Spatial Ecology of the Human Tongue Dorsum Microbiome

A fundamental question in microbial ecology is how microbes are spatially organized with respect to each other and their host. A test bed for examining this question is the tongue dorsum, which harbors a complex and important microbial community. Here, we use multiplexed fluorescence spectral imaging to investigate the organization of the tongue microbiome at micron to hundred-micron scales. We design oligonucleotide probes for taxa both abundant and prevalent, as determined by sequence analysis. Imaging reveals a highly structured spatial organization of microbial consortia, ranging in linear dimension from tens to hundreds of microns. The consortia appear to develop from a core of epithelial cells, with taxa clustering in domains suggestive of clonal expansion. Quantitative proximity analysis provides the basis for a model of tongue dorsum microbiome organization and dynamics. Our work illustrates how high-resolution analysis of micron-scale organization provides insights into physiological functions and microbiome-host interactions

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1(-/7) mice

BackgroundThe use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory effects. The abundance of A. muciniphila is associated with a healthy gut in early mid- and later life. However, the effects of A. muciniphila on a decline in intestinal health during the aging process are not investigated yet. We supplemented accelerated aging Ercc1(-/7) mice with A. muciniphila for 10weeks and investigated histological, transcriptional and immunological aspects of intestinal health.ResultsThe thickness of the colonic mucus layer increased about 3-fold after long-term A. muciniphila supplementation and was even significantly thicker compared to mice supplemented with Lactobacillus plantarum WCFS1. Colonic gene expression profiles pointed towards a decreased expression of genes and pathways related to inflammation and immune function, and suggested a decreased presence of B cells in colon. Total B cell frequencies in spleen and mesenteric lymph nodes were not altered after A. muciniphila supplementation. Mature and immature B cell frequencies in bone marrow were increased, whereas B cell precursors were unaffected. These findings implicate that B cell migration rather than production was affected by A. muciniphila supplementation. Gene expression profiles in ileum pointed toward a decrease in metabolic- and immune-related processes and antimicrobial peptide production after A. muciniphila supplementation. Besides, A. muciniphila decreased the frequency of activated CD80(+)CD273(-) B cells in Peyer's patches. Additionally, the increased numbers of peritoneal resident macrophages and a decrease in Ly6C(int) monocyte frequencies in spleen and mesenteric lymph nodes add evidence for the potentially anti-inflammatory properties of A. muciniphila.ConclusionsAltogether, we show that supplementation with A. muciniphila prevented the age-related decline in thickness of the colonic mucus layer and attenuated inflammation and immune-related processes at old age. This study implies that A. muciniphila supplementation can contribute to a promotion of healthy aging.Peer reviewe

Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer

Aromatase inhibitors are the major first-line treatment of estrogen receptor-positive breast cancer, but resistance to treatment is common. To date, no biomarkers have been validated clinically to guide subsequent therapy in these patients. In this study, we mapped the genome-wide chromatin-binding profiles of estrogen receptor alpha (ER alpha), along with the epigenetic modifications H3K4me3 and H3K27me3, that are responsible for determining gene transcription (n = 12). Differential binding patterns of ER alpha, H3K4me3, and H3K27me3 were enriched between patients with good or poor outcomes after aromatase inhibition. ER alpha and H3K27me3 patterns were validated in an additional independent set of breast cancer cases (n = 10). We coupled these patterns to array-based proximal gene expression and progression-free survival data derived from a further independent cohort of 72 aromatase inhibitor-treated patients. Through this approach, we determined that the ER alpha and H3K27me3 profiles predicted the treatment outcomes for first-line aromatase inhibitors. In contrast, the H3K4me3 pattern identified was not similarly informative. The classification potential of these genes was only partially preserved in a cohort of 101 patients who received first-line tamoxifen treatment, suggesting some treatment selectivity in patient classification. (C) 2013 AACR

Recommended reporting items for epidemic forecasting and prediction research : the EPIFORGE 2020 guidelines

