58 research outputs found
Incidence, clinical characteristics and management of inflammatory bowel disease in Spain: large-scale epidemiological study
- Author
- Abraldes Bechiarelli A.
- Aguas M.
- Alcalá M. J.
- Alonso-Abreu I.
- Alonso-Galán H.
- Barreiro de Acosta M.
- Barrio. J.
- Benítez J. M.
- Ber Y.
- Bermejo F.
- Blázquez Gómez I.
- Bosch O.
- Botella B.
- Bouhmidi A.
- Cabriada J. L.
- Calafat M.
- Calvet X.
- Camargo R.
- Carmona A.
- Casanova M. J.
- Castaño-Milla C.
- Castro E.
- Chaparro M.
- Crespo Suarez B.
- Cruz N.
- Diz-Lois Palomares M. T.
- Duque J. M.
- Echarri A.
- Esteve Comas M.
- Fernández Rosáenz H.
- Fernández Salgado E.
- Fernández-Salazar L.
- Ferreiro-Iglesias R.
- Forcelledo J. L. F.
- Fuentes Coronel A. M.
- Galve M. L.
- García-Esquinas E.
- Garre A.
- Ginard D.
- Gisbert J. P.
- Gomollón F.
- Gordillo J.
- Guerra del Río E.
- Gutiérrez A.
- Gómez-Valero J. A.
- Hernández Camba A.
- Hernández L.
- Hernández V.
- Hernández-Martínez Á.
- Herreros Martínez B.
- Hervías D.
- Huguet J. M.
- Irisarri R.
- Iyo E.
- Jiménez N.
- Kolle L.
- Kutz M.
- Ledezma C.
- Lluis L.
- Lorente Poyatos R.
- Lucendo A. J.
- López Serrano P.
- Maroto N.
- Marrero J. M.
- Martí Romero L.
- Martín-Arranz M. D.
- Martínez Pascual C.
- Martínez-Cerezo F. J.
- Marín-Jiménez I.
- Mata L.
- Menacho M.
- Mir A.
- Monrobel A.
- Montealegre M.
- Muñoz Vicente M.
- Navarro P.
- Navarro-Llavat M.
- Nerín de la Puerta J.
- Nicolás I.
- Novella Durán M. T.
- Núñez Ortiz A.
- Opio V.
- Ortiz de Zarate J.
- Piñero C.
- Ponferrada Díaz Á.
- Pozzati L.
- Ramírez Palanca J. J.
- Riestra S.
- Rivero M.
- Robledo P.
- Rodríguez Mondéjar S.
- Rodríguez C.
- Rodríguez-Artalejo F.
- Roncero Ó.
- Sabat M.
- Sampedro M. J.
- Sapiña A.
- Sesé Abizanda E.
- Sicilia B.
- Sierra M.
- Soler M.
- Spicakova K.
- Sánchez Rodríguez E.
- Tejada M.
- Torra Alsina S.
- Torrella Cortés E.
- Torres Domínguez Y.
- Varela Trastoy P.
- Vega P.
- Vela M.
- Vera-Mendoza I.
- Vicente R.
- Zapata E. M.
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2021
- Field of study
(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100, 000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery. © 2021 by the authors. Licensee MDPI, Basel, Switzerland
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
- Author
- Abid M
- Accini JL
- Acuña S
- Adawi F
- Adenuga B
- Adina PM
- Ageev F
- Aguilar-Orozco R
- Ahmad Z
- Aimaretti G
- Aizenberg D
- Akahori H
- Akhmedzhanov N
- Akinboboye O
- Akright L
- Al Mahmeed W
- Alanko J
- Alappat P
- Alawad M
- Alfonso T
- Alimard R
- Alvarez C
- Alvarisqueta A
- Alzohaili O
- Ambos A
- Amerena J
- Amolina I
- Andjelic Jelic M
- Andrade M
- Andrews R
- Antorrena I
- Arana C
- Araneda G
- Arango J
- Ariani M
- Arnold S
- Arora C
- Arteaga JM
- Assaad S
- Atar S
- Avram RI
- Azad N
- Azzam S
- Baccaro C
- Bailey G
- Bain S
- Barbarash O
- Barbarich V
- Bartolacci I
- Bascil Tutuncu N
- Basu A
- Bayram E
- Bednarski J
- Belousov Y
- Ben Abdallah N
- Benjamin S
- Berns S
- Berra C
- Bertrand O
- Bhargava R
- Bhatnagar D
- Bickerton A
- Bijata-Bronisz R
- Block B
- Boberg G
- Bodi V
- Bokarev I
- Bolshakova O
- Bordonava A
- Borzadek E
- Botelho RV
- Botella M
- Botero R
- Boyarkin M
- Bragança N
- Breisblatt W
- Bright T
- Bronnum-Schou J
- Browne D
- Bryniarski L
- Bunster L
- Burgess L
- Burton J
- Bustamante Labarta M
- Busz-Papiez B
- Byrd L
- Caccavo A
- Calderon J
- Calella P
- Campeau J
- Camsari A
- Cantero M
- Cardosa-Torres F
- Cariou B
- Carranza-Madrigal J
- Castillo G
- Castro E
- Castro MG
- Catargi B
- Cerqueira MJ
- Chacra A
- Chavez C
- Chen L
- Chiang CE
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- Chiu YW
- Chochinov R
- Chopda M
- Chopra V
- Christensen T
- Christofides E
- Chumakova G
- Chumburidze V
- Chung CH
- Chung WJ
- Ciardullo AV
- Cif A
- Claggett Brian
- Cobos L
- Codutti R
- Coetzee K
- Cohen O
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- Commendatore V
- Consoli A
- Contzen C
- Cooper J
- Corbalán R
- Cornel JH
- Coronel J
- Correa Flores RM
- Costamagna O
- Creteanu G
- Cucinotta D
- Cuello J
- Cure C
- Czajkowska-Kaczmarek E
- Danilova L
- Dans A
- Dawood G
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- De La Fuente J
- De Moraes Junior J
- De Salazar M
- De Souza J
- Dekkers P
- Del Prato S
- Delchev A
- Delgado E
- Delibasi T
- Delport E
- Dempsey M
- Deshpande N
- Di Marco S
- Diaz Rafael
- Dickstein Kenneth
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- Dmitry P
- Dong Y
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- Dragomir D
- Drzewiecka A
- Du J
- Duarte J
- Duarte-Vera Y
- Ducena K
- Ducloux R
- Dulak E
- Dumas R
- Duran Garcia S
- Dussaillant G
- Dutta R
- Dwivedi S
- Eagerton D
- East C
- Ebrahim I
- Efrati S
- Eggers G
- Eki Y
- Elder C
- ELIXA Investigators
- Ellis G
- Elorza J
- Enciso F
- Escalante M
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- Fasching P
- Feitosa G
- Ferariu IE
- Fernandez A
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- Forti A
- Foucauld J
- Frederiks J
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- Godoy G
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- Takahashi A
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- Tardif JC
- Tardif Jean-Claude
- Tase A
- Tesloianu DN
- Thawani H
- Thomsen KK
- Thomson S
- Thrasher J
- Timonera M
- Todua F
- Tokmakova M
- Torp-Pedersen C
- Torres C
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- Tsoukas G
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- Turcios E
- Turgeman Y
- Turner J
- Twahirwa M
- Tzekova M
- Ueng KC
- Ulla M
- Umpierrez G
- Urboniene A
- Urdiales P
- Uribe M
- Vaid B
- Vallejos J
- Van Gaal W
- Van Zyl L
- Vance C
- Vasko P
- Vazquez-Garcia A
- Velasco-Sanchez R
- Venter T
- Vico M
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- Viktorova I
- Villalobos R
- Vinereanu D
- Vinhas M
- Vishnevsky A
- Vorokhobina N
- Wainstein J
- Waisman F
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- Warner A
- Warnica JW
- Watanabe S
- Watson H
- Weber S
- Webster B
- Wei Xiaodan
- Weindorff K
- Welch M
- Welker J
- Westerberg B
- White A
- White L
- Whitelaw D
- Wilczewski P
- Wilding J
- Wiles P
- Williams M
- Wu WC
- Wynne A
- Wyss F
- Xu B
- Yakusevich V
- Yakushin S
- Yamada T
- Yang J
- Yang J
- Yang Y
- Yañez M
- Yeap B
- Yigit Z
- Yocono M
- Yordanov V
- Yuen K.
