8 research outputs found
Financial Losses in Smoking and Its Consequences in BANGLADESH
- Publication venue
- The International Institute for Science, Technology and Education (IISTE)
- Publication date
- 09/09/2012
- Field of study
Smoking is a mega problem in Bangladesh. Financial losses and consequences of smoking in Bangladesh are the main spotlights of this study. Huge financial losses are involved in this ghastly habit. Losses are occupied in individual, family and national levels. Its indirect losses are found significant. This paper presents the bad effects of smoking in the form of direct and indirect losses. Smoker is not only the affected person of smoking but also the others. In consequences part, it reveals the main issues that are held responsible for problems in family and society as a whole. It identifies the main causes of smoking. The vision of this writing is refrain people from smoking. The vision is also followed by a vital issue i.e. economic viewpoint of Bangladesh. Finally, it sets some recommendations for overcoming awful effects of smoking. Key Words: Smoking, Financial Losses, Direct Losses, Indirect Losses, Opportunity Cost, Consequences, Banglades
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial
- Author
- Aamir Afridi
- Aamir Ghafoor
- Aamir Husain
- Aasia Kayani
- Aasia Kayani
- Aasim Yusuf
- Abby Harper-Payne
- Abby Oglesby
- Abdelmounem Abdo
- Abdelmounem Eltayeib Abdo
- Abdul Wahid
- Abdus Khan
- Abid Ali
- Abrar Shaikh
- Achuth Shenoy
- Adam Bailey
- Adamu Ahmed
- Adamu Samaila
- Adedayo Oluyomi Tade
- Adeel Afzal
- Adeela Irfan
- Adeeqa Aman
- Adefemi Afolabi
- Adefemi Afolabi
- Adefemi Afolabi
- Adefemi Afolabi
- Adegboyega Akere
- Adegboyega Akere
- Adeleke Adekoya
- Ademola Tolulope Adebanjo
- Adewale Aderounmu
- Adil Chang
- Adnan Amin
- Adrian Barry
- Adrian Boyle
- Adrian Cotirlet
- Adrian Stanley
- Ahmad Taj
- Ahmed Shaker
- Aijaz Ahmed
- Aiman Mushir
- Ajay Adhikaree
- Ajay Adhikaree
- Akande Ajayi
- Alan Barkun
- Alastair Stevenson
- Alexander Atiri
- Alexandra Newman
- Alison Jefferey
- Alistair McNair
- Amanda Cowton
- Amanda Whileman
- Amber Geer
- Ameet Kumar
- Aminu Nahuche
- Amir Khan
- Amjad Ali
- Amjad Hussain
- Amy Brenner
- Amy Brenner
- Anam Bangash
- Andee Zakaria
- Andrei Ragea
- Andrei Voiosu
- Andrew Allison
- Andrew Appelboam
- Andrew Brown
- Andrew Dongo
- Andrew Kinnon
- Andrew Thayne
- Andrew Veitch
- Andrew Veitch
- Andrew Veitch
- Angiy Michael
- Anna Quinn
- Anne Hayes
- Anthony Kehoe
- Anu Mitra
- Anu Mitra
- Anuj K.C.
- Arben Beqiri
- Areej Al Balkhi
- Aroudra Outtandy
- Ashraf Helmy
- Asifa Aslam
- Avril Kuhrt
- Avto Megreladze
- Aye-Aye Thi
- Azeberoje Osueni
- Baadur Mosidze
- Barbara Watkins
- Ben Rayner
- Bernadette Gallagher
- Bernard Ndungu
- Besik Melikidze
- Beverley Faulkner
- Blasi
- Bobby Wellsh
- Bobby Wellsh
- Bogdan Busuioc
- Bogdan Mateescu
- Brenner
- Brenner
- Bukola Fawole
- Bukola Fawole
- Camelia Chioncel
- Carly Swann
- Carolyn Hughes
- Carrie Demetriou
- Catherine Gilliam
- Catherine Jarvis
- Catriona Bryceland
- Charlotte Owen
- Chelci Squires
- Chigozirim Onyekpere
- Chris Gough
- Chris Macdonald
- Chris Metcalfe
- Chris Roukas
- Christiane Vorwerk
- Christine Lambe
- Christopher Ekwunife
- Christopher Hawkey
- Claire Burnett
- Claire Dowty
- Coats
- Colin Bergin
- Collette Barrow
