04-8.69], temporary contracts [aOR 2.26 95%CI 1.29-3.98] and salaries between 751-1,200€ per month [aOR 1.74 95% CI 1.04-2.92] were more likely to report sickness presenteeism. Also, recent immigrants with good self-perceived health and good mental health were more likely to report presenteeism than Spanish-born workers with the same good health indicators.</p> <p>Conclusions</p> <p>Immigrant workers report more sickness presenteeism than their Spanish-born counterparts. These results could be related to precarious work and employment conditions of immigrants. Immigrant workers should benefit from the same standards of social security, and of health and safety in the workplace that are enjoyed by Spanish workers.</p

Clinical relevance of timing of assessment of ICU mortality in patients with moderate-to-severe Acute Respiratory Distress Syndrome

Mortality is a frequently reported outcome in clinical studies of acute respiratory distress syndrome (ARDS). However, timing of mortality assessment has not been well characterized. We aimed to identify a crossing-point between cumulative survival and death in the intensive care unit (ICU) of patients with moderate-to-severe ARDS, beyond which the number of survivors would exceed the number of deaths. We hypothesized that this intersection would occur earlier in a successful clinical trial vs. observational studies of moderate/severe ARDS and predict treatment response. We conducted an ancillary study of 1580 patients with moderate-to-severe ARDS managed with lung-protective ventilation to assess the relevance and timing of measuring ICU mortality rates at different time-points during ICU stay. First, we analyzed 1303 patients from four multicenter, observational cohorts enrolling consecutive patients with moderate/severe ARDS. We assessed cumulative ICU survival from the time of moderate/severe ARDS diagnosis to ventilatory support discontinuation within 7-days, 28-days, 60-days, and at ICU discharge. Then, we compared these findings to those of a successful randomized trial of 277 moderate/severe ARDS patients. In the observational cohorts, ICU mortality (487/1303, 37.4%) and 28-day mortality (425/1102, 38.6%) were similar (p = 0.549). Cumulative proportion of ICU survivors and non-survivors crossed at day-7; after day-7, the number of ICU survivors was progressively higher compared to non-survivors. Measures of oxygenation, lung mechanics, and severity scores were different between survivors and non-survivors at each point-in-time (p < 0.001). In the trial cohort, the cumulative proportion of survivors and non-survivors in the treatment group crossed before day-3 after diagnosis of moderate/severe ARDS. In clinical ARDS studies, 28-day mortality closely approximates and may be used as a surrogate for ICU mortality. For patients with moderate-to-severe ARDS, ICU mortality assessment within the first week of a trial might be an early predictor of treatment response

