446 research outputs found
Ultrabroad-bandwidth multifrequency Raman generation
We report on the modeling of transient stimulated rotational Raman scattering in H2 gas. We predict a multifrequency output, spanning a bandwidth greater than the pump frequency, that may be generated without any significant delay with respect to the pump pulses. The roles of dispersion and transiency are quantified
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Landmine policy in the near-term: a framework for technology analysis and action
Any effective solution to the problem of leftover landmines and other post-conflict unexploded ordnance (UXO) must take into account the real capabilities of demining technologies and the availability of sufficient resources to carry out demining operations. Economic and operational factors must be included in analyses of humanitarian demining. These factors will provide a framework for using currently available resources and technologies to complete this task in a time frame that is both practical and useful. Since it is likely that reliable advanced technologies for demining are still several years away, this construct applies to the intervening period. It may also provide a framework for utilizing advanced technologies as they become available. This study is an economic system model for demining operations carried out by the developed nations that clarifies the role and impact of technology on the economic performance and viability of these operations. It also provides a quantitative guide to assess the performance penalties arising from gaps in current technology, as well as the potential advantages and desirable features of new technologies that will significantly affect the international community`s ability to address this problem. Implications for current and near-term landmine and landmine technology policies are drawn
PLASMA CONCENTRATIONS OF METHADONE DURING POSTOPERATIVE PATIENT-CONTROLLED EXTRADURAL ANALGESIA
Plasma concentrations of methadone were measured by gas chromatography in 16 patients receiving extradural methadone by continuous infusion for relief of postoperative pain. Venous blood samples were taken after a loading dose of extradural methadone 2 mg and during infusion of 0.46 mg hâ1 plus patient-controlled increments of 0.2-1 mg. Mean (SD) plasma concentration of methadone was 9.8 (2.1) ng mlâ1 at 15 min; this did not change significantly during the first 2 h, after which it increased gradually to 32.2 (4.6) ng mlâ1 (P < 0.001) at the end of 24 h. The mean quantity of extradural methadone required to produce effective analgesia was 10.3 (1.8) mg during the first 12 h after operation and 6 (1.0) mg for the subsequent 12 h. The mean amount of methadone for effective analgesia on the second day was 7.6 (1.1) mg. No adverse effects were detected during the 2-3 days of methadone therapy. Plasma concentration of methadone increased significantly during patient-controlled infusion of extradural methadone in the first 24 h after operation, suggesting rapid vascular uptake. Systemic activity of the drug contributes to the analgesic effect of extradural methadon
-BaBO deep UV monolithic walk-off compensating tandem
The generation of watt-level cw narrow-linewidth sources at specific deep UV
wavelengths corresponding to atomic cooling transitions usually employs
external cavity-enhanced second-harmonic generation (SHG) of moderate-power
visible lasers in birefringent materials. In this work, we investigate a novel
approach to cw deep-UV generation by employing the low-loss BBO in a monolithic
walkoff-compensating structure [Zondy {\it{et al}}, J. Opt. Soc. Am. B
{\bf{20}} (2003) 1675] to simultaneously enhance the effective nonlinear
coefficient while minimizing the UV beam ellipticity under tight focusing. As a
preliminary step to cavity-enhanced operation, and in order to apprehend the
design difficulties stemming from the extremely low acceptance angle of BBO, we
investigate and analyze the single-pass performance of a mm monolithic
walk-off compensating structure made of 2 optically-contacted BBO plates cut
for type-I critically phase-matched SHG of a cw nm dye laser. As
compared with a bulk crystal of identical length, a sharp UV efficiency
enhancement factor of 1.65 has been evidenced with the tandem structure, but at
nm from the targeted fundamental wavelength, highlighting the
sensitivity of this technique when applied to a highly birefringent material
such as BBO. Solutions to angle cut residual errors are identified so as to
match accurately more complex periodic-tandem structure performance to any
target UV wavelength, opening the prospect for high-power, good beam quality
deep UV cw laser sources for atom cooling and trapping.Comment: 21 pages, 8 figures, to appear in Opt. Commu
Effective suppression of parametric instabilities with decoupled broadband lasers in plasma
A theoretical analysis for the stimulated Raman scattering (SRS) instability driven by two laser beams with certain frequency difference is presented. It is found that strong coupling and enhanced SRS take place only when the unstable regions for each beam are overlapped in the wavenumber space. Hence a threshold of the beam frequency difference for their decoupling is found as a function of their intensity and plasma density. Based upon this, a strategy to suppress the SRS instability with decoupled broadband lasers (DBLs) is proposed. A DBL can be composed of tens or even hundreds of beamlets, where the beamlets are distributed uniformly in a broad spectrum range such as over 10% of the central frequency. Decoupling among the beamlets is found due to the limited beamlet energy and suitable frequency difference between neighboring beamlets. Particle-in-cell simulations demonstrate that SRS can be almost completely suppressed with DBLs under the laser intensity ⌠1015 W/cm2. Moreover, stimulated Brillouin scattering (SBS) will be suppressed simultaneously with DBLs can be attractive for driving inertial confined fusion