Funding: MIDAS Coordination Center and the National Institutes of General Medical Sciences (NIGMS 1U24GM132013) for supporting travel to the face-to-face consensus meeting by members of the Working Group. NGR was supported by the National Institutes of General Medical Sciences (R35GM119582). Travel for SV was supported by the National Institutes of General Medical Sciences (1U24GM132013-01). BMA was supported by Bill & Melinda Gates through the Global Good Fund. RL was funded by a Royal Society Dorothy Hodgkin Fellowship.Background  The importance of infectious disease epidemic forecasting and prediction research is underscored by decades of communicable disease outbreaks, including COVID-19. Unlike other fields of medical research, such as clinical trials and systematic reviews, no reporting guidelines exist for reporting epidemic forecasting and prediction research despite their utility. We therefore developed the EPIFORGE checklist, a guideline for standardized reporting of epidemic forecasting research. Methods and findings  We developed this checklist using a best-practice process for development of reporting guidelines, involving a Delphi process and broad consultation with an international panel of infectious disease modelers and model end users. The objectives of these guidelines are to improve the consistency, reproducibility, comparability, and quality of epidemic forecasting reporting. The guidelines are not designed to advise scientists on how to perform epidemic forecasting and prediction research, but rather to serve as a standard for reporting critical methodological details of such studies. Conclusions  These guidelines have been submitted to the EQUATOR network, in addition to hosting by other dedicated webpages to facilitate feedback and journal endorsement.Publisher PDFNon peer reviewe

Correction:How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020)

(Current Biology 30, R1014–R1018; September 21, 2020) As a result of an author oversight in the originally published version of this article, a number of errors were introduced in the author list and affiliations. First, the middle initials were omitted from the names of several authors. Second, the surname of Dr. van Dam was mistakenly written as “Dam.” Third, the first name of author Bernhard Englitz was misspelled as “Bernard” and the surname of author B.J.A. Pollux was misspelled as “Pullox.” Finally, Dr. Keijer's first name was abbreviated rather than written in full. These errors, as well as various errors in the author affiliations, have now been corrected online

Shared heritability and functional enrichment across six solid cancers

Correction: Nature Communications 10 (2019): art. 4386 DOI: 10.1038/s41467-019-12095-8Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.Peer reviewe

Shared heritability and functional enrichment across six solid cancers

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis

Magrath Store News (May 22, 1986)

