341 research outputs found
Inhibition of the Nicotinic Acetylcholine Receptors by Cobra Venom α-Neurotoxins: Is There a Perspective in Lung Cancer Treatment?
- Author
- A Catassi
- A De Ambrosis
- A Grozio
- Alessandra Forlani
- Angela Alama
- AV Feofanov
- AV Osipov
- B Witkop
- C Fruchart-Gaillard
- Cristina Bruzzo
- D de Totero
- DC Lam
- DL Carlisle
- ER Spindel
- F Barbieri
- HK Plummer 3rd
- HM Schuller
- HM Schuller
- HM Schuller
- HM Schuller
- HS Sekhon
- I Casciano
- I Wessler
- Ida Casciano
- JD Minna
- L Paleari
- L Paleari
- L Paleari
- L Paleari
- L Paleari
- L Paleari
- M Romani
- Massimo Romani
- MD Li
- MR Spitz
- P Russo
- R Davis
- R Maneckjee
- RD Egleton
- RD Egleton
- RJ Hung
- S Nirthanan
- T Iwaguchi
- TE Thorgeirsson
- VI Tsetlin
- VV Kukhtina
- William C. S. Cho
- Y Feng
- YN Utkin
- Yuri Utkin
- Zita Cavalieri
- Publication venue
- Public Library of Science
- Publication date
- 13/06/2011
- Field of study
Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nAChRs) and the activation of downstream pathways that block apoptosis and promote neo-angiogenesis. The nAChRs of the α7 subtype are present on a wide variety of cancer cells and their inhibition by cobra venom neurotoxins has been proposed in several articles and reviews as a potential innovative lung cancer therapy. However, since part of the published results was recently retracted, we believe that the antitumoral activity of cobra venom neurotoxins needs to be independently re-evaluated
Naturally Occurring Variants of Human Α9 Nicotinic Receptor Differentially Affect Bronchial Cell Proliferation and Transformation
- Author
- A Catassi
- A Chikova
- A Grozio
- A Masuda
- ADJ Maus
- AK Jones
- AM Hosie
- Anna Chikova
- BJ Proskocil
- CF Newland
- CH Lee
- CH Wu
- CI Amos
- DB Sattelle
- EG Severance
- Eliana Saul Furquim Werneck Abdelhay
- H Hiel
- H Xie
- J Arredondo
- JC Willey
- K Ohno
- KA West
- L Paleari
- L Paleari
- L Paleari
- M Verbitsky
- P Richard
- P Russo
- RJ Hung
- S Zia
- Sergei A. Grando
- SH Tu
- SJ Lansdell
- SW Baxter
- T Lang
- TE Thorgeirsson
- TK Hei
- VT Nguyen
- Y Tian
- YL Shih
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Isolation of polyadenilated mRNA from human immortalized bronchial epithelial cell line BEP2D revealed the presence of multiple isoforms of RNA coded by the CHRNA9 gene for α9 nicotinic acetylcholine receptor (nAChR). BEP2D cells were homozygous for the rs10009228 polymorphism encoding for N442S amino acid substitution, and also contained mRNA coding for several truncated isoforms of α9 protein. To elucidate the biologic significance of the naturally occurring variants of α9 nAChR, we compared the biologic effects of overexpression of full-length α9 N442 and S442 proteins, and the truncated α9 variant occurring due to a loss of the exon 4 sequence that causes frame shift and early termination of the translation. These as well as control vector were overexpressed in the BEP2D cells that were used in the assays of proliferation rate, spontaneous vs. tobacco nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced cellular transformation, and tumorigenicity in cell culture and mice. Overexpression of the S442 variant significantly increased cellular proliferation, and spontaneous and NNK-induced transformation. The N442 variant significantly decreased cellular transformation, without affecting proliferation rate. Overexpression of the truncated α9 significantly decreased proliferation and suppressed cellular transformation. These results suggested that α9 nAChR plays important roles in regulation of bronchial cell growth by endogenous acetylcholine and exogenous nicotine, and susceptibility to NNK-induced carcinogenic transformation. The biologic activities of α9 nAChR may be regulated at the splicing level, and genetic polymorphisms in CHRNA9 affecting protein levels, amino acid sequence and RNA splicing may influence the risk for lung cancer
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for \u3b2-Thalassemia