- Yupanqui H
- Zadionchenko V
- Zalevskaya A
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- Zarankiene R
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- Zidi B
- Zorkun C
- Zubiate C
- Publication venue
- Springer Nature
- Publication date
- 01/01/2012
- Field of study
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
7th Drug hypersensitivity meeting: part two
- Author
- Abuzgaia A.M.
- Acar E.A.
- Aguiar R.
- Aihara M.
- Aktas A.
- Al-Attar Z.
- Albert F.
- Alfirevic A.
- Alhaidari M.
- Alhilali K.
- Alonso A.B.
- Alvarez A.
- Alzahrani A.
- Amaral L.
- Andreu I.
- Antipkin Y.
- Aouam K.
- Aoyama Y.
- Aranda C.
- Ardeniz F.Ö.
- Ardern-Jones M.R.
- Ariza A.
- Arreola A.M.
- Arribas F.
- Aumiler M.R.
- Ausperger K.M.
- Azoury M.E.
- Azukizawa H.
- Balakirski G.
- Barbaud A.
- Baron J.M.
- Barona C.T.
- Barreira P.
- Barrionuevo E.
- Barzylovych V.
- Bauvin O.
- Baysal T.
- Bechara R.
- Beeghly-Fadiel A.
- Bellón T.
- Belo J.
- Benito-Garcia F.
- Bensaïd B.
- Bernad A.
- Berry N.
- Betts C.
- Bibián B.L.
- Bindslev-Jensen C.
- Blanca M.
- Blanca-López N.
- Blanco A.J.
- Blanco A.J.
- Blanco M.A.J.
- Bogas G.
- Bom A.T.
- Boni E.
- Borobia A.M.
- Boteanu C.
- Boughattas N.A.
- Bozbey H.U.
- Breynaert C.
- Bridts C.H.
- Bulut G.
- Burgos Pimentel A.M.
- Buyuozturk S.
- Cabañas R.
- Cabezas P.G.
- Cadinha S.
- Campo P.
- Canto G.
- Canto M.G.
- Cardoso B.K.
- Carolino F.
- Carrapatoso I.
- Carreiro-Martins P.
- Castañer J.L.
- Castells M.
- Cegec I.
- Cernadas J.R.
- Chaabane A.
- Chadly Z.
- Chambel M.
- Chang Y-C
- Chang Y-S
- Chen Y-T
- Cheng C.
- Cherit J.D.
- Chiriac A.
- Cho S-H
- Choi J.C.
- Chopra A.
- Chorda C.P.
- Chordá C.P.
- Chow L.
- Chung W-H
- Claude N.
- Colakoglu B.
- Collado D.
- Cornejo-García J.A.
- Corona J.A.B.
- Coronel V.P.
- Correia M.
- Correia S.
- Coskun R.
- Cosme J.
- Cruz C.R.
- Da Silva Franco J.F.
- Da Silva J.P.
- Dalgiç C.T.
- De Abajo F.J.
- De Castro E.D.
- De Francisco A.M.M.
- De La Cruz Hoyos B.
- De La Losa F.P.
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- Publication date
- 01/01/2016
- Field of study
No abstract availabl
Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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- Field of study
Correction: Volume: 10 Issue: 1 Article Number: 44 DOI: 10.1186/s13601-020-00351-w Published: OCT 26 2020Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.Peer reviewe
Global economic burden of unmet surgical need for appendicitis
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- Aaniana K.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Chong CL
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- El Halawany M
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- El Mesery S
- El Sayed GS
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- El Shoura Y
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- El-Dien KS
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- El-Kashef H
- El-Latif NK
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- El-Sagheer N
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- Elazoul M
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- Elbisomy KH
- Eldafrawy M
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- Eldeeb AZ
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- EldosoukyMohammed A
- Elebute O
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- Elena G
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- Elfiky M
- Elfil M
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- Elfouly Y
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- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
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- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
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- Elsabbagh N
- Elsameea AA
- Elsawahly DME
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- Elsayed NAR
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- Elsemelawy R
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- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
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- Elwy E
- Elzahed N
- Elzayat I
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- Elzowawi F
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- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
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- Essam M
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- Esteban E
- Estee MM
- Estupinian S
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- Etienne S
- Etman M
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- Evajelista CV
- Evans D
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- Eyssartier E
- Ezzat E
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- Faccincani R
- Fadel A
- Fahiem A
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- Farhangmehr N
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- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
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- Fernandes C
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- Filatau A
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- Frisk B
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- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci AA
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah SK
- Kamarulzamil SNA
- Kamil R
- Kamya S
- Kanani A
- Kandil AM
- Kandil H
- Kang MK
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- Karabacak U
- Karabelias G
- Karabulut K
- Karahan SR
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
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- Karjiker P
- Karkeet M
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- Karlo R
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- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem EA
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke KR
- Kelany M
- Kenibar A
- Kennedy ED
- Kennedy M
- Kennedy R
- Keogh K
- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
- Khan K
- Khan MA
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- Khan ZA
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- Khatri C
- Khatri C
- Khattab K
- Khedr AE-RH
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khouri Ferreira SA
- Khreishi R
- Khreishi R
- Khulu LB
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim MY-H
- Kim S-H
- Kim SB
- Kimaro M
- Kinandu K
- King R
- King S
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- Kiran RP
- Kirby A
- Kirishnan A
- Kirupagaran A
- Kiudelis M
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- Klappenbach R
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- Koay KL
- Kobal BB
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- Koh PY
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- Kojo ATT
- Kojo ATT
- Kojo ATT
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong SN
- Kong V
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- Konstantina K
- Kontos M
- Kordorwu HEK
- Korkolis D
- Kosai NR
- Kosai NR
- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Kretzmann H
- Krishna K
- Kruspi S
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- Kushwaha S
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- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- L'Heveder A
- La Brocca A
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- Labib P
- Ladukas A
- Lafferty K
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- Lakshmi HN
- Lam FY
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- Lam WH
- Lamanna GL
- Lanau MIV
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- Landolfo G
- Lap G
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- Lasheen A
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- Latif A
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- Laugzemys E
- Laurie K
- Lauzikas G
- Law JH
- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Lazzarini Cury AD
- Le VTH
- Leal A
- Leal M
- Leanne Almanon C
- Lecompte J-F
- Lee C
- Lee EX
- Lee F
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- Leppaniemi A
- Leppaniemi A
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- Leung MF
- Leusink A
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- Li KKK
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- Liew I
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- Lilford R
- Lilford R
- Lim G
- Lim H
- Lim J
- Lim PJ
- Lim SJ
- Lim SJ
- Lim SY
- Limache S
- Limaye N
- Limoges B
- Linares Delgado MSDFT
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- Litvin A
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- Livingston M
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- lo Conte A
- loaloa MR
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Machain Vega GM
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- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