- Conor Deasy
- Conor Deasy
- Cook
- Courtenay Howe
- Daisy Mackle
- Dalia Ahmed
- Daniel Balaban
- Daniel Gilbert
- Daniel Hetherington
- Daniel Marks
- Daniel Pearson
- Daniela Manno
- Daniela Manno
- Danielle Beaumont
- Danielle Prowse
- Daniyan Muhammad
- David Hartin
- David Henry
- David Hobday
- David I'anson
- David Yeo
- Davit Kazaishvili
- Dawn Trodd
- Diane Simpson
- Donogh Maguire
- Dorina Pestroiu Calescu
- Edith Nonyelum Okeke
- Edries Tejan
- Edward Hartley
- Elaine Hardy
- Elaine Ng
- Emma Austin
- Emma Stoddard
- Emuobor Odeghe
- Enadeghe Eghaghe
- Eni Balogun
- Essa Khan
- Fady Nagy
- Faheem Butt
- Fazal Rahman
- Felicia Onoviran
- Fionn Bellis
- Folasade Adenike Bello
- Folasade Adenike Bello
- Frank Coffey
- Funmilola Wuraola
- Gabrielle May
- Gavin Wright
- Gayle Clifford
- Geoffrey Bellhouse
- Geoffrey Bellhouse
- Georgia Bercades
- Georgina Butt
- Ghias Tayyab
- Gia Tomadze
- Gluud
- Haider Zaigham Baqai
- Hakim Miah
- Haleema Shakur-Still
- Haleema Shakur-Still
- Haleema Shakur-Still
- Hamza Arshad
- Hannah Cotton
- Haroon Zahoor
- Hearnshaw
- Heather Jarman
- Helen Sweeting
- Helio Fornieles Pérez
- Holly Maguire
- Hussein Khamis
- Hussein Khamis
- Ian Gilmore
- Ian Gilmore
- Ian Roberts
- Ian Roberts
- Ian Roberts
- Ian Roberts
- Imogen Brooks
- Imogen Skene
- Imogen Skene
- Iram Saeed
- Irshad Hussain
- Irshad Hussain
- Isobel Bradbury
- Iulia Pintilie
- Jack Cuzick
- Jackie Berry
- Jacob de Wolff
- James East
- James Gagg
- James Shutt
- James Turvill
- Jamie Barbour
- Jane Hunt
- Jane Martin
- Janet Johnstone
- Jason Kendall
- Jason Klein
- Jason Pott
- Javaria Khan
- Jayne Foot
- Jeff Keep
- Jemma Tanner
- Jennifer Small
- Jiffre Din
- Joanna Tambellini
- Joanne Thunder
- Joaquin Alvarez Gregori
- Joaquín Álvarez Gregori
- John Greenaway
- John Jones
- Jonathan Simmons
- Jonathan Simmons
- Jonathon Snook
- Jordi Margalef
- Julia Grahamslaw
- Julian Humphrey
- Julie Tregonning
- Julio Gil Onandia
- Junaid Mushtaq
- Jung Ryu
- Kate Clayton
- Katharine Ker
- Katharine Ker
- Kay Finney
- Kehinde Osisanya
- Kelly Needham
- Kelvin Voon
- Kenneth Halligan
- Kenneth Halligan
- Khairul Azis
- Khalid Mahmood Nasir
- Khalid Yahya
- Khushboo Priya
- Kiran Bal
- Kiran Javaid
- Kiran Javaid
- Kris Pillay
- Laura Carrington
- Laura Hunter
- Laura O'Rourke
- Laura Ranopa
- Lauren Frimley
- Lecker
- Lee Joon
- Lisa McClelland
- Lisa Sawers
- Lisman
- Louisa Chan
- Louisa Chan
- Louise Chandler
- Lucian Negreanu
- Lucy Jones
- Lucy Parker
- Luke Lawton
- Luke Lawton
- Lynsey Flowerdew
- Madeleine Cargill
- Maggie Bell
- Majid Soomro
- Majid Soomro
- Mandy Grocutt
- Mansoor Ahmad
- Mansoor Ul Haq
- Maqbool Reki
- Marcel Tanău
- Maria Price
- Maria Ramos
- Mariam Hassan
- Mariana Jinga
- Marion McNaught
- Marium Waqar
- Martin James
- Martin Thomas
- Mary Doona
- Marzouqah Al Anazi
- Masykurin Mafauzy
- Matthew Banks
- Matthew Reed
- Matthew Rutter
- Mazen Naga
- Mia Reid
- Miland Joshi
- Mobeen Kayani
- Mohammad Hisyam
- Mohammad Jahit
- Mohammad Khalid
- Mohammad Shukri Bin Jahit
- Mohammad Zaher
- Mohammed Abdel Monem
- Mohammed Ashfaq
- Mohsin Ali
- Monday Yilkudi
- Monica Arribas
- Monica Arribas
- Morten Draegebo
- Mostafa Saiid
- Mouzam Shaikh
- Muhammad Afzal
- Muhammad Arif Nadeem
- Muhammad Arif Nadeem
- Muhammad Imran
- Muhammad Ishfaq
- Muhammad Khurram
- Muhammad Muaaz
