38 research outputs found
âSouthern Rightsâ and Yankee Humor: A Confederate-Federal Jacksonville newspaper
- Author
- Publication venue
- 'Information Bulletin on Variable Stars (IBVS)'
- Publication date
- 12/04/2021
- Field of study
During the War for Southern Independence, Jacksonville was occupied by Federal forces several times for varying periods. On October 5, 1862, the town was seized for the second time, having just been abandoned hurriedly by most of the inhabitants who had not already left their homes earlier in the war
Who knows best? A Q methodology study to explore perspectives of professional stakeholders and community participants on health in low-income communities
- Author
- A Morgan
- B Barr
- B Baumberg
- B McKeown
- C Bambra
- C Putland
- Cam Donaldson
- D Ogilvie
- DJ Mattson
- DJ Mattson
- EC Chamberlain
- Fatma Ibrahim
- G Dahlgren
- G McCartney
- G Valentine
- H Graham
- H Lundell
- H Mason
- J Popay
- J Ritchie
- JP Mackenbach
- K Garthwaite
- K Smith
- KE Smith
- L Friedli
- M Blaxter
- M Douglas
- M Mackenzie
- M Mackenzie
- M Petticrew
- M Whitehead
- Marmot M
- MRC
- Neil McHugh
- Olga Biosca
- P Kline
- P Schmolck
- R Baker
- Rachel Baker
- RG Wilkinson
- S Jeffares
- S Ndumbe-Eyoh
- S Watts
- SA Haslam
- SR Brown
- W Stephenson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Abstract Background Health inequalities in the UK have proved to be stubborn, and health gaps between best and worst-off are widening. While there is growing understanding of how the main causes of poor health are perceived among different stakeholders, similar insight is lacking regarding what solutions should be prioritised. Furthermore, we do not know the relationship between perceived causes and solutions to health inequalities, whether there is agreement between professional stakeholders and people living in low-income communities or agreement within these groups. Methods Q methodology was used to identify and describe the shared perspectives (âsubjectivitiesâ) that exist on i) why health is worse in low-income communities (âCausesâ) and ii) the ways that health could be improved in these same communities (âSolutionsâ). Purposively selected individuals (n =â53) from low-income communities (n =â25) and professional stakeholder groups (n =â28) ranked ordered sets of statements â 34 âCausesâ and 39 âSolutionsâ â onto quasi-normal shaped grids according to their point of view. Factor analysis was used to identify shared points of view. âCausesâ and âSolutionsâ were analysed independently, before examining correlations between perspectives on causes and perspectives on solutions. Results Analysis produced three factor solutions for both the âCausesâ and âSolutionsâ. Broadly summarised these accounts for âCausesâ are: i) âUnfair Societyâ, ii) âDependent, workless and lazyâ, iii) âIntergenerational hardshipsâ and for âSolutionsâ: i) âEmpower communitiesâ, ii) âPaternalismâ, iii) âRedistributionâ. No professionals defined (i.e. had a significant association with one factor only) the âCausesâ factor âDependent, workless and lazyâ and the âSolutionsâ factor âPaternalismâ. No community participants defined the âSolutionsâ factor âRedistributionâ. The direction of correlations between the two sets of factor solutions â âCausesâ and âSolutionsâ â appear to be intuitive, given the accounts identified. Conclusions Despite the plurality of views there was broad agreement across accounts about issues relating to money. This is important as it points a way forward for tackling health inequalities, highlighting areas for policy and future research to focus on
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
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- Wyllie D. H.
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- Xue X.
- Yadav A.
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- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
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- Zanella I.
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- Zhou W.
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- Zongo O.
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- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2â4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
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- C Kaye
- C Lynch
- C Lyons
- C McCulloch
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- C Pothecary
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- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
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- C Vigurs
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- C Whitton
- C Whyte
- C Wrey Brown
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- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
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- D Baptista
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- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
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- D Martin
- D McGlynn
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- D Melia
- D Menzies
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- D Potoczna
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- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
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- J Birch
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- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
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- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
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- J Harris
- J Hatton
- J Hawes
- J Highgate
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- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
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- Keating Sean
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- Stephanie Roberts
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- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
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- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
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- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
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- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, PÂ =Â 1.65Â ĂÂ 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, PÂ =Â 2.3Â ĂÂ 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, PÂ =Â 3.98Â ĂÂ Â 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, PÂ =Â 4.99Â ĂÂ 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam KreÌštowski
- Adriana RozÌy
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna SzaĆkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. âArminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
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- Claudio Ferri
- Clemens M. Wendtner
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- Eva C. Schulte
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- F. Williams
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- Federica Gaia Miraglia
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- Stephan Ossowski
- Susan Walker
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- Susanna Guerrini
- SĆawomir Pancewicz
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- Tammy Gilchrist
- Thorsten Brenner
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- Tiziana Bachetti
- Tomas Luther
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- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
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- Urszula Polowianiuk
- V. Amin
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- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
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- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
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- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
- J Lin Daniel
- J Lowery Aoife
- J McCluney Simon
- J Mehigan Brian
- J Mills Sarah
- J Pachl (Birmingham Children's Hospital) Max
- J Rogers Luke
- J Ryan \uc9anna
- J Scurrah Rachel
- J Shackcloth Michael
- J Smart Neil
- J Steinkamp Pieter
- J Tejero-Pintor Francisco
- J Thomas Amy
- J Torres Antonio
- J Warren Oliver
- J Warren Oliver
- J Williams Katherine
- James RW Hall (Stepping Hill Hospital) Claire Hall
- James's Hospital) Conor P Barry (St.
- Jamil Tahir
- Jayaraju (University Hospital of Wales) Ullas
- Jenner Edward
- JG Chase Thomas
- Jha Shane Lester (James Cook University Hospital) Madan
- Jimenez-Higuera Elisa
- Jimeno Jaime
- JM Dunne Naomi
- JM Ferguson Henry
- Jo\ue3o Lima Maria
- Johnstone Jack
- Jones Mark
- Jordan: Mahmoud Al-Masri Gela).
- JS Wall Joshua
- Judkins Nicholas
- JW Wilkin Richard
- K Abou Chaar Mohamad
- K Ambler Graeme
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Brown Allison
- K Fusai Giuseppe
- K Gill Charn
- K Kamarajah Sivesh
- K Patel Panna
- K Ubhi Harmony
- K Weerasinghe Chamindri
- K\uf6nigsrainer Alfred
- Kalidindi Venugopala
- Kamal Mona
- Kang Chong
- Kara Yasin
- Karam Edward
- Karim Ahmed
- Kashora Florence
- KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
- Kearney (Beaumont Hospital) David
- Khajuria Apoorva
- Khan Azam
- Khan Umul
- Khatri Chetan
- Kinross James
- Kler Aaron
- Klimopoulos (Evangelismos General Hospital) Serafeim
- Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
- Kolias Angelos
- Kolias Angelos
- Kontovounisios Christos
- Kourdouli (Leicester Royal Infirmary) Amar
- Krishnan Emily
- Kristinsson Sverrir
- Kruijff Schelto
- KS Viswanath Yirupaiahgari
- Kudsk-Iversen S\uf8ren
- Kufeji Dorothy
- Kulkarni Rugved
- Kurihara Hayato
- L Biffl Walter
- L Coleman Natasha
- L Collins Michelle
- L Engel (Temple University Hospital) Jamie
- L Fowler Amy
- L Garcia Galocha Jose
- L Hughes Jane
- L J\uf6nsson (Bispebjerg Hospital Maria
- L Labib Peter
- L Marsh (Scripps Memorial Hospital) Christopher
- L McKevitt Kevin
- L Osorio Alexander
- L Romera Jose
- L Serevina Olivia
- L Venn Mary
- L Venn Mary
- L Venn Mary
- L Wright Franklin
- L Young Alastair
- L\ue1zaro Andr\ue9
- La Torre Filippo
- Laface (Ospedale Vittorio Emanuele III Letizia
- Lami Mariam
- Landaluce-Olavarria Aitor
- Laura Hansen 9
- Lawani Ismail
- Lawday (Southmead Hospital) Samuel
- Lawday Samuel
- Le Roy Bertrand
- Lecco) Asst
- Lecolle Katia
- Lederhuber Hans
- Lederhuber Hans
- Leeds)
- Leicester)
- Leventoglu Sezai
- Li Elizabeth
- Li Elizabeth
- Li Zoe
- Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
- Liew Ignatius
- Ligure (SV) Pietra
- Lima Buarque Igor
- Lisi Giorgio
- Lizzi Vincenzo
- Lo Terence
- Lombardia) Regione
- Lomiento Daniele
- Longhi Marco
- Lopez Antonanzas (Hospital Clinico San Carlos Leyre
- Losada Ruiz Manuel
- Lostis Emilie
- Lostoridis Eftychios
- Loubani Mahmoud
- Lowy- Benoliel Alejandro
- Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
- Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
- luis Blas Laina Juan
- Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
- Luke Louis
- Lunevicius Raimundas
- Luraghi Marco
- Lye George
- M Alrahawy (Menofiya University Hospital) Mahmoud
- M Andreani Stefano
- M Ashoush Fouad
- M Bajomo Oreoluwa
- M Blundell Chris
- M Cicerchia Pierfranco
- M Connolly Tara
- M Diez-Alonso Manuel
- M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
- M Emslie Katy
- M Harrison Ewen
- M Holbrook Charlotte
- M Isolani Simone
- M Keatley James
- M Leite-Moreira Andr\ue9
- M Mithany Reda H
- M Mohan Helen
- M Mohan Helen
- M Monteiro Joana
- M Morgom (Tripoli Central Hospital) Marwa
- M Muguerza Jose
- M Nunes Quentin
- M Nygaard Rachel
- M Omar Aneel Bhangu Omar
- M Philp Matthew
- M Pollok Joerg
- M Rooney Siobhan
- M Sampietro Gianluca
- M Sewards Joseph
- M Tang Alethea
- M Trout Isobel
- M Walters (Harborview Medical Center Andrew
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
- Mabrouk Islam
- Macchi Alberto
- MacDonald Luisa
- Machairas (Royal Free Hospital) Nikolaos
- Madonini Marco
- Madrid)
- Madrid)
- Magalh\ue3es Maia Mariana
- Magne Augestad Knut
- Magowan Drew
- Maha H Haqqani (Boston Medical Center) Frederick T Drake
- Maisonneuve Emeline
- Majkowska Agata
- Majkowski (Northern General Hospital Lawrence
- Mak (Queen Elizabeth Hospital Birmingham) Jason
- Malabarba Stefano
- Malerba Michele
- Maninder Kalkat 7
- Mannan Syed
- Manson Joanna
- Mansuri Ahmer
- Mantoglu (Sakarya University Research and Educational Hospital) Baris