An archive of the Magrath Trading Store News.The University of Lethbridge Library received permission from the Wes Balderson to digitize and display this content.4 MAGRATH TRADING CO. STORE NEWS PHONES: OFFICE 758-3033 GROCERIES 758-3535 DRY GOODS 758-3252 HARDWARE 758-3065 * ‘ UPSTRAIRS' & STORE NEWS 758-6377 STORE HOURS: Monday, Tuesday, Thursday, Friday & Saturday..................................... 8 a.m. to 6 p.m. Wednesday................................................ ..................................................................................8 a.m. to 1 p.m. / THURSDAY, MAY 22nd,. 1986.......................................................................... MAGRATH, ALBERTA **************************************************************************************** LADIES READY WEAR DEPT. #2055 style Shirts Occ- Jewellery > for Sunday special Boys' White Dress Shirts in Polyester/Cottop. Be ready and those asions. New Summer Knit Dresses styled by "Kates Sportswear . Cotton & Polyester in plains, stripes and figures. Red, Blue, Turquoise. PRICED FROM CO-ORDINATES Many groupings to choose from in popular Name Brands of Paris Star, Peruzza, Snazzie. Included are Blazers, Jackets, Skirts, Pants, Capri Pants. Popular colors of the season that are most Select sporty styles or dressy styles in these new fabrics and style creations. becoming, lovely WnderBia New Medium Sport Bra With Lace Hast soft cup with dainty lace trim on inside V of cup. * SIZES: 4 to 16 NECKLACES T Be 1ur j to see our display of Sp j_ng & Summer Jewellery wha i _n the Ladies Ready-To Wear Neck aces, Earrings, Pins, Bra : ¡lets, A good selection of & UP. YOU WILL FIND A GOOD ASSORTMENT OF SUMMER FOOTWEAR FOR KIDDIES, MISSES AND LADIES. ®sw HOME BRANO Reynolds Home Hardware i'xr>c oiAHf’C OM7f«s-.nv V AAA.CMÌO HOME BRAND HEAVY DITTY APPLIANCE CASTERS Set of 4. - TURBINE VENT 2325-451-10 Removes'heat & moisture. Uses no energy. Base in­cluded. 12” dia. GSW RESIDENTIAL WATER HEATERS Quality water heaters for years of dependable service. All tanks are pressure tested and equipped with anti-corrosion fittings Interior and exterior casings are painted prior to assembly for maximum durability. 50% more insulation than most water heaters, that means saving money! A complete line of GSW replacement parts áre available IF you ever need them. 33 GAL. GAS. 3284-190-1 BENCHMARK“ W x 16 Too CARBIDE Ti? SAW BLADE WE HAVE A GOOD STOCK OF GARDEN SEEDS, SEED POTATOES. ONION SETS. &. DECKER W COMPOUND MITRE SAW . B Ring UP s púad buy! Save 0099 BLACKS DECKER Rotating table with 5 position stops, gear ' driven blade, automatic retracting guard, 51 4" cutting width, calibrated bevel post ad* ~ justs to 4511. Includes 1- cross cut blade, blade . wrench and work stop. Complete with a 2 year warranty. OUR REG. 12.99 HAMILTON Glass WALLAND DOOR MIRROR Top quality and distortion free. Measures 12 x 48 ‘ REYNOLDS ALUMINUM 7 FT. 4-WAY LADDER For use as jftet^adder, tres­tle ladder dKmfiCion ladder Flair base With anti-skid feet. Extends tcffl ft. U35-1201 ----- SHEPHERD 30,000 B.T.U Front dual controls, push button ignitér. 400 sq. in. cooking area Y N 0 L D S _ ftALUMINUM STEP LADDER. BENCHMARK” SCREWDRIVER «1 Complete with belt carry case. 5 I screwdrivers in 1. Full torque can be I applied to cap without loosening it. ' Available in Beige, White or Brown. STILL A NICE SELECTION OF BEDDING PLANTS. $1.25 WE ARE STILL MISSING OUR GREEN APPLIANCE MCT.-R. IF vqu HAVE PLEASE RETURN IT. THANKS. Do you like having fun with girls aged six to nine years, teaching them games, songs, skills, and crafts'5 How about camping, service to others/ and nature? If this sounds Like something you’d like to become involved in, consider becoming a Brownie leader next year. Ive need women who are willing to spend up to two hours a week at a Brownie meeting, planning the activities I In addition, Girl encourages all take trainings knowledge, skills, • "We build and another hour for the meeting. Guides of Canada adult members to to improve their and leadership ability, leaders”, from the youngest Brownie to the most experienced Guider. Donna Ferguson and Judy Hoibak (with the help of Jackie Moors) have been the Brownie leaders in Magrath for five years, working with groups of 15 to 24 girls, and we extend thanks to thorn. They have now stepped down to go