- Muhammad Nasir
- Muhammad Qamar
- Muhammad Shafi
- Muhammad Umar
- Muhammad Zubair
- Muhyuddin Brukan
- Mujahid Aslam
- Mumtaz Marwat
- Muttiullah Mutti
- Muttiullah Mutti
- Muttiullah Mutti
- Muttiullah Mutti
- Myles
- Myriam Benyahia
- Nadeem Iqbal
- Naeem Aslam
- Nancy Ukwu
- Natasha Christmas
- Nayia Golfi
- Nicholas Watson
- Nick Mathieu
- Nicola Haeger
- Nicola Jacques
- Nicola Palmer
- Nigel Quashi
- Nigel Trudgill
- Nigel Trudgill
- Nighat Fatima
- Nil Amri
- Nino Grubelashvili
- Nizam Hashim
- Noureen Misbah
- Oakland
- Oguamanam Okezie Enwere
- Okafor Nnaemaka
- Ola Afolabi
- Oladapo Olayemi
- Oladapo Olayemi
- Olatunji Shonoiki
- Olawale Badejo
- Olivia Boulton
- Olu Orugun
- Olufunmilayo Lesi
- Olujide Okunade
- Olukayode Arowolo
- Olusade Adetayo
- Oluwole Olaomi
- Omar Ashoush
- Omer Omer
- Paul Cumpstay
- Paul Jhalli
- Peter Swallow
- Phil Edwards
- Phil Edwards
- Philip Boger
- Philip Devereaux
- Philip Kaye
- Pinkey Sachdev
- Quratul ain Ghalib
- Rachel Atkins
- Rachel Comer
- Rachel O'Brien
- Racquel Carpio
- Radu Bogdan Mateescu
- Raghavendra Kamath
- Rajaventhan Srirajaskanthan
- Raoul Mansukhani
- Raoul Mansukhani
- Richard Gray
- Richard Jackson
- Richard Pollok
- Richard Pollok
- Rita Das
- Rizwana Chaudhri
- Rizwana Chaudhri
- Rizwana Chaudhri
- Rob Jackson
- Roberts
- Roberts
- Romaih Al-Idari
- Rosalyn Squire
- Rose Ugiagbe
- Rufina Igetei
- Ruhama Uddin
- Ruth Fazakerley
- Ruth Worner
- Ruxandra Oprita
- Saadia Noreen
- Saafan Saafan
- Saba Arshad
- Sadaf Sattar
- Saif Al-Nahhas
- Saif Al-Nahhas
- Saifullah Goraya
- Sajjad Ali
- Sajjad Yaqoob
- Saleh Channa
- Sally Beer
- Salman Azhar
- Samuel Guest
- Samuel McBride
- Samuel Olatoke
- Sana Shaikh
- Sandeep Kumar
- Sanjay Singh
- Santosh Kumar
- Sarah Hearnshaw
- Sarah Moreton
- Sarah Rounding
- Sarah Wilson
- Serag Esmat
- Sergey Kostrov
- Shafqat Iqbal
- Shahida Tarar
- Shaik Farid
- Shakur
- Shankar Baral
- Sharmeen Aslam
- Shazad Afzal
- Shehroze Khan
- Sheik Pahary
- Sheraz Saleem
- Sherbat Khan
- Shweta Gidwani
- Shyang Yee Lim
- Sian Davies
- Simon Barnes
- Simon Carley
- Simon Everett
- Simon Stanworth
- Simon Stanworth
- Simon Tucker
- Simona Bataga
- Sinead Helyar
- Sir Young Yam
- Sivakumar
- Sneha Kansagra
- Sohaib Ahmed
- Stanley
- Stephanie Bell
- Stephen Haig
- Stephen Hood
- Steve Goodacre
- Steven Barden
- Stuart Paterson
- Sue Wakeford
- Suresh David
- Susan Fowler
- Susan Thornton
- Susie Hardwick
- Syed Ahmad
- Syed Shah
- Taemi Kawahara
- Tahir Bashir
- Tahir Rizvi
- Tamar Gogichaishvili
- Tamar Gogichaishvili
- Tanveer Hussain
- Tanya de Weymarn
- Tayyab Akhter
- Tayyaba Saif
- Tazaeen Kazmi
- Tehseen Hameed
- Temitope Oke
- Thomas Bartram
- Tim Godfrey
- Timothy Coats
- Timothy Coats
- Timothy Harris
- Timothy Harris
- Timothy Harris
- Tinuola Fakoya
- Toafiq Raji
- Ton Lisman
- Tony Brady
- Tracey Johnston
- Tracey Pepple
- Tristan Dyer
- Ubedullah Bughio
- Uchenna Ijoma
- Umar Riaz
- van Leerdam
- Vania Loureiro
- Victoria Murray
- Vijay Sah
- Vijay Yadav
- Vipul Jairath
- Vipul Jairath
- Wajahat Shafi
- Wan Najmi
- Wasim Uddin
- Wojciech Sawicki
- Xin Yi
- Yasir Iqbal
- Zafar Iqbal Chaudhry
- Zakawat Rasheed
- Zeeshan Ali
- Zuhrirahimi Ramli
- Publication venue
- 'Elsevier BV'
- Publication date
- 18/06/2020
- Field of study
Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma.
Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We
aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding.
Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries.
Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the
minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and
had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were
randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical
apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to
100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a
maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h
for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to
allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients
who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable.
This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124.
Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid
(5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated
treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the
tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18).
Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and
placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein
thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of
5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98).
Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our
results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a
randomised trial
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
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- Ang HL
- Ang JJ
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- Anwar S
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- Appleton S
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- Feldman M
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
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- Zubikarai G
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Differences Between Premenopausal And Postmenopausal Coronary Artery Disease (CAD) Risk Factors and Clinical Profile
- Author
- Publication venue
- 'Siddharth Health Research and Social Welfare Society'
- Publication date
- 24/08/2024
- Field of study
Introduction: Coronary artery disease is the leading cause of mortality and morbidity of both men and women accounting for over one third of total deaths [1]. It has reached epidemic proportion among Indians. It accounts for 1 out of 3 women death regardless of the race or ethnicity [2]. In women, the annual mortality rate from CAD is high. Objective: To assess the differences between premenopausal and postmenopausal coronary artery disease (CAD) risk factors, clinical manifestation, clinical profile and angiographic characteristics. Methods: A prospective observation study was conducted at cardiology department, NICVD, Dhaka, Bangladesh from January to December 2019. Total 200 female CAD patients were drawn from the cardiology department. The subjects were enrolled in accordance with the criterion of diameter stenosis ≥50% in left mean and ≥70% in LAD, LCX and ECA in at least one invasive coronary angiogram. Patients with pulmonary embolism, aortic aneurysm, congenital heart disease, rheumatic heart disease, myocarditis, or cardiomyopathy were excluded. A total of 50 premenopausal cases and 150 postmenopausal cases were enrolled according to their status at the time of diagnosis. All patients underwent percutaneous coronary intervention and were given conventional drug therapy for coronary artery disease during follow-up. Results: Differences were compared between the 2 groups. Fewer premenopausal women suffered from hypertension (46% versus 82%, P< 0.001), type 2 diabetes (10% versus 36%, P = 0.001), and hyperlipidemia (4% versus 36%, P<0.001), but more had a positive family history of premature CAD (42% versus 26%, P = 0.03). Acute coronary syndrome (ACS) was more frequently seen in premenopausal women (80% versus 48%, P < 0.001), and their left anterior descending branch was the vessel most often involved (68%). The cumulative recurrence rate was 1.76 times higher in postmenopausal patients than premenopausal patients. Clinical diagnosis (HR = 2.54, 95%CI: 1.21-4.85, P = 0.02) and type 2 diabetes (HR = 4.10, 95%CI: 2.37-8.83, P = 0.004) were two factors that influenced recurrence in premenopausal subjects, while the clinical diagnosis (HR = 1.93, 95%CI: 1.59-3.46, P = 0.03) and Gensini score (HR =1.20, 95% CI: 1.11-1.45, P = 0.02) were influencing factors in the postmenopausal patients. Symptoms among younger women were atypical, but the onset of disease was faster and more urgent. Conclusion: Our study clarified the differences between postmenopausal and premenopausal women with respect to risk factors, clinical symptoms, cardiovascular features, and recurrence rate, and provided a reference for further study on the mechanism and prognosis in postmenopausal or premenopausal CAD patients
Solanopubamine, a rare steroidal alkaloid from Solanum schimperianum: Synthesis of some new alkyl and acyl derivatives, their anticancer and antimicrobial evaluation
- Author
- Abdel-Sattar
- Adnan J. Al-Rehaily
- Ali
- Angenot
- Arif
- Cham
- Cham
- Chang
- Chen
- Coune
- Daunter
- Gaffield
- Gaffield
- Giri
- Han
- He
- Ikhlas A. Khan
- Jamal Mustafa
- Kim
- Kumari
- Kupchan
- Lagunin
- Lamoral-Theys
- Lavie
- Lee
- Lie Ken Jie
- Ma
- Mai M. Al-Oqail
- Mohammad
- Mohammad S. Ahmad
- Mustafa
- Mustafa
- Mustafa
- Mustafa
- Nagao
- Niño
- Pinkerton
- Rahman
- Saleem
- Shabana I. Khan
- Takanori
- Wafaa H. Hassan
- Wang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial
- Author
- Aamir Afridi (9020687)
- Aamir Ghafoor (7575572)
- Aamir Husain (9020810)
- Aasia Kayani (6164375)
- Aasim Yusuf (9020828)
- Abby Harper-Payne (9020537)
- Abby Oglesby (9020426)
- Abdelmounem Abdo (9021089)
- Abdelmounem Eltayeib Abdo (9020198)
- Abdul Wahid (4395094)
- Abdus Khan (5280116)
- Abid Ali (3123210)
- Abrar Shaikh (9020759)
- Achuth Shenoy (9020639)
- Adam Bailey (6013856)
- Adamu Ahmed (9020894)
- Adamu Samaila (9020909)
- Adedayo Oluyomi Tade (9020879)
- Adeel Afzal (9020822)
- Adeela Irfan (9020807)
- Adeeqa Aman (9020792)
- Adefemi Afolabi (7105229)
- Adegboyega Akere (3993119)
- Adeleke Adekoya (9020876)
- Ademola Tolulope Adebanjo (9020921)
- Adewale Aderounmu (9020861)
- Adil Chang (9020699)
- Adnan Amin (3340584)
- Adrian Barry (9020216)
- Adrian Boyle (3283776)
- Adrian Cotirlet (9021053)
- Adrian Stanley (7810184)
- Ahmad Taj (9020684)
- Ahmed Shaker (9020954)
- Aijaz Ahmed (4524742)
- Aiman Mushir (9020705)
- Ajay Adhikaree (9020195)
- Akande Ajayi (9020915)
- Alan Barkun (4392202)
- Alastair Stevenson (9020597)
- Alexander Atiri (9020870)
- Alexandra Newman (9020471)
- Alison Jefferey (9020459)
- Alistair McNair (9020555)
- Amanda Cowton (9020384)
- Amanda Whileman (9020516)
- Amber Geer (9020099)
- Ameet Kumar (9020762)
- Aminu Nahuche (9020912)
- Amir Khan (216804)
- Amjad Ali (51075)
- Amjad Hussain (66687)
- Amy Brenner (5351024)
- Anam Bangash (9020654)
- Andee Zakaria (9020978)
- Andrei Ragea (9021044)
- Andrei Voiosu (9021050)
- Andrew Allison (379424)
- Andrew Appelboam (9020339)
- Andrew Brown (126751)
- Andrew Dongo (305209)
- Andrew Kinnon (9020546)
- Andrew Thayne (9020171)
- Andrew Veitch (7105238)
- Angiy Michael (9020357)
- Anna Quinn (9020153)
- Anne Hayes (5437334)
- Anthony Kehoe (95765)
- Anu Mitra (9020534)
- Anuj K.C. (9021080)
- Arben Beqiri (9021104)
- Areej Al Balkhi (9021095)
- Aroudra Outtandy (9020147)
- Ashraf Helmy (9020960)
- Asifa Aslam (9020813)
- Avril Kuhrt (9020531)
- Avto Megreladze (9021032)
- Aye-Aye Thi (9020234)
- Azeberoje Osueni (9020906)
- Baadur Mosidze (4593895)
- Barbara Watkins (9020375)
- Ben Rayner (9020624)
- Bernadette Gallagher (9020285)
- Bernard Ndungu (9020141)
- Besik Melikidze (9021020)
- Beverley Faulkner (9020438)
- Bobby Wellsh (9020207)
- Bogdan Busuioc (9021047)
- Bogdan Mateescu (6397388)
- Bukola Fawole (3573140)
- Camelia Chioncel (9021041)
- Carly Swann (9020282)
- Carolyn Hughes (9020120)
- Carrie Demetriou (9020510)
- Catherine Gilliam (9020105)
- Catherine Jarvis (9020279)
- Catriona Bryceland (9020348)
- Charlotte Owen (4349491)
- Chelci Squires (9020165)
- Chigozirim Onyekpere (9020891)
- Chris Gough (9020228)
- Chris Macdonald (9020606)
- Chris Metcalfe (528710)
- Chris Roukas (9020162)
- Christiane Vorwerk (7600901)
- Christine Lambe (9020246)
- Christopher Ekwunife (9020888)
- Christopher Hawkey (7105232)
- Claire Burnett (9020240)
- Claire Dowty (9020327)
- Colin Bergin (9020264)
- Collette Barrow (9020081)
- Conor Deasy (4391167)
- Courtenay Howe (9020117)
- Daisy Mackle (9020342)
- Dalia Ahmed (6319790)
- Daniel Balaban (9021062)
- Daniel Gilbert (9020102)
- Daniel Hetherington (9020114)
- Daniel Marks (3628709)
- Daniel Pearson (6915041)
- Daniela Manno (448227)
- Danielle Beaumont (6164360)
- Danielle Prowse (6164366)
- Daniyan Muhammad (9020897)
- David Hartin (9020465)
- David Henry (27846)
- David Hobday (9020609)
- David I'anson (9020123)
- David Yeo (495350)
- Davit Kazaishvili (9021023)
- Dawn Trodd (9020417)
- Diane Simpson (3201741)
- Donogh Maguire (9020309)
- Dorina Pestroiu Calescu (9021038)
- Edith Nonyelum Okeke (9020933)
- Edries Tejan (9020843)
- Edward Hartley (9020276)
- Elaine Hardy (9020267)
- Elaine Ng (9020999)
- Emma Austin (9020075)
- Emma Stoddard (9020261)
- Emuobor Odeghe (9020900)
- Enadeghe Eghaghe (9020873)
- Eni Balogun (6164363)
- Essa Khan (9020750)
- Fady Nagy (9020948)
- Faheem Butt (9020540)
- Fazal Rahman (9020723)
- Felicia Onoviran (9020390)
- Fionn Bellis (9020588)
- Folasade Adenike Bello (6166208)
- Frank Coffey (5344826)
- Funmilola Wuraola (9020864)
- Gabrielle May (9020483)
- Gavin Wright (436365)
- Gayle Clifford (9020543)
- Geoffrey Bellhouse (9020297)
- Georgia Bercades (9020318)
- Georgina Butt (9020495)
- Ghias Tayyab (9020774)
- Gia Tomadze (8715897)
- Haider Zaigham Baqai (9020801)
- Hakim Miah (9020138)
- Haleema Shakur-Still (5351027)
- Hamza Arshad (9020648)
- Hannah Cotton (9020399)
- Haroon Zahoor (9020660)
- Heather Jarman (3830791)
- Helen Sweeting (91575)
- Helio Fornieles Pérez (9021101)
- Holly Maguire (9020225)
- Hussein Khamis (9020183)
- Ian Gilmore (1338066)
- Ian Roberts (27002)
- Imogen Brooks (9020087)
- Imogen Skene (9020303)
- Iram Saeed (9020825)
- Irshad Hussain (2119519)
- Isobel Bradbury (9020345)
- Iulia Pintilie (9021056)
- Jack Cuzick (21012)
- Jackie Berry (9020396)
- Jacob de Wolff (9020636)
- James East (8266047)
- James Gagg (9020474)
- James Shutt (9020420)
- James Turvill (9020570)
- Jamie Barbour (9020630)
- Jane Hunt (9020591)
- Jane Martin (2609944)
- Janet Johnstone (9020306)
- Jason Kendall (9020435)
- Jason Klein (626502)
- Jason Pott (3715327)
- Javaria Khan (9020735)
- Jayne Foot (9020477)
- Jeff Keep (201686)
- Jemma Tanner (9020168)
- Jennifer Small (1353045)
- Jiffre Din (9020969)
- Joanna Tambellini (9020414)
- Joanne Thunder (9020270)
- Joaquin Alvarez Gregori (9020204)
- Joaquín Álvarez Gregori (9021098)
- John Greenaway (9020519)
- John Jones (2102023)
- Jonathan Simmons (9020060)
- Jonathon Snook (9020393)
- Jordi Margalef (9020582)
- Julia Grahamslaw (9020288)
- Julian Humphrey (9020585)
- Julie Tregonning (9020522)
- Julio Gil Onandia (9020108)
- Junaid Mushtaq (9020777)
- Jung Ryu (9020321)
- Kate Clayton (9020354)
- Katharine Ker (3706612)
- Kay Finney (9020222)
- Kehinde Osisanya (9020930)
- Kelly Needham (9020144)
- Kelvin Voon (9021008)
- Kenneth Halligan (9020054)
- Khairul Azis (9020972)
- Khalid Mahmood Nasir (9020768)
- Khalid Yahya (9020816)
- Khushboo Priya (9021074)
- Kiran Bal (9020078)
- Kiran Javaid (6164372)
- Kris Pillay (9020549)
- Laura Carrington (9020093)
- Laura Hunter (2822147)
- Laura O'Rourke (9020411)
- Laura Ranopa (9020156)
- Lauren Frimley (9020096)
- Lee Joon (9021017)
- Lisa McClelland (9020351)
- Lisa Sawers (9020231)
- Louisa Chan (6317819)
- Louise Chandler (9020504)
- Lucian Negreanu (9021068)
- Lucy Jones (6949329)
- Lucy Parker (7698881)
- Luke Lawton (9020210)
- Lynsey Flowerdew (9020627)
- Madeleine Cargill (9020090)
- Maggie Bell (9020453)
- Majid Soomro (3514601)
- Mandy Grocutt (9020579)
- Mansoor Ahmad (9020690)
- Mansoor Ul Haq (9020819)
- Maqbool Reki (9020753)
- Marcel Tanău (9021065)
- Maria Price (9020450)
- Maria Ramos (221562)
- Mariam Hassan (6457790)
- Mariana Jinga (9021059)
- Marion McNaught (9020576)
- Marium Waqar (9020702)
- Martin James (618107)
- Martin Thomas (1385559)
- Mary Doona (9020447)
- Marzouqah Al Anazi (9021092)
- Masykurin Mafauzy (9020987)
- Matthew Banks (9020315)
- Matthew Reed (3643819)
- Matthew Rutter (9020405)
- Mazen Naga (9020945)
- Mia Reid (9020159)
- Miland Joshi (3706609)
- Mobeen Kayani (9020741)
- Mohammad Hisyam (9020996)
- Mohammad Jahit (9021014)
- Mohammad Khalid (94154)
- Mohammad Shukri Bin Jahit (9020186)
- Mohammad Zaher (9020201)
- Mohammed Abdel Monem (9020966)
- Mohammed Ashfaq (9020501)
- Mohsin Ali (2177244)
- Monday Yilkudi (9020927)
- Monica Arribas (5809226)
- Morten Draegebo (9020573)
- Mostafa Saiid (9020951)
- Mouzam Shaikh (9020795)
- Muhammad Afzal (83943)
- Muhammad Arif Nadeem (2863970)
- Muhammad Imran (282621)
- Muhammad Ishfaq (6700175)
- Muhammad Khurram (3123207)
- Muhammad Muaaz (9020681)
- Muhammad Nasir (1425508)
- Muhammad Qamar (9020657)
- Muhammad Shafi (7168253)
- Muhammad Umar (604981)
- Muhammad Zubair (728141)
- Muhyuddin Brukan (9020975)
- Mujahid Aslam (9020693)
- Mumtaz Marwat (9020831)
- Muttiullah Mutti (7105235)
- Myriam Benyahia (9020084)
- Nadeem Iqbal (9020726)
- Naeem Aslam (9020651)
- Nancy Ukwu (9020855)
- Natasha Christmas (9020498)
- Nayia Golfi (9020111)
- Nicholas Watson (7205597)
- Nick Mathieu (9020564)
- Nicola Haeger (9020429)
- Nicola Jacques (5454563)
- Nicola Palmer (1763722)
- Nigel Quashi (9020150)
- Nigel Trudgill (7293002)
- Nighat Fatima (788832)
- Nil Amri (9020993)
- Nino Grubelashvili (9021029)
- Nizam Hashim (9020984)
- Noureen Misbah (9020738)
- Oguamanam Okezie Enwere (9020936)
- Okafor Nnaemaka (9020852)
- Ola Afolabi (9020378)
- Oladapo Olayemi (7137005)
- Olatunji Shonoiki (9020882)
- Olawale Badejo (9020849)
- Olivia Boulton (9020300)
- Olu Orugun (9020612)
- Olufunmilayo Lesi (9020903)
- Olujide Okunade (9020177)
- Olukayode Arowolo (9020858)
- Olusade Adetayo (9020180)
- Oluwole Olaomi (9020846)
- Omar Ashoush (9020942)
- Omer Omer (9020558)
- Paul Cumpstay (9020489)
- Paul Jhalli (9020273)
- Peter Swallow (9020642)
- Phil Edwards (102667)
- Philip Boger (9020369)
- Philip Devereaux (9020069)
- Philip Kaye (687495)
- Pinkey Sachdev (9020765)
- Quratul ain Ghalib (9020666)
- Rachel Atkins (8042036)
- Rachel Comer (9020372)
- Rachel O'Brien (9020291)
- Racquel Carpio (9020219)
- Radu Bogdan Mateescu (9020192)
- Raghavendra Kamath (9020213)
- Rajaventhan Srirajaskanthan (9020645)
- Raoul Mansukhani (9020057)
- Richard Gray (2619970)
- Richard Jackson (458071)
- Richard Pollok (691605)
- Rita Das (118901)
- Rizwana Chaudhri (5351030)
- Rob Jackson (9020126)
- Romaih Al-Idari (9020255)
- Rosalyn Squire (9020462)
- Rose Ugiagbe (9020867)
- Rufina Igetei (9020924)
- Ruhama Uddin (9020174)
- Ruth Fazakerley (633044)
- Ruth Worner (9020441)
- Ruxandra Oprita (9021035)
- Saadia Noreen (9020717)
- Saafan Saafan (9020963)
- Saba Arshad (9020663)
- Sadaf Sattar (9020708)
- Saif Al-Nahhas (9020363)
- Saifullah Goraya (9020711)
- Sajjad Ali (2865626)
- Sajjad Yaqoob (9020834)
- Saleh Channa (9020789)
- Sally Beer (9020333)
- Salman Azhar (194007)
- Samuel Guest (9020258)
- Samuel McBride (9020618)
- Samuel Olatoke (8998202)
- Sana Shaikh (4035188)
- Sandeep Kumar (145759)
- Sanjay Singh (69314)
- Santosh Kumar (106550)
- Sarah Hearnshaw (9020444)
- Sarah Moreton (9020423)
- Sarah Rounding (9020249)
- Sarah Wilson (669311)
- Serag Esmat (9020939)
- Sergey Kostrov (9020132)
- Shafqat Iqbal (9020756)
- Shahida Tarar (9020744)
- Shaik Farid (9020981)
- Shankar Baral (9021077)
- Sharmeen Aslam (9020714)
- Shazad Afzal (9020381)
- Shehroze Khan (9020678)
- Sheik Pahary (9020492)
- Sheraz Saleem (9020720)
- Sherbat Khan (9020747)
- Shweta Gidwani (9020552)
- Shyang Yee Lim (9021005)
- Sian Davies (9020336)
- Simon Barnes (9020567)
- Simon Carley (9020513)
- Simon Everett (9020387)
- Simon Stanworth (3414986)
- Simon Tucker (9020252)
- Simona Bataga (9021071)
- Sinead Helyar (9020402)
- Sir Young Yam (9021011)
- Sneha Kansagra (9020129)
- Sohaib Ahmed (9020783)
- Stephanie Bell (9020468)
- Stephen Haig (9020360)
- Stephen Hood (9020633)
- Steve Goodacre (11696)
- Steven Barden (9020600)
- Stuart Paterson (9020603)
- Sue Wakeford (9020480)
- Suresh David (9020066)
- Susan Fowler (6192608)
- Susan Thornton (9020312)
- Susie Hardwick (9020432)
- Syed Ahmad (4282963)
- Syed Shah (3623408)
- Taemi Kawahara (68178)
- Tahir Bashir (730627)
- Tahir Rizvi (9020798)
- Tamar Gogichaishvili (9020189)
- Tanveer Hussain (413615)
- Tanya de Weymarn (9020561)
- Tayyab Akhter (9020732)
- Tayyaba Saif (9020672)
- Tazaeen Kazmi (9020786)
- Tehseen Hameed (9020669)
- Temitope Oke (9020840)
- Thomas Bartram (9020486)
- Tim Godfrey (9020366)
- Timothy Coats (3575405)
- Timothy Harris (9020294)
- Tinuola Fakoya (9020837)
- Toafiq Raji (9020885)
- Ton Lisman (46337)
- Tony Brady (9020072)
- Tracey Johnston (9020408)
- Tracey Pepple (6164369)
- Tristan Dyer (9020615)
- Ubedullah Bughio (9020696)
- Uchenna Ijoma (9020918)
- Umar Riaz (9020729)
- Vania Loureiro (9020456)
- Victoria Murray (9020243)
- Vijay Sah (9021083)
- Vijay Yadav (4612135)
- Vipul Jairath (5809229)
- Wajahat Shafi (9020675)
- Wan Najmi (9020990)
- Wasim Uddin (9020780)
- Wojciech Sawicki (9020621)
- Xin Yi (180644)
- Yasir Iqbal (23922)
- Zafar Iqbal Chaudhry (9020771)
- Zakawat Rasheed (9020804)
- Zeeshan Ali (5950430)
- Zuhrirahimi Ramli (9021002)
- Publication venue
- Publication date
- 20/06/2020
- Field of study
BackgroundTranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding.MethodsWe did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124.FindingsBetween July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98).InterpretationWe found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial.</div
Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- Abellán M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Za’nouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes García F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akhter Rahman MM
- Akilli H
- Akin E
- Akkour K
- Akkulak Murat
- Akmenkalne L
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
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- on behalf of the COVIDSurg Collaborative
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- Камалов А
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study
Delaying surgery for patients with a previous SARS-CoV-2 infection
- Author
- A A Ali Karar
- A A Kerawala
- A A Marra
- A Abad Gurumeta
- A Abad-Motos
- A Abdelmajeed
- A Abdelrahman
- A Abdelsamed
- A Abdulkareem
- A Aboelkassem Ibrahim
- A Abouassi
- A Abreu da Silva
- A Abubakar
- A Acher
- A Aderombi
- A Adeyeye
- A Adiamah
- A Aggarwal
- A Aghayeva
- A Agnes
- A Agrawal
- A Ahmeidat
- A Aimé
- A Ajlan
- A Al-Habib
- A Al-Mohammad
- A Al-Mukhtar
- A Aladeojebi
- A Alamri
- A Alanbuki
- A Alatar
- A Alburakan
- A Alfaro-Goldaracena
- A Alhamed
- A Alhefdhi
- A Almeciga
- A Almeida
- A Alomair
- A Alonso Poza
- A Alsaif
- A Anastasi
- A Antic
- A Anzak
- A Aprile
- A Arminio
- A Arulanantham
- A Askari
- A Asqalan
- A Athanasiou
- A Ayhan
- A Ayman
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- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
- Y Bashir
- Y El Bouazizi
- Y Fayed
- Y H Lam
- Y Kanemitsu
- Y Kara
- Y Kirmizi
- Y Levy-Zauberman
- Y Litvina
- Y Perez
- Y T Liew
- Y Tanase
- Y Viswanath
- Y Ying
- Z Al-Ishaq
- Z Aldayri
- Z Aliyeva
- Z Bayhan
- Z Chia
- Z Dzamic
- Z H Belkhadir
- Z Inic
- Z Jawad
- Z Jezdic
- Z Katusic
- Z Krivokapic
- Z Lakkis
- Z Li
- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Á De la Hoz Rodríguez
- Á Fernández Camuñas
- É Ryan
- Ž Grubač
- А Камалов
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl