A Spatio-Temporal Bayesian Model for Estimating the Effects of Land Use Change on Urban Heat Island

The urban heat island (UHI) phenomenon has been identified and studied for over two centuries. As one of the most important factors, land use, in terms of both composition and configuration, strongly influences the UHI. As a result of the availability of detailed data, the modeling of the residual spatio-temporal autocorrelation of UHI, which remains after the land use effects have been removed, becomes possible. In this study, this key statistical problem is tackled by a spatio-temporal Bayesian hierarchical model (BHM). As one of the hottest areas in China, southwest China is chosen as our study area. Results from this study show that the difference of UHI levels between different cities in southwest China becomes large from 2000 to 2015. The variation of the UHI level is dominantly driven by temporal autocorrelation, rather than spatial autocorrelation. Compared with the composition of land use, the configuration has relatively minor influence upon UHI, due to the terrain in the study area. Furthermore, among all land use types, the water body is the most important UHI mitigation factor at the regional scale

Identifying Human-Induced Spatial Differences of Soil Erosion Change in a Hilly Red Soil Region of Southern China

Soil erosion (SE) processes are closely related to natural conditions and human activities, posing a threat to environment and society. Identifying the human impact on regional SE changes is increasingly essential for pertinent SE management. Jiangxi province is studied here as a representative area of hilly-red-soil regions within southern China. The main objectives of this study were to investigate the changing trend of SE within Jiangxi and identify human impacts on regional SE change from the perspective of spatial differences, through a new approach based on a gravity-center model. Our results showed that SE status presented an overall amelioration from 1990 to 2015, while the average soil erosion modulus (SEM) declined from 864 to 281 Mg/(km2·a). Compared to the situation under human and natural impacts, human-induced spatial differences of SE change demonstrated that the western and northwest regions showed stronger negative effects; the southern region shifted towards negative effects; the northeast region presented a much weaker negative effect. Our results indicated that 4 cities with strong negative effects need more attention in further SE management suited to their local conditions and development, and also suggested that the approach based on a gravity-center has potential for identifying the human impact on regional SE change from the perspective of spatial patterns

Association between ambient air pollution and daily hospital admissions for ischemic stroke: A nationwide time-series analysis.

BACKGROUND:Evidence of the short-term effects of ambient air pollution on the risk of ischemic stroke in low- and middle-income countries is limited and inconsistent. We aimed to examine the associations between air pollution and daily hospital admissions for ischemic stroke in China. METHODS AND FINDINGS:We identified hospital admissions for ischemic stroke in 2014-2016 from the national database covering up to 0.28 billion people who received Urban Employee Basic Medical Insurance (UEBMI) in China. We examined the associations between air pollution and daily ischemic stroke admission using a two-stage method. Poisson time-series regression models were firstly fitted to estimate the effects of air pollution in each city. Random-effects meta-analyses were then conducted to combine the estimates. Meta-regression models were applied to explore potential effect modifiers. More than 2 million hospital admissions for ischemic stroke were identified in 172 cities in China. In single-pollutant models, increases of 10 μg/m3 in particulate matter with aerodynamic diameter <2.5 μm (PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) and 1 mg/m3 in carbon monoxide (CO) concentrations were associated with 0.34% (95% confidence interval [CI], 0.20%-0.48%), 1.37% (1.05%-1.70%), 1.82% (1.45%-2.19%), 0.01% (-0.14%-0.16%), and 3.24% (2.05%-4.43%) increases in hospital admissions for ischemic stroke on the same day, respectively. SO2 and NO2 associations remained significant in two-pollutant models, but not PM2.5 and CO associations. The effect estimates were greater in cities with lower air pollutant levels and higher air temperatures, as well as in elderly subgroups. The main limitation of the present study was the unavailability of data on individual exposure to ambient air pollution. CONCLUSIONS:As the first national study in China to systematically examine the associations between short-term exposure to ambient air pollution and ischemic stroke, our findings indicate that transient increase in air pollution levels may increase the risk of ischemic stroke, which may have significant public health implications for the reduction of ischemic stroke burden in China

Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery

Antiosteoporosis gene-based drug development strategies are presently focused on targeting osteoblasts to either suppress bone loss or increase bone mass. Although siRNA/microRNA-based gene therapy has enormous potential, it is severely limited by the lack of specific cell-targeting delivery systems. We report an osteoblast-targeting peptide (SDSSD) that selectively binds to osteoblasts <i>via</i> periostin. We developed SDSSD-modified polyurethane (PU) nanomicelles encapsulating siRNA/microRNA that delivers drugs to osteoblasts; the data showed that SDSSD–PU could selectively target not only bone-formation surfaces but also osteoblasts without overt toxicity or eliciting an immune response <i>in vivo</i>. We used the SDSSD–PU delivery system to deliver anti-miR-214 to osteoblasts and our results showed increased bone formation, improved bone microarchitecture, and increased bone mass in an ovariectomized osteoporosis mouse model. SDSSD–PU may be a useful osteoblast-targeting small nucleic acid delivery system that could be used as an anabolic strategy to treat osteoblast-induced bone diseases