on to other things, but they are more than willing to help the people who take their place with ideas, suggestions, and even pitching in when a hand is needed. As well, the other Guiders in Magrath will be glad to extend whatever help is required. If you are interested, please contact Iris English 758­3751, as soon as possible. M.D. OF CARDSTON NO. 6 TENDER: of Cardston No. 6 has a used welder for sale. For more please call the M.D. Shop The sealed tenders M.D. Council Meeting Monday, May 26th. Please submit your sealed tender to the Mun­icipal Administrator by 9 a.m. Monday, May 26 1986. Highest or any tender not necessarily accepted. Dwight J. Stanford, Municipal Admin. Box 580, Cardston, AB. TOK 0K0. 653-4977. M.D. OF CARDSTON NO. 6 - ASSISTANT MUNICIPAL ADMINISTRATOR Applications are invited for the position of Assistant Mun­icipal Administrator for the M.D. of Cardston No. 6. The successful candidate must have a good accounting back­ground, catgut er experience, and good communication ski 11 s Minicipal experience would be an asset. Individuals int­erested in the above position should submit a derailed re­sume, with salary expectations before 9:00 a.m. ibrday, May 26, 1986 to: Dvight J. Stanford, Municipal Administ­rator, Box 580, M.D. of Cardston No. 6,. Cardston, AB. The M.D. acetylene information at 653-3712. will be opened at rhe HUDSON BAY MOHAIR THROWS -PHYSICAL EDUCATION Cardston High School requires a Physical Education Teacher for Boys Physical Education arri other ass-ign-ments for the 1986-87 School term. The caididate will have a strong knowledge of basketball. For details con­tact: Mr. Leroy Walker at 653-4951 (school) 653-3082 (home) or Mr. Darryll Leavitt at 653-4951 (school) 653-2078 (hare) Send resume and references to: Dr. E.F. Bardock, Superint­endent of Schools, Cardston School Div. No. 2, Box 10, Cardston, AB. TOK CKO. Closing Date - May 23, 1986. SUMMER EMPLOYMENT: Twa reactivating aids to vrork with patients 55 plus in the hospital setting. Students inter­ested please contact the Magrath General Hospital. Dead­line for applications is May 23rd, 1986. SWIMWEAR King size Bath Sheets in soft, thick absorbent terry. Brown only. REGULAR.$16.95 Girls, Misses and Ladies Swim wear for the coming season. PRICED FROM SHOWER CURTAIN BLANKETS REGULAR $79.95 Handsome plaids in a nice selection of shades Plastic Shower Curt­ains in assorted floral patterns. SIZE: 70x72. REG$7.95 REQUEST FOR TENDER: Developing Accounting System for '■agrath/ Cardston Handicap Association. To meet with ••^ogram Manager and Treasurer concerning requirements of Auditing and Accounting. Closes June 2. 1986. Con­tact Joyce Holladay, 758-6484, Box 2M, Magrath - or Meryl Hough, President of the Association, Box 544, Magrath, Phone 653-3351 or 758-6281. ATTENTICN: The Southern Alberta 4-H Alumni is Hold­ing a SUi-MER CABARET Saturday, June 28. 1986 at the Grassy lake Camunity Hall. 8 p.m. to 2. a.n. The Band is Joy Ride (variety). A nidnlgnr lui i will be served. $7/person or$12/couple, 18 years or older. Oiling facilities are available for anyone requir­ing them. For tickets please call Valeric ^r-linson at 758-6768. FOR RENT: 3 bedroom apartment. Phone 758-3797. GARDEN SPOT FOR USE - already ploughed, ready for planting. Eda Kosma. - Phone 758-3236. WE HAVE A GOOD SELECTION OF BEDDING PLANTS - 17CTTART.es FLOWERS, ETC, Hardware Dept. * gjJSIC TEACHER - ¿ASIRLDGE EUMSvrARV SCHCu., CARDSKA. The candidate will be responsible for the music program ‘ in this new school. P ' ’ _ Principal., Phone 653-3757 (hone 653-3151). Seiri resume ' tp Ik. E. F. Bardock, Cardston School DLv. #2, Box 10 Cards^on, AB. TOK 0K0. Closing Date - May 26, 1986. ’ GARDEN CITY GARDEN CLUB 3he regular meeting of the Garden City Garde Club will be held Wednesday. May 28th at 7 p.m. in the Magrath High School Library. There will e a guest speaker speaking on Tunnel Gardening, Bring any extra plants, seeds, etc. for the Plant Sale. Everyone welcome. For details contact Mr. R. Broadhead,» * REG, $5/95 Gingham Checks in assort ed colors and sizes of checks. GINGHAM CHECKS KINDERGARTEN MEETING _ Thursday, may 22nd, 7:30 p.m. Magrath Elementary Library. Husbands’and wives are encouraged to attend. Linda Saxton will be talking about the 3 Class Proposal. Division of classes will be announced and sign ups for snacks and visits will be done. We need everyone's att­endance. Magrath Local Advisory Committee. 