Oficinas com adolescentes do MST: sexualidade, diversidade sexual e gênero

O objetivo do presente artigo é apresentar as oficinas sobre sexualidade, diversidade sexual e gênero, realizadas em uma escola de agroeocologia do Movimento dos Trabalhadores Rurais Sem Terra (MST). Participaram 36 adolescentes e jovens, com idade entre 15 e 24 anos, da mesma turma do curso de agroecologia. A demanda que nos foi endereçada, tanto pelos educandos como pela coordenação da escola, foi trabalhar com o tema sexualidade. Realizamos 15 encontros semanais no ano de 2015, com 2 horas de duração, com os seguintes temas geradores: gênero e relacionamentos abusivos, diversidade sexual, infecções sexualmente transmissíveis e métodos contraceptivos. As técnicas utilizadas foram variadas: dinâmicas de grupo, mitos e verdades, exibição e discussão de filmes (curtas e longas). Nas oficinas, trabalhamos de uma forma dinâmica, esclarecendo dúvidas, proporcionando experiências e situações que estimulassem a reflexão e a expressão de vivências, para superar o enfoque do binômio saúde-doença

Doença de Parkinson, exercício físico e qualidade de vida: uma revisão / Parkinson's disease, exercise and quality of life: a review

A Doença de Parkinson é caracterizada como uma doença neurológica crônica, degenerativa e progressiva que acomete o sistema motor. A doença de Parkinson ainda não tem cura. O tratamento pode ser feito de forma medicamentosa, por meio do uso de fármacos, cirurgias e tratamentos adjuvantes que se constitui por exercício físico associado a fisioterapia. A prática regular de exercício físico tem sido fundamental para amenizar ou retardar o aparecimento dos sintomas e garantir independência para os parkinsonianos. Desta forma, este estudo objetivou analisar os benefícios proporcionados pelo exercício físico aos indivíduos com doença de Parkinson. Trata-se de uma revisão integrativa da literatura, com buscas realizadas nas bases de dados SciELO, Lilacs e Medline. Os descritores utilizados foram “doença de Parkinson”, “exercício físico” e “qualidade de vida”, utilizou-se como critérios de inclusão, artigos publicados no período de 2000 a 2020 e trabalhos completos. Os principais benefícios promovidos pelo exercício físico relatados foram melhora da marcha, equilíbrio, flexibilidade e mobilidade funcional. 

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Measurement of associated W plus charm production in pp collisions at √s=7 TeV

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CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Funder: Breast Cancer Now (BCN); doi: https://doi.org/10.13039/100009794Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265Funder: U.S. Department of Health & Human Services | National Institutes of Health (NIH)Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2009-223175, HEALTH-F2-2009-223175Funder: Genome Canada (Génome Canada); doi: https://doi.org/10.13039/100008762Funder: Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada); doi: https://doi.org/10.13039/501100000024Funder: Quebec Breast cancer Foundation Genome QuebecFunder: U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM); doi: https://doi.org/10.13039/100000092Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))Funder: European Union’s Horizon 2020Funder: Deutsche Krebshilfe (German Cancer Aid); doi: https://doi.org/10.13039/501100005972Funder: BCAST - European Union’s Horizon 2020Funder: Breast Cancer Now; doi: https://doi.org/10.13039/501100007913Abstract: Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10–18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10–8). Conclusions: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women

OFICINA COM ADOLESCENTES DO MST: PRECONCEITO E CONVIVÊNCIA COLETIVA

Apesar de todas as conquistas dos movimentos sociais no que se refere à educação do campo, as crianças e jovens do Movimento dos Trabalhadores Rurais Sem-Terra (MST) vivenciam situações de preconceito por sua pertença, quando estudam em escolas não vinculadas ao movimento, vivencias que os marcam profundamente. O preconceito pela pertença ao MST que vem a se somar a diversos outros, foi o tema demandado para ser trabalhado em nosso projeto de extensão, realizado em uma escola técnica de agroecologia fruto de uma parceria entre o MST e o Instituto Federal Tecnológico do Paraná (ITFPR). Os participantes do projeto foram adolescentes e jovens, com idades que variam entre 15 e 24 anos, sete são do sexo feminino e os demais do sexo masculino, todos oriundos de acampamentos e assentamentos da reforma agrária. A metodologia adotada no trabalho foi a realização de oficinas com o tema principal “preconceito e convivência coletiva” e os seguintes temas geradores: possibilidades e limites frente às diferenças, preconceito e empatia, empatia e comunicação, preconceito racial e bullying. Foram realizados oito encontros semanais, com duração de 2 h. Concluímos que a metodologia das oficinas se mostrou efetiva ao ir além dos aspectos educativos/informativos, abarcando e trabalhando com os significados afetivos, os sentimentos e as vivências, proporcionando espaço para a fala, a reflexão e a elaboração, tanto individual como coletiva. Além de potencializar o contexto favorável a formação humana que o MST construiu ao longo da sua existência.Palavras-chave: Oficina; adolescentes, MST

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Objective. Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods. Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results. We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 034, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions. rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers. (C) 2015 Elsevier Inc. All rights reserved.Peer reviewe