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- Manfreda S
- Mangan C
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- Manipal CE
- Maniscalco A
- Mann T
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- Mano MJB
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- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
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- Mensah E
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- Mentula P
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- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Moe TT
- Mogan YP
- Moghazy ME
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- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
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- Mok YT
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- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
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- Moreira G
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
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- Mshelbwala P
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- Negida A
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- Nepogodiev D
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- Nevieraite V
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- Nnajiuba H
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- Nwabuoku E
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- Nwokoro C
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- Palomino Castillo VD
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- Peycelon M
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- Pezelj N
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- Picciariello A
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- Pinkney T
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- Primavesi F
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- Pronin S
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- Punja V
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- Qureshi AU
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- Ray S
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- Razmdjou S
- Razuri C
- Razzaque J
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- Rees CM
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- Rocke A
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- Roslani AC
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- Rudzenskaite A
- Ruiz Panez W
- Ruiz-Tovar J
- Rulie AS
- Runigamugabo E
- Russo AA
- Rutkowski W
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- Saad MM
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- Saad S
- Saadeh R
- Saami M
- Saar S
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- Sabour FA
- Sabry A
- Sacco M
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- Sadek A
- Sadig N
- Saeed AM
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- Saeed M
- Saeed M
- Safa H
- Sahbaz NA
- Sahel S
- Saidbadr A
- Sakr A
- Sakr A
- Sakr R
- Salah A
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- Salah OM
- Salama M
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- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
- Salusso P
- Sam ZH
- Samalavicius NE
- Samaraweera DI
- Samih H
- Samir A
- Samison LH
- Sammarco G
- Sammut K
- Sampson C
- Samson G
- Samuel D
- Samuel SA
- Samy M
- Samy M
- Samy S
- Sanad A
- Sanchez Samaniego C
- Sanchez B
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- Sander A
- Sandler S
- Sandoval Barrantes AM
- Sanni HA
- Sanz S
- Sapci I
- Saqlain M
- Sarafilovic H
- Saraste D
- Saravia F
- Sarmah P
- Sarsik S
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- Sasia D
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- Sayma EA
- Scalabre A
- Scalabre A
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- Schiavone R
- Schivo D
- Schmid R
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- Schultz JK
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- Scott M
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- Segovia Lohse HA
- Seif M
- Seifelnasr O
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- Selvaggi F
- Selvaggi L
- Semeda N
- Semiz A
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- Tabiri S
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- Wold TB
- Wolf B
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- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
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- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
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- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
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- Ziff O
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- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
- Author
- Abdul Latiff Amir Hamzah
- Abdullah Baharudin
- Aberer Werner
- Abusada Nancy
- Adcock Ian
- Afani Alejandro
- Agache Ioana
- Aggelidis Xenofon
- Agustin Jenifer
- Akdis Cezmi A.
- Akdis Cezmi A.
- Akdis Mubeccel
- Al-Ahmad Mona
- Al-Zahab Bassam Abou
- Alburdan Hussam
- Aldrey-Palacios Oscar
- Alvarez Cuesta Emilio
- Alwan Salman Hiba
- Alzaabi Ashraf
- Amade Salma
- Ambrocio Gene
- Angles Rosana
- Annesi-Maesano Isabella
- Ansotegui Ignacio J.
- Anto Josep M.
- Anto Josep M.
- Ara Bardajo Paula
- Arasi Stefania
- Arrais Margarete
- Arshad Hasan
- Artesani Maria-Cristina
- Asayag Estrella
- Avolio Francesca
- Azhari Khuzama
- Bachert Claus
- Bagnasco Diego
- Baiardini Ilaria
- Bajrovic Nissera
- Bakakos Petros
- Bakeyala Mongono Sergio
- Balotro-Torres Christine
- Barba Sergio
- Barbara Cristina
- Barbosa Elsa
- Barreto Bruno
- Bartra Joan
- Basagana Xavier
- Bateman Eric D.
- Battur Lkhagvaa
- Bedbrook Anna
- Bedolla Barajas Martin
- Beghe Bianca
- Bekere Antra
- Bel Elizabeth
- Ben Kheder Ali
- Bennoor Kazi S.
- Benson Mikael
- Berghea Elena-Camelia
- Bergmann Karl-Christian
- Bernardini Roberto
- Bernstein David
- Bewick Mike
- Bialek Slawomir
- Bialoszewski Artur
- Bieber Thomas
- Billo Nils E.
- Bilo Maria-Beatrice
- Bindslev-Jensen Carsten
- Bjermer Leif
- Blain Hubert
- Blain Hubert
- Bobolea Irina
- Bochenska Marciniak Malgorzata
- Bond Christine
- Boner Attilio
- Bonini Matteo
- Bonini Sergio
- Bosnic-Anticevich Sinthia
- Bosse Isabelle
- Botskariova Sofia
- Bouchard Jacques
- Boulet Louis-Philippe
- Bourret Rodolphe
- Bousquet Jean
- Bousquet Philippe
- Braido Fulvio
- Briggs Andrew
- Brightling Christopher E.
- Brozek Jan
- Brussino Luisa
- Buhl Roland
- Bumbacea Roxana
- Buquicchio Rosalva
- Burguete Cabanas Maria-Teresa
- Bush Andrew
- Busse William W.
- Buters Jeroen
- Caballero-Fonseca Fernan
- Calderon Moises A.
- Calvo Mario
- Camargos Paulo
- Camuzat Thierry
- Canevari F. R.
- Cano Antonio
- Canonica G. Walter
- Capriles-Hulett Arnaldo
- Caraballo Luis
- Cardona Vicky
- Carlsen Kai-Hakon
- Carmona Pirez Jonas
- Caro Jorge
- Carr Warner
- Carreiro-Martins Pedro
- Carreon-Asuncion Fredelita
- Carriazo Ana-Maria
- Carrion y Ribas Carme
- Casale Thomas
- Castor Mary-Ann
- Castro Elizabeth
- Caviglia A. G.
- Cecchi Lorenzo
- Cepeda Sarabia Alfonso
- Chalubinski Maciej
- Chandrasekharan Ramanathan
- Chang Yoon-Seok
- Chato-Andeza Victoria
- Chatzi Lida
- Chatzidaki Christina
- Chavannes Niels H.
- Chaves Loureiro Claudia
- Chavez Garcia Aurora-Alejandra
- Chelninska Marta
- Chen Yuzhi
- Cheng Lei
- Chinthrajah Sharon
- Chivato Tomas
- Chkhartishvili Ekaterine
- Christoff George
- Chrystyn Henry
- Chu Derek K.
- Chua Antonio
- Chuchalin Alexander
- Chung Kian Fan
- Ciceran Alberto
- Cingi Cemal
- Ciprandi Giorgio
- Cirule Ieva
- Coelho Ana-Carla
- Compalati Enrico
- Constantinidis Jannis
- Correia de Sousa Jaime
- Costa David
- Costa Elisio Manuel
- Coste Andre
- Cottini M.
- Cox Linda
- Crisci Carlos
- Crivellaro Maria Angiola
- Cruz Alvaro A.
- Cullen John
- Custovic Adnan
- Cvetkovski Biljana
- Czarlewski Wienczyslawa
- Czarlewski Wienczyslawa
- D'Amato Gennaro
- da Silva Jane
- Dahl Ronald
- Dahlen Sven-Erik
- Daniilidis Vasilis
- Darjazini Nahhas Louei
- Darsow Ulf
- Davies Janet
- de Blay Frederic
- De Feo Giulia
- De Guia Eloisa
- de la Luz Hortensia Garcia Cruz Maria
- de la Torre Navarrete Jose-Ricardo
- de los Santos Chato
- De Manuel Keenoy Esteban
- De Vries Govert
- De Wang Yun
- del Carmen Costa Dominguez Maria
- Deleanu Diana
- Demoly Pascal
- Denburg Judah
- Devillier Philippe
- Didier Alain
- Dimic Janjic Sanja
- Dimou Maria
- Dinh-Xuan Anh Tuan
- Djukanovic Ratko
- Do Ceu Texeira Maria
- Dokic Dejan
- Dominguez Silva Margarita Gabriela
- Douagui Habib
- Douladiris Nikolaos
- Doulaptsi Maria
- Dray Gerard
- Dubakiene Ruta
- Dupas Eve
- Durham Stephen
- Duse Marzia
- Dykewicz Mark
- Ebo Didier
- Edelbaher Natalija
- Eiwegger Thomas
- Eklund Patrik
- El-Gamal Yehia
- El-Sayed Shereen S.
