Effect of neem fertilizer rates and weed control methods on the growth and yield of soybeans (Glycine max (L.) merrill) in north Central Nigeria

Two field experiments were conducted at the Research Farm of the Ibrahim Badamasi Babangida University, Lapai, Niger State during the 2018 and 2019 rainy seasons to determine the effect of neem fertilizer rates and weed control methods on the growth and yields of soybeans. The experimental treatments were made up of four neem fertilizer rates (0, 50, 100 and 150 kg ha-1) and six weed control methods (pendimethalin at 1.5 kg a.i ha-1 followed by one hoe weeding, pendimethalin at 2.0 kg a.i. ha-1 followed by diuron at 1.5 kg a.i ha-1, weeding once at 3 WAS, weeding twice at 3 and 6 WAS, weed free and weedy check. The experiment was a 3 × 3 factorial experiment laid out in a Randomize complete block design replicated three times. TGX 1448 – 2E variety of soybean was used for the study. Result showed that weed control efficiency was better with the use of 150 kg ha-1 of neem fertilizer, while decrease in weed dry matter was obtained at 50 kg ha-1. Increase in number of leaves and leaf area were encouraged with 150 kg ha-1 of neem fertilizer. Weed free treatments recorded the highest grain yield and 100 seed weight of soybean. Pendimethalin at 1.5 or 2.0 kg a.i ha-1 supplemented with one hoe weeding or diuron at 1.5 kg a.i ha-1 respectively can be an alternative for better control of weeds to obtain greater yield of soybean in the study area

Blockchain-based DDoS attack mitigation protocol for device-to-device interaction in smart homes

Smart home devices are vulnerable to a variety of attacks. The matter gets more complicated when a number of devices collaborate to launch a colluding attack (e.g. Distributed-Denial-of-Service (DDoS)) in a network (e.g., Smart home). To handle these attacks, most studies have hitherto proposed authentication protocols that cannot necessarily be implemented in devices, especially during Device-to-Device (D2D) interactions. Tapping into the potential of Ethereum blockchain and smart contracts, this work proposes a lightweight authentication mechanism that enables safe D2D interactions in a smart home. The Ethereum blockchain enables the implementation of a decentralized prototype as well as a peer-to-peer distributed ledger system. The work also uses a single server queuing system model and the authentication mechanism to curtail DDoS attacks by controlling the number of service requests in the system. The simulation was conducted twenty times, each with varying number of devices chosen at random (ranging from 1 to 30). Each requester device sends an arbitrary request with a unique resource requirement at a time. This is done to measure the system’s consistency across a variety of device capabilities. The experimental results show that the proposed protocol not only prevents colluding attacks, but also outperforms the benchmark protocols in terms of computational cost, message processing, and response time

Lowland Rice Nutrient Responses for the Guinea and Sudan Savannas of Nigeria

Copyright © 2018 by the American Society of Agronomy This is an open access article doi:10.2134/agronj2017.08.046

Lowland Rice Nutrient Responses for the Guinea and Sudan Savannas of Nigeria

Yield response of irrigated lowland rice (Oryza sativa L.) to nutrient application was determined to improve the information base for fertilizer use in the Sudan and Southern Guinea Savannas of Nigeria. Economically optimal rates (EOR) and agronomic efficiency (AE) were determined. Five N levels and four levels each P, K, and Zn were evaluated with two varieties at two locations. Nitrogen effects varied by variety and location but mean paddy yield with 0 kg ha–1 N was 3.4 Mg ha–1 and was increased by 1.3 Mg ha–1 with 40 kg ha–1 N. The mean EOR of N with fertilizer use cost to paddy price ratios (CP) of 2 to 6 were 56 to 38 kg ha–1 N, respectively. Yield increases with P, K and Zn application were infrequent. Paddy yield was increased in one of four cases with up to 1.5 kg ha–1 Zn. There were no paddy yield increases but some decreases with application of Mg-S-B in addition to N-P-K-Zn. The overall AE of N at EOR with a CP of 4 was 25.3 kg kg–1. The profit potential of N application was greater for Faro 44 compared with Faro 52 at both locations. Financially constrained farmers who opt to apply N at 50 compared with 100% EOR when CP was 4 can expect 16% less yield increase but 67% higher AE and value to cost ratio. Application of fertilizer N, maybe with P at Kadawa, can be highly profitable for irrigated lowland rice in these agroecological zones