- Manu Nichola
- Manzoni 56 Via
- Maqsood Afnan
- Marano Alessandra
- Marchbank Adrian
- Marcos-Santos Pablo
- Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
- Marqueta De Salas Maria
- Marrano Enrico
- Mart\uedn-Rom\ue1n Lorena
- Mart\uednez P\ue9rez Carolina
- Mart\uednez-dePaz Fernando
- Martel Lozano Saida
- Martin (St Mary's Hospital) Guy
- Martin Emmeline
- Martin Janet
- Martin-Albo Lorena
- Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
- Martinelli Fabio
- Martinez-German Antonio
- Martinez-Pinedo Carlos
- Martins Ricardo
- Marwan Hisham
- Marzi Federica
- MAS Baig Mirza
- Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
- Mater Studiorum University of Bologna) Alma
- Mathieu (CHU Besan\ue7on) Pierre
- Matute-Najarro Maria-Soledad
- Maw Andrew
- Mazingi Dennis
- Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
- McCanny (Antrim Area Hospital) Andrew
- McKenzie Katherine
- McLarty (Northumbria NHS Hospital Trust) Nicola
- McPherson Iain
- Medina Esther
- Mediratta Saniya
- Medone Marzia
- Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
- Mele Simone
- Melero-Cort\ue9s Lidia
- Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
- Mendon\ue7a Ata\uedde Gomes Gustavo
- Mendoza-Moreno Fernando
- Meneghini Simona
- Merate
- Mercante Giuseppe
- Merdrignac (Rennes University Hospital) Aude
- Metallidis Symeon
- Michel (Pinderfields Hospital) Martin
- Migliore Marco
- Milan)
- Milan)
- Milan)
- Miller Douglas
- Minaya- Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Mingoli Andrea
- Minto Gary
- Mirabella Antonello
- Misra Nikhil
- Mitrasinovic Stefan
- Miu Victor
- Moawad (Royal Victoria Hospital) Nader
- Mochet Sylvie
- Modabber Ali
- Mohammad Adam
- Mohan Midhun
- Moliner-S\ue1nchez Carmen
- Mondov\uec)
- Mongelli Francesco
- Monteleone (Ospedale San Leopoldo Mandic Michela
- Montuori Mauro
- Moore Rachel
- Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
- Morales Dieter
- Morales Xavier
- Morelli Luca
- Morelli Lucia
- Morgan Richard
- Morris Chris
- Mortini Pietro
- Mosca Angelo
- Moszkowicz David
- Moszkowicz David
- Motter Dema
- Moug Susan
- Mukherjee Samrat
- Munoz Rivas Ana
- Murcia)
- N Bence Matthew
- N Hopkinson David
- N Mashbari Hassan
- N Mashbari Hassan
- N Mashbari Hassan
- N Naumann David
- N Rao Jagan
- N Townshend David
- N\ufa\uf1ez Jordi
- Najdy Manhal
- Nakas (Glenfield Hospital Apostolos
- Namazov Ilgar
- Naredla Pradyumna
- Nasef Emmhamed
- Nassa Heeam
- Nath Rahul
- Navarro-S\ue1nchez Antonio
- Nazarian (Bupa Cromwell Hospital) Scarlet
- Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
- Negri Giampiero
- Nehra Deepika
- Neil-Dwyer Jason
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri Jacopo
- Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
- Newton (Manchester Royal Infirmary) Katy
- Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
- Niquen Milagros
- Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
- Nogueiro Jorge
- Nogues Pevidal (Royo Villanova) Ana
- Novara)
- Ntirenganya Faustin
- Nugent Michael
- O Ademuyiwa Adesoji
- O Kavanagh Dara
- O Larkin John
- Oca\uf1a Juan
- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
- Okechukwu Valentine
- Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
- Oliveira Ana
- OM Abdalla Mutwakil
- Omar M Omar
- OO Ayorinde John
- Osagie-Clouard (Epsom &
- Osman (Walsall Manor Hospital) Khabab
- Ottolina Jessica
- Ourieff (Mount Sinai Hospital) Jared
- Outani Oumaima
- Oyewole Bankole
- P Arnaud Alexis
- P Arnaud Alexis
- P Arnaud Alexis
- P Baker Markus
- P Belgaumkar Ajay
- P Boddy Alexander
- P Duffy (Nottingham City Hospital) John
- P Evans Jonathan
- P Hazelton Joshua
- P Jones Andrew
- P Jones Robert
- P Joyce Doireann
- P Kisiel Aaron
- P Pezzuto Anna
- P Singh Rabindra
- P\ue9rez-Gonz\ue1lez Marta
- P\ue9rez-Saborido Baltasar
- Pacheco-Sanchez David
- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
- Pai (Hammersmith Hospital) Madhava
- Paiella Salvatore
- Paisley (Brighton and Sussex NHS Trust Samuel
- Palermo)
- Palini Gianmarco
- Palmeri Matteo