- El-Sayed Zeinab A.
- El-Seify Magda
- Emuzyte Regina
- Enecilla Lourdes
- Erhola Marina
- Espinoza Contreras Jesus Guillermo
- Espinoza Heidilita
- Farrell John
- Fernandez Lenora
- Fimbres Jimenez Paola
- Fink Wagner Antje
- Fiocchi Alessandro
- Fokkens Wytske J.
- Folletti Lenia
- Fonseca Joao A.
- Fonseca Susana C.
- Fontaine Jean-Francois
- Forastiere Francesco
- Fuentes Perez Jose Miguel
- Gaerlan-Resureccion Emily
- Gaga Mina
- Galvez Romero Jose Luis
- Gamkrelidze Amiran
- Garcia Cobas Cecilia Yvonne
- Garcia Alexis
- Gayraud Jacques
- Gelardi Matteo
- Gemicioglu Bilun
- Gennimata Dimitra
- Genova Sonya
- Gereda Jose
- Gerth van Wijk Roy
- Giuliano Antonio
- Gomez Rene-Maximiliano
- Gonzalez Ballester Miguel-Ange
- Gonzalez Diaz Sandra
- Gotua Maia
- Grigoreas Christos
- Grisle Ineta
- Guidacci Marta
- Guldemond Nick
- Gutter Zdenek
- Guzman Antonieta
- Haahtela Tari
- Haahtela Tari
- Halloum Ramsa
- Halpin David
- Hamelmann Eckard
- Hammadi Suleiman
- Harvey Richard
- Heffler Enrico
- Heinrich Joachim
- Hejjaoui Adnan
- Hellquist-Dahl Birthe
- Hernandez Velazquez Luiana
- Hew Mark
- Hossny Elham
- Howarth Peter
- Hrubisko Martin
- Huerta Villalobos Yunuen Rocio
- Humbert Marc
- Husain Salina
- Hyland Michael
- Iaccarino Guido
- Iaccarino Guido
- Ibrahim Moustafa
- Ilina Nataliya
- Illario Maddalena
- Incorvaia Cristoforo
- Infantino Antonio
- Irani Carla
- Ispayeva Zhanat
- Ivancevich Juan Carlos
- Jares Edgardo E. J.
- Jarvis Deborah
- Jassem Ewa
- Jenko Klemen
- Jimeneracruz Uscanga Ruben Dario
- Johnston Sebastian L.
- Joos Guy
- Jost Maja
- Julge Kaja
- Jung Ki-Suck
- Just Jocelyne
- Jutel Marek
- Kaidashev Igor
- Kalayci Omer
- Kalyoncu Fuat
- Kapsali Jeni
- Kardas Przemyslaw
- Karjalainen Jussi
- Kasala Carmela A.
- Katotomichelakis Michael
- Kavaliukaite Loreta
- Keil Thomas
- Keith Paul
- Khaitov Musa
- Khaltaev Nikolai
- Kim You-Young
- Kirenga Bruce
- Kleine-Tebbe Jorg
- Klimek Ludger
- Ko Fanny W.
- Koffi N'Goran Bernard
- Kompoti Evangelia
- Kopac Peter
- Koppelman Gerard
- Koren Jeverica Anja
- Koskinen Seppo
- Kosnik Mitja
- Kostka Tomasz
- Kostov Kosta V.
- Kowalski Marek L.
- Kralimarkova Tanya
- Kramer Vrscaj Karmen
- Kraxner Helga
- Kreft Samo
- Kritikos Vicky
- Kudlay Dmitry
- Kuitunen Mikael
- Kull Inger
- Kuna Piotr
- Kupczyk Maciej
- Kvedariene Violeta
- Kyriakakou Marialena
- Lalek Nika
- Landi Massimo
- Lane Stephen
- Larenas-Linnemann Desiree E.
- Lau Susanne
- Laune Daniel
- Lavrut Jorge
- Le Lan
- Lenzenhuber Martina
- Leo Gualtiero
- Lessa Marcus
- Levin Michael
- Li Jing
- Lieberman Philip
- Liotta Giuseppe
- Lipworth Brian
- Liu Xuandao
- Lobo Rommel
- Lodrup Carlsen Karin C.
- Lombardi Carlo
- Louis Renaud
- Loukidis Stelios
- Lourenco Olga
- Luna Pech Jorge A.
- Madjar Bojan
- Maggi Enrico
- Magnan Antoine
- Mahboub Bassam
- Mair Alpana
- Maitland van der Zee Anke-Hilse
- Makela Mika
- Makris Michael
- Malling Hans-Jorgen
- Mandajieva Mariana
- Manning Patrick
- Manousakis Manolis
- Maragoudakis Pavlos
- Marseglia Gianluigi
- Marshall Gailen
- Masjedi Mohammad Reza
- Maspero Jorge F.
- Matta Campos Juan Jose
- Maurer Marcus
- Mavale-Manuel Sandra
- Meco Cem
- Melen Erik
- Melioli Giovanni
- Melo-Gomes Elisabete
- Meltzer Eli O.
- Menditto Enrica
- Menzies-Gow Andrew
- Merk Hans
- Michel Jean-Pierre
- Micheli Yann
- Miculinic Neven
- Midao Luis
- Mihaltan Florin
- Mikos Nikolaos
- Milanese Manlio
- Milenkovic Branislava
- Mitsias Dimitrios
- Moalla Bassem
- Moda Giuliana
- Mogica Martinez Maria Dolores
- Mohammad Yousser
- Moharra Frances-Montserrat
- Moin Mostafa
- Molimard Mathieu
- Momas Isabelle
- Mommers Monique
- Monaco Alessandro
- Montefort Stephen
- Montenegro Lucia-Elvira
- Monti Riccardo
- Mora Dory
- Morais-Almeida Mario
- Mosges Ralph
- Mostafa Badr Eldin
- Mullol Joaquim
- Munter Lars
- Muraro Antonella
- Murray Ruth
- Musarra Antonio
- Mustakov Tihomir
- Naclerio Robert
- Nadeau Kari C.
- Nadif Rachel
- Nakonechna Alla
- Namazova-Baranova Leyla
- Navarro-Locsin Gretchen
- Neffen Hugo
- Nekam Kristof
- Neou Angelos
- Nettis Eustachio
- Neuberger Daniel
- Nicod Laurent
- Nicola Stefania
- Niederberger-Leppin Verena
- Niedoszytko Marek
- Nieto Antonio
- Novellino Ettore
- Nunes Elizabete
- Nyembue Dieudonne
- O'Hehir Robyn E.
- Odjakova Cvetanka
- Ohta Ken
- Okamoto Yoshitaka
- Okubo Kimi
- Oliver Brian
- Onorato Gabrielle L.
- Orru Maria Pia
- Ortiz Valeria Garcia
- Ouedraogo Solange
- Ouoba Kampadilemba
- Padilla Francisco-Javier
- Paggiaro Pier Luigi
- Pagkalos Aris
- Pajno Giovanni
- Pala Gianni
- Palaniappan S. P.
- Pali-Scholl Isabella
- Palkonen Susanna
- Palmer Stephen
- Panaitescu Bunu Carmen
- Panzner Petr
- Papadopoulos Nikos G.
- Papanikolaou Vasilis
- Papi Alberto
- Paralchev Bojidar
- Paraskevopoulos Giannis
- Park Hae-Sim
- Passalacqua Giovanni
- Patella Vincenzo
- Pavord Ian
- Pawankar Ruby
- Pedersen Soren
- Peleve Susete
- Pellegino Simona
- Pereira Ana
- Pereira Mariana
- Perez Tamara
- Perna Andrea
- Peroni Diego
- Pfaar Oliver
- Pham-Thi Nhan
- Pigearias Bernard
- Pin Isabelle
- Pinto Barnaro Sousa
- Piskou Konstantina
- Pitsios Constantinos
- Plavec Davor
- Poethig Dagmar
- Pohl Wolfgang
- Poplas Susic Antonija
- Popov Todor A.
- Portejoie Fabienne
- Potter Paul
- Poulsen Lars
- Prados-Torres Alexandra
- Prarros Fotis
- Price David
- Prokopakis Emmanuel
- Puggioni Francesca
- Puig-Domenech Elisa
- Puy Robert
- Rabe Klaus
- Rabotti Silvia
- Raciborski Filip
- Ramos Josephine
- Recalcati Cristina
- Recto Marysia T.
- Reda Shereen M.
- Regateiro Frederico S.
- Reider Norbert
- Reitsma Sietze
- Repka-Ramirez Susana
- Ridolo Erminia
- Rimmer Janet
- Rivero Yeverino Daniela
- Rizzo Jose Angelo
- Robalo-Cordeiro Carlos
- Roberts Graham
- Robles Karen
- Roche Nicolas
- Rodriguez Gonzalez Monica
- Rodriguez Zagal Erendira
- Rolla Giovanni
- Rolland Christine
- Roller-Wirnsberger Regina
- Roman Rodriguez Miguel
- Romano Antonino
- Romantowski Jan
- Rombaux Philippe
- Romualdez Joel
- Rosado-Pinto Jose
- Rosario Nelson
- Rosenwasser Lanny
- Rossi Oliviero
- Rottem Menachem
- Rouadi Philip W.
- Rovina Nikoleta
- Rozman Sinur Irma
- Ruiz Segura Lucy Tania
- Ruiz Mauricio
- Ryan Dermot
- Sagara Hironori
- Sakai Daiki
- Sakurai Daiju
- Saleh Wafaa
- Salimaki Johanna
- Samitas Konstantinos
- Samolinski Boleslaw
- Sanchez Coronel Maria Guadalupe
- Sanchez-Borges Mario
- Sanchez-Lopez Jaime
- Sansonna Melissa
- Sarafoleanu Codrut
- Sarquis Serpa Faradiba
- Sastre Joaquin
- Savi Eleonora
- Savonyte Agne
- Sawaf Bisher
- Scadding Glenis K.
- Scheire Sophie
- Schmid-Grendelmeier Peter
- Schuhl Juan Francisco
- Schunemann Holger
- Schvalbova Maria
- Schwarze Jorgen
- Scichilone Nicola
- Senna Gianenrico
- Sepulveda Cecilia
- Serrano Elie
- Shamai Sara
- Sheikh Aziz
- Sheikh Aziz
- Shields Mike
- Shishkov Vasil
- Siafakas Nikos
- Simeonov Alexander
- Simons Estelle F. E. R.
- Sisul Juan Carlos
- Sitkauskiene Brigita
- Skrindo Ingelbjorg
- Soklic Kosak Tanja
- Sole Dirceu
- Sondermann Martin
- Sooronbaev Talant
- Soto-Martinez Manuel
- Soto-Quiros Manuel
- Sova Milan
- Soyka Michael
- Specjalski Krzysztof
- Sperl Annette
- Spranger Otto
- Stamataki Sofia
- Stefanaki Lina
- Stellato Cristiana
- Stelmach Rafael
- Strandberg Timo
- Stute Petra
- Subramaniam Abirami
- Suppli Ulrik Charlotte
- Sutherland Michael
- Sylvestre Silvia
- Syrigou Aikaterini
- Taborda Barata Luis
- Takovska Nadejda
- Tan Frances
- Tan Rachel
- Tan Vincent
- Tang Ing Ping
- Taniguchi Masami
- Tannert Line
- Tantilipikorn Pongsakorn
- Tattersall Jessica
- Tesi Filippo
- Thieme Uta
- Thijs Carel
- Thomas Mike
- To Teresa
- Todo-Bom Ana Maria
- Togias Alkis
- Tomazic Peter-Valentin
- Tomic-Spiric Vesna
- Toppila-Salmi Sanna
- Torres Jaen Maria-Jose
- Toskala Elina
- Tran Thien Quan Vu
- Triggiani Massimo
- Triller Katja
- Triller Nadja
- Tsiligianni Ioanna
- Uberti M.
- Ulmeanu Ruxandra
- Urbancic Jure
- Urrutia Pereira Marilyn
- Vachova Martina
- Valdes Felipe
- Valenta Rudolf
- Valentin Rostan Marylin
- Valero Antonio
- Valiulis Arunas
- Vallianatou Mina
- Valovirta Erkka
- Van Eerd Michiel
- Van Ganse Eric
- van Hage Marianne
- Vandenplas Olivier
- Vasankari Tuula
- Vassileva Dafina
- Velasco Munoz Cesar
- Ventura Maria Teresa
- Vera-Munoz Cecilia
- Viart Frederic
- Vicheva Dilyana
- Vichyanond Pakit
- Vidal Alain
- Vidgren Petra
- Viegi Giovanni
- Vogelmeier Claus
- Von Hertzen Leena
- Vontetsianos Theodoros
- Vourdas Dimitris
- Wagenmann Martin
- Walker Samantha
- Wallace Dana
- Waserman Susan
- Wehner Katrin
- Wickman Magnus
- Williams Dennis
- Williams Sian
- Wilson Nicola
- Wong Gary
- Woo Kent
- Wozniak Lucyna
- Wright John
- Wroczynski Piotr
- Xepapadaki Paraskevi
- Yakovliev Plamen
- Yamaguchi Masao
- Yan Kwok
- Yap Yoke Yeow
- Yassin Mais
- Yawn Barbara
- Yiallouros Panayiotis
- Yorgancioglu Arzu
- Yoshihara Shigemi
- Young Ian
- Yusuf Osman B.
- Zaidi Asghar
- Zaitoun Fares
- Zalud Petra
- Zar Heather
- Zedda M. T.
- Zernotti Mario E.
- Zhang Luo
- Zhong Nanshan
- Zidarn Mihaela
- Zuberbier Torsten
- Zuberbier Torsten
- Zubrinich Celia
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe
Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
- Author
- Abdul Latiff Amir Hamzah
- Abdullah Baharudin
- Aberer Werner
- Abusada Nancy
- Adcock Ian
- Afani Alejandro
- Agache Ioana
- Aggelidis Xenofon
- Agustin Jenifer
- Akdis Cezmi A.
- Akdis Cezmi A.
- Akdis Mubeccel
- Al-Ahmad Mona
- Al-Zahab Bassam Abou
- Alburdan Hussam
- Aldrey-Palacios Oscar
- Alvarez Cuesta Emilio
- Alwan Salman Hiba
- Alzaabi Ashraf
- Amade Salma
- Ambrocio Gene
- Angles Rosana
- Annesi-Maesano Isabella
- Ansotegui Ignacio J.
- Anto Josep M.
- Anto Josep M.
- Ara Bardajo Paula
- Arasi Stefania
- Arrais Margarete
- Arshad Hasan
- Artesani Maria-Cristina
- Asayag Estrella
- Avolio Francesca
- Azhari Khuzama
- Bachert Claus
- Bagnasco Diego
- Baiardini Ilaria
- Bajrovic Nissera
- Bakakos Petros
- Bakeyala Mongono Sergio
- Balotro-Torres Christine
- Barba Sergio
- Barbara Cristina
- Barbosa Elsa
- Barreto Bruno
- Bartra Joan
- Basagana Xavier
- Bateman Eric D.
- Battur Lkhagvaa
- Bedbrook Anna
- Bedolla Barajas Martin
- Beghe Bianca
- Bekere Antra
- Bel Elizabeth
- Ben Kheder Ali
- Bennoor Kazi S.
- Benson Mikael
- Berghea Elena-Camelia
- Bergmann Karl-Christian
- Bernardini Roberto
- Bernstein David
- Bewick Mike
- Bialek Slawomir
- Bialoszewski Artur
- Bieber Thomas
- Billo Nils E.
- Bilo Maria-Beatrice
- Bindslev-Jensen Carsten
- Bjermer Leif
- Blain Hubert
- Blain Hubert
- Bobolea Irina
- Bochenska Marciniak Malgorzata
- Bond Christine
- Boner Attilio
- Bonini Matteo
- Bonini Sergio
- Bosnic-Anticevich Sinthia
- Bosse Isabelle
- Botskariova Sofia
- Bouchard Jacques
- Boulet Louis-Philippe
- Bourret Rodolphe
- Bousquet Jean
- Bousquet Philippe
- Braido Fulvio
- Briggs Andrew
- Brightling Christopher E.
- Brozek Jan
- Brussino Luisa
- Buhl Roland
- Bumbacea Roxana
- Buquicchio Rosalva
- Burguete Cabanas Maria-Teresa
- Bush Andrew
- Busse William W.
- Buters Jeroen
- Caballero-Fonseca Fernan
- Calderon Moises A.
- Calvo Mario
- Camargos Paulo
- Camuzat Thierry
- Canevari F. R.
- Cano Antonio
- Canonica G. Walter
- Canonica G. Walter
- Capriles-Hulett Arnaldo
- Caraballo Luis
- Cardona Vicky
- Carlsen Kai-Hakon
- Carmona Pirez Jonas
- Caro Jorge
- Carr Warner
- Carreiro-Martins Pedro
- Carreon-Asuncion Fredelita
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- Casale Thomas
- Castor Mary-Ann
- Castro Elizabeth
- Caviglia A. G.
- Cecchi Lorenzo
- Cepeda Sarabia Alfonso
- Chalubinski Maciej
- Chandrasekharan Ramanathan
- Chang Yoon-Seok
- Chato-Andeza Victoria
- Chatzi Lida
- Chatzidaki Christina
- Chavannes Niels H.
- Chaves Loureiro Claudia
- Chavez Garcia Aurora-Alejandra
- Chelninska Marta
- Chen Yuzhi
- Cheng Lei
- Chinthrajah Sharon
- Chivato Tomas
- Chkhartishvili Ekaterine
- Choi Hak-Jong
- Christoff George
- Chrystyn Henry
- Chu Derek K.
- Chua Antonio
- Chuchalin Alexander
- Chung Kian Fan
- Ciceran Alberto
- Cingi Cemal
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- Cirule Ieva
- Coelho Ana-Carla
- Compalati Enrico
- Constantinidis Jannis
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- Costa David
- Costa Elisio Manuel
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- Cottini M.
- Cox Linda
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- Cristol Jean-Paul
- Crivellaro Maria Angiola
- Cruz Alvaro A.
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- Custovic Adnan
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- Czarlewski Wienczyslawa
- Czarlewski Wienczyslawa
- D'Amato Gennaro
- da Silva Jane
- Dahl Ronald
- Dahlen Sven-Erik
- Daniilidis Vasilis
- Darjazini Nahhas Louei
- Darsow Ulf
- Davies Janet
- de Blay Frederic
- De Feo Giulia
- De Guia Eloisa
- de la Luz Hortensia Garcia Cruz Maria
- de la Torre Navarrete Jose-Ricardo
- de los Santos Chato
- De Manuel Keenoy Esteban
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- Do Ceu Texeira Maria
- Dokic Dejan
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- Douagui Habib
- Douladiris Nikolaos
- Doulaptsi Maria
- Dray Gerard
- Dubakiene Ruta
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- Durham Stephen
- Duse Marzia
- Dykewicz Mark
- Ebo Didier
- Edelbaher Natalija
- Eiwegger Thomas
- Eklund Patrik
- El-Gamal Yehia
- El-Sayed Shereen S.
- El-Sayed Zeinab A.
- El-Seify Magda
- Emuzyte Regina
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- Espinoza Contreras Jesus Guillermo
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- Farrell John
- Fernandez Lenora
- Fimbres Jimenez Paola
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- Fiocchi Alessandro
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- Fokkens Wytske J.
- Folletti Lenia
- Fonseca Joao A.
- Fonseca Joao A.
- Fonseca Susana C.
- Fontaine Jean-Francois
- Forastiere Francesco
- Fuentes Perez Jose Miguel
- Gaerlan-Resureccion Emily
- Gaga Mina
- Galvez Romero Jose Luis
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- Garcia Alexis
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- Hew Mark
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- Jimeneracruz Uscanga Ruben Dario
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- Karjalainen Jussi
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- Kostov Kosta V.
- Kowalski Marek L.
- Kralimarkova Tanya
- Kramer Vrscaj Karmen
- Kraxner Helga
- Kreft Samo
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- Lourenco Olga
- Luna Pech Jorge A.
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- Mair Alpana
- Maitland van der Zee Anke-Hilse
- Makela Mika
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- Mandajieva Mariana
- Manning Patrick
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- Maurer Marcus
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- Orru Maria Pia
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- Pali-Scholl Isabella
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- Palmer Stephen
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- Panzner Petr
- Papadopoulos Nikos G.
- Papanikolaou Vasilis
- Papi Alberto
- Paralchev Bojidar
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- Perna Andrea
- Peroni Diego
- Pfaar Oliver
- Pham-Thi Nhan
- Pigearias Bernard
- Pin Isabelle
- Pinto Barnaro Sousa
- Piskou Konstantina
- Pitsios Constantinos
- Plavec Davor
- Poethig Dagmar
- Pohl Wolfgang
- Poplas Susic Antonija
- Popov Todor A.
- Portejoie Fabienne
- Potter Paul
- Poulsen Lars
- Prados-Torres Alexandra
- Prarros Fotis
- Price David
- Prokopakis Emmanuel
- Puggioni Francesca
- Puig-Domenech Elisa
- Puy Robert
- Rabe Klaus
- Rabotti Silvia
- Raciborski Filip
- Ramos Josephine
- Recalcati Cristina
- Recto Marysia T.
- Reda Shereen M.
- Regateiro Frederico S.
- Reider Norbert
- Reitsma Sietze
- Repka-Ramirez Susana
- Reynes Jacques
- Ridolo Erminia
- Rimmer Janet
- Rivero Yeverino Daniela
- Rizzo Jose Angelo
- Robalo-Cordeiro Carlos
- Roberts Graham
- Robles Karen
- Roche Nicolas
- Rodriguez Gonzalez Monica
- Rodriguez Zagal Erendira
- Rolla Giovanni
- Rolland Christine
- Roller-Wirnsberger Regina
- Roman Rodriguez Miguel
- Romano Antonino
- Romantowski Jan
- Rombaux Philippe
- Romualdez Joel
- Rosado-Pinto Jose
- Rosario Nelson
- Rosenwasser Lanny
- Rossi Oliviero
- Rottem Menachem
- Rouadi Philip W.
- Rovina Nikoleta
- Rozman Sinur Irma
- Ruiz Segura Lucy Tania
- Ruiz Mauricio
- Ryan Dermot
- Sagara Hironori
- Sakai Daiki
- Sakurai Daiju
- Saleh Wafaa
- Salimaki Johanna
- Samitas Konstantinos
- Samolinski Boleslaw
- Sanchez Coronel Maria Guadalupe
- Sanchez-Borges Mario
- Sanchez-Lopez Jaime
- Sansonna Melissa
- Sarafoleanu Codrut
- Sarquis Serpa Faradiba
- Sastre Joaquin
- Savi Eleonora
- Savonyte Agne
- Sawaf Bisher
- Scadding Glenis K.
- Scheire Sophie
- Schmid-Grendelmeier Peter
- Schuhl Juan Francisco
- Schunemann Holger
- Schvalbova Maria
- Schwarze Jorgen
- Scichilone Nicola
- Senna Gianenrico
- Sepulveda Cecilia
- Serrano Elie
- Shamai Sara
- Sheikh Aziz
- Sheikh Aziz
- Shields Mike
- Shishkov Vasil
- Siafakas Nikos
- Simeonov Alexander
- Simons Estelle F. E. R.
- Sisul Juan Carlos
- Sitkauskiene Brigita
- Skrindo Ingelbjorg
- Soklic Kosak Tanja
- Sole Dirceu
- Sondermann Martin
- Sooronbaev Talant
- Soto-Martinez Manuel
- Soto-Quiros Manuel
- Sova Milan
- Soyka Michael
- Specjalski Krzysztof
- Sperl Annette
- Spranger Otto
- Stamataki Sofia
- Stefanaki Lina
- Stellato Cristiana
- Stelmach Rafael
- Strandberg Timo
- Stute Petra
- Subramaniam Abirami
- Suppli Ulrik Charlotte
- Sutherland Michael
- Sylvestre Silvia
- Syrigou Aikaterini
- Taborda Barata Luis
- Takovska Nadejda
- Tan Frances
- Tan Rachel
- Tan Vincent
- Tang Ing Ping
- Taniguchi Masami
- Tannert Line
- Tantilipikorn Pongsakorn
- Tattersall Jessica
- Tesi Filippo
- Thieme Uta
- Thijs Carel
- Thomas Mike
- To Teresa
- Todo-Bom Ana Maria
- Togias Alkis
- Tomazic Peter-Valentin
- Tomic-Spiric Vesna
- Toppila-Salmi Sanna
- Torres Jaen Maria-Jose
- Toskala Elina
- Tran Thien Quan Vu
- Triggiani Massimo
- Triller Katja
- Triller Nadja
- Tsiligianni Ioanna
- Uberti M.
- Ulmeanu Ruxandra
- Urbancic Jure
- Urrutia Pereira Marilyn
- Vachova Martina
- Valdes Felipe
- Valenta Rudolf
- Valentin Rostan Marylin
- Valero Antonio
- Valiulis Arunas
- Vallianatou Mina
- Valovirta Erkka
- Van Eerd Michiel
- Van Ganse Eric
- van Hage Marianne
- Vandenplas Olivier
- Vasankari Tuula
- Vassileva Dafina
- Velasco Munoz Cesar
- Ventura Maria Teresa
- Vera-Munoz Cecilia
- Viart Frederic
- Vicheva Dilyana
- Vichyanond Pakit
- Vidal Alain
- Vidgren Petra
- Viegi Giovanni
- Vogelmeier Claus
- Von Hertzen Leena
- Vontetsianos Theodoros
- Vourdas Dimitris
- Wagenmann Martin
- Walker Samantha
- Wallace Dana
- Waserman Susan
- Wehner Katrin
- Wickman Magnus
- Williams Dennis
- Williams Sian
- Wilson Nicola
- Wong Gary
- Woo Kent
- Wozniak Lucyna
- Wright John
- Wroczynski Piotr
- Xepapadaki Paraskevi
- Yakovliev Plamen
- Yamaguchi Masao
- Yan Kwok
- Yap Yoke Yeow
- Yassin Mais
- Yawn Barbara
- Yiallouros Panayiotis
- Yorgancioglu Arzu
- Yoshihara Shigemi
- Young Ian
- Yusuf Osman B.
- Zaidi Asghar
- Zaitoun Fares
- Zalud Petra
- Zar Heather
- Zedda M. T.
- Zernotti Mario E.
- Zhang Luo
- Zhong Nanshan
- Zidarn Mihaela
- Zuberbier Torsten
- Zuberbier Torsten
- Zubrinich Celia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity
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Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis
- Author
- Aarnouste R
- Alisjahbana B
- Alisjahbana B
- Annisa J
- Apriani L
- Bazavan I
- Beigier M
- Bicu M
- Bicuti S
- Bosman M
- Burada F
- Capitanescu I
- Castro B
- Chaidir L
- Chegou N
- Cimpoeru A
- Cioboata R
- Ciocoiu A
- Ciontea M
- Ciurea M
- Clenciu D
- Cliff J
- Cliff JM
- Coronel J
- Coronel J
- Critchley J
- Critchley JA
- Cucu M
- Demetrian A
- Dewi N
- Dockrell H
- Dockrell HM
- Dorobantu S
- du Plessis W
- du Toit L
- Dubreu V
- Dudau M
- Eckold C
- Eckold C
- Editoiu C
- Firanescu A
- Flores J
- Florescu A
- Gheonea I
- Golinski R
- Griffiths U
- Grint D
- Gunawan Y
- Haks M
- Hill P
- Imaculata S
- Ioana M
- Ioana M
- Joosten S
- Kaufmann S
- Kerry-Barnard S
- Kerry-Barnard S
- Kleynhans L
- Kleynhans L
- Koesoemadinata R
- Kumar V
- Kumar V
- Lachmandas E
- Laurence Y
- Lepadat A
- Limascca R
- Livia R
- Lopez S
- Loxton A
- Malherbe S
- Malherbe ST
- McAllister S
- Moore D
- Mota M
- Netea M
- Nicoli E
- Nitu F
- Olaru M
- Olteanu M
- Ottenhoff T
- Panduru N
- Papurica M
- Pearson F
- Permana H
- Plesea R
- Popa A
- Popa SG
- Popescu EL
- Prins N
- Riza A
- Riza A-L
- Ronacher K
- Ronacher K
- Ruesen C
- Ruslami R
- Ruslami R
- Santoso P
- Selamolela M
- Serban-Sosoi S
- Smith B
- Soeroto A
- Soetedjo N
- Solano W
- Stamatoiu L
- Stanley K
- Stanley K
- Streata I
- Streba C
- Susilawati N
- Tataru T
- Thiart L
- Tshivhula H
- Ugarte-Gil C
- Ugarte-Gil C
- Valutanu I
- van Crevel R
- van Crevel R
- van der Spuy G
- van Rensburg I
- Verrall A
- Villaizan K
- Vladu I
- Vrieling F
- Wagman C
- Walzl G
- Walzl G
- Weiner J
- Wijmenga C
- Wijmenga C
- Yunivita V
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 13/06/2020
- Field of study
Supplementary Data:
Supplementary materials are available at Clinical Infectious Diseases online at https://academic.oup.com/cid/article/72/1/69/5857148#274319223 . Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author.Copyright © The Author(s) 2020. Background:
People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity.
Methods:
Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to <6.5%), TB-only patients, and healthy controls in 4 countries: South Africa, Romania, Indonesia, and Peru. Differential blood gene expression was determined by RNA-seq (n = 249).
Results:
Diabetes increased the magnitude of gene expression change in the host transcriptome in TB, notably showing an increase in genes associated with innate inflammatory and decrease in adaptive immune responses. Strikingly, patients with IH and TB exhibited blood transcriptomes much more similar to patients with diabetes-TB than to patients with only TB. Both diabetes-TB and IH-TB patients had a decreased type I interferon response relative to TB-only patients.
Conclusions:
Comorbidity in individuals with both TB and diabetes is associated with altered transcriptomes, with an expected enhanced inflammation in the presence of both conditions, but also reduced type I interferon responses in comorbid patients, suggesting an unexpected uncoupling of the TB transcriptome phenotype. These immunological dysfunctions are also present in individuals with IH, showing that altered immunity to TB may also be present in this group. The TB disease outcomes in individuals with IH diagnosed with TB should be investigated further.European Union’s Seventh Framework Programme (FP7 2007-2013 - Health) under grant agreement No 305279
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Ö
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- Ž
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- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
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- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf Am
- Abdelrouf Dm
- Abdelshafy M
- Abdelshakour M
- Abdrabou Ak
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- Abudeeb H
- Abuowda Y
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- Alghamdi Msa
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- Alhabli I
- Alhady K
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- Alhazmi W
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- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
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- Antezana D
- Anthoulakis C
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- Anwar Aw
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- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
- Arafa O
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- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
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- Ashour A
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- Ayad S
- Ayandipo O
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- Ayyar S
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- Aziz Mra
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- Azmitia Jra
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- Balalis D
- Baldacchino M
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- Balila Rmh
- Balkan Aza
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- Balmaceda R
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- Balogun F
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- Baluch F
- Bamford R
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- Beisa V
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- Benammi S
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- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezzina M
- Bhangu A
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- Bhargava A
- Bharj Is
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- Bhatnagar A
- Bhattacharya S
- Bhopal Kf
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- Bianco F
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- de Leó
- De Leon MZP
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- de Lima CVB
- De Luca E
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- Deckelbaum Dl
- Decker E
- Decoud Hp
- Dedekind B
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- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
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- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
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- Francois P
- Francois-Coridon H
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- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
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- Gamil D
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- Gan Yy
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- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
- Goh Cc
- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
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- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
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- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
- Hall Nj
- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
- Hammad A
- Hammad Am
- Hampton M
- Hampton Mi
- Hamsho W
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
- Hantour U
- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
- Heath J
- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
- Henderson L
- Henderson L
- Heng He
- Henric N
- Henry F
- Henshall De
- Herebat A
- Herikstad R
- Herrera N
- Herrera-Matta J
- Herrod P
- Hervieux E
- Hervieux E
- Hesham O
- Hettiarachchi Ts
- Hewage K
- Heywood Eg
- Highcock S
- Hilal K
- Hinojosa C
- Hjertberg M
- Hjertberg M
- Hmila S
- Ho A
- Ho Cw
- Ho W
- Ho Wc
- Hodonou F
- Hogea M
- Holte S
- Holton P
- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
- Hosh M
- Hossaini S
- Hossameldin A
- Houlden C
- Howells L
- Howie Ee
- Hrora A
- Huaman E
- Huaraya Rc
- Humm G
- Hunter K
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Husseiny R
- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
- Iftikhar Z
- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
- Irtan S
- Irwin G
- Irwin G
- Irwin G
- Irwin G
- Ishak N
- Iskandar F
- Ismaï
- Ismaï
- Ismaï
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- Ismail A
- Ismail M
- Ismail M
- Ismail Mjb
- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
- Iyer D
- Iyer D
- Iyer D
- Jabal Ms
- Jabbar A
- Jaber S
- Jackson P
- Jacobe M
- Jaffry Z
- Jaffry Z
- Jaich R
- Jain P
- Jama Gm
- Jamal L
- Janardha Kc
- Janik M
- Jankus T
- Jaradat D
- Jaramillo Ra
- Jarmin M
- Jasaitis K
- Javaid M
- Javed O
- Javed O
- Jawaid M
- Jayathilake Ab
- Jck Ng
- Jean-Francois C
- Jeffery A
- Jeffery A
- Jenner E
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- Jennings V
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- Jensen E
- Jenvey C
- Jeo Ws
- Jeon H
- Jeremic L
- Jethwani Dl
- Jeyakumar J
- Jeyakumar J
- Jha M
- Jimenez J
- Jimenez-Morillas P
- Joel Lwl
- Johanna N
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- Jokubauskas M
- Jokubauskas M
- Jokubonis K
- Jones C
- Jones C
- Jones E
- Jones Tf
- Jonnalagadda R
- Joosten J
- Jordan H
- Jotautas V
- Jotautas V
- Jovine E
- Jovine E
- Jubran Af
- Juciute S
- Julaihi R
- Jurdell E
- Kaafarani H
- Kabariti R
- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci Aa
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah Sk
- Kamarulzamil Sna
- Kamil R
- Kamya S
- Kanani A
- Kandil Am
- Kandil H
- Kang Mk
- Kanta Th
- Karabacak U
- Karabelias G
- Karabulut K
- Karahan Sr
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
- Karim R
- Karim S
- Karismaningtyas H
- Karjiker P
- Karkeet M
- Karkeet M
- Karlo R
- Karlo R
- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem Ea
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke Kr
- Kelany M
- Kenibar A
- Kennedy Ed
- Kennedy M
- Kennedy R
- Keogh K
- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
- Khan K
- Khan Ma
- Khan R
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- Khan T
- Khan Za
- Kharsa S
- Khatri C
- Khatri C
- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khreishi R
- Khreishi R
- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim My
- Kim Sb
- Kim Sh
- Kimaro M
- Kinandu K
- King R
- King S
- King S
- Kinnera Sv
- Kiran Rp
- Kirby A
- Kirishnan A
- Kirupagaran A
- Kiudelis M
- Kjellin A
- Kkk Li
- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
- Koh C
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- Kojo Att
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- Komolafe O
- Kondrotas P
- Kong C
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- Kong V
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- Konstantina K
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Kyriazanos I
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- Kyziridis D
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- La Brocca A
- la Medina AR
- la Medina AR
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- Labib P
- Ladukas A
- Lafferty K
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- Lakshmi Hn
- Lam Fy
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- Laufer Lav
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- Law Jh
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- Lawther R
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- Lo Conte A
- Loaloa Mr
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- Loizides S
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- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
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- Magee C
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
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- Mesbah N
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- Metwally Mm
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mizzi C
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- Mlotshwa M
- Moaty M
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- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed Ae
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- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
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- Molina G
- Mollo Mc
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora Jjv
- Morais Pab
- Morales C
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- Morandi E
- Moreira G
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- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
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- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
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- Muralha N
- Murphy J
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- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
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- Musyoka Ck
- Mutabazi Az
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- Mutlu D
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- Muzio E
- Myers J
- Mykoniatis I
- Næ
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- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Narvestad Jk
- Nashaat A
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- Nasher O
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- Nasir A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
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- Nel D
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- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
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- Nsengimana Vjp
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- Ntirenganya F
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- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Ortiz N
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- Oshati O
- Oshodi O
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- Othman M
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- Ozben V
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- Palma Af
- Paludi Ma
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- Papaskarlatos Ia
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- Parseliunas A
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- Pastora J
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- Patoulias I
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- Picardo A
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- Preckailaite E
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- Razek T
- Razmdjou S
- Razuri C
- Razzaque J
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- Redota Map
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- Sabour Fa
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- Samaniego Cs
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- Senanayake Kj
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- Ukwenya Y
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- Urniež
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- Xerri T
- Xerri T
- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
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