115 cm. wide. _ denim FLORAL PRINTED SPORT DENIMS Popular Denim in Navy with contrasting floral patterns. 158 cm wide. REGULAR$12.95 . .................................I.195 Ladies VACATION BIBLE SCHOOL: Vacation Bible School will be held the week of July 28-August 1. The next organizational meeting will be held Wednesday, June ,4th at 7 p.m. in the United Church Hall. We need more teachers and helpers for V.B.S. to hapen. For more information call: 758-6601 Kathy Weing. Clutch Purses and Wallets in leather. Styled by Buxton and Pitt Leather. Nice Graduation gifts. NOTICE: St. John's Lutheran Church is hold­ing Worship Services all summer at 7 p.m. We are being served by pastors from Leth­bridge and Coaldale. REG. $35.00 GARDEN CITY FERTILIZER LADIES SLOW PITCH HOME GAMES. .Tues. May 13th, Thurs. May 15th, Tues. May 20 Wed. — •’ '* - -- ' » June June 17th, Thurs. June 19, Monday, June 23 -Wed. ---- — Wed. . All games start at 7 p.m. (shale). Hope to see you a on. Thanks for your support. May 21, Mon. May 26, Wed. May 28, Tues. 3, Thurs. June 5, Thursday, June 12, Tues. June 25, Thurs. July 3, Tues. July Sth, July 9, Thurs. July 10, Tues. July 15. North East Diamond 11 out to cheer us We have including Pendants, Bush. Gifts nice selection Pins, T " Stationery. ] Slips and Gowns. of Graduation Gifts Letter Openers, Souvenir Spoons —1. Eye Make-Up, Lipsticks, a You are cordially invited to attend an Open House in the new Welling Ward Chapel at 7 p.m. on May 24th. There will be a short program, refreshments and a tour of the building. St. Joseph s C.W.L. held their May meeting at the home of Marie Sabey of Tuesday, May 13th. Reports were given on: 1. May Crowning on Sunday, May 11th. 2. Gifts of geraniums on Mother's day. 3. Report of delegates to the Diocesan CWL Convention at Fort Macleod on May 2,3,4. 4. Results of April 26th Bake Sale. 5. The attendance of four members at St. Pat­rick's CWL 60th Anniversary tea. Upcoming events: 1. Mass for the Graduates from the parish - Stacy Barnett and Richard Niznikowski on Sunday, May 18th. 2. Parish Picnic at Woolford Park on June 29th. 3. St. Joseph's CWL 25th Anniv­ersary Celebration on June 22nd. Membershps are now due from Membership Convenor Elizabeth Stanek. ‘ • • • « Treasury Branch will be celebrating their 5th Birthday on May 23rd, 1986. Light refreshments will e served from 10 a.m. to 6 p.m. Everyone welcome. FOR SALE: 1973 - 19 ft. Travel Trailer, low mileage. Sleeps 6. Phone 758-6709. REG.$8.50 "Skeleton style Hair Brushes in assorted sizes and colors. Chantilly or Musk Hand Lotion, moistur­izing, special edit­ion. 480 ml. Men’s Pyjamas in Cotton & Polyester and Flannel­ette. A choice of plain shades or figured REG* $29.95 PYJAMAS in assorted colors. Welf tailored, comi ortably styled. REGULAR$25.00 REG $39.95 to$45.00 20%0ff Men's SWEATERS SHAKER KNITS The Season's most Pants 1 Rack of Men's Dress Pants in Polyester also Corduroy Slacks in popular styles and shades. popular Pullover Sweater in Shaker Knit. COLORS: Grey, Teal,, Blue/White. REGULAR 1Q95 25.00 M.D. OF CARDSTON NO. 6 PUBLIC HEARING Aay 26, 1986, beginning at 10 a.m. General Municipal Plan: The M.D. of Cards ton No. 6 has a proposed General Municipi;! that will be discussed at a Public Hearing at 10 a.m. on Monday, May 2%th, 1986, A general Municipal Plan is a planning document under the Planning Act that provides use pol­icies and guidelines. The General Municipal Plan is intended to: a. implement the Oldman River Regional Plan through consideration of the relevance of the plan's policies to the requirements of the M.D. b. provide land use and development policies, c. consider the future needs of the M.D. for more comprehen­sive reviews of planning issues. If you have any questions, or would like to review the ' General Municipal Plan, please contact the M.D. office. Dwight J. Stanford, Municipal Administrator, Box 580, Cardston, AB. T9K 0K0. • JOY SCHOOL: Registrations are now being acc­epted for the fall of 1986=1987 school year. This is a pre-school program designed for 4 year-olds. The curriculum covers such subjects as: The Joy of the Earth, The Joy of Obedience, The Joy of- Hdhesty, The Joy of Imagination and Creativity, The Joy of Goal Striving & Order, The Joy of Friendship, The Joy of Individual Uniqueness, etc. Joy School will be held each Tuesday and Thursday morning or afternoon. Please phone early for your preference as classes will be limited to 10 children. Phone Shirley Edwards, 758-6368 days. Phone Jackie Barnett at 758-3066 evenings. WORK WANTED: Experienced Plumber looking for work. Call Ron McKenzie. 