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Gene therapy clinical trials require rigorous non-clinical studies in the most relevant models to assess the benefit-to-risk ratio. To support the clinical development of gene therapy for \u3b2-thalassemia, we performed in vitro and in vivo studies for prediction of safety. First we developed newly GLOBE-derived vectors that were tested for their transcriptional activity and potential interference with the expression of surrounding genes. Because these vectors did not show significant advantages, GLOBE lentiviral vector (LV) was elected for further safety characterization. To support the use of hematopoietic stem cells (HSCs) transduced by GLOBE LV for the treatment of \u3b2-thalassemia, we conducted toxicology, tumorigenicity, and biodistribution studies in compliance with the OECD Principles of Good Laboratory Practice. We demonstrated a lack of toxicity and tumorigenic potential associated with GLOBE LV-transduced cells. Vector integration site (IS) studies demonstrated that both murine and human transduced HSCs retain self-renewal capacity and generate new blood cell progeny in the absence of clonal dominance. Moreover, IS analysis showed an absence of enrichment in cancer-related genes, and the genes targeted by GLOBE LV in human HSCs are well known sites of integration, as seen in other lentiviral gene therapy trials, and have not been associated with clonal expansion. Taken together, these integrated studies provide safety data supporting the clinical application of GLOBE-mediated gene therapy for \u3b2-thalassemia
Measurement of the production cross-section of positive pions in the collision of 8.9 GeV/c protons on beryllium
- Author
- A. Aguilar
- A. Artamonov
- A. Bagulya
- A. Blondel
- A. Cervera-Villanueva
- A. De Min
- A. De Santo
- A. Grant
- A. Grossheim
- A. Guglielmi
- A. Guskov
- A. Kayis-Topaksu
- A. Krasnoperov
- A. Semak
- A. Tonazzo
- A. Tornero
- A. Zhemchugov
- B. Popov
- C. Booth
- C. Buttar
- C. Gößling
- C. Meurer
- C. Pattison
- C. Wiebusch
- D. Dedovitch
- D. Gibin
- D. Khartchenko
- D. Kolev
- D. Orestano
- D. Schmitz
- E. Aliu
- E. Di Capua
- E. Radicioni
- E. Tcherniaev
- F. Bobisut
- F. Ferri
- F. Paleari
- F. Pastore
- F. Vannucci
- F.J.P. Soler
- G. Barr
- G. Chelkov
- G. Folger
- G. Giannini
- G. Grégoire
- G. Prior
- G. Santin
- G. Vidal-Sitjes
- G.B. Mills
- I. Kato
- I. Papadopoulos
- I. Tsukerman
- J. Burguet-Castell
- J. Dumarchez
- J. Martín-Albo
- J. Panman
- J. Pasternak
- J.J. Gómez-Cadenas
- J.S. Graulich
- K. Zuber
- L. Coney
- L. Howlett
- L. Tortora
- M. Anfreville
- M. Apollonio
- M. Baldo-Ceolin
- M. Bogomilov
- M. Bonesini
- M. Campanelli
- M. Chizhov
- M. Ellis
- M. Gostkin
- M. Kirsanov
- M. Mezzetto
- M. Paganoni
- M. Sorel
- M.C. Morone
- M.G. Catanesi
- M.G. Catanesi
- M.G. Catanesi
- M.H. Ahn
- N. Polukhina
- P. Arce
- P. Chimenti
- P. Gorbunov
- P. Gruber
- P. Hodgson
- P. Novella
- P. Temnikov
- P. Zucchelli
- R. Edgecock
- R. Engel
- R. Schroeter
- R. Tsenov
- R. Veenhof
- S. Agostinelli
- S. Borghi
- S. Bunyatov
- S. Giani
- S. Gilardoni
- S. Piperov
- S. Robbins
- The HARP Collaboration M.G. Catanesi
- U. Dore
- U. Gastaldi
- V. Ammosov
- V. Grichine
- V. Ivanchenko
- V. Koreshev
- V. Palladino
- V. Serdiouk
- V. Tereshchenko
- V. Zaets
- Y. Nefedov
- Z. Kroumchtein
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
The double-differential production cross-section of positive pions,
d2σπ+/dpdΩ, measured in the HARP experiment is presented.
The incident particles are 8.9 GeV/c protons directed onto a beryllium target
with a nominal thickness of 5% of a nuclear interaction length. The measured
cross-section has a direct impact on the prediction of neutrino fluxes for the
MiniBooNE and SciBooNE experiments at Fermilab. After cuts, 13 million protons
on target produced about 96,000 reconstructed secondary tracks which were used
in this analysis. Cross-section results are presented in the kinematic range
0.75 GeV/c < pπ < 6.5 GeV/c and 30 mrad < θπ < 210 mrad in
the laboratory frame.Comment: 39 pages, 21 figures. Version accepted for publication by Eur. Phys.
J.
Immunohistochemical detection and regulation of α5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis
- Author
- AD Maus
- B Taylor
- BL Hogan
- BN Gomperts
- C Liu
- D Bertrand
- D Lazzaro
- D Warburton
- DL Carlisle
- EE Morrisey
- H Wan
- H Wan
- H Wan
- H Yang
- I Wessler
- IB Tager
- J Lindstrom
- JL Sporty
- K Ikeda
- K Maouche
- K Sandberg
- L Paleari
- L Zhou
- L Zhou
- M Koutsourakis
- PR Reynolds
- PR Reynolds
- PR Reynolds
- RH Costa
- RJ Bohinski
- S Kimura
- S Zia
- SD Reynolds
- SH Hsia
- SW Rogers
- T Huang
- V Besnard
- Y Maeda
- Y Wang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>α<sub>5 </sub>nicotinic acetylcholine receptor (nAChR) subunits structurally stabilize functional nAChRs in many non-neuronal tissue types. The expression of α<sub>5 </sub>nAChR subunits and cell-specific markers were assessed during lung morphogenesis by co-localizing immunohistochemistry from embryonic day (E) 13.5 to post natal day (PN) 20. Transcriptional control of α<sub>5 </sub>nAChR expression by FoxA2 and GATA-6 was determined by reporter gene assays.</p> <p>Results</p> <p>Steady expression of α<sub>5 </sub>nAChR subunits was observed in distal lung epithelial cells during development while proximal lung expression significantly alternates between abundant prenatal expression, absence at PN4 and PN10, and a return to intense expression at PN20. α<sub>5 </sub>expression was most abundant on luminal edges of alveolar type (AT) I and ATII cells, non-ciliated Clara cells, and ciliated cells in the proximal lung at various periods of lung formation. Expression of α<sub>5 </sub>nAChR subunits correlated with cell differentiation and reporter gene assays suggest expression of α<sub>5 </sub>is regulated in part by FoxA2, with possible cooperation by GATA-6.</p> <p>Conclusions</p> <p>Our data reveal a highly regulated temporal-spatial pattern of α<sub>5 </sub>nAChR subunit expression during important periods of lung morphogenesis. Due to specific regulation by FoxA2 and distinct identification of α<sub>5 </sub>in alveolar epithelium and Clara cells, future studies may identify possible mechanisms of cell differentiation and lung homeostasis mediated at least in part by α<sub>5</sub>-containing nAChRs.</p
Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC
- Author
- A. A. Abdelalim
- A. A. Carter
- A. A. Grillo
- A. A. Komar
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. Snesarev
- A. A. Solodkov
- A. Abdesselam
- A. Ahmad
- A. Akiyama
- A. Aloisio
- A. Alonso
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Anisenkov
- A. Annovi
- A. Antonaki
- A. Antonov
- A. Artamonov
- A. Astbury
- A. Astvatsatourov
- A. B. Fenyuk
- A. B. Lazarev
- A. Bangert
- A. Barashkou
- A. Barbaro Galtieri
- A. Baroncelli
- A. Battaglia
- A. Beddall
- A. Belloni
- A. Bertin
- A. Bingul
- A. Blondel
- A. Bocci
- A. Bogdanchikov
- A. Bogouch
- A. Borisov
- A. Boveia
- A. Braem
- A. Brandt
- A. Bruni
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. Canepa
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Chafaq
- A. Cheplakov
- A. Chilingarov
- A. Christov
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Cortes-Gonzalez
- A. D. Doxiadis
- A. D. Hawkins
- A. D. Hershenhorn
- A. D. Pilkington
- A. De Salvo
- A. De Santo
- A. Dell’Acqua
- A. Dewhurst
- A. Di Ciaccio
- A. Di Girolamo