- Parente Alessandro
- Parlanti Daniele
- Parmar Chetan
- Pascual Angela
- Pata Francesco
- Pata Francesco
- Patel Mahul
- Pathak Abhijit
- Patil Sangram
- Pattyn Piet
- Peckham- Cooper Adam
- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
- Pedrazzani Corrado
- Pellino Gianluca
- Pereira Andr\ue9
- Pereira-Neves Ant\uf3nio
- Perez-Diaz Md
- Perivoliotis (General University Hospital of Larissa) Konstantinos
- Perkins Clare
- Perotto (CHU Saint Etienne) Ornella
- Perra Teresa
- Petrone Patrizio
- Phenix George
- Piacenza)
- Picazo Sara
- Picon-Rodriguez Rafael
- Piloni Martina
- Pingarr\uf3n-Mart\uedn Lorena
- Pinotti Enrico
- Pizzini Paolo
- PM de Vries Jean-Paul
- Pockney Peter
- Podolsky Dina
- Poggioli Gilberto
- Pompili Cecilia
- Pontari Michael
- Porcu Alberto
- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
- Prita Daliya 8
- Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
- PTSurg ItSURG
- Pujol-Muncunill Roger
- Puppo Andrea
- Q Mehdi (University of Texas Medical Branch) Mohammad
- Quante Markus
- Quintana-Villamandos Bego\uf1a
- Qureshi Ali
- R Burke Joshua
- R Davidson Brian
- R Dixon Jan
- R Fretwell Kenneth
- R Gujjuri Rohan
- R Gujjuri Rohan
- R Kowal Mikolaj
- R O\u2019Neill John
- R Sarma Diwakar
- R Spalding Duncan
- R Springford Laurie
- Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
- Radenkovic Dejan
- Rahman Saad (Medway Maritime Hospital) Abdel
- Rakvin Ivan
- Ramallo-Sol\ueds Irene
- Ramcharan Sean
- Ramos Diego
- Ramos-Bonilla Antonio
- Ramos-De la Medina Antonio
- Ramzi Joussi
- Rathinam Sridhar
- Rausa Emanuele
- Ravaioli Matteo
- Ravindran Sharanya
- Raymond (Royal Lancaster Infirmary) Thomas
- Razik Aisha
- Redfern (Furness General Hospital) Jennifer
- Reguera-Rosal Julio
- Rey-Biel Juan
- Rey-Valcarcel Cristina
- RG Sheel Andrea
- Ribolla Marta
- Richards Tomos
- Richmond (University of Maryland Medical Center) Michael
- Righini (Ospedale del Delta Erminio
- Rio-Gomez Javier
- Riuniti Villa Sofia-Cervello Ospedali
- Riyat Harjoat
- Rizvi Sana
- Roberts Keith
- Roberts Matthew
- Robertson (University Hospitals Coventry and Warwickshire) Stuart
- Robertson (University of Arkansas for Medical Sciences) Ronald
- Robin-Valle Alvaro
- Rochon Melissa
- Rojo Mikel
- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
- Rottoli Matteo
- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
- Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
- Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
- Ruzzenente Andrea
- Ryska Ondrej
- S Abdelaal (Alexandria Main University Hospital) Ahmed
- S Al Maadany Faraj
- S Faria Carlos
- S Hammond John
- S Hossain Fahad
- S Jeyaretna Deva
- S Jones Conor
- S Khan (Queen Alexandra Hospital) Jim
- S Moura Francisco
- S Ng-Kamstra Joshua
- S Sica Giuseppe
- S Tamimy Muhammad
- S Wadley Martin
- S\ue1nchez- Arteaga Alejandro
- SA Taher Ahmed
- Saez Carlos
- Sahnan Kapil
- Sahni Arun
- Salim Ali
- Salvia Roberto
- Sammarco Giuseppe
- Sampaio-Alves Mafalda
- San Miguel-Mendez Carlos
- Sanchez del Pueblo Cristina
- Sanchez-Fuentes Maria-Nieves
- Sanchez-Pelaez Daniel
- Sanchez-Perez Coral
- Sanchez-Rubio Maria
- Sancho-Muriel Jorge
- Sanchon Fructuoso Lorena
- Sanders Julie
- Santero-Ramirez Maria-Pilar
- Santora Thomas
- Santoro Antonio
- Santos Irene
- Sapienza Paolo
- Sartarelli (Sant\u2019Orsola Hospital Lodovico
- Sarveswaran Janahan
- Sasia Diego
- Sassari) A. O. U.
- Saudemont Alain
- Saudi-Moro Sef
- Saxena Dolly
- Saxena Shobhit
- Sayasneh Ahmad
- Scalabre Aurelien
- Schache Andrew
- Schiavina Riccardo
- Schineis (Charit\ue9 University Medicine Christian
- Schreckenbach Teresa
- Scorza Antonella
- Scott Lucy
- Seegert (ProMedica Toledo Hospital) Sara
- Seguin-Givelet Agathe
- Senent-Boza Ana
- Serrano Gonz\ue1lez Javier
- Sette Laghi Asst
- Seymour Keith
- Shabana Amanda
- Shah (The Whittington Hospital) Sujay
- Shah Jigar
- Shah Karishma
- Shah Preena
- Shakir Taner
- Shalaby (Mansoura University Hospital) Mostafa
- Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
- Shaw Richard
- Sheffield)
- Shehata Sameh
- Shelley Hwang E.
