The Stuttering Poet: A Deleuzian Reading of a Laforguian Poetics

This article explores the complex relationship between the yankee, the Impressionist and the minoritarian in Laforgue's work and suggests that Deleuze's notions of the minor and of stuttering, and his analysis of the characteristics of Anglo-American writing, are particularly pertinent to our understanding of Laforgue's poetics. There is a nineteenth-century context for the minor, but there is a danger that we capitulate to a ‘majoritarian’ criticism if we too quickly espouse lines of filiation. The article constructs an account of Laforgue's developing perception of, and relationship with, verse prosody by examining how he scumbles the outlines and activity of syllables, how he pushes line-structure into a terrain vague, how he re-orientates accent towards the qualitative and tunes the acoustic to Hartmann's Unconscious. His uses of the imperative and infinitive, and their associated punctuations, are related to his responses to Impressionism. The argument ends with reflections on Deleuzian becoming in Laforgue

Introduction: Multimodal Anthropology and the Politics of Invention

This essay and the articles included in this special issue theorize the possibilities – and pitfalls – that emerge as anthropologists utilise a combination of audio, video, text, still images, performance methodologies, and web platforms to iteratively, collaboratively, and sensually generate relations with research participants, interdisciplinary colleagues and beyond. We are not necessarily interested in developing multimedia approaches to representing or disseminating anthropological knowledge – rather, we are concerned with how multimodality may contribute to a politics of invention for the discipline. We argue that multimodality offers a line of flight for an anthropology yet to come: multi-sensorial rather than text-based, performative rather than representational, and inventive rather than descriptive. This reimagined anthropology requires a move away from established forms of authorship, representation and academic publishing towards projects that experiment with unanticipated forms, collaborations, audiences and correspondences – including questioning what the open in Open Access should signify, as Anand Pandian (2018) has compellingly argued. As importantly, a focus on multimodality and invention invites a reconsideration of the pedagogy of anthropology – both in the sense of what gets formally taught within the disciplinary canon, and in relation to the manifold ways of teaching and learning together that emerge during fieldwork, not always made visible, and which exceed the textual and conceptual domain. Indeed, we use multimodality and invention to refer to the multiple ways of doing ethnography - and the resulting multiple anthropologies - that create ways of knowing and learning together differently. In the essay that follows we offer several provocations that multimodality and invention produce with regards to pedagogy, publication, and collaboration – which are picked up in novel ways in each of the articles included as part of this collection. Our essay is not meant as an enclosure, or a boundary, but rather a framing – that is, a point of view or an orientation to the multiple questions that emerge in each of the essays, where the respective anthropologists rethink engagement, form, and purpose in their ethnographic endeavours. We draw from John Jackson Jr. to argue that framing is at once “a gesture toward contextualization (a conceptual framing of the relevant issues) and a singular impression captured in time (as in the presentation of a framed painting or the relative irreducibility of a film or video still)”. Taking Jackson Jr.’s second point to heart, we offer this introductory essay as a still image by which to see with and through the ethnographic engagements of others. In this still image, the concepts of multimodality and invention are unpacked and interrogated in ways we hope offer an alternative way to think about ethnography and anthropological theory in a moment where the discipline is grappling with how to find ways to engage more effectively with the increasingly fractured and precarious worlds we inhabit

Mobile Asteroid Surface Scout (MASCOT) - Design, Development and Delivery of a Small Asteroid Lander Aboard Hayabusa2

MASCOT is a small asteroid lander launched on December 3rd, 2014, aboard the Japanese HAYABUSA2 asteroid sample-return mission towards the 980 m diameter C-type near-Earth asteroid (162173) 1999 JU3. MASCOT carries four full-scale asteroid science instruments and an uprighting and relocation device within a shoebox-sized 10 kg spacecraft; a complete lander comparable in mass and volume to a medium-sized science instrument on interplanetary missions. Asteroid surface science will be obtained by: MicrOmega, a hyperspectral near- to mid-infrared soil microscope provided by IAS; MASCAM, a wide-angle Si CMOS camera with multicolour LED illumination unit; MARA, a multichannel thermal infrared surface radiometer; the magnetometer, MASMAG, provided by the Technical University of Braunschweig. Further information on the conditions at or near the lander‘s surfaces is generated as a byproduct of attitude sensors and other system sensors. MASCOT uses a highly integrated, ultra-lightweight truss-frame structure made from a CFRP-foam sandwich. It has three internal mechanisms: a preload release mechanism, to release the structural preload applied for launch across the separation mechanism interface; a separation mechanism, to realize the ejection of MASCOT from the semi-recessed stowed position within HAYABUSA2; and the mobility mechanism, for uprighting and hopping. MASCOT uses semi-passive thermal control with Multi-Layer Insulation, two heatpipes and a radiator for heat rejection during operational phases, and heaters for thermal control of the battery and the main electronics during cruise. MASCOT is powered by a primary battery during its on-asteroid operational phase, but supplied by HAYABUSA2 during cruise for check-out and calibration operations as well as thermal control. All housekeeping and scientific data is transmitted to Earth via a relay link with the HAYABUSA2 main-spacecraft, also during cruise operations. The link uses redundant omnidirectional UHF-Band transceivers and patch antennae on the lander. The MASCOT On-Board Computer is a redundant system providing data storage, instrument interfacing, command and data handling, as well as autonomous surface operation functions. Knowledge of the lander’s attitude on the asteroid is key to the success of its uprighting and hopping function. The attitude is determined by a threefold set of sensors: optical distance sensors, photo electric cells and thermal sensors. A range of experimental sensors is also carried. MASCOT was build by the German Aerospace Center, DLR, with contributions from the French space agency, CNES. The system design, science instruments, and operational concept of MASCOT will be presented, with sidenotes on the development of the mission and its integration with HAYABUSA2

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Alzheimer’s disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals—16,036 AD cases and 16,522 controls. Next to variants in TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Additionally, the rare-variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential drivers of respective AD-genome-wide association study loci. Variants associated with the strongest effect on AD risk, in particular loss-of-function variants, are enriched in early-onset AD cases. Our results provide additional evidence for a major role for amyloid-β precursor protein processing, amyloid-β aggregation, lipid metabolism and microglial function in AD

Co-inertie de deux variables aléatoires hilbertiennes et approximation B-spline application en foresterie

International audienc

Calipso não se consolava com a partida de Ulisses: a ilha da igualdade Calypso could not get over the departure of Ulysses: an isle of equality

Quando, em 1987, Jacques Rancière publicou O mestre ignorante, de Joseph Jacotot, o método universal de emancipação intelectual e o aprendizado de leitura sem mestre explicador inscreviam o nome de seu autor no livro de ouro dos precursores da escola e da pedagogia. Após uma releitura do estatuto que, em 1911, o Dictionnaire de pédagogie de Ferdinand Buisson lhe havia conferido, Stéphane Douailler, professor do departamento de filosofia da Universidade Paris VIII, busca ressaltar, neste breve artigo, algumas das linhas de ruptura graças às quais o livro de Jacques Rancière conseguiu estilizar a aventura de Jacotot num paradigma excepcional da questão filosófica da igualdade das inteligências e da emancipação universal, na contramão das verdades em torno das quais, historicamente, a escola se fundou.<br>When, in 1987, Jacques Rancière published The ignorant schoolmaster, by Joseph Jacotot, the universal method of intellectual emancipation and reading training without an explaining master definitively entered the gallery of school and education precursors. After reviewing the status he was given by the Dictionnaire de Pédagogie edited by Buisson, in 1911, Stéphane Douailler, professor at the department of philosophy at the University of Paris 8, attempts to draw out some of the rupture lines through which Rancière's book succeeded to stylize the adventure of Jacotot into an exceptional paradigm of the philosophical question of intelligence equality and universal emancipation, that went against the tide of the truths around which school was historically founded

Equine saliva metabolome analysis during anestrus, estrus cycle and early gestation for the identification of salivary biomarkers of reproductive stages

International audiencePrecision livestock farming using metabolomic to acquire precise and real-time data can help farmers in individual animal management and decision making. Moreover, saliva collection is a non-invasive, painless and easy sampling method. Thus, this study proposes a metabolomic analysis in mare saliva during reproductive stages to identify salivary biomarkers to detect their reproductive stage in a welfare friendly production system. Saliva samples from 6 mares were collected in the seasonal anestrus, in the follicular phase 3, 2 and 1 day before ovulation and the day when ovulation was detected, in the luteal phase 6 days after ovulation and in gestation 18 days after ovulation and insemination. Metabolome analysis was performed by 1 -nuclear magnetic resonance spectroscopy. We identified 59 discriminant metabolites in saliva after repeated-measures one-way ANOVA tests. Creatine concentration significantly decreased from 2 days before ovulation until the day when ovulation was detected. Thus, a drop in salivary creatine concentration could allow detection of ovulation. Alanine concentration during anestrus was significantly higher than during follicular phase. Thus, alanine could be a candidate salivary biomarker of anestrus to estrus cycle transition. We showed previously that pregnenolone concentration was significantly higher during early gestation than during anestrus or follicular phase (Goudet et al., 2022, Frontiers in Animal Science, 3: 1055179). In conclusion, salivary biomarkers of ovarian cyclicity, ovulation and early gestation can be proposed. Further studies with a greater number of animals are in progress to confirm the reliability of these candidate biomarkers