- A. Di Mattia
- A. Di Simone
- A. Do Valle Wemans
- A. Doria
- A. Dos Anjos
- A. Dotti
- A. Dudarev
- A. D’Orazio
- A. E. Barton
- A. E. Kiryunin
- A. Engl
- A. Eppig
- A. Ereditato
- A. F. Saavedra
- A. Farbin
- A. Farilla
- A. Favareto
- A. Ferrari
- A. Ferrer
- A. Ferretto Parodi
- A. Filippas
- A. Filipčič
- A. Firan
- A. Floderus
- A. Formica
- A. Forti
- A. Foussat
- A. G. Buckley
- A. G. Goussiou
- A. G. Kholodenko
- A. G. Myagkov
- A. G. Olchevski
- A. G. Schamov
- A. Gaponenko
- A. Gemmell
- A. Gershon
- A. Gibson
- A. Glazov
- A. Gomes
- A. Gonidec
- A. Gorišek
- A. Guida
- A. Gupta
- A. Haas
- A. Hamilton
- A. Harvey
- A. Henrichs
- A. Hoecker
- A. Hoummada
- A. Huettmann
- A. I. Etienvre
- A. I. Kononov
- A. I. Mincer
- A. Irles Quiles
- A. Ishikawa
- A. J. Armbruster
- A. J. Barr
- A. J. Beddall
- A. J. Fowler
- A. J. Lankford
- A. J. Lowe
- A. J. Martin
- A. J. Tanasijczuk
- A. Jantsch
- A. Jeremie
- A. Juste Rozas
- A. K. Ciftci
- A. K. Morley
- A. Kaczmarska
- A. Kapliy
- A. Kasmi
- A. Kastanas
- A. Khanov
- A. Khodinov
- A. Khomich
- A. Khoroshilov
- A. Kiryunin
- A. Klier
- A. Klimentov
- A. Knue
- A. Kootz
- A. Korn
- A. Korol
- A. Kotwal
- A. Koutsman
- A. Krasznahorkay
- A. Kreisel
- A. Kruth
- A. Kugel
- A. Kupco
- A. L. Maslennikov
- A. L. Read
- A. La Rosa
- A. Larner
- A. Leger
- A. Leung Fook Cheong
- A. Lewis
- A. Limosani
- A. Lipniacka
- A. Lister
- A. Lleres
- A. Loginov
- A. Lounis
- A. Lucotte
- A. Ludwig
- A. M. Bach
- A. M. Castaneda Hernandez
- A. M. Cooper-Sarkar
- A. M. Henriques Correia
- A. M. Kiver
- A. M. Leyko
- A. M. Litke
- A. M. Moisseev
- A. M. Nairz
- A. M. Rahimi
- A. M. Zaitsev
- A. Macchiolo
- A. Maio
- A. Manabe
- A. Mann
- A. Manousakis-Katsikakis
- A. Manz
- A. Mapelli
- A. Marin
- A. Marzin
- A. Mastroberardino
- A. Mayne
- A. McCarn
- A. Meade
- A. Mehta
- A. Mengarelli
- A. Messina
- A. Milov
- A. Misiejuk
- A. Moraes
- A. Muir
- A. N. Karyukhin
- A. N. Sisakyan
- A. Nagarkar
- A. Napier
- A. Negri
- A. Nelson
- A. Neusiedl
- A. Nikiforov
- A. Nisati
- A. Ochi
- A. Oh
- A. Olariu
- A. Olszewski
- A. Onofre
- A. Ouraou
- A. Ovcharova
- A. P. Colijn
- A. P. Vorobiev
- A. Pacheco Pages
- A. Palma
- A. Papadelis
- A. Paramonov
- A. Passeri
- A. Penson
- A. Perus
- A. Petridis
- A. Phan
- A. Pinder
- A. Poblaguev
- A. Policicchio
- A. Polini
- A. Poppleton
- A. Pranko
- A. Quadt
- A. R. Davison
- A. R. Gillman
- A. R. Stradling
- A. R. Weidberg
- A. Redelbach
- A. Reichold
- A. Reinsch
- A. Renaud
- A. Richards
- A. Rimoldi
- A. Robichaud-Veronneau
- A. Robson
- A. Roe
- A. Romaniouk
- A. Rose
- A. Rozanov
- A. Ruiz-Martinez
- A. S. Cerqueira
- A. S. Chisholm
- A. S. Kozhin
- A. S. Mete
- A. S. Randle-Conde
- A. S. Thompson
- A. Salamon
- A. Salnikov
- A. Salvucci
- A. Salzburger
- A. Sanchez
- A. Sansoni
- A. Sbrizzi
- A. Schwartzman
- A. Schöning
- A. Seiden
- A. Sfyrla
- A. Shibata
- A. Shmeleva
- A. Sidoti
- A. Sircar
- A. Soffer
- A. Soukharev
- A. Staude
- A. Straessner
- A. Strandlie
- A. Succurro
- A. T. Doyle
- A. T. H. Arce
- A. T. Watson
- A. T. Waugh
- A. Taffard
- A. Talyshev
- A. Tonoyan
- A. Tricoli
- A. Trivedi
- A. Trzupek
- A. Tua
- A. Tudorache
- A. Tykhonov
- A. Undrus
- A. V. Akimov
- A. V. Ivashin
- A. V. Larionov
- A. V. Pleskach
- A. Vaniachine
- A. Vartapetian
- A. Ventura
- A. Vest
- A. Vogel
- A. Warburton