758-3136. GARAGE SALE: Saturday, May 24th, 10 a.m. to 4 p.m. in the Alley behind 175West 1st Ave. Mates bed, tires, truck seat, door's, chord organ, encyclopedias, books, plus much, much more. Phone 758-3096 for more information. NOTICE: St. Joseph's Catholic Sunday School's last session will be Sunday, May 25th, 10 to 11 a.m. WANTED: Empty Tobacco cans or 1.5 1 Empress Peanut Butter cans. Vai Isaacson, 758-6809. Mr. & Mrs. Lindon Bone of Brooks were weekend visitors in Magrath. Mr. & Mrs. Lloyd Handley of Armstrong, B.c. are renewing acquaintances in Magrath and area. Health Unit SPEECH & HEARING FACTS .It is estimated that approximately 5% of the population have speech and language disorders and a com- Speech-Language and Hearing Department Chinook Health Untt. parable number are hearing impaired. Observing: May is Speech & Hearing .Awareness Mont’ . Mrs.jLeta Overn of Edmonton is visiting with relatives and friends in Magrath and dis­trict, the guest of her son-un-law and daughter Roy & Joy Johnson of Spring Coulee. HAVE YOU FORGOTTEN? I have. Some time ago I loaned a large orange Duracel Electric lantern to someone. I'm getting old - I've forgotten who it was - please let me I.?;. if you are the one. B.J. Itasmussen. Ph. 758-3514. FOR RENT: 2. bedroom apartment. Contact Tanco, Phone 758-3404. . The computer ? > a great invention. There are just as any mistakes as ever but they are nobod 's fault. GARDEN PLOUGHING & DISCING. Dt.rric- Passe- Phone 758-3572 SEE THE STANLEY U-INSTALL DELUXE GARAGE DOOR OPENER - complete with 1/3 h.p. motor, digital craasritter with 1024 variable code combination, twin light:, -.-.'id : 11- the momitiug hardware. Save 60.00. $179.99. Hardware Dept. MEALS ON WHEELS NOTICE The Volunteer Committee which now administers the program consists of: Karen Bourne - Chairperson. Jean Butlin - Secretary/Treasurer. Vinessa Hamilton- Driver Co-Ordinator. Mildred Harker - Driver Co-Ordinator. ■ Individuals wishing to receive meals must first visit their physician and have him sign a recommendation form. Recipients are responsible for the cost, of the meals which price is currently set at$4.70 per meal. If you have any concerns regarding thé program or if you have suggestions for improvement, please feel free to con­tact any committee member. Memberships in the Magrath Meals On Wheels Association are available from any committee member at a cost of 1.00 each. We need your support in this vical unity service. conun- FOOTHILLS 4-H BEEF SHOW & SALE Circle the date - June 4th, on your calendar, then plan to support the 4-H members by attending this special event. Members are busy finishing their calves and training them for the ring. A host of leaders and volunteers from the comm­unity are making all the other arrange­ments and tending to necessary details. The activities will be held in the Cardston Agridome. Show time is 1 p.m. Sale time is 7 p.m. Between these events plan to enjoy a scrumptious beef barbecue 3.00. This is a tradition in itself and Crowe certainly does a superb job with beef. Approximately 50 calves will be competing from clubs in Mountain View, Jefferson and Cardston (Chinook). Our other 4-H Beef Club, Del Bonita, will show their calves with the Lethbridge Clubs in Lethbridge on July 3rd. for Jini the Men's Western style Denim Jackets. A choice of lined or unlined styles,- REG. $4 9.95 20Men’s Dress Casuals WESTERN SHIRTS Men's Western Shirts in long or short sleeve. Assorted plaids in a nice selection of colors. Western cut yoke. Snap button trim. REG.$19.95 to $29.95 DENIM JACKETS Hush Puppies in popular casual styled for Men. Oxford tie with beige top. Foam sole, REG.$49.95 3S’5 FOR RENT: Available June 1st, small, clean, 2 bedroom house with full basement. On large lot with nice garden spot. Damage deposit re­quired. Phone 758-3188. Craig Godionton. FOR SALE OR RENT: Older home in Magrath, close in. For more information call 271-3894, Calgary WORK DAY: Magrath Rod & Gun Club will hold a Work Day Saturday, May 31st at Jensen Dam. Camp kitchen re-construction. Work will start at 9 a.m. Lunch served. PRICED FROM •t Men’s Dress Socks in Nylon, Cotten, Wool Blend. Assorted styles and colors. Plain and fancy knits. (1- 1,1« •i J N .