- Shen Ban Vin
- Shenfine Amy
- Sheridan Kelda
- Sherief Ahmed
- Sherif Mohamed
- Shinkwin Michael
- Shu Sebastian
- Siaw-Acheampong Kwabena
- Sileri (San Raffaele Scientific Institute Pierpaolo
- Singh Abhinav
- Singh Shailendra
- Sinha Sanjay
- Siragusa (Policlinico Tor Vergata Hospital Leandro
- Sivaprakasam Rajesh
- Sivayoganathan Sriharan
- SJ Ledesma Frances
- Smillie Robert
- Smith (Countess of Chester Hospital) Claire
- Smith Andrew
- Smith Christopher
- Sochorova (Royal Liverpool University Hospital) Dana
- Society of Coloproctology (ESCP) European
- Society of Colorectal Surgery (SICCR) Italian
- Soggiu Fiammetta
- Sohrabi (St Bartholomew's Hospital) Catrin
- Sohrabi (Whipps Cross University Hospital) Catrin
- Sohrabi Catrin
- Solari (Royal Gwent Hospital) Francesca
- Solli Piergiorgio
- Soreide Kjetil
- Soto Montesinos Cristina
- SpainSurg
- Spinelli Antonino
- Spinelli Antonino
- Spoletini (Sant'Eugenio Hospital) Domenico
- Spriano Giuseppe
- Sravanam Sanskrithi
- Ssentongo (Pennsylvania State University) Paddy
- Stanger Sophie
- Stavroulias Dionisios
- Steel (Sunderland Royal Hospital) Ben
- Stella Marco
- Stewart Robbie
- Stringer Sally
- Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
- Sulen Nina
- Sundar Sudha
- Sundhu (Aintree University Hospital) Matthew
- Surgical Research Collaborative (ISRC) Irish
- Suri (University of California Davis Health Avni
- Swansea)
- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
- Szatmary Peter
- T Colonna Emily
- T Enjuto Diego
- T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
- TA Neely David
- Tabiri Stephen
- Tadross Daniel
- Taglietti Lucio
- Tansey (Princess Alexandra Hospital) Rosamond
- Tartaglia Dario
- Tawheed (Endemic Medicine Department Ahmed
- Tayeh Salim
- Testa Valentina
- Tewari Nilanjana
- Thoenissen Philipp
- Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
- Thrush Jessica
- Tierney Sean
- Tiwari Abhinav
- Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
- Toledo Enrique
- Tonini Valeria
- Torkington Jared
- Torzilli Guido
- Totty Joshua
- Tousidonis Manuel
- Townend Philip
- Townsend Catherine
- Trompeter (St George's Hospital) Alex
- Trotta Francesco
- Truant St\ue9phanie
- Trujillo-D\uedaz Jeancarlos
- Tsoulfas George
- Tsoulfas Georgios
- Turco Celia
- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
- Turrado- Rodriguez Victor
- Turri Giulia
- Tustin (Cumberland Infirmary) Harry
- Tyler Jayne
- Tzedakis Stylianos
- Tzovaras George
- Ullah Ramzan
- Unit\ue0 Sanitaria Locale di Ferrara Azienda
- United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
- United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
- Urban (University of Colorado Hospital) Shane
- Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
- Usai Antonella
- V Bhavaraju Avi
- V Comini Lara
- V Feo Carlo
- V Marino Marco
- V Shaw Abigail
- V\ue1zquez- Fern\ue1ndez Andrea
- Vaccarella (Azienda Ospedaliera Gianpaolo
- Valdes- Hernandez Javier
- Valsecchi Luca
- Vashisht Rajiv
- VCO) Asl
- Venkatesan (Glan Clwyd Hospital) Gowtham
- Vera-Mansilla Cristina
- Vergari (Ospedali Riuniti di Ancona) Roberto
- Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
- Vidya Raghavan
- Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
- Vijay Vardhini
- Vimalachandran Dale
- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
- Vulliamy Paul
- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
- W L\uf6ffler Markus
- Wall Rosemary
- Wallwork Kate
- Ward Alex
- Warwick (University Hospital Southampton) David
- Waseem Saima
- Weaver Helen
- Wells Fiona
- Wen Jiaxin
- West Raha
- Whitehall Emma
- Wild Laura
- Wilkins Alex
- Williams Gethin
- Williams Matthew
- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
- Zanini Nicola
- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28â2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65â3·22], p\textless0·0001), American Society of Anesthesiologists grades 3â5 versus grades 1â2 (2·35 [1·57â3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01â2·39], p=0·046), emergency versus elective surgery (1·67 [1·06â2·63], p=0·026), and major versus minor surgery (1·52 [1·01â2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Standards of Evidence for Efficacy, Effectiveness, and Scale-up Research in Prevention Science: Next Generation
- Author
- A Petrosino
- A Schirm
- AA Fagan
- AC Wagenaar
- AC Wagenaar
- AS Bryk
- AS Gerber
- AT Menting
- B Muthen
- BA Nosek
- BA Rabin
- BR Flay
- BR Flay
- C Enders
- C Glisson
- C Wing
- CA Löfholm
- CB Fisher
- CH Brown
- CH Brown
- CL Ringwalt
- D Hallfors
- D Hallfors
- D Hedeker
- DA Kenny
- DC Des Jarlais
- DC Gottfredson
- DC Gottfredson
- Deborah Gorman-Smith
- Denise C. Gottfredson
- DL Fixsen
- DL Olds
- DM Murray
- DS Elliott
- DT Campbell
- DT MacKinnon
- E Mayo-Wilson
- F Gardner
- F Gardner
- Frances E. M. Gardner
- GA Aarons
- George W. Howe
- GM Curran
- H Pashler
- H Pashler
- HS Bloom
- HT Chen
- Irwin N. Sandler
- J Hutchings
- J Ludwig
- JA Durlak
- JA Ioannidis
- JC Valentine
- JD Allen
- JE Hunter
- JJ Diaz
- JL Schafer
- JPA Ioannidis
- K Imai
- K Winokur Early
- Kathryn M. Zafft
- KF Schulz
- KW Griffin
- LA Rohrbach
- LA Rohrbach
- LH Supplee
- M Foster
- M Makel
- M Nerlove
- MK Campbell
- ML Bloomquist
- MS Forgatch
- P Chamberlain
- P Montgomery
- P Montgomery
- PZ Schochet
- RE Glasgow
- RL Spoth
- RL Spoth
- S Glazerman
- SA Shumaker
- SA Wolchik
- SL Zeger
- SM Scariano
- Social and Character Development Research Consortium
- SP Grant
- ST Ennett
- T Malti
- TD Cook
- TD Cook
- TD Cook
- TD Cook
- Thomas D. Cook
- W Trochim
- WH Greene
- WMK Trochim
- WR Shadish
- WR Shadish
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
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- Baruah R.
- Bashyal A.
- Basikolo C.
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- Battle C.
- Bauchmuller K.
- Baxter N.
- Baya N.
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- Beadle J.
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- Beavis S.
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- Bedini J.L.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study
- Author
- Aamir A
- Abdelbadiee S
- Abdullah S
- Abiola OO
- Abras A
- Abu E
- Abu-Arafeh H
- Achara A
- Adam M
- Adams LAT
- Adams P
- Aggarwal N
- Ahmad A
- Ahmad S
- Ahmed B
- Ahmed H
- Ahmed J
- Ahmed R
- Akintade O
- Alareed A
- Alhadadi B
- Ali J
- Allain TJ
- Allen J
- Alsahab M
- Amarnani R
- Amin Z
- Anderson C
- Andrusca A
- Annamalai A
- Ansell M
- Appiah-Odame P
- Arkle T
- Ashton C
- Astaire E
- Austin K
- Babar L
- Babb L
- Bahsoon F
- Baillie J
- Baldwin JBG
- Ball K
- Bargaoanu I
- Barlow C
- Baron A
- Basker K
- Batho R
- Bazaraa A
- Bedi S
- Beeley LJ
- Beharry K
- Behbahani A
- Behbahani A
- Bei ZX
- Bell C
- Bertagne M
- Berwick L
- Beveridge L
- Bhakta S
- Bhat G
- Bhattacharya S
- Bhatti J
- Bilton E
- Blair M
- Bowden H
- Bowen E
- Bowman MA
- Box E
- Bremakumar S
- Briggs L
- Broadhurst K
- Brown H
- Browne M
- Bryant C
- Bullock S
- Bultynck C
- Burton JK
- Bygate R
- Byravan S
- Caines L
- Cairns C
- Cameron E
- Campbell A
- Capek E
- Carter S
- Cavaliere C
- Chai CS
- Chamberlain H
- Chamboult A-L
- Champion J
- Chapman G
- Cheah KL
- Cheema A
- Chevolleau J
- Chilton A
- Chourot C
- Christie L
- Christodoulides N
- Chuter C
- Clayton V
- Cleaver SL
- Clements HA
- Coffey F
- Cohen S
- Connell L
- Connor L
- Cook A
- Cooper F
- Cooper O
- Copeland C
- Cox N
- Cricklow T
- Croft P
- Crofts J
- Cummings L
- Cunningham EL
- Currie H
- Cushen C
- Dama S
- Darko S
- Davies R
- Davies-Morris J
- Davis D
- De Mucha PV
- Deacon E
- Debrah K
- Deosaran J
- Dhillon A
- Doherty C
- Dove J
- Dovey J
- Drozdowska B
- Durcan R
- Durrant SK
- Edwards S
- Einarsson A
- Elliott E
- Elliott M
- Ellis EJ
- Enfield-Bance A
- Evans E
- Evans J
- Evans O
- Evans S
- Faheem W
- Fancourt S
- Farah R
- Faruq S
- Fenneley G
- Ferguson EEC
- Fergusson N
- Ferreira AS
- Fisken E
- Foster K
- Fraser D
- Frewen J
- Furmedge D
- Gallagher M
- Gaskell N
- Gaunt V
- Gaywood J
- Giblin E
- Giddings J
- Giet L
- Giles A
- Giridharan K
- Glasser M
- Glasser M
- Gluck I
- Goujon M
- Govindji S
- Grange R
- Greaves I
- Green J
- Gregory J
- Griffiths E
- Grundmann N
- Gui J
- Gupta A
- Gurung S
- Hackett B
- Haddad N
- Haley M
- Hall G
- Hall SA
- Handley O
- Harbinson A
- Harkin T
- Hart J
- Hayat Y
- Headlam J
- Healy R
- Henderson N
- Henderson S
- Herbert F
- Hindley E
- Hodhody G
- Hoffman K
- Holmes EAM
- Horner S
- Hornsby A
- Horton R
- Houldershaw K
- House S
- Hughes C
- Hunt C
- Hunt W
- Hunter E
- Hussain A
- Hussain Z
- Ibanichuka J
- Ikhwan WIC
- Ingamells N
- Iqbal S
- Irvine J
- Irwin SJ
- Iwu C
- Jackson P
- Jackson P
- Jackson TA
- Jacques H
- Jagdeo S
- Jakupaj A
- Janagal S
- Jatti P
- Jay E
- Jelley B
- Jenkin R
- Jewell E
- Jones HT
- Jones K
- Jones L
- Jones P
- Kabia A
- Kadir I
- Kalyaani V
- Kantczak A
- Katz-Summercorn C
- Kay A
- Kearney M
- Kelly D
- Khalid AB
- Khambay E
- Khan A
- Khan A
- Khizar B
- Khor M
- Kiani M
- King R
- Kirrane K
- Konda N
- Koshedo S
- Krishan A
- Kuek DKC
- Kumar A
- Kumbun G
- Kunaselan L
- Lai J
- Large J
- Laud R
- Layton GR
- Le Poideven A
- Leah E
- Lee H
- Lee T
- Leishman F
- Lewis A
- Lim SK
- Lim VH
- Lin J
- Livesey J
- Lochlainn MN
- Lonsdale-Eccles E
- Love R
- Lowes O
- Lucocq JE
- Lyon E
- MacCuish AH
- Macdonald FE
- Macharouthu A
- Mackenzie ER
- Macrae V
- Madden KF
- Magill L
- Mahmood AW
- Majid Z
- Makin S
- Mani S
- Marshall J
- Masoli J
- Matheswaran Y
- Matthews NR
- Matthews SA
- Mayor K
- Mazzoleni A
- McCauley H
- McClean A
- McClelland SB
- McCluskey HJ
- McCluskey L
- McCormack R
- McCormack V
- McCready J
- McCulloch A
- McDonald H
- McErlean CM
- McGonigal G
- McKay S
- McKeown W
- McNicholas E
- McQuillan A
- McShane D
- Menezes R
- Meyer C
- Miller CJ
- Miller H
- Millichamp K
- Millner H
- Mills S
- Mishra P
- Mishra R
- Mitchell O
- Mithrakumar P
- Moad M
- Mohammedseid-Nurhussien A
- Moore E
- Moore K
- Moorey H
- Morgan B
- Morgan H
- Morrison K
- Morrow A
- Morrow O
- Mosley A
- Mukundan M
- Mullarkey E
- Mumtaz E
- Murphy-Ackroyd E
- Murray AA
- Murthy S
- Mustafa Z
- Naeem F
- Nagumantry S
- Naish G
- Nandra T
- Naqvi H
- Nashed N
- Ng L
- Ngan EEY
- Nicholls I
- Nightingale P
- Nneamaka A
- Noble J
- Norman E
- Nwabufor P
- Nynaes O
- O'shea K
- Obi IT
- Offer M
- Ofoche G
- Ostrowski C
- Page V
- Pailing A
- Pang N
- Parkinson M
- Parry F
- Parry S
- Patel MD
- Patel R
- Patterson K
- Peck G
- Pendleton H
- Perry R
- Pettler S
- Pinkney T
- Pope L
- Porter L
- Porter-Bent S
- Poynton J
- Prasad V
- Prendergast EL
- Pullen R
- Pyc W
- Quinn S
- Quinn T
- Radoja S
- Rai N
- Ramakrishna S
- Rashid S
- Rayner H
- Raza M
- Reay A
- Reidm J
- Rice C
- Richardson S
- Rickard F
- Rimmer L
- Robinson HJ
- Robson R
- Ronan L
- Rose EC
- Ross A
- Rutter S
- Ryan A
- Sahnan K
- Saliu D
- Sami F
- Sampson EL
- San MSS
- Sarma D
- Satharasinghe L
- Scarlett D
- Scott D
- Sehmbi G
- Sen M
- Seymour E
- Shah H-A
- Shahid M
- Shakeel S
- Shaw ME
- Shepherd A
- Sloan GW
- Smith A
- Smith GM
- Smith N
- Speed J
- Sprosen C
- Stambollouian K
- Stapley SM
- Stirling A
- Stratton E
- Straughan J
- Studley M
- Subhan Z
- Sundara S
- Swietoslawski A
- Syed N
- Tan F
- Tantam K
- Taranu R
- Taylor A
- Taylor E
- Taylor J
- Taylor J
- Taylor-Rowan M
- Tencheva A
- Tetlow S
- Thake M
- Thayabaran D
- Thomas P
- Thyn T
- Timperley A
- Tinson G
- Todd O
- Torsney K
- Traill PK
- Treml J
- Tse C
- Tumi E
- Turton S
- Tyagi B
- Ul Ain Q
- Usmani K
- Valentine J
- Vardon H
- Varghese J
- Vasudev A
- Vedutla T
- Velusamy K
- Venkat S
- Virk J
- Visvaratnam P
- Wahballa A
- Walker A
- Walter A
- Waraich H
- Warwicker S
- Watson H
- Watt N
- Webb H
- Welch C
- Wheeler A
- Whyte L
- Wilcockson J
- Wilkes C
- Williamson E
- Williamson K
- Willott R
- Wilson D
- Wilson D
- Wilson DS
- Wilson F
- Wilson JB
- Wilson MSJ
- Winearls S
- Wong L
- Wong TW
- Woodman H
- Woodward BL
- Wrathall A
- Wright E
- Wright S
- Wu C
- Wu E
- Wynne L
- Yap ZJ
- Young LJ
- Yule O
- Yunus A
- Publication venue
- Springer
- Publication date
- 24/12/2022
- Field of study
Purpose Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8â4.6) in CFS 4 vs 1â3; OR 12.4 (6.2â24.5) in CFS 8 vs 1â3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3â1.9) in CFS 4 compared to 0.2 (0.1â0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
- Author
- Abano N
- Abbott L
- Abbott W
- Abdul-Hamid A
- Abdul-Saheb M
- Abousleiman Y
- Abubakar S
- Adedoyin T
- Adie K
- Affley B
- Ahlquist K
- Ahmad N
- Ahmed A
- Ahmed S
- Ahmed Z
- Al Hussayni S
- Al-Samarrai N
- Alam I
- Alam S
- Ali A
- Ali K
- Allen C
- Allen J
- Allison J
- Allsop H
- Allsop L
- Almadenboyle C
- Alvares W
- Alwis L
- Alwis L
- Amero J
- Amis E
- Amlani S
- Amor K
- Anazodo C
- Anderson R
- Andrews J
- Anjum T
- Annamalai A
- Annison F
- Anthony A
- Appiatse G
- Archer J
- Argandona L
- Arif S
- Armer C
- Armstrong L
- Aruldoss P
- Arundell L-L
- Ashcroft P
- Asokanathan A
- Aubrey B
- Augustin M
- Auld G
- Austin D
- Awolesi J
- Ayer J
- Azim A
- Badiani B
- Bahk A
- Bailey D
- Bailey L
- Bakawala R
- Baker J
- Baker P
- Balami J
- Balasubramanian V
- Balian L
- Ball J
- Ball L
- Balogun I
- Bamford E
- Bamford J
- Banaras A
- Barber M
- Barbon E
- Barcroft H
- Barker J
- Barron C
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- Barry A
- Barugh A
- Bate J
- Bateman G
- Bates M
- Bathula R
- Beadle H
- Beadling T
- Beard R
- Beardmore C
- Bedford C
- Bedford E
- Begum Y
- Bell A
- Bell J
- Bell J
- Bell S
- Bell S
- Bellfield R
- Benford A
- Bent C
- Benton L
- Beranova E
- Beranova E
- Besley S
- Bhalla A
- Bhandari M
- Bharaj K
- Bhargava M
- Bhattad M
- Bhome G
- Billingham S
- Birns J
- Black T
- Blackburn J
- Blackburn R
- Blair G
- Blane S
- Blight A
- Blight A
- Bloom S
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- Bohannan E
- Bokhari M
- Bolton M
- Bond K
- Booth C
- Booth L
- Borley J
- Borley J
- Boulton A
- Boulton R
- Bower R
- Bowers R
- Bowie E
- Bowler H
- Bowring A
- Box C
- Bradfield S
- Bradshaw E
- Brady M
- Brammer S
- Bray H
- Breeds J
- Brewer C
- Brezitski M
- Bridger H
- Brighouse-Johnson C
- Brodie C
- Brodie F
- Brookes L
- Brotheridge S
- Brotherton L
- Broughton D
- Brown C
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- Burgess D
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- Burn I