- A. White
- A. Wildauer
- A. Wilson
- A. Yamamoto
- A. Yurkewicz
- A. Zaytsev
- A. Zemla
- A. Zhemchugov
- A. Zoccoli
- A. Zsenei
- A.-E. Nuncio-Quiroz
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- B. A. Dolgoshein
- B. A. Petersen
- B. A. Schumm
- B. Abbott
- B. Abi
- B. Alvarez Gonzalez
- B. Aubert
- B. Brau
- B. Brelier
- B. Budick
- B. Butler
- B. C. LeGeyt
- B. C. Smith
- B. Caron
- B. Chapleau
- B. Clement
- B. D. Cooper
- B. De Lotto
- B. Demirkoz
- B. DeWilde
- B. Di Girolamo
- B. Di Micco
- B. Dowler
- B. E. Cox
- B. Epp
- B. Esposito
- B. Fatholahzadeh
- B. G. Pope
- B. Gaur
- B. Giacobbe
- B. Gibbard
- B. Gorini
- B. Gosdzik
- B. Guo
- B. H. Samset
- B. H. Smart
- B. Heinemann
- B. J. Gallop
- B. J. O’Brien
- B. Jackson
- B. K. Gjelsten
- B. K. Wosiek
- B. Kaplan
- B. Laforge
- B. Lemmer
- B. Lenzi
- B. Li
- B. Liberti
- B. Lund-Jensen
- B. Lundberg
- B. M. Barnett
- B. M. Hawes
- B. M. M. Allbrooke
- B. M. Salvachua Ferrando
- B. M. Waugh
- B. M. Wynne
- B. Malaescu
- B. Mansoulie
- B. Martin
- B. Martin
- B. Martin dit Latour
- B. Maček
- B. Meirose
- B. Mindur
- B. Nicquevert
- B. Nordkvist
- B. Osculati
- B. P. Kerševan
- B. Panes
- B. Penning
- B. Pinto
- B. R. Ko
- B. R. Mellado Garcia
- B. Radics
- B. Resende
- B. Ruckert
- B. S. Acharya
- B. Sellden
- B. Simmons
- B. Sopko
- B. Spurlock
- B. Stelzer
- B. Stugu
- B. Szeless
- B. T. King
- B. Toczek
- B. Toggerson
- B. Trocmé
- B. Vachon
- B. Wrona
- B. Yabsley
- B. Zabinski
- B. Zhou
- B. Åsman
- C. A. Chavez Barajas
- C. A. Edwards
- C. A. Jung
- C. A. Solans
- C. Alexa
- C. Amelung
- C. Anastopoulos
- C. Arnault
- C. Ay
- C. B. Gwilliam
- C. Bacci
- C. Belanger-Champagne
- C. Benchouk
- C. Bernius
- C. Bertella
- C. Bini
- C. Biscarat
- C. Blocker
- C. Bohm
- C. Borer
- C. Bourdarios
- C. Bromberg
- C. C. Ohm
- C. Caramarcu
- C. Caso
- C. Chen
- C. Ciocca
- C. Clement
- C. Cojocaru
- C. Collard
- C. Collins-Tooth
- C. Conta
- C. Cowden
- C. Cuenca Almenar
- C. Cuthbert
- C. D. Burgard
- C. Da Via
- C. Dallapiccola
- C. Debenedetti
- C. Del Papa
- C. Deluca
- C. De La Taille
- C. Dionisi
- C. Doglioni
- C. Driouichi
- C. Escobar
- C. F. Anders
- C. Fabre
- C. Feng
- C. Ferretti
- C. Fukunaga
- C. G. Lester
- C. G. Zhu
- C. Gabaldon
- C. Galea
- C. García
- C. Gatti
- C. Gay
- C. Gemme
- C. Geweniger
- C. Glasman
- C. Goeringer
- C. Goy
- C. Guicheney
- C. Guyot
- C. Gwenlan
- C. Gössling
- C. Haber
- C. Handel
- C. Heller
- C. Helsens
- C. Hensel
- C. Horn
- C. Isaksson
- C. Issever
- C. J. Curtis
- C. J. Kenney
- C. J. Oram
- C. J. Potter
- C. Joram
- C. Kourkoumelis
- C. Kummer
- C. L. Lampen
- C. Lacasta
- C. Lange
- C. Lapoire
- C. Lasseur
- C. Le Maner
- C. Lebel
- C. Leggett
- C. Leroy
- C. Limbach
- C. Liu
- C. Luci
- C. M. Buttar
- C. M. Hawkes
- C. M. Hernandez
- C. Maiani
- C. Maidantchik
- C. Malone
- C. Mattravers
- C. Melachrinos
- C. Menot
- C. Meroni
- C. Meyer
- C. Meyer
- C. Mills
- C. Mora Herrera
- C. N. Booth
- C. N. P. Gee
- C. Omachi
- C. Oropeza Barrera
- C. Osuna
- C. P. Bee
- C. P. Buszello
- C. P. Marino
- C. P. Paleari
- C. P. Ward
- C. Padilla Aranda
- C. Petridou
- C. Pizio
- C. Posch
- C. R. Boddy
- C. R. Royon
- C. Rembser
- C. Roda
- C. Rudolph
- C. Ruwiedel
- C. Sandoval
- C. Santamarina Rios
- C. Santoni
- C. Sbarra
- C. Schiavi
- C. Schmitt
- C. Schroeder
- C. Schwanenberger