Reseñas de libros

Granero Martín, Francisco. Agua y ciudad, Análisis de estratégias y procesos de planificación. Quince a diecinueve (Por José Mª Gentil Baldrich), pp. 4-5.-- Parra Bañón, José Joaquín. Pensamiento arquitectónico na obra de José Saramago. Acerca da arquitectura da casa (Por José Mª Gentil Baldrich) pp. 5-6.-- Gentil Baldrich, ]osep María, Yanguas Álvarez de Toledo, Ana. Rito V Fiesta: Una aproximación a la arquitectura efímera sevillana (Por Javier García-Gutiérrez Mosteiro) pp. 7-8.-- Puebla Pons, Juan. La plástica del espacio (Por Josep Maria Montaner y Joan Fontbernat) pp. 8.-- Gómez-Blanco Pontes, Antonio J. Dibujar Granada. La Gran Vía de Colón Por Joaquín Casado de Amezúa) pp.9.-- Almagro Gorbea, Antonio. Levantamiento arquitectónico (Por Joaquín Casado de Amezúa) pp.9-10.-- Villalobos Alonso, Daniel. Hasta los pies del Himalaya. Cuaderno de dibujos de Viaje (Por Fernando Linares García) pp. 10-11.-- Fernández Martín,J.J., et. al. Las ruinas de Dios. Arquitectura olvidada en la provincia de Valladolid (Por Fernando Linares García) pp.11.12.-- Delgado Yanes, Magali y Redondo Domínguez, Ernest, Dibujo a mano alzada para arquitectos (Por Lluís Villanueva Bartrina) pp.13-14.-- Edición digital del libro de actas del IX Congreso EGA pp.14.-- Costa Buján, Pablo y Franco Taboada, José Antonio. Análisis gráfico y propuestas de intervención en puertos de Galicia pp.15.-- Franco Taboada, José Antonio, Tarrío Carrodeguas, Santiago. El conjunto catedralicio de Tuy.Documentación Gráfica pp.16.-- Solana Suárez, Enrique, et. al. Crisis del barrio tradicional: ruptura, mutación o continuidad (Por Luis Doreste Chirino) pp.17.-- Bellido Blanco, D. Santiago. El río Duero. Influencia del entorno natural en la conformación del paisaje humanizado pp.18-19.-- Higón Calvet, José Luis. Contribuciones al estudio del asoleo geométrico. Procedimientos para el cálculo del factor de obstrucción solar. Aplicaciones p.19-20.-- Linares Garcia, Fernando. La arquitectura de las Brañas de Somiedo -Asturias- pp.20-21.-- Martínez Ivars, Carlos Salvador. El dibujo arquitectónico en la construcción de la ciudad de Alicante: Del derribo de las murallas a los años treinta pp.21-22.-- Gutiérrez Labory, Eisa Ma. Le Corbusier, el control geométrico matemático de la forma pp22.-- Martín-González Armingol, Manuel. Mies van Der Rohe: Recursos expresivos y elementos arquitectónicos, a través de los archivos depositados en el Museo de Arte Moderno de New York pp.23-24.-- Mata Botella, Elena. El análisis gráfico de la casa pp.24-27.-- Los pabellones españoles en las exposiciones universales e internacionales a partir de 1937 pp.27.-- El ininterrumpido dibujar de Javier Seguí (Por Javier García-Gutiérrez Mosteiro) pp.28.29.-- X Congreso Internacional de Expresión Gráfica Arquitectónica (por Joaquín Casado de Amezúa, Antonio Gómez-Blanco Pontes) pp.29.-- IV Jornadas de Fotogrametría Arquitectónica (Por Jesús San José Alonso) pp.30.-- Dibujos del Alcázar de Sevilla (Por José A. Ruiz de la Rosa) pp.30-31.-- Miguel García Lisón (Por Juan Puebla Pons) pp.32.-- Cándido Orts Bayarri (Por Rafael Contel Comenge) pp.32.-- José Ignacio González Moreno (Por Carmen García Reig) pp.33.-- Julio Vidaurre Jofre (Por Enrique Rabasa Díaz) pp.33.-- Santiago Roqueta (Por Javier Monedero) pp.34Gentil Baldrich, JM.; García- Gutiérrez Mosteiro, J.; Montaner, JM.; Fontbernat, J.; Casado De Amezúa, J.; Linares García, F.; Villanueva Bartrina, L.... (2005). Reseñas de libros. EGA Expresión Gráfica Arquitectónica. 10(10):4-35. https://doi.org/10.4995/ega.2005.10327OJS435101

Reseñas de libros

Carrasca Hortal, José y Millán Gómez, Antonio. La Estructura Gótica Catalana. Sobre los conceptos de media y espacio. El problema de la forma en la cubierta (Por Antonio Millán) pp. 4.-- Verd Herrero, Antonio. Dibujo del natural. Manual de texto docente universitario (Por Antonio Verd) pp.5-6.-- Caninva, Luigi. L'Architettura romana (Por Carlos de San Antonio Gómez) pp.6-7.-- Villalobos Alonso, Daniel. La mirada de Fisac (Por Alberto Grijalba Bengoetxea)pp.8.-- Jiménez Martín, Alfonso et al. La catedral gótica de Sevilla. Fundación y fábrica de la obra nueva (Por Enrique Rabasa Díaz) pp.8-9.-- García-Gutiérrez Mosteiro, Javier. Narciso Pascual y Colomer (1808-1870). Arquitecto del Madrid isabelino (Por Enrique Rabasa Díaz) pp.9-10.-- Valladolid. Bellido Blanco, Santiago. Cuaderno de apuntes (Por Fernando Lmares García) pp.10-11.-- Lopez-Peláez, José Manuel. Maestros cercanos de un arquitecto (Por Javier García-Gutiérrez Masteiro) pp.12.-- Garcia Bueno, Antonio. Dibujando la Alhambra (Por Joaquín Casado de Amezúa Vázquez) pp.13-14.-- Chías Navarro, Pilar y Abad Balboa, Tomás. Eduardo Torroja. Obras y proyectos (Por Jorge Llopis Verdú) pp.14-15.-- Gómez i Serrano, Josep y Font, Juan. La forma de la Villa de Madrid. Soporte gráfico para la información histórica de la ciudad (Por Jorge Llopis Verdú) pp.15-16.-- Nagore, Fernando. Geometría métrica y descriptiva para arquitectos (Por José Antonio Ruiz de le Rosa) pp.16-17.-- Rabasa Diaz, Enrique y el Centro de los Oficios de LeónGuía práctica de la estereotomía de la piedra (Por José CalvoLópez) pp.18-19.-- Hernández Iviartinez, Ascensión. La clonación arquitectónica (Por José Joaquín Parra 8añón) pp.20-21.-- Gentil Baldrich, José María y Yanguas Álvarez de Toledo, Ana. Fernando Barquín y Barón Joaquín Barquín y Barón Imágenes de su archivo en los fondos FIDAS (Por José Manuel Pala) pp.21-22.-- Escoda Pastor, Carmen. El magnetismo del lugar en la arquitectura pp.23.-- Herrero Vázquez, Eduardo Alejandro. Compases de mano, compases de ojo: la Geometrización de la Realidad según Laussedat (POr Adrien Javary) pp.24-25.-- Castaño Perea, Enrique. Arquitectura y música: Policoralidad en la Capilla Real del Alcázar de Madrid pp.25-26.-- Piquer Cases, Juan Carlos. Los modelos digitales en la arquitectura, desarrollo del proyecto e investigación patrimonial. Palacio Real de Valencia (1239-1810): análisis y reconstrucción virtual sobre la planta de Vicente Gascó de 1761 (Por Juan Carlos Piquer Cases) pp.26-28.-- Pérez Naya, Antonia. Arquitectura del silencio y la memoria. Análisis de los cementerios de la Costa da Morte gallega (Por JAfT) pp. 28-29.-- Falcón Meraz, José Manuel. La expresión de una línea museística singular (Por Juan Puebla) pp.29-30.-- 11Seminario Internacional "Color en el Diseño y la Arquitectura" pp.32.-- Taller de Pintura con Antonio López E.T.S. de Pamplona, septiembre de 2006 y 2007 (Por Inmacu/ada .liméne: Cabal/ero) pp.32-35.-- Arquitectura y autopsia: análisis gráficos de algunos restos de la inexistente Universidad laboral de Sevilla (Por José Joaquín Parra Bañón) pp.36-37Milán Gómez, A.; Verd Herrero, A.; De San Antonio Gomez, JC.; Grijalba Bengoetxea, A.; Rabasa Díaz, E.; Linares García, F.; García-Gutiérrez Mosteiro, J.... (2008). Reseñas de libros. EGA Expresión Gráfica Arquitectónica. 13(13):4-37. https://doi.org/10.4995/ega.2008.10266OJS437131