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- Butt G
- Bwalya A
- Byrne A
- Cageao J
- Cain R
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- Cannon E
- Cape A
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- Carter T
- Cartwright B
- Cassidy T
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- Causley C
- Ceccarelli D
- Chadbourn I
- Chadha D
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- Chamberlain A
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- Christie D
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- Christmas N
- Chun Y
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- Claydon F
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- Corbett T
- Corrigan P
- Cotterill D
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- Eastwood MJ
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- Edwards A
- Edwards B
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- Egerton S
- Eglinton C
- Eglinton C
- El Nour A
- El Tawil S
- Eldridge L
- Elitova S
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- Farquhar F
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- Foote L
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- Frith A
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- Fung Lo S
- Funnell S
- Furnace J
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- Gaba W
- Gadi N
- Gainsborough N
- Gallen B
- Gallifent R
- Gamble GE
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- Gartrell I
- Gautam N
- Gaylard J
- Ghani U
- Ghatala R
- Ghouri I
- Ghulam R
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- Gillian A
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- Gohil S
- Goldenberg L
- Golding W
- Goldsworthy M
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- Gunathilagan G
- Guo F
- Gupwell K
- Guthrie LB
- Guyler P
- Hackett M
- Hagan S
- Hague A
- Haider S
- Haigh S
- Hairsine B
- Hakkak J
- Haley M
- Hall F
- Hamid U
- Hamill D
- Hamilton A
- Hamilton H
- Hammond T
- Hancevic M
- Handley D
- Hankey GJ
- Hankin V
- Hann G
- Hannon N
- Haque K
- Haque M
- Haque N
- Hardwick A
- Hare C
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- Hargroves D
- Haritakis M
- Haritakis M
- Harkness K
- Harlekar P
- Harman P
- Harper M
- Harrington F
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- Harrison L
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- Harvey M
- Hasan A
- Hashmi A
- Hassan A
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- Hassan M
- Hawkes-Blackburn M
- Hayden D
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- Hedges A
- Hedstrom A
- Hemsley A
- Hervey S
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- Hoeritzauer I
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- Holden M
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- Hollinshead P
- Holloway A
- Holmes C
- Homan JE
- Honour S
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- Horton J
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- Howe J
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- Hurford F
- Hurley L
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- Johnson A
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- Jones V
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- Joyson A
- Justin F
- Kabash H
- Kalathil L
- Kalita M
- Kalladka D
- Kamara C
- Kambafwile M
- Kamuriwo L
- Kane I
- Kauldhar K
- Kavanagh K
- Kawafi K
- Keeling A
- Keeling E
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- Keenan S
- Kelavkar S
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- Kemp LJ
- Kennedy J
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- Kidd M
- Kidd S
- Kingwell H
- Kirthivasan R
- Krasinska-Chavez M
- Krishnamurthy R
- Krishnan M
- Kullane S
- Kumar P
- Kumar S
- Kundu A
- Kunhunny S
- Kyu M
- Ladner R
- Lambert C
- Lampard R
- Landicho M
- Lane C
- Lane L
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.
Findings
Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839â1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26â6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38â2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months.
Interpretation
Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
Funding
UK Stroke Association and NIHR Health Technology Assessment Programme