Scelestum pectus: incesto, magnicidio y parricidio en Edipo Rey de Séneca. Análisis lexicográfico de un crimen

La presente investigación analiza los discursos emitidos por el personaje Edipo en la tragedia Edipo Rey de Séneca. Nos enfocaremos en el léxico, es decir, en el vocabulario empleado por el autor romano para referirse a las categorías de las transgresiones cometidas por Edipo desde el momento en que huye a Tebas hasta el desencadenamiento del hecho trágico. El análisis se realiza a partir del estudio en la lengua original de la tragedia, el latín. De dicho análisis lexicográfico se obtuvo como resultado principal la existencia de un vocabulario especializado para denominar los tipos de crímenes cometidos por el rey, evidenciándose, por un lado, el empleo de un léxico común con otras tragedias de Séneca como Medea, Hercules Furens y Phaedra y, por el otro, la permanencia argumentativa en la presentación de los hechos con respecto a la obra Edipo Rey de Sófocles, especialmente cuando el personaje principal es arrebatado por la ira

Individualidade e desenvolvimento moral em J. S. Mill

O fio condutor dos argumentos apresentados por J. S. Mill em On Liberty é de que o aperfeiçoamento da humanidade tem como fonte infalível e permanente o espírito da liberdade. Nosso objetivo é mostrar que o conceito de liberdade milliana se equilibra entre a promoção do cultivo da individualidade, na sua mais ampla pluralidade, e o desenvolvimento moral da sociedade.The guiding thread of the arguments presented by J. S. Mill in On Liberty is that the development of humanity has its infallible and permanent source in the spirit of freedom. Our objective is to show that the Millian concept of freedom is balanced between the individuality’s cultivation, in its widest plurality, and the moral development of the society

Yoghurt and curd cheese addition to wheat bread dough: Impact on in vitro starch digestibility and estimated glycemic index

The effect of yoghurt and curd cheese additions on pasting properties, starch digestibility and estimated glycemic index of wheat bread were studied. Yoghurt and curd cheese incorporations (6% up to 25% w/w) promoted considerable changes on starch performance based on gelatinization and final dough consistency properties. These changes led to a significant impact on starch digestibility, reducing significantly the rapidly digestible starch while increasing the resistant starch. The estimated glycemic index reflected the changes promoted on starch performance from both dairy products addition, at higher level tested (25%): a significant reduction of around 30% for yoghurt bread and 38% for curd cheese bread, was obtained, resulting in medium to low (55–69) glycemic index breads. Correlations were found between pasting properties, starch digestibility and glycemic index, revealing that the effects observed are proportional to the levels of dairy products added. Microstructure images of the starch granules supported these findingsinfo:eu-repo/semantics/publishedVersio

Cetuximab plus platinum-based chemotherapy in head and neck Squamous Cell Carcinoma: a retrospective study in a single Comprehensive European Cancer Institution

Background: The use of cetuximab in combination with platinum (P) plus 5-fluorouracil (F) has previously been demonstrated to be effective in the treatment of metastatic squamous cell cancer of head and neck (SCCHN). We investigated the efficacy and outcome of this protocol as a first-line treatment for patients with recurrent or metastatic disease. We evaluated overall-survival (OS), progression-free-survival (PFS), overall response rate (ORR) and the treatment toxicity profile in a retrospective cohort. Patients and Methods: This study enrolled 121 patients with untreated recurrent or metastatic SCCHN. The patients received PF+ cetuximab every 3 weeks for a maximum of 6 cycles. Patients with stable disease who received PF+ cetuximab continued to receive cetuximab until disease progressed or unacceptable toxic effects were experienced, whichever occurred first. Results: The median patient age was 53 (37-78) years. The patient cohort was 86.8% male. The addition of cetuximab to PF in the recurrent or metastatic setting provided an OS of 11 months (Confidential Interval, CI, 95%, 8.684-13.316) and PFS of 8 months (CI 95%, 6.051-9.949). The disease control rate was 48.9%, and the ORR was 23.91%. The most common grade 3 or 4 adverse events in the PF+ cetuximab regimen were febrile neutropenia (5.7%), skin rash (3.8%) and mucosistis (3.8%). Conclusions: The results of this study suggest that cetuximab plus platinum-fluorouracil chemotherapy is a good option for systemic treatment in advanced SSCHN patients. This regimen has a well-tolerated toxicity profile.info:eu-repo/semantics/publishedVersio

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

The leishmaniases are diseases that affect millions of people across the world, in particular visceral leishmaniasis (VL) which is fatal unless treated. Current standard of care for VL suffers from multiple issues and there is a limited pipeline of new candidate drugs. As such, there is a clear unmet medical need to identify new treatments. This paper describes the optimization of a phenotypic hit against Leishmania donovani, the major causative organism of VL. The key challenges were to balance solubility and metabolic stability while maintaining potency. Herein, strategies to address these shortcomings and enhance efficacy are discussed, culminating in the discovery of preclinical development candidate GSK3186899/DDD853651 (<b>1</b>) for VL

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder