Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients

Objective. To retrospectively evaluate ANCA testing in a cohort of unselected Greek in- and outpatients. Methods. In 10803 consecutive serum samples, ANCA were tested by indirect immunofluorescence (IIF) and ELISA. ELISA in inpatients was performed only on IIF positive sera. Results. Low prevalence (6.0%) of IIF positive samples was observed. Among these samples, 63.5% presented perinuclear (p-ANCA), 9.3% cytoplasmic (c-ANCA) and 27.2% atypical (x-ANCA) pattern. 16.1% of p-ANCA were antimyeloperoxidase (anti-MPO) positive, whereas 68.3% of c-ANCA were antiproteinase-3 (anti-PR3) positive. Only 17 IIF negative outpatients' samples were ELISA positive. ANCA-associated vasculitides (AAV), connective tissue disorders and gastrointestinal disorders represented 20.5%, 23.9%, and 21.2% of positive results, respectively. AAV patients exhibited higher rates of MPO/PR3 specificity compared to non-AAV (93.8% versus 8%). Conclusions. This first paper on Greek patients supports that screening for ANCA by IIF and confirming positive results by ELISA minimize laboratory charges without sacrificing diagnostic accuracy

Platforms and Publishers: The End of an Era

Since our last report was published in June 2018, the shift in the journalism landscape has been seismic. Advertising revenues have continued to plummet and newsrooms across the country have experienced mass layoffs. In turn, publishers have scrambled to adapt their business models and priorities in an ever-changing and volatile media ecosystem—one still dominated by platforms despite the large-scale public reckoning with their effects on society and democracy. There is no telling how publishers will fare in the coming years as platforms undergo perhaps their most dramatic transformations since their foray into publishing products in 2015. However, one thing is certain: Despite facing increasing antitrust scrutiny and calls for regulation, platforms are more powerful than ever. Over time, they have come to control the online information ecosystem and, increasingly, in the case of Facebook and Google, are among the news industry’s top funders. It is in this context that many of the publishing executives and employees we interviewed described the “end of an era.” But as is clear in the report, this does not mean the end of their cooperation with platforms. It refers, rather, to the end of optimism that scale and ad-based platform products will bring about meaningful revenue and audience growth. From the rise of paywalls and reader revenue initiatives to the diversification of revenue streams through live events and podcasts, publishers are attempting to regain control over the future of their businesses

An empirical comparison of convertible bond valuation models

This paper empirically compares three convertible bond valuation models. We use an innovative approach where all model parameters are estimated by the Marquardt algorithm using a subsample of convertible bond prices. The model parameters are then used for out-of-sample forecasts of convertible bond prices. The mean absolute deviation is 1.86% for the Ayache-Forsyth-Vetzal model, 1.94% for the Tsiveriotis-Fernandes model, and 3.73% for the Brennan-Schwartz model. For this and other measures of fit, the Ayache-Forsyth-Vetzal and Tsiveriotis-Fernandes models outperform the Brennan-Schwartz model

Wound dehiscence: is still a problem in the 21th century: a retrospective study

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to evaluate the risk factors of wound dehiscence and determine which of them can be reverted.</p> <p>Methods</p> <p>We retrospectively analyzed 3500 laparotomies. Age over 75 years, diagnosis of cancer, chronic obstructive pulmonary disease, malnutrition, sepsis, obesity, anemia, diabetes, use of steroids, tobacco use and previous administration of chemotherapy or radiotherapy were identified as risk factors</p> <p>Results</p> <p>Fifteen of these patients developed wound dehiscence. Emergency laparotomy was performed in 9 of these patients. Patients who had more than 7 risk factors died.</p> <p>Conclusion</p> <p>It is important for the surgeon to know that wound healing demands oxygen consumption, normoglycemia and absence of toxic or septic factors, which reduces collagen synthesis and oxidative killing mechanisms of neutrophils. Also the type of abdominal closure may plays an important role. The tension free closure is recommended and a continuous closure is preferable. Preoperative assessment so as to identify and remove, if possible, these risk factors is essential, in order to minimize the incidence of wound dehiscence, which has a high death rate.</p

Simulation of incompressible viscous flows around moving objects by a variant of immersed boundary-Lattice Boltzmann method

A variant of immersed boundary-lattice Boltzmann method (IB-LBM) is presented in this paper to simulate incompressible viscous flows around moving objects. As compared with the conventional IB-LBM where the force density is computed explicitly by Hook's law or the direct forcing method and the non-slip condition is only approximately satisfied, in the present work, the force density term is considered as the velocity correction which is determined by enforcing the non-slip condition at the boundary. The lift and drag forces on the moving object can be easily calculated via the velocity correction on the boundary points. The capability of the present method for moving objects is well demonstrated through its application to simulate flows around a moving circular cylinder, a rotationally oscillating cylinder, and an elliptic flapping wing. Furthermore, the simulation of flows around a flapping flexible airfoil is carried out to exhibit the ability of the present method for implementing the elastic boundary condition. It was found that under certain conditions, the flapping flexible airfoil can generate larger propulsive force than the flapping rigid airfoil

Why are convertible bond announcements associated with increasingly negative issuer stock returns? An arbitrage-based explanation

While convertible offerings announced between 1984 and 1999 induce average abnormal stock returns of −1.69%, convertible announcement effects over the period 2000–2008 are more than twice as negative (−4.59%). We hypothesize that this evolution is attributable to a shift in the convertible bond investor base from long-only investors towards convertible arbitrage funds. These funds buy convertibles and short the underlying stocks, causing downward price pressure. Consistent with this hypothesis, we find that the differences in announcement returns between the Traditional Investor period (1984–1999) and the Arbitrage period (2000–September 2008) disappear when controlling for arbitrage-induced short selling associated with a range of hedging strategies. Post-issuance stock returns are also in line with the arbitrage explanation. Average announcement effects of convertibles issued during the Global Financial Crisis are even more negative (−9.12%), due to a combination of short-selling price pressure and issuer, issue, and macroeconomic characteristics associated with these offerings

Cross-Reactive Sensor Arrays for the Detection of Peptides in Aqueous Solution by Fluorescence Spectroscopy

A simple but powerful method for the sensing of peptides in aqueous solution has been developed. The transition-metal complexes [PdCl2(en)], [{RhCl2Cp*}2], and [{RuCl2(p-cymene)} 2] were combined with six different fluorescent dyes to build a cross-reactive sensor array. The fluorescence response of the individual sensor units was based on competitive complexation reactions between the peptide analytes and the fluorescent dyes. The collective response of the sensor array in a time-resolved fashion was used as an input for multivariate analyses. A sensor array comprised of only six metal-dye combinations was able to differentiate ten different dipeptides in buffered aqueous solution at a concentration of 50 uM. Furthermore, the cross-reactive sensor could be used to obtain information about the identity and the quantity of the pharmacologically interesting dipeptides carnosine and homocarnosine in a complex biological matrix, such as deproteinized human blood serum. The sensor array was also able to sense longer peptides, which was demonstrated by differentiating mixtures of the nonapeptide bradykinin and the decapeptide kallidin