PCIM:a project control and inhibiting‐factors management model

In construction projects, the aim of project control is to ensure projects finish on time, within budget, and achieve other project objectives. During the last few decades, numerous project control methods have been developed and adopted by project managers in practice. However, many existing methods focus on describing what the processes and tasks of project control are; not on how these tasks should be conducted. There is also a potential gap between principles that underly these methods and project control practice. As a result, time and cost overruns are still common in construction projects, partly attributable to deficiencies of existing project control methods and difficulties in implementing them. This paper describes a new project cost and time control model, the project control and inhibiting factors management (PCIM) model, developed through a study involving extensive interaction with construction practitioners in the UK, which better reflects the real needs of project managers. A set of good practice checklist is also developed to facilitate implementation of the model

Wound Healing, Antioxidants and Toxicological Properties of Root Extracts of Kigelia africana (Lam.) Benth

The root extracts of Kigelia africana were screened for antibacterial and wound healing properties, using hole-plate bioassay and excision wound model on rats, respectively. Catalase activity, glutathione level and lipid peroxidation were assayed in the granulated tissues and liver homogenates. Chemical compositions of the root were determined using standard methods. Complete wound healing was observed on day 16 in group administered with 120mg/ml and on the 19th day in groups administered 90 and 60mg/ml of the extract. Clinical features indicate redness, scab formation, exudations and some other typical changes. The control and antibiotic treated groups show more redness compared to third day. The hydrolytic and organic solvent fractions show significant (p< 0.05) inhibitory activities on woun

Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Mammalian homologs of the yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of action remains to be defined. Recently, syntaxin 17 (Stx17), a SNARE with major roles in autophagy, was shown to bind mAtg8s. Here we broadened the analysis of potential mAtg8-SNARE interactions and identified LC3-interacting regions (LIRs) in several SNAREs. Syntaxin 16 (Stx16), and its cognate SNARE partners all have LIR motifs and bind mAtg8s. A knockout in STX16 caused defects in lysosome biogenesis whereas a double STX16 and STX17 knockout completely blocked autophagic flux and decreased mitophagy, pexophagy, xenophagy, and ribophagy. Mechanistic analyses revealed that mAtg8s and Stx16 maintained several aspects of lysosomal compartments including their functionality as platforms for active mTOR. These findings reveal a broad direct interaction of mAtg8s with SNAREs with impact on membrane remodeling in eukaryotic cells and expand the roles of mAtg8s to lysosome biogenesis.</p

Immunomodulatory Effects of Neem (Azadirachta indica) Leaf Aqueous Extracts in Cockerels Vaccinated and Experimentally Infected with Infectious Bursal Disease Virus

The aim of the present work was to study the immunomodulatory potentials of aqueous extract of Neem (Azadirachta indica) leaf in cockerels vaccinated and/ or infected with infectious bursal disease virus (IBDV). Four hundred and eighty (480) day old cockerels were used and allocated into 8 groups. The birds were grouped as vaccinated/ unvaccinated, challenged/ unchallenged, neem leaf treated/ untreated groups. The IBD vaccines (intermediate plus strain) were given at 14 and 28 days of age while the experimental infection using very virulent IBD virus (vvIBDV) was inoculated at 35 days of age and the extracts were given from day old to 6 week old.Serum samples were collected on first day and on weekly intervals while post challenge, onset of the disease, clinical signs and mortality rate were recorded. The results obtained showed higher antibody titre, faster seroconversion, mild clinical sign and very low mortality in the neem leaf treated groups. These results indicated that the neem leaf aqueous extract has immunomodulatory potentials by increasing the antibody titre post vaccination and the ability to prevent mortality

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London