2-(4-Chloro­phen­yl)-1,5-diphenyl-3-tosyl­imidazolidin-4-one

In the title compound, C28H23ClN2O3S, the central imidazolidine ring adopts a twisted conformation and the S atom has distorted tetra­hedral geometry. The crystal packing is stabilized by C—H⋯O, C—H⋯π and π–π inter­actions [centroid–centroid distance = 3.8302 (10) Å]

Homogeneous and heterogeneous catalysts for multicomponent reactions

[EN] Organic synthesis performed through multicomponent reactions is an attractive area of research in organic chemistry. Multicomponent reactions involve more than two starting reagents that couple in an exclusive ordered mode under the same reaction conditions to form a single product which contains the essential parts of the starting materials. Multicomponent reactions are powerful tools in modern drug discovery processes, because they are an important source of molecular diversity, allowing rapid, automated and high throughput generation of organic compounds. This review aims to illustrate progress in a large variety of catalyzed multicomponent reactions performed with acid, base and metal heterogeneous and homogeneous catalysts. Within each type of multicomponent approach, relevant products that can be obtained and their interest for industrial applications are presented.The authors wish to gratefully acknowledge the Generalitat Valenciana for the financial support in the project CONSOLIDER-INGENIO 2010 (CSD2009-00050)Climent Olmedo, MJ.; Corma Canós, A.; Iborra Chornet, S. (2012). Homogeneous and heterogeneous catalysts for multicomponent reactions. RSC Advances. 2(1):16-58. https://doi.org/10.1039/c1ra00807bS16582

Synthesis and characterization of 5-(cyclohexylsulfanyl)- 4-aryl-1,2,3-selena/ thiadiazoles

305-309The synthesis and characterization of new 5-(cyclohexylsulfanyl)-4-aryl-1,2,3-selena/ thiadiazoles, obtained from the -sulfanyl semicarbazones are described. The structures of these compounds have been established by ¹H NMR, ¹³C NMR and single crystal X-ray diffraction

Copper(I)-Catalyzed Three Component Reaction of Sulfonyl Azide, Alkyne, and Nitrone Cycloaddition/Rearrangement Cascades: A Novel One-Step Synthesis of Imidazolidin-4-ones

A novel one-pot azide–alkyne/ketenimine–nitrone cycloaddition sequence that is induced by copper(I) and allows the transformation of sulfonyl azides, alkynes, and nitrones to highly substituted imidazolidin-4-ones is described. The corresponding heterogeneous version utilizing Cu(I)-modified zeolites as recyclable heterogeneous catalysts shows marginally improved yield and diastereoselectivity

Copper-Catalyzed Sulfonyl Azide–Alkyne Cycloaddition Reactions: Simultaneous Generation and Trapping of Copper–Triazoles and −Ketenimines for the Synthesis of Triazolopyrimidines

First simultaneous generation and utilization of both copper–triazole and −ketenimine intermediates in copper-catalyzed sulfonyl azide–alkyne cycloaddition reactions is achieved for the one-pot synthesis of triazolopyrimidines via a novel copper-catalyzed multicomponent cascade of sulfonyl azides, alkynes, and azirines. Significantly, the reaction proceeds under very mild conditions in good yields