«lllildl l1l * 1 TOWN CLEAN UP . May 30th is Town Clean Up. The town will have trucks available for pick up of large items if citizens will contact the Town Office. ROTOTILLING & MOWING - Tod Kendrick. 758-3620 FOR SALE: 45 gal. drums with lids - for food storage or burning barrels. $4.00 each. Phone 758-6602. SENIOR CITIZENS BUS TRIP - to Frank Slide and the Gladstone Ranch on Thursday, June 5th is finalized. The bus will load at the Drop In Centre at 9:15 a.m. to leave at 9:30 a.m. The cost is$20 and should be paid to Wallace Baker by May 21st. Pushing ahead of the housewives wait­ing in line at the supermarket, a smartly dressed woman with only one item hurriedly tried to pay for it. "You don't mind if I get ahead of you just to pay for this one can of dog food, do you?’ she asked the shopper at the head of the line. "Goodness no," was the saccharine answer. "If you're that hungry, go right ahead." . BE SURE TO GET YOUR BEDDING OUT PLANTS WHILE OUR STOCK IS PLENTIFUL. A GOOD ASSORTMENT OF VEGETBALES, FLOWERS, etc. Hardware Dept. Round Steak 63? INSIDE * r Sirloin Tip Roast tender Pork Chops L0IS 30NELESS. ... .. 8» Wieners B „ t K ....... .... • ■ ■ ■ COIL, OLYMPIC suddenly in Milk River of Wednesday, May 14th i986 at the age of 59 years, beloved husband of Mrs. Eunice Minor of Coutts, Alberta. Born, raised and educated in Magrath, Bob served m the Canadian Army for two years dur­ing World War 11. He married Eunice Void on August 8th, 1951 in Magrath. In 1953 they noved to Coutts where Bob worked as a Customs Inspector up to the time of his passing. He was very active in the Coutts United Church. • Besides his loving wife Eunice he is sur­vived by three daughters Mrs. Holly Sekiya of Calgary, Ms. Lori Minor and Mrs. Shelly Good­man both of Edmonton; one son Leonard of Sask­atoon; seven grandchildren; four sisters, Mrs. Louise Dow of Magrath, Mrs. Norma Seward of Choteau, Mont., Mrs. Jean Wyman of Kent, Wash and Mrs. Marilyn Durrant of St. George, Utah. Funeral Services were held in the Coutts United Church Saturday afternoon with Rev. James Ruxton officiating. Interment followed in the Coutts Cemetery. • * 350 ym ***************** Dates for local fairs have been announc­ed - Magrath Agricultural Fair - July 25th Cardston Agricultural Fair - August 8 & 9.' Fair committees are busy with their prep­arations, exhibitors with readying their exhibits. Contact our office for judging standards books and find out what judges look for and how to prepare exhibits. Financial Management Fact Sheets are available to farm families. Ask for your copy of the series which includes: 1. Int­roduction to Financial Planning. 2. Budget­ing. 3. Handling Income. 4. Savings. 5. Banks: Use Them to Your Advantage. 6. Cred­it: Use Only as Directed. 7. Insurance: Risk Management. 8. Planning Your Estate. 9. Protect Family Security: Make,.a Will. Iris Armfelt. D.H.E. Cardston.’ NEW SPORT CO-ORDINATES IN TOPS, SLACKS CAPRI PANTS, JACKETS, BLOUSES FOR SUMMER HOLIDAY WEAR. Ladies Ready-To-Wear Dept. DISTRICT HOME ECONOMIST NEWS galling All Secretaries: My goal in the next little^while is to compile an up-to-date master —st- of a11 the women's organizations, clubs, groups, in my district. To accomplish this I would¿really appreciate it if a contact person from each would either write or phone with these details; name of organization, executive members membership numbers, a contact person - address and the phone number. Thank you in advance for your Cooperation. ' IN_SEARCH OF QUILT EXHIBITORS: Canada Packers supports Provincial Quilt Competitions in sev­eral provinces in Canada. Are we in Alberta also interested in such a competition two - three years from now. If you are please send your name, address and phone number to: Rae Hunter, Program Consultant, Alberta Agri­culture, 201, J.G. O'Donohue Building, 7000 - 113 st. Edmonton, Alberta. There may be three levels of competition - local,; regional/district and provincial. The quilts would be a double bed size. LOOKING AHEAD We’re ever looking for sòme goal Which we may never reach; Experience, to every man A lesson first must teach. We dream of wealth and luxur