Clinical Predictors of Hyperperfusion Syndrome Following Carotid Stenting: Results From a National Prospective Multicenter Study

[Objectives] The aim of the HISPANIAS (HyperperfusIon Syndrome Post-carotid ANgIoplasty And Stenting) study was to define CHS rates and develop a clinical predictive model for cerebral hyperperfusion syndrome (CHS) after carotid artery stenting (CAS).[Background] CHS is a severe complication following CAS. The presence of clinical manifestations is estimated on the basis of retrospective reviews and is still uncertain.[Methods] The HISPANIAS study was a national prospective multicenter study with 14 recruiting hospitals. CHS was classified as mild (headache only) and moderate-severe (seizure, impaired level of consciousness, or development of focal neurological signs).[Results] A total of 757 CAS procedures were performed. CHS occurred in 22 (2.9%) patients, in which 16 (2.1%) had moderate-severe CHS and 6 (0.8%) had mild CHS (only headache). The rate of hemorrhages was 0.7% and was associated with high mortality (20%). Pre-operative predictors of moderate-severe CHS in multivariate analysis were female sex (odds ratio [OR]: 3.24; 95% confidence interval [CI]: 1.11 to 9.47; p = 0.03), older patients (OR: 1.09; 95% CI: 1.01 to 1.17; p = 0.02), left carotid artery treated (OR: 4.13; 95% CI: 1.11 to 15.40; p = 0.03), and chronic renal failure (OR: 6.29; 95% CI: 1.75 to 22.57; p = 0.005). The area under the curve of this clinical and radiological model was 0.86 (95% CI: 0.81 to 0.92; p = 0.001).[Conclusions] The rate of CHS in the HISPANIAS study was 2.9%, with moderate-severe CHS of 2.1%. CHS was independently associated with female sex, older age, history of chronic kidney disease, and a treated left carotid artery. Although further investigations are needed, the authors propose a model to identify high-risk patients and develop strategies to decrease CHS morbidity and mortality in the future.This study was supported by a Spanish grant from the Instituto de Salud Carlos III (ISCIII-FIS IP14/00971, 2014–2017). The ITRIBIS project has the registration number REGPOT-2013-1. Cooperative Cerebrovascular Disease Research Network (INVICTUS+) (RD16/0019/0015). Dr. Mancha is supported by a Río Hortega contract (CM16/00015). Abbott and Grifols have partial financial supported the conduction of the HISPANIAS project but had no role in the design of the study, interpretation of the data, or manuscript approval.Peer reviewe

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field