- C. Serfon
- C. Stanescu
- C. Suhr
- C. T. Potter
- C. Taylor
- C. Topfel
- C. Troncon
- C. Tsarouchas
- C. Vellidis
- C. W. Loh
- C. Wang
- C. Weiser
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- T. Ženiš
- Th. D. Papadopoulou
- U. Bitenc
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- V. A. Bednyakov
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- X. Lou
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- X. Ruan
- X. S. Anduaga
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- Y. A. Kurochkin
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- Y. Davygora
- Y. Doi
- Y. F. Ryabov
- Y. Fang
- Y. Gusakov
- Y. Hasegawa
- Y. Hernández Jiménez
- Y. Homma
- Y. Ikegami
- Y. Ilchenko
- Y. Jiang
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. Liu
- Y. Mahalalel
- Y. Makida
- Y. Ming
- Y. Munwes
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Pylypchenko
- Y. Rozen
- Y. S. Gao
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Suzuki
- Y. Suzuki
- Y. Takahashi
- Y. Takubo
- Y. Tanaka
- Y. Tayalati
- Y. Unno
- Y. V. Grishkevich
- Y. Wu
- Y. Xie
- Y. Yamazaki
- Y. Yang
- Y. Yang
- Y. Yao
- Y. Yasu
- Y. Zhou
- Y. Zhu
- Y. Zolnierowski
- Yu. M. Sviridov
- Z. Czyczula
- Z. D. Greenwood
- Z. Dolezal
- Z. Drasal
- Z. Hajduk
- Z. Hubacek
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. Marshall
- Z. Meng
- Z. Qian
- Z. Qin
- Z. Rurikova
- Z. V. Krumshteyn
- Z. van Kesteren
- Z. Weng
- Z. Yan
- Z. Yang
- Z. Zajacova
- Z. Zenonos
- Z. Zhan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/03/2012
- Field of study
The uncertainty on the calorimeter energy response to jets of particles is
derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the
calorimeter response to single isolated charged hadrons is measured and
compared to the Monte Carlo simulation using proton-proton collisions at
centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009
and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter
response to specific types of particles (positively and negatively charged
pions, protons, and anti-protons) is measured and compared to the Monte Carlo
predictions. Finally, the jet energy scale uncertainty is determined by
propagating the response uncertainty for single charged and neutral particles
to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3%
for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table,
submitted to European Physical Journal
Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone
- Author
- Publication venue
- 'Ferrata Storti Foundation (Haematologica)'
- Publication date
- 29/12/2016
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
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- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Abi B
- Abolins M
- Abramowicz H
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- Acharya BS
- Adams DL
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- Castaneda-Miranda E
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- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang Q
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
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- Abdallah J
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- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
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