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Use of alternating-Z doubling in high-dynamic-range tripling: design and evaluation of an optimized prototype tripler
We designed and tested an alternating-Z tripler that consisted of two detuned, Type-1, potassium dihydrogen phosphate (KD*P) doublers and one KD*P mixer. The crystal thicknesses were, respectively, 13, 10 and 10 mm, and the detunings of the doublers were +420 and -520 ”rad. All three crystals were fabricated from 80% deuterated KDP. Conversion efficiency was measured and calculated for input 1053- nm pulses with approximately rectangular waveforms and durations of either 1 or 6 ns, and for 20-ns pulses that exhibited intensity variation by a factor of 10. The measured peak conversion efficiency was more than 80%, and energy conversion efficiencies ranged from 62-80% depending on the waveform of the input pulse. The expected large dynamic range in input intensity, 9-10, was observed, and the measured and calculated efficiencies were in excellent agreement
A 750 mW, continuous-wave, solid-state laser source at 313 nm for cooling and manipulating trapped 9Be+ ions
We present a solid-state laser system that generates 750 mW of
continuous-wave single-frequency output at 313 nm. Sum-frequency generation
with fiber lasers at 1550 nm and 1051 nm produces up to 2 W at 626 nm. This
visible light is then converted to UV by cavity-enhanced second-harmonic
generation. The laser output can be tuned over a 495 GHz range, which includes
the 9Be+ laser cooling and repumping transitions. This is the first report of a
narrow-linewidth laser system with sufficient power to perform fault-tolerant
quantum-gate operations with trapped 9Be+ ions by use of stimulated Raman
transitions.Comment: 9 pages, 4 figure
Research on nonlinear optical materials: an assessment
The seven papers making up this assessment are based on the Workshop on Nonlinear Optical Materials held in April 1986
Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).
Homocysteine is produced physiologically in all cells, and is present in plasma of healthy individuals (plasma [HCy]: 3-10ÎŒM). While rare genetic mutations (CBS, MTHFR) cause severe hyperhomocysteinemia ([HCy]: 100-200ÎŒM), mild-moderate hyperhomocysteinemia ([HCy]: 10-100ÎŒM) is common in older people, and is an independent risk factor for stroke and cognitive impairment. As B-vitamin supplementation (B6, B12 and folate) has well-validated homocysteine-lowering efficacy, this may be a readily-modifiable risk factor in vascular contributions to cognitive impairment and dementia (VCID). Here we review the biochemical and cellular actions of HCy related to VCID. Neuronal actions of HCy were at concentrations above the clinically-relevant range. Effects of HCy <100ÎŒM were primarily vascular, including myocyte proliferation, vessel wall fibrosis, impaired nitric oxide signalling, superoxide generation and pro-coagulant actions. HCy-lowering clinical trials relevant to VCID are discussed. Extensive clinical and preclinical data support HCy as a mediator for VCID. In our view further trials of combined B-vitamin supplementation are called for, incorporating lessons from previous trials and from recent experimental work. To maximise likelihood of treatment effect, a future trial should: supply a high-dose, combination supplement (B6, B12 and folate); target the at-risk age range; and target cohorts with low baseline B-vitamin status. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock
Relativistic Brownian Motion
Stimulated by experimental progress in high energy physics and astrophysics,
the unification of relativistic and stochastic concepts has re-attracted
considerable interest during the past decade. Focusing on the framework of
special relativity, we review, here, recent progress in the phenomenological
description of relativistic diffusion processes. After a brief historical
overview, we will summarize basic concepts from the Langevin theory of
nonrelativistic Brownian motions and discuss relevant aspects of relativistic
equilibrium thermostatistics. The introductory parts are followed by a detailed
discussion of relativistic Langevin equations in phase space. We address the
choice of time parameters, discretization rules, relativistic
fluctuation-dissipation theorems, and Lorentz transformations of stochastic
differential equations. The general theory is illustrated through analytical
and numerical results for the diffusion of free relativistic Brownian
particles. Subsequently, we discuss how Langevin-type equations can be obtained
as approximations to microscopic models. The final part of the article is
dedicated to relativistic diffusion processes in Minkowski spacetime. Due to
the finiteness of velocities in relativity, nontrivial relativistic Markov
processes in spacetime do not exist; i.e., relativistic generalizations of the
nonrelativistic diffusion equation and its Gaussian solutions must necessarily
be non-Markovian. We compare different proposals that were made in the
literature and discuss their respective benefits and drawbacks. The review
concludes with a summary of open questions, which may serve as a starting point
for future investigations and extensions of the theory.Comment: review article, 159 pages, references updated, misprints corrected,